POGLUT3

Summary

POGLUT3 (protein O-glucosyltransferase 3, HGNC:28496) is a protein-coding gene on chromosome 11q22.3, encoding Protein O-glucosyltransferase 3 (Q7Z4H8). Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C.

Enables UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Involved in protein O-linked glycosylation via serine. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system.

Source: NCBI Gene 143888 — RefSeq curated summary.

At a glance

• GWAS associations: 17
• Clinical variants (ClinVar): 77 total
• MANE Select transcript: NM_153705

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28496
Approved symbol	POGLUT3
Name	protein O-glucosyltransferase 3
Location	11q22.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC33424
Ensembl gene	ENSG00000178202
Ensembl biotype	protein_coding
OMIM	618503
Entrez	143888

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000323468, ENST00000434945, ENST00000524787, ENST00000530318, ENST00000530529, ENST00000532730, ENST00000706523, ENST00000706524, ENST00000706525

RefSeq mRNA: 3 — MANE Select: NM_153705 NM_001363502, NM_001363503, NM_153705

CCDS: CCDS41711

Canonical transcript exons

ENST00000323468 — 8 exons

Exon	Start	End
ENSE00001291189	108482006	108482222
ENSE00001294164	108498165	108498384
ENSE00001305657	108479301	108479495
ENSE00001322032	108481180	108481376
ENSE00001329287	108490970	108491167
ENSE00002151080	108472116	108474952
ENSE00003493170	108486157	108486440
ENSE00003647984	108477607	108477711

Expression profiles

Bgee: expression breadth ubiquitous, 240 present calls, max score 95.20.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.9988 / max 136.0063, expressed in 1723 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
122150	10.1223	1674
122152	1.9870	1078
122151	1.3411	863
122153	0.5343	337
122148	0.0140	10

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	95.20	gold quality
placenta	UBERON:0001987	94.56	gold quality
tendon	UBERON:0000043	93.67	gold quality
smooth muscle tissue	UBERON:0001135	93.56	gold quality
stromal cell of endometrium	CL:0002255	93.22	gold quality
tendon of biceps brachii	UBERON:0008188	93.10	gold quality
layer of synovial tissue	UBERON:0007616	92.84	gold quality
cardiac muscle of right atrium	UBERON:0003379	92.82	gold quality
descending thoracic aorta	UBERON:0002345	91.77	gold quality
upper arm skin	UBERON:0004263	91.66	silver quality
thoracic aorta	UBERON:0001515	91.60	gold quality
ascending aorta	UBERON:0001496	91.50	gold quality
right coronary artery	UBERON:0001625	90.94	gold quality
gall bladder	UBERON:0002110	90.21	gold quality
left uterine tube	UBERON:0001303	90.11	gold quality
endocervix	UBERON:0000458	90.05	gold quality
synovial joint	UBERON:0002217	90.05	gold quality
superficial temporal artery	UBERON:0001614	89.96	gold quality
corpus epididymis	UBERON:0004359	89.89	gold quality
cauda epididymis	UBERON:0004360	89.89	gold quality
aorta	UBERON:0000947	89.84	gold quality
body of uterus	UBERON:0009853	89.84	gold quality
ventricular zone	UBERON:0003053	89.83	gold quality
urethra	UBERON:0000057	89.82	gold quality
uterine cervix	UBERON:0000002	89.60	gold quality
colonic epithelium	UBERON:0000397	89.26	gold quality
uterus	UBERON:0000995	89.17	gold quality
endometrium	UBERON:0001295	89.16	gold quality
myometrium	UBERON:0001296	88.73	gold quality
left coronary artery	UBERON:0001626	88.67	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.74
E-CURD-88	no	597.36

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

119 targeting POGLUT3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-656-3P	100.00	72.15	2788
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-450B-5P	99.92	71.48	3175

Literature-anchored findings (GeneRIF, showing 1)

• POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1. (PMID:34411563)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	poglut3	ENSDARG00000021408
mus_musculus	Poglut3	ENSMUSG00000034487
rattus_norvegicus	Poglut3	ENSRNOG00000007177

Paralogs (2): POGLUT2 (ENSG00000134901), POGLUT1 (ENSG00000163389)

Protein

Protein identifiers

Protein O-glucosyltransferase 3 — Q7Z4H8 (reviewed: Q7Z4H8)

Alternative names: KDEL motif-containing protein 2, Protein O-xylosyltransferase POGLUT3

All UniProt accessions (4): Q7Z4H8, A0A9L9PX09, A0A9L9PY40, H0YEM3

UniProt curated annotations — full annotation on UniProt →

Function. Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway.

Subcellular location. Endoplasmic reticulum lumen.

Pathway. Protein modification; protein glycosylation.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the KDELC family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q7Z4H8-1	1	yes
Q7Z4H8-2	2
Q7Z4H8-3	3

RefSeq proteins (3): NP_001350431, NP_001350432, NP_714916* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001298	Filamin/ABP280_rpt	Repeat
IPR006598	CAP10	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR014756	Ig_E-set	Homologous_superfamily
IPR017868	Filamin/ABP280_rpt-like	Repeat
IPR051091	O-Glucosyltr/Glycosyltrsf_90	Family

Pfam: PF00630, PF05686

Catalyzed reactions (Rhea), 2 shown:

• L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+) (RHEA:58116)
• L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+) (RHEA:62016)

UniProt features (18 total): sequence conflict 7, splice variant 4, glycosylation site 2, signal peptide 1, chain 1, sequence variant 1, repeat 1, short sequence motif 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z4H8-F1	93.16	0.88

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 61, 306

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 138 (showing top): WHITEHURST_PACLITAXEL_SENSITIVITY, chr11q22, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS, FREDERICK_PRKCI_TARGETS, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5, DOUGLAS_BMI1_TARGETS_UP, GOBP_PROTEIN_O_LINKED_GLYCOSYLATION, GOBP_GLYCOPROTEIN_METABOLIC_PROCESS, SENESE_HDAC3_TARGETS_DN, GOCC_ENDOPLASMIC_RETICULUM_LUMEN, MARSON_BOUND_BY_FOXP3_STIMULATED, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, MASSARWEH_TAMOXIFEN_RESISTANCE_UP, GOMF_HEXOSYLTRANSFERASE_ACTIVITY

GO Biological Process (3): protein O-linked glycosylation via glucose (GO:0180059), obsolete protein glycosylation (GO:0006486), obsolete protein O-linked glycosylation via serine (GO:0018242)

GO Molecular Function (8): UDP-glucosyltransferase activity (GO:0035251), UDP-xylosyltransferase activity (GO:0035252), glucosyltransferase activity (GO:0046527), EGF-domain serine glucosyltransferase activity (GO:0140561), EGF-domain serine xylosyltransferase activity (GO:0140562), protein binding (GO:0005515), transferase activity (GO:0016740), glycosyltransferase activity (GO:0016757)

GO Cellular Component (3): endoplasmic reticulum lumen (GO:0005788), endomembrane system (GO:0012505), endoplasmic reticulum (GO:0005783)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
UDP-glycosyltransferase activity	2
protein O-linked glycosylation	1
glucosyltransferase activity	1
xylosyltransferase activity	1
hexosyltransferase activity	1
UDP-glucosyltransferase activity	1
UDP-xylosyltransferase activity	1
binding	1
catalytic activity	1
transferase activity	1
endoplasmic reticulum	1
intracellular organelle lumen	1
vacuole	1
plasma membrane	1
cellular anatomical structure	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

560 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
POGLUT3	POFUT1	Q9H488	625
POGLUT3	C11orf65	Q8NCR3	615
POGLUT3	GXYLT1	Q4G148	575
POGLUT3	NPAT	Q14207	573
POGLUT3	ELMOD1	Q8N336	554
POGLUT3	EOGT	Q5NDL2	515
POGLUT3	EXPH5	Q8NEV8	487
POGLUT3	GXYLT2	A0PJZ3	479
POGLUT3	XXYLT1	Q8NBI6	475
POGLUT3	SLC35F2	Q8IXU6	446
POGLUT3	POGLUT2	Q6UW63	394
POGLUT3	TMEM40	Q8WWA1	366
POGLUT3	NOTCH3	Q9UM47	343
POGLUT3	CUL5	Q93034	343
POGLUT3	TMEM243	Q9BU79	343

IntAct

42 interactions, top by confidence:

A	B	Type	Score
FBXO6	MAN2B1	psi-mi:“MI:0914”(association)	0.640
CRIPTO	AIP	psi-mi:“MI:0914”(association)	0.640
	PLOD2	psi-mi:“MI:0914”(association)	0.530
FBXO2	TMEM131L	psi-mi:“MI:0914”(association)	0.530
BMP1	TLL1	psi-mi:“MI:0914”(association)	0.530
TMEM106A	B4GALT3	psi-mi:“MI:0914”(association)	0.530
POGLUT3	TUFM	psi-mi:“MI:0915”(physical association)	0.400
POGLUT3	HSPA5	psi-mi:“MI:0915”(physical association)	0.400
POGLUT3	CFTR	psi-mi:“MI:0915”(physical association)	0.370
CFTR	POGLUT3	psi-mi:“MI:0915”(physical association)	0.370
M		psi-mi:“MI:0914”(association)	0.350
CANX	HLA-A	psi-mi:“MI:0914”(association)	0.350
PDGFRA	GXYLT2	psi-mi:“MI:0914”(association)	0.350
LLCFC1	POTEF	psi-mi:“MI:0914”(association)	0.350
SCGB2A2	RTL8C	psi-mi:“MI:0914”(association)	0.350
C1QTNF7	AGRN	psi-mi:“MI:0914”(association)	0.350
NAAA	HAX1	psi-mi:“MI:0914”(association)	0.350
MFAP4	QSOX1	psi-mi:“MI:0914”(association)	0.350
PRG2	QSOX1	psi-mi:“MI:0914”(association)	0.350
CBLN4	AGRN	psi-mi:“MI:0914”(association)	0.350
LILRA5	HGS	psi-mi:“MI:0914”(association)	0.350
ST8SIA5	CLGN	psi-mi:“MI:0914”(association)	0.350
TMEM25	CRLF1	psi-mi:“MI:0914”(association)	0.350
ENPP7	PDIA4	psi-mi:“MI:0914”(association)	0.350
SP6	GPX1	psi-mi:“MI:0914”(association)	0.350
PRSS50	TUBB	psi-mi:“MI:0914”(association)	0.350

BioGRID (90): KDELC2 (Affinity Capture-MS), KDELC2 (Affinity Capture-MS), KDELC2 (Proximity Label-MS), VWA1 (Affinity Capture-MS), KDELC2 (Affinity Capture-MS), KDELC2 (Co-fractionation), KDELC2 (Co-fractionation), KDELC2 (Co-fractionation), KDELC2 (Co-fractionation), GRHPR (Co-fractionation), KDELC2 (Co-fractionation), KDELC2 (Co-fractionation), KDELC2 (Co-fractionation), KDELC2 (Co-fractionation), KDELC2 (Co-fractionation)

ESM2 similar proteins: A4IID1, A5D7I4, A5PK45, A9X1C8, G5E897, O12971, O60568, O77783, O95803, P52848, P52849, P52850, P70428, P97464, Q02353, Q16394, Q3UHN9, Q5F407, Q5IGR6, Q5IGR7, Q5IGR8, Q5M854, Q5R6K5, Q5RBC3, Q5U367, Q5U4X8, Q6EV56, Q6GMK0, Q6GQI7, Q6GQK9, Q6IS24, Q6UW63, Q6ZQ11, Q7TT15, Q7Z4H8, Q812F8, Q86X52, Q8K297, Q8NBJ5, Q8VHI3

Diamond homologs: A0NDG6, B0X1Q4, G3V9D0, G5E897, Q16QY8, Q29AU6, Q566E5, Q5E9Q1, Q6UW63, Q7Z4H8, Q7ZVE6, Q8BYB9, Q8NBL1, Q8T045, Q9JHP7, Q5K8R6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 56 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
ERAD pathway	6	21.7×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

77 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	66
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1151 predictions. Top by Δscore:

Variant	Effect	Δscore
11:108474959:C:CT	acceptor_gain	1.0000
11:108474960:G:C	acceptor_gain	1.0000
11:108477603:TGAC:T	donor_loss	1.0000
11:108477604:GACC:G	donor_loss	1.0000
11:108477605:A:AT	donor_loss	1.0000
11:108477606:C:A	donor_loss	1.0000
11:108477633:AAAG:A	donor_gain	1.0000
11:108477707:TTTTC:T	acceptor_gain	1.0000
11:108477708:TTTC:T	acceptor_gain	1.0000
11:108477710:TC:T	acceptor_gain	1.0000
11:108477711:CC:C	acceptor_gain	1.0000
11:108477713:T:G	acceptor_loss	1.0000
11:108477719:G:C	acceptor_gain	1.0000
11:108477720:T:C	acceptor_gain	1.0000
11:108477720:T:TC	acceptor_gain	1.0000
11:108479363:T:TA	donor_gain	1.0000
11:108479492:TGTA:T	acceptor_gain	1.0000
11:108479496:C:CC	acceptor_gain	1.0000
11:108479503:A:AC	acceptor_gain	1.0000
11:108479503:A:C	acceptor_gain	1.0000
11:108481175:CATA:C	donor_loss	1.0000
11:108481176:ATAC:A	donor_loss	1.0000
11:108481177:TAC:T	donor_loss	1.0000
11:108481178:A:C	donor_loss	1.0000
11:108481179:C:CA	donor_loss	1.0000
11:108481261:T:TA	donor_gain	1.0000
11:108481377:C:CA	acceptor_loss	1.0000
11:108481378:T:A	acceptor_loss	1.0000
11:108482014:C:A	donor_gain	1.0000
11:108486299:T:TA	donor_gain	1.0000

AlphaMissense

3305 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:108486199:G:C	F214L	0.995
11:108486199:G:T	F214L	0.995
11:108486201:A:G	F214L	0.995
11:108479461:G:T	A378D	0.993
11:108481324:G:C	S318R	0.993
11:108481324:G:T	S318R	0.993
11:108481326:T:G	S318R	0.993
11:108481339:G:C	F313L	0.993
11:108481339:G:T	F313L	0.993
11:108481341:A:G	F313L	0.993
11:108481358:T:A	K307I	0.992
11:108486190:G:C	F217L	0.992
11:108486190:G:T	F217L	0.992
11:108486192:A:G	F217L	0.992
11:108481329:C:G	D317H	0.991
11:108481357:T:A	K307N	0.991
11:108481357:T:G	K307N	0.991
11:108482123:A:G	W262R	0.991
11:108482123:A:T	W262R	0.991
11:108481312:C:A	R322S	0.988
11:108481312:C:G	R322S	0.988
11:108482181:A:C	D242E	0.988
11:108482181:A:T	D242E	0.988
11:108482182:T:A	D242V	0.988
11:108482182:T:C	D242G	0.988
11:108482182:T:G	D242A	0.988
11:108479452:C:G	R381T	0.987
11:108482183:C:G	D242H	0.987
11:108481313:C:A	R322M	0.986
11:108479490:C:A	K368N	0.985

dbSNP variants (sampled 300 via entrez): RS1000007132 (11:108482662 C>T), RS1000282722 (11:108488683 A>C), RS1000353504 (11:108495743 T>C), RS1000386513 (11:108495999 G>A,T), RS1000405849 (11:108496075 T>C), RS1000424642 (11:108488606 A>G), RS1000560731 (11:108474406 C>A,T), RS1000899291 (11:108483886 C>G), RS1000911927 (11:108483942 G>A,T), RS1001011796 (11:108484247 A>G), RS1001047174 (11:108484181 T>C), RS1001164232 (11:108476237 G>A,T), RS1001233073 (11:108495329 C>G), RS1001255677 (11:108488186 A>G), RS1001291686 (11:108488184 C>T)

Disease associations

OMIM: gene MIM:618503 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

17 associations (top):

Study	Trait	p-value
GCST004601_159	Red blood cell count	2.000000e-11
GCST004602_201	Mean corpuscular volume	2.000000e-17
GCST004710_6	Renal cell carcinoma	2.000000e-10
GCST005075_1	Breast Cancer in BRCA1 mutation carriers	2.000000e-06
GCST005075_6	Breast Cancer in BRCA1 mutation carriers	1.000000e-06
GCST005076_14	Breast cancer (estrogen-receptor negative)	4.000000e-08
GCST005076_19	Breast cancer (estrogen-receptor negative)	2.000000e-06
GCST005077_10	Breast cancer	5.000000e-11
GCST005077_3	Breast cancer	4.000000e-13
GCST006585_1607	Blood protein levels	1.000000e-68
GCST007250_11	Nonunion in individuals with fractures	3.000000e-07
GCST009158_30	Uterine fibroids	1.000000e-27
GCST010002_248	Refractive error	4.000000e-19
GCST011378_4	Brain-derived neurotrophic factor levels	2.000000e-10
GCST90002390_41	Mean corpuscular hemoglobin	1.000000e-40
GCST90002396_502	Mean reticulocyte volume	2.000000e-21
GCST90002400_473	Plateletcrit	2.000000e-33

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004305	erythrocyte count
EFO:0009707	fractures, ununited
EFO:0011018	brain-derived neurotrophic factor measurement
EFO:0004527	mean corpuscular hemoglobin
EFO:0010701	mean reticulocyte volume
EFO:0007985	platelet crit

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	decreases expression, increases expression	3
sodium arsenite	decreases expression, increases expression	2
Acetaminophen	decreases expression	2
Cisplatin	affects cotreatment, decreases expression, increases expression	2
Valproic Acid	affects expression, decreases expression	2
Aflatoxin B1	decreases methylation	2
Particulate Matter	increases expression, affects cotreatment, increases abundance	2
bisphenol F	increases expression	1
pirinixic acid	affects binding, increases activity, increases expression	1
bisphenol A	increases expression	1
cobaltous chloride	decreases expression	1
isobutyl alcohol	affects cotreatment, increases abundance, increases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
NSC 689534	affects binding, decreases expression	1
Sunitinib	decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Azathioprine	decreases expression	1
Benzo(a)pyrene	increases expression	1
Copper	decreases expression, affects binding	1
Diuron	decreases expression	1
Folic Acid	affects cotreatment, decreases expression	1
Gasoline	affects cotreatment, increases abundance, increases expression	1
Ivermectin	decreases expression	1
Methotrexate	affects cotreatment, decreases expression	1
Naled	affects expression	1
Polycyclic Aromatic Hydrocarbons	increases expression, affects cotreatment, increases abundance	1
Quercetin	decreases expression	1
Smoke	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.