POLK-AS1

Summary

POLK-AS1 (POLK antisense RNA 1, HGNC:40460) is a long non-coding RNA gene on chromosome 5q13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40460
Approved symbol	POLK-AS1
Name	POLK antisense RNA 1
Location	5q13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000248881
Ensembl biotype	lncRNA
Entrez	144699901

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000511329

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000511329 — 2 exons

Exon	Start	End
ENSE00002026447	75599127	75599380
ENSE00002036667	75598482	75598981

Expression profiles

Bgee: expression breadth ubiquitous, 115 present calls, max score 85.44.

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.44	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.77	gold quality
colonic epithelium	UBERON:0000397	81.00	gold quality
bone marrow cell	CL:0002092	77.09	gold quality
skeletal muscle tissue	UBERON:0001134	75.37	gold quality
ventricular zone	UBERON:0003053	75.01	gold quality
bone marrow	UBERON:0002371	74.93	gold quality
ganglionic eminence	UBERON:0004023	70.49	gold quality
cortical plate	UBERON:0005343	69.25	gold quality
hindlimb stylopod muscle	UBERON:0004252	69.18	gold quality
liver	UBERON:0002107	68.52	gold quality
tonsil	UBERON:0002372	68.12	gold quality
monocyte	CL:0000576	64.58	gold quality
prefrontal cortex	UBERON:0000451	64.56	gold quality
superior frontal gyrus	UBERON:0002661	64.47	gold quality
cortex of kidney	UBERON:0001225	64.36	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	62.77	gold quality
kidney	UBERON:0002113	61.89	gold quality
urinary bladder	UBERON:0001255	60.86	gold quality
blood	UBERON:0000178	60.23	gold quality
frontal cortex	UBERON:0001870	59.99	gold quality
islet of Langerhans	UBERON:0000006	59.54	gold quality
muscle of leg	UBERON:0001383	59.11	gold quality
right lobe of liver	UBERON:0001114	58.33	gold quality
cerebral cortex	UBERON:0000956	56.70	gold quality
myometrium	UBERON:0001296	56.53	gold quality
gastrocnemius	UBERON:0001388	56.50	gold quality
lung	UBERON:0002048	56.21	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	56.03	gold quality
adrenal tissue	UBERON:0018303	56.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.