POLH-AS1

Summary

POLH-AS1 (POLH antisense RNA 1, HGNC:40459) is a long non-coding RNA gene on chromosome 6p21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40459
Approved symbol	POLH-AS1
Name	POLH antisense RNA 1
Location	6p21.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP3-337H4.8
Ensembl gene	ENSG00000203362
Ensembl biotype	lncRNA
Entrez	111216283
RNAcentral	URS000041CE64 — lncRNA, 990 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000417591

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417591 — 2 exons

Exon	Start	End
ENSE00001595209	43590890	43591362
ENSE00001776781	43588230	43588746

Expression profiles

Bgee: expression breadth ubiquitous, 176 present calls, max score 74.01.

Top tissues by expression

218 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	74.01	silver quality
sural nerve	UBERON:0015488	69.76	gold quality
colonic epithelium	UBERON:0000397	67.73	silver quality
vena cava	UBERON:0004087	66.83	silver quality
ventricular zone	UBERON:0003053	66.65	gold quality
ganglionic eminence	UBERON:0004023	64.83	gold quality
tendon of biceps brachii	UBERON:0008188	64.77	gold quality
cortical plate	UBERON:0005343	64.50	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	63.98	silver quality
adrenal tissue	UBERON:0018303	63.87	gold quality
cerebellar vermis	UBERON:0004720	63.53	silver quality
cartilage tissue	UBERON:0002418	62.80	gold quality
body of pancreas	UBERON:0001150	62.30	gold quality
skeletal muscle tissue	UBERON:0001134	61.00	silver quality
stromal cell of endometrium	CL:0002255	60.76	gold quality
sperm	CL:0000019	59.87	silver quality
esophagus squamous epithelium	UBERON:0006920	59.85	gold quality
parotid gland	UBERON:0001831	59.67	gold quality
muscle tissue	UBERON:0002385	59.54	silver quality
pancreas	UBERON:0001264	59.37	gold quality
monocyte	CL:0000576	59.14	gold quality
pons	UBERON:0000988	58.95	gold quality
deltoid	UBERON:0001476	58.95	silver quality
bone marrow	UBERON:0002371	58.90	silver quality
leukocyte	CL:0000738	58.83	gold quality
tonsil	UBERON:0002372	57.99	gold quality
buccal mucosa cell	CL:0002336	57.97	gold quality
mucosa of sigmoid colon	UBERON:0004993	57.95	gold quality
biceps brachii	UBERON:0001507	57.72	gold quality
nipple	UBERON:0002030	57.68	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.74

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Comprehensive analysis of POLH-AS1 as a prognostic biomarker in hepatocellular carcinoma. (PMID:39242532)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.