POGLUT2

Summary

POGLUT2 (protein O-glucosyltransferase 2, HGNC:19350) is a protein-coding gene on chromosome 13q33.1, encoding Protein O-glucosyltransferase 2 (Q6UW63). Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C.

This gene encodes a protein product localized to the lumen of the endoplasmic reticulum. As a member of the endoplasmic reticulum protein family the encoded protein contains a Lys-Asp-Glu-Leu or KDEL motif located at the extreme C-terminus which prevents all endoplasmic reticulum resident proteins from being secreted. Proteins carrying this motif are bound by a receptor in the Golgi apparatus so that the receptor-ligand complex returns to the endoplasmic reticulum. A processed non-transcribed pseudogene located in an intron of a sodium transporter gene on chromosome 5 has been defined for this gene. This gene has multiple transcript variants which are predicted to encode distinct isoforms.

Source: NCBI Gene 79070 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 87 total
• MANE Select transcript: NM_024089

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19350
Approved symbol	POGLUT2
Name	protein O-glucosyltransferase 2
Location	13q33.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC5302, EP58
Ensembl gene	ENSG00000134901
Ensembl biotype	protein_coding
OMIM	611613
Entrez	79070

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 8 protein_coding, 4 retained_intron, 2 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000376004, ENST00000460338, ENST00000484943, ENST00000486540, ENST00000706516, ENST00000706517, ENST00000706518, ENST00000706519, ENST00000706520, ENST00000706521, ENST00000706522, ENST00000884207, ENST00000884208, ENST00000933311, ENST00000933312, ENST00000957245

RefSeq mRNA: 2 — MANE Select: NM_024089 NM_001318732, NM_024089

CCDS: CCDS9504

Canonical transcript exons

ENST00000376004 — 10 exons

Exon	Start	End
ENSE00000686125	102791258	102791430
ENSE00001469134	102798489	102798976
ENSE00001832927	102784281	102784512
ENSE00003459379	102787834	102787923
ENSE00003563213	102786232	102786339
ENSE00003602958	102789012	102789221
ENSE00003637326	102793601	102793806
ENSE00003661664	102790901	102791138
ENSE00003678111	102796804	102797009
ENSE00003679201	102793341	102793418

Expression profiles

Bgee: expression breadth ubiquitous, 226 present calls, max score 86.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.5500 / max 82.4776, expressed in 1532 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
138111	8.0869	1505
138110	1.4631	834

Top tissues by expression

268 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	86.86	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.66	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.29	gold quality
cartilage tissue	UBERON:0002418	83.71	gold quality
secondary oocyte	CL:0000655	83.69	gold quality
smooth muscle tissue	UBERON:0001135	82.97	gold quality
tibia	UBERON:0000979	82.49	gold quality
oocyte	CL:0000023	82.45	gold quality
ventricular zone	UBERON:0003053	82.02	gold quality
periodontal ligament	UBERON:0008266	80.68	gold quality
body of uterus	UBERON:0009853	80.68	gold quality
gall bladder	UBERON:0002110	79.93	gold quality
myometrium	UBERON:0001296	79.92	gold quality
ganglionic eminence	UBERON:0004023	79.45	gold quality
endometrium	UBERON:0001295	79.06	gold quality
embryo	UBERON:0000922	78.49	gold quality
right ovary	UBERON:0002118	78.40	gold quality
thoracic aorta	UBERON:0001515	78.05	gold quality
ascending aorta	UBERON:0001496	78.03	gold quality
pigmented layer of retina	UBERON:0001782	77.98	gold quality
uterus	UBERON:0000995	77.95	gold quality
left coronary artery	UBERON:0001626	77.59	gold quality
descending thoracic aorta	UBERON:0002345	77.44	gold quality
ovary	UBERON:0000992	77.01	gold quality
calcaneal tendon	UBERON:0003701	76.87	gold quality
tendon of biceps brachii	UBERON:0008188	76.86	silver quality
left ovary	UBERON:0002119	76.80	gold quality
parietal pleura	UBERON:0002400	76.80	gold quality
coronary artery	UBERON:0001621	76.56	gold quality
endocervix	UBERON:0000458	76.46	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.97
E-MTAB-6911	no	233.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

32 targeting POGLUT2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-3663-3P	99.84	70.39	798
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-12129	99.72	67.45	1311
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-548AV-5P	99.60	70.84	2107
HSA-MIR-548K	99.60	70.84	2107
HSA-MIR-217-5P	99.49	69.93	1419
HSA-MIR-8054	99.48	70.81	2084
HSA-MIR-377-3P	99.37	70.18	1905
HSA-MIR-6807-3P	99.15	69.23	1275
HSA-MIR-4705	99.10	69.10	1091
HSA-MIR-876-3P	98.76	68.23	945
HSA-MIR-6501-3P	98.71	67.45	1480
HSA-MIR-509-3-5P	97.21	67.74	1517

Literature-anchored findings (GeneRIF, showing 3)

• This paper reports data on mouse Kdelc1 (PMID:11167020)
• Our results suggest that GA733-2-Fc conjugated to ER-retention motif KDEL is a more efficient antigen to prevent tumor growth induced by colorectal carcinoma and minimize an allergic response. (PMID:30249898)
• POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1. (PMID:34411563)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	poglut2	ENSDARG00000031971
mus_musculus	Poglut2	ENSMUSG00000026047
rattus_norvegicus	Poglut2	ENSRNOG00000011740

Paralogs (2): POGLUT1 (ENSG00000163389), POGLUT3 (ENSG00000178202)

Protein

Protein identifiers

Protein O-glucosyltransferase 2 — Q6UW63 (reviewed: Q6UW63)

Alternative names: Endoplasmic reticulum resident protein 58, KDEL motif-containing protein 1, Protein O-xylosyltransferase POGLUT2

All UniProt accessions (5): A0A9L9PX85, A0A9L9PXK3, A0A9L9PXM5, A0A9L9PY35, Q6UW63

UniProt curated annotations — full annotation on UniProt →

Function. Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway.

Subcellular location. Endoplasmic reticulum lumen.

Post-translational modifications. N-glycosylated.

Pathway. Protein modification; protein glycosylation.

Similarity. Belongs to the KDELC family.

RefSeq proteins (2): NP_001305661, NP_076994* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001298	Filamin/ABP280_rpt	Repeat
IPR006598	CAP10	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR014756	Ig_E-set	Homologous_superfamily
IPR017868	Filamin/ABP280_rpt-like	Repeat
IPR051091	O-Glucosyltr/Glycosyltrsf_90	Family

Pfam: PF00630, PF05686

Catalyzed reactions (Rhea), 2 shown:

• L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+) (RHEA:58116)
• L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+) (RHEA:62016)

UniProt features (17 total): strand 7, glycosylation site 2, sequence conflict 2, signal peptide 1, chain 1, repeat 1, short sequence motif 1, sequence variant 1, turn 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
9W47	X-RAY DIFFRACTION	1.79
2DI7	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6UW63-F1	92.77	0.88

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 302, 414

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 173 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, MODULE_255, MODULE_317, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS, MODULE_206, DODD_NASOPHARYNGEAL_CARCINOMA_UP, JAATINEN_HEMATOPOIETIC_STEM_CELL_UP, IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR, MILI_PSEUDOPODIA_CHEMOTAXIS_DN, GOBP_PROTEIN_O_LINKED_GLYCOSYLATION, GOBP_GLYCOPROTEIN_METABOLIC_PROCESS, GOCC_ENDOPLASMIC_RETICULUM_LUMEN, MODULE_69

GO Biological Process (3): protein O-linked glycosylation via glucose (GO:0180059), obsolete protein glycosylation (GO:0006486), obsolete protein O-linked glycosylation via serine (GO:0018242)

GO Molecular Function (8): UDP-glucosyltransferase activity (GO:0035251), UDP-xylosyltransferase activity (GO:0035252), glucosyltransferase activity (GO:0046527), EGF-domain serine glucosyltransferase activity (GO:0140561), EGF-domain serine xylosyltransferase activity (GO:0140562), protein binding (GO:0005515), transferase activity (GO:0016740), glycosyltransferase activity (GO:0016757)

GO Cellular Component (5): nucleoplasm (GO:0005654), endoplasmic reticulum lumen (GO:0005788), cytosol (GO:0005829), endomembrane system (GO:0012505), endoplasmic reticulum (GO:0005783)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
UDP-glycosyltransferase activity	2
cytoplasm	2
protein O-linked glycosylation	1
glucosyltransferase activity	1
xylosyltransferase activity	1
hexosyltransferase activity	1
UDP-glucosyltransferase activity	1
UDP-xylosyltransferase activity	1
binding	1
catalytic activity	1
transferase activity	1
nuclear lumen	1
endoplasmic reticulum	1
intracellular organelle lumen	1
vacuole	1
plasma membrane	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

396 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
POGLUT2	FLNA	P21333	808
POGLUT2	POFUT1	Q9H488	643
POGLUT2	GXYLT1	Q4G148	628
POGLUT2	GXYLT2	A0PJZ3	607
POGLUT2	XXYLT1	Q8NBI6	590
POGLUT2	BIVM	Q86UB2	541
POGLUT2	EOGT	Q5NDL2	520
POGLUT2	EGF	P01133	472
POGLUT2	POGLUT3	Q7Z4H8	394
POGLUT2	NOTCH3	Q9UM47	355
POGLUT2	ZNF607	Q96SK3	348
POGLUT2	XYLT1	Q86Y38	313
POGLUT2	ZC3H12C	Q9C0D7	301
POGLUT2	COLGALT1	Q8NBJ5	300
POGLUT2	DPY19L1	Q2PZI1	300
POGLUT2	UNC5A	Q6ZN44	300

IntAct

66 interactions, top by confidence:

A	B	Type	Score
B3GNT3	PGRMC1	psi-mi:“MI:0914”(association)	0.670
CALCOCO2	TBKBP1	psi-mi:“MI:0914”(association)	0.640
BMP1	TLL1	psi-mi:“MI:0914”(association)	0.530
	PLOD2	psi-mi:“MI:0914”(association)	0.530
ELSPBP1	PFDN1	psi-mi:“MI:0914”(association)	0.530
C1orf54	EXTL3	psi-mi:“MI:0914”(association)	0.530
POGLUT2	GOLGA4	psi-mi:“MI:0915”(physical association)	0.400
Ankrd28	PPP6R3	psi-mi:“MI:0914”(association)	0.350
CUL2	ANXA2P2	psi-mi:“MI:0914”(association)	0.350
CUL3	PXDNL	psi-mi:“MI:0914”(association)	0.350
TAZ	MANBA	psi-mi:“MI:0914”(association)	0.350
LOXL3	MSI1	psi-mi:“MI:0914”(association)	0.350
MFAP4	CRLF1	psi-mi:“MI:0914”(association)	0.350
PDGFRA	GXYLT2	psi-mi:“MI:0914”(association)	0.350
SCGB2A2	RTL8C	psi-mi:“MI:0914”(association)	0.350
TAFAZZIN	MANBA	psi-mi:“MI:0914”(association)	0.350
TRAV20	MAP2K7	psi-mi:“MI:0914”(association)	0.350
LCN6	COCH	psi-mi:“MI:0914”(association)	0.350
POGLUT2	HSPA5	psi-mi:“MI:0914”(association)	0.350
ITGB8	TARS3	psi-mi:“MI:0914”(association)	0.350
TMEM106A	TMEM131L	psi-mi:“MI:0914”(association)	0.350
BRICD5	TMEM131L	psi-mi:“MI:0914”(association)	0.350
LY86	TMEM131L	psi-mi:“MI:0914”(association)	0.350
PTCH1	TMEM131L	psi-mi:“MI:0914”(association)	0.350
GML	POTEF	psi-mi:“MI:0914”(association)	0.350
IL5RA	POTEF	psi-mi:“MI:0914”(association)	0.350
LCN6	POTEF	psi-mi:“MI:0914”(association)	0.350
LYPD4	POTEF	psi-mi:“MI:0914”(association)	0.350

BioGRID (85): KDELC1 (Affinity Capture-MS), KDELC1 (Affinity Capture-MS), KDELC1 (Synthetic Lethality), KDELC1 (Affinity Capture-MS), KDELC1 (Affinity Capture-MS), KDELC1 (Affinity Capture-MS), KDELC1 (Affinity Capture-MS), KDELC1 (Affinity Capture-MS), KDELC1 (Affinity Capture-MS), KDELC1 (Protein-RNA), KDELC1 (Proximity Label-MS), KDELC1 (Proximity Label-MS), KDELC1 (Affinity Capture-MS), KDELC1 (Proximity Label-MS), KDELC1 (Proximity Label-MS)

ESM2 similar proteins: A4IID1, A5D7I4, A9X1C8, O77836, O95461, O95803, P38649, P97464, Q13822, Q16394, Q4R854, Q5F407, Q5IGR8, Q5M854, Q5RBC3, Q5REP8, Q5U4X8, Q659X0, Q66PG2, Q66PG3, Q6EV76, Q6EV77, Q6GMK0, Q6GQI7, Q6GQK9, Q6IS24, Q6KFX9, Q6UW63, Q7TT15, Q812F8, Q812G0, Q86X52, Q8BJQ9, Q8HY56, Q8HYB2, Q8IYK4, Q8N6G5, Q8SPR2, Q8TDX6, Q9BYC5

Diamond homologs: A0NDG6, B0X1Q4, G3V9D0, G5E897, Q16QY8, Q29AU6, Q566E5, Q5E9Q1, Q6UW63, Q7Z4H8, Q7ZVE6, Q8BYB9, Q8NBL1, Q8T045, Q9JHP7, Q5K8R6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 89 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Metabolism of carbohydrates and carbohydrate derivatives	5	10.5×	9e-03
Neutrophil degranulation	12	4.9×	6e-04

GO biological processes:

GO term	Partners	Fold	FDR
collagen fibril organization	6	16.4×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

87 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	74
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1785 predictions. Top by Δscore:

Variant	Effect	Δscore
13:102789007:CTTA:C	donor_loss	1.0000
13:102789008:TTAC:T	donor_loss	1.0000
13:102789009:TA:T	donor_loss	1.0000
13:102789010:A:C	donor_loss	1.0000
13:102789011:C:CG	donor_loss	1.0000
13:102789220:TG:T	acceptor_gain	1.0000
13:102791250:T:C	donor_gain	1.0000
13:102791426:TTCAC:T	acceptor_gain	1.0000
13:102791428:CAC:C	acceptor_gain	1.0000
13:102791429:ACC:A	acceptor_loss	1.0000
13:102791431:C:CC	acceptor_gain	1.0000
13:102791431:CTAG:C	acceptor_loss	1.0000
13:102791432:T:A	acceptor_loss	1.0000
13:102793335:ACTT:A	donor_loss	1.0000
13:102793336:CTTA:C	donor_loss	1.0000
13:102793337:TTA:T	donor_loss	1.0000
13:102793338:TA:T	donor_loss	1.0000
13:102793340:C:CT	donor_loss	1.0000
13:102793595:TTGTA:T	donor_loss	1.0000
13:102793596:TGTA:T	donor_loss	1.0000
13:102793597:GTAC:G	donor_loss	1.0000
13:102793598:TACC:T	donor_loss	1.0000
13:102793599:ACC:A	donor_loss	1.0000
13:102793600:C:CT	donor_loss	1.0000
13:102793802:CGGCC:C	acceptor_gain	1.0000
13:102793803:GGCC:G	acceptor_gain	1.0000
13:102793804:GCC:G	acceptor_gain	1.0000
13:102793805:CC:C	acceptor_gain	1.0000
13:102793805:CCC:C	acceptor_gain	1.0000
13:102793805:CCCTA:C	acceptor_loss	1.0000

AlphaMissense

3350 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:102791065:A:G	W307R	1.000
13:102791065:A:T	W307R	1.000
13:102791390:T:A	D238V	1.000
13:102793383:A:C	F210L	1.000
13:102793383:A:T	F210L	1.000
13:102793385:A:G	F210L	1.000
13:102791048:G:C	S312R	0.999
13:102791048:G:T	S312R	0.999
13:102791050:T:G	S312R	0.999
13:102791053:C:G	D311H	0.999
13:102791055:C:G	R310P	0.999
13:102791058:C:T	G309E	0.999
13:102791059:C:A	G309W	0.999
13:102791059:C:G	G309R	0.999
13:102791059:C:T	G309R	0.999
13:102791313:C:G	D264H	0.999
13:102791332:A:C	C257W	0.999
13:102791337:A:G	W256R	0.999
13:102791337:A:T	W256R	0.999
13:102791389:G:C	D238E	0.999
13:102791389:G:T	D238E	0.999
13:102791390:T:C	D238G	0.999
13:102791390:T:G	D238A	0.999
13:102791391:C:G	D238H	0.999
13:102791398:A:C	N235K	0.999
13:102791398:A:T	N235K	0.999
13:102793374:G:C	F213L	0.999
13:102793374:G:T	F213L	0.999
13:102793376:A:G	F213L	0.999
13:102793384:A:C	F210C	0.999

dbSNP variants (sampled 300 via entrez): RS1000152944 (13:102797996 A>G), RS1000173440 (13:102800346 G>C), RS1000289572 (13:102800108 G>A), RS1000801366 (13:102786981 T>C), RS1000926456 (13:102792983 C>G), RS1001233756 (13:102786667 A>C,T), RS1001249005 (13:102786057 C>T), RS1001295254 (13:102798873 G>C), RS1001301370 (13:102785826 A>G), RS1001561098 (13:102799146 T>A), RS1001671953 (13:102786075 T>C), RS1001791115 (13:102792599 A>G), RS1002274119 (13:102787302 C>T), RS1002299502 (13:102797753 A>C,T), RS1002306712 (13:102787039 T>C,G)

Disease associations

OMIM: gene MIM:611613 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	4
bisphenol A	decreases expression, affects cotreatment, increases expression	2
sodium arsenite	decreases expression	2
Tetrachlorodibenzodioxin	decreases expression	2
Cadmium Chloride	decreases expression	2
bisphenol F	affects cotreatment, increases expression	1
dicrotophos	decreases expression	1
kojic acid	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
nickel sulfate	decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
abrine	decreases expression	1
NSC 689534	affects binding, decreases expression	1
Zoledronic Acid	decreases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, decreases expression	1
Arbutin	increases expression	1
Copper	affects binding, decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Diazinon	increases methylation	1
Dimethyl Sulfoxide	increases expression	1
Doxorubicin	affects expression	1
Indomethacin	affects cotreatment, increases expression	1
Iron	increases expression	1
Ivermectin	decreases expression	1
Quercetin	decreases expression	1
Urethane	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Cyclosporine	decreases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.