POP5

Summary

POP5 (POP5 ribonuclease P/MRP subunit, HGNC:17689) is a protein-coding gene on chromosome 12q24.31, encoding Ribonuclease P/MRP protein subunit POP5 (Q969H6). Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. It is a common-essential gene (DepMap: required in 99.1% of cancer cell lines).

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5’-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex.

Source: NCBI Gene 51367 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 19 total — 1 pathogenic
• Cancer dependency (DepMap): dependent in 99.1% of screened cell lines (common-essential)
• MANE Select transcript: NM_015918

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17689
Approved symbol	POP5
Name	POP5 ribonuclease P/MRP subunit
Location	12q24.31
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000167272
Ensembl biotype	protein_coding
OMIM	609992
Entrez	51367

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 15 protein_coding, 5 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000341039, ENST00000357500, ENST00000511394, ENST00000535245, ENST00000539716, ENST00000541834, ENST00000542568, ENST00000542776, ENST00000543355, ENST00000906575, ENST00000906576, ENST00000906577, ENST00000906578, ENST00000906579, ENST00000906580, ENST00000906581, ENST00000906582, ENST00000930091, ENST00000930092, ENST00000930093, ENST00000930094, ENST00000930095

RefSeq mRNA: 2 — MANE Select: NM_015918 NM_015918, NM_198202

CCDS: CCDS9202, CCDS9203

Canonical transcript exons

ENST00000357500 — 5 exons

Exon	Start	End
ENSE00001379374	120581115	120581257
ENSE00002303901	120578764	120579412
ENSE00003467103	120581343	120581402
ENSE00003546420	120579774	120579923
ENSE00003667745	120579514	120579597

Expression profiles

Bgee: expression breadth ubiquitous, 287 present calls, max score 96.43.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.8707 / max 125.1835, expressed in 1785 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133668	14.8707	1785

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	96.43	gold quality
right adrenal gland	UBERON:0001233	96.20	gold quality
right adrenal gland cortex	UBERON:0035827	96.09	gold quality
adenohypophysis	UBERON:0002196	95.97	gold quality
metanephros cortex	UBERON:0010533	95.67	gold quality
left adrenal gland cortex	UBERON:0035825	95.66	gold quality
left adrenal gland	UBERON:0001234	95.58	gold quality
pituitary gland	UBERON:0000007	95.53	gold quality
right lobe of thyroid gland	UBERON:0001119	95.50	gold quality
adrenal cortex	UBERON:0001235	95.32	gold quality
left lobe of thyroid gland	UBERON:0001120	94.91	gold quality
right lobe of liver	UBERON:0001114	94.90	gold quality
right uterine tube	UBERON:0001302	94.87	gold quality
spleen	UBERON:0002106	94.71	gold quality
adrenal gland	UBERON:0002369	94.58	gold quality
body of pancreas	UBERON:0001150	94.54	gold quality
thyroid gland	UBERON:0002046	94.54	gold quality
apex of heart	UBERON:0002098	94.51	gold quality
granulocyte	CL:0000094	94.42	gold quality
right atrium auricular region	UBERON:0006631	93.67	gold quality
rectum	UBERON:0001052	93.61	gold quality
small intestine Peyer’s patch	UBERON:0003454	93.54	gold quality
left coronary artery	UBERON:0001626	93.49	gold quality
transverse colon	UBERON:0001157	93.42	gold quality
cardiac atrium	UBERON:0002081	93.38	gold quality
right ovary	UBERON:0002118	93.25	gold quality
adult mammalian kidney	UBERON:0000082	93.23	gold quality
heart left ventricle	UBERON:0002084	93.23	gold quality
lymph node	UBERON:0000029	93.21	gold quality
ileal mucosa	UBERON:0000331	93.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.82

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

21 targeting POP5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3618	99.69	68.57	1012
HSA-MIR-6716-5P	99.56	68.62	1244
HSA-MIR-7159-5P	99.53	72.12	2472
HSA-MIR-136-5P	99.50	67.26	1153
HSA-MIR-4318	99.38	66.94	1505
HSA-MIR-1912-3P	99.32	67.40	936
HSA-MIR-3692-5P	99.29	67.04	1421
HSA-MIR-1295B-5P	99.03	67.50	810
HSA-MIR-412-3P	98.86	66.89	712
HSA-MIR-6754-3P	98.84	66.60	889
HSA-MIR-26B-3P	98.71	67.49	1102
HSA-MIR-4703-5P	98.53	70.13	1645
HSA-MIR-3942-5P	98.52	69.51	1517
HSA-MIR-7114-5P	98.51	67.87	1349
HSA-MIR-4662A-5P	98.48	67.18	1007
HSA-MIR-4733-3P	98.35	65.20	994
HSA-MIR-7113-5P	97.88	67.33	1735
HSA-MIR-3190-3P	97.61	66.95	1406
HSA-MIR-4288	97.11	67.23	1636
HSA-MIR-6858-3P	96.37	64.41	771
HSA-MIR-2861	95.24	65.47	1056

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.1% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 2)

• Molecular mechanism by which Cartilage-hair hypolasia-associated mutations affect the function of RNase MRP. (PMID:18164267)
• archaeal homologs of the human RNase P proteins Pop5 and Rpp30 (PMID:25704799)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	pop5	ENSDARG00000053452
mus_musculus	Pop5	ENSMUSG00000060152
rattus_norvegicus	Pop5	ENSRNOG00000001199
drosophila_melanogaster	Pop5	FBGN0036696
caenorhabditis_elegans		WBGENE00013422

Protein

Protein identifiers

Ribonuclease P/MRP protein subunit POP5 — Q969H6 (reviewed: Q969H6)

All UniProt accessions (1): Q969H6

UniProt curated annotations — full annotation on UniProt →

Function. Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.

Subunit / interactions. Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the ‘finger’ subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the ‘palm’ subcomplex, and RPP21, POP4 and RPP38 form the ‘wrist’ subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5.

Subcellular location. Nucleus. Nucleolus.

Miscellaneous. The last C-terminal 19 amino acids are not required for complex association and RNase activity.

Similarity. Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q969H6-1	1	yes
Q969H6-2	2

RefSeq proteins (2): NP_057002, NP_937845 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002759	Pop5/Rpp14/Rnp2-like	Family
IPR016819	RNase_P/MRP_POP5	Family
IPR038085	Rnp2-like_sf	Homologous_superfamily

Pfam: PF01900

Enzyme classification (BRENDA):

• EC 3.1.26.5 — ribonuclease P (BRENDA: 188 organisms, 407 substrates, 80 inhibitors, 54 Km, 43 kcat entries)

Substrate kinetics (BRENDA)

24 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
HUMAN PRE-TRNATYR	0.0001–0.0005	5
PRE-TRNATYR	—	5
PRE-TRNAASP	—	4
PTRNATYR	0.0002–0.0305	4
TRNA PRECURSOR	—	4
PRE-TRNA-TYR	0.0001	2
PRE-TRNATHR(AGT)	0.0035–0.05	2
RNASE P RIBOSWITCH A	0.0064–0.0081	2
TRNAPHE (G+1) PRECURSOR	—	2
TRNATYR	—	2
PMINI3PBUG	0.0013	1
PRE-TRNA	—	1
PRE-TRNA SUPS1 TRNASER	0.0002	1
PRE-TRNA-ASP	0.0003	1
PRE-TRNA-CYS	0.0006	1

UniProt features (6 total): sequence conflict 3, chain 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

5 structures.

PDB	Method	Resolution (Å)
9UH7	ELECTRON MICROSCOPY	2.84
9UH9	ELECTRON MICROSCOPY	3.47
6AHU	ELECTRON MICROSCOPY	3.66
6AHR	ELECTRON MICROSCOPY	3.92
9UHA	ELECTRON MICROSCOPY	3.93

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q969H6-F1	90.76	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 154

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6784531	tRNA processing in the nucleus

MSigDB gene sets: 133 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOMF_ENDONUCLEASE_ACTIVITY, GOMF_RNA_NUCLEASE_ACTIVITY, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GOMF_NUCLEASE_ACTIVITY, GOBP_TRNA_METABOLIC_PROCESS, AATGGAG_MIR136, PUJANA_CHEK2_PCC_NETWORK, MUELLER_PLURINET, GOMF_RNA_ENDONUCLEASE_ACTIVITY, ROSS_LEUKEMIA_WITH_MLL_FUSIONS, BLALOCK_ALZHEIMERS_DISEASE_UP, TIEN_INTESTINE_PROBIOTICS_24HR_UP, MORF_AATF, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS

GO Biological Process (3): tRNA 5’-leader removal (GO:0001682), rRNA processing (GO:0006364), tRNA processing (GO:0008033)

GO Molecular Function (4): ribonuclease P activity (GO:0004526), ribonuclease P RNA binding (GO:0033204), RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (7): ribonuclease MRP complex (GO:0000172), nucleoplasm (GO:0005654), nucleolar ribonuclease P complex (GO:0005655), nucleolus (GO:0005730), multimeric ribonuclease P complex (GO:0030681), nucleus (GO:0005634), ribonuclease P complex (GO:0030677)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
tRNA processing	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
endoribonuclease complex	2
nuclear lumen	2
tRNA 5’-end processing	1
rRNA metabolic process	1
ribosome biogenesis	1
tRNA metabolic process	1
tRNA-specific ribonuclease activity	1
RNA endonuclease activity producing 5’-phosphomonoesters, hydrolytic mechanism	1
RNA binding	1
nucleic acid binding	1
binding	1
sno(s)RNA-containing ribonucleoprotein complex	1
cellular anatomical structure	1
nucleolus	1
multimeric ribonuclease P complex	1
nuclear protein-containing complex	1
intracellular membraneless organelle	1
ribonuclease P complex	1
intracellular membrane-bounded organelle	1
ribonucleoprotein complex	1

Protein interactions and networks

STRING

804 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
POP5	RPP30	P78346	998
POP5	POP4	O95707	993
POP5	RPP38	P78345	986
POP5	RPP25	Q9BUL9	978
POP5	RPP40	O75818	963
POP5	POP7	O75817	891
POP5	RPLP1	P05386	779
POP5	PTER	Q96BW5	655
POP5	PRORP	O15091	648
POP5	DCLRE1A	Q6PJP8	591
POP5	POP1	Q99575	544
POP5	RPP25L	Q8N5L8	534
POP5	RPP21	Q9H633	514
POP5	COPS7B	Q9H9Q2	383
POP5	RPP14	O95059	353

IntAct

87 interactions, top by confidence:

A	B	Type	Score
RPP25	POP7	psi-mi:“MI:0914”(association)	0.810
RPP30	POP5	psi-mi:“MI:0915”(physical association)	0.740
RPP30	POP7	psi-mi:“MI:0914”(association)	0.730
CCDC102B	POP5	psi-mi:“MI:0915”(physical association)	0.720
TRAF1	POP5	psi-mi:“MI:0915”(physical association)	0.720
POP5	CEP44	psi-mi:“MI:0915”(physical association)	0.720
POP5	CCDC102B	psi-mi:“MI:0915”(physical association)	0.720
POP5	POP4	psi-mi:“MI:0915”(physical association)	0.670
POP4	POP5	psi-mi:“MI:0915”(physical association)	0.670
RPP14	POP5	psi-mi:“MI:0915”(physical association)	0.670
RPP25	POP5	psi-mi:“MI:0915”(physical association)	0.670
RPP14	RPP40	psi-mi:“MI:0914”(association)	0.670
C18orf21	POP7	psi-mi:“MI:0914”(association)	0.640
POP4	POP7	psi-mi:“MI:0914”(association)	0.640
REL	POP5	psi-mi:“MI:0915”(physical association)	0.560
CAMK2B	POP5	psi-mi:“MI:0915”(physical association)	0.560
POP5	KRT40	psi-mi:“MI:0915”(physical association)	0.560
POP5	REL	psi-mi:“MI:0915”(physical association)	0.560
POP5	CAMK2B	psi-mi:“MI:0915”(physical association)	0.560
KRT40	POP5	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (61): POP5 (Two-hybrid), POP5 (Two-hybrid), POP5 (Two-hybrid), CCDC102B (Two-hybrid), CEP44 (Two-hybrid), KRT40 (Two-hybrid), POP5 (Affinity Capture-MS), POP5 (Affinity Capture-MS), POP5 (Affinity Capture-MS), POP5 (Affinity Capture-MS), POP5 (Affinity Capture-MS), POP5 (Affinity Capture-MS), POP5 (Affinity Capture-MS), POP5 (Affinity Capture-MS), RPP25 (Reconstituted Complex)

ESM2 similar proteins: A0A1L8F8I9, A2ARP1, B8B624, E7EXT2, F1S5L4, O95822, P0C644, P0C7N9, P28005, P38208, P41229, P53370, P97564, Q08BC6, Q14AI0, Q14BI7, Q1JQ92, Q24087, Q24169, Q28647, Q2KI89, Q32PH0, Q3MHU3, Q3U0M1, Q5BJI6, Q5GJ77, Q5JS54, Q61586, Q66I84, Q68F70, Q6AWV1, Q6GL75, Q6GMB0, Q6PD24, Q75B32, Q7XAM0, Q7Z2Z2, Q7ZU90, Q811G0, Q8BSA9

Diamond homologs: Q1JQ92, Q54EP3, Q5BJI6, Q969H6, Q9DB28, Q6AWV1, Q9UU90

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
POP5	“form complex”	“Ribonuclease MRP complex”	binding
POP5	“form complex”	“Nucleolar ribonuclease P complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 37 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
tRNA processing	6	107.1×	8e-10
tRNA processing in the nucleus	8	78.8×	5e-12
rRNA processing in the nucleus and cytosol	6	48.2×	8e-08
rRNA processing	6	43.9×	1e-07
Major pathway of rRNA processing in the nucleolus and cytosol	6	18.5×	1e-05
Metabolism of RNA	8	16.7×	3e-07

GO biological processes:

GO term	Partners	Fold	FDR
rRNA processing	6	27.4×	4e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

19 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	16
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
4682808	GRCh37/hg19 12q24.21-24.33(chr12:116422123-133777902)x3	Pathogenic

SpliceAI

748 predictions. Top by Δscore:

Variant	Effect	Δscore
12:120581338:CTTA:C	donor_loss	1.0000
12:120581339:TTAC:T	donor_loss	1.0000
12:120581340:TA:T	donor_loss	1.0000
12:120581341:A:AC	donor_gain	1.0000
12:120581341:A:AT	donor_loss	1.0000
12:120581342:C:CC	donor_gain	1.0000
12:120579653:T:C	acceptor_gain	0.9900
12:120581096:T:TA	donor_gain	0.9900
12:120581097:C:A	donor_gain	0.9900
12:120581106:C:CA	donor_gain	0.9900
12:120581181:CGAGG:C	donor_gain	0.9900
12:120581342:CCT:C	donor_gain	0.9900
12:120579924:C:CC	acceptor_gain	0.9800
12:120581341:AC:A	donor_gain	0.9800
12:120581342:CC:C	donor_gain	0.9800
12:120579410:CTC:C	acceptor_gain	0.9700
12:120579652:C:CC	acceptor_gain	0.9700
12:120579759:C:CT	donor_gain	0.9700
12:120579814:T:TA	donor_gain	0.9700
12:120581102:AGCGC:A	donor_gain	0.9700
12:120581111:G:A	donor_gain	0.9700
12:120581160:C:CA	donor_gain	0.9700
12:120581342:CCTG:C	donor_gain	0.9700
12:120581342:CCTGT:C	donor_gain	0.9700
12:120579651:ACTTT:A	acceptor_gain	0.9600
12:120579652:CTTTC:C	acceptor_gain	0.9600
12:120581152:T:TA	donor_gain	0.9600
12:120579760:C:CT	donor_gain	0.9500
12:120579656:C:CT	acceptor_gain	0.9300
12:120579776:C:A	donor_gain	0.9300

AlphaMissense

1047 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:120581343:C:A	R7M	0.999
12:120579594:G:A	T106I	0.998
12:120581144:C:T	G45D	0.997
12:120579581:A:C	C110W	0.996
12:120579583:A:G	C110R	0.996
12:120579597:C:T	G105D	0.996
12:120579776:C:T	G104E	0.996
12:120579910:A:C	N59K	0.996
12:120579910:A:T	N59K	0.996
12:120581153:C:A	G42V	0.996
12:120581153:C:T	G42E	0.996
12:120581343:C:G	R7T	0.996
12:120581348:C:A	K5N	0.996
12:120581348:C:G	K5N	0.996
12:120579570:A:G	L114P	0.995
12:120579572:G:C	F113L	0.995
12:120579572:G:T	F113L	0.995
12:120579574:A:G	F113L	0.995
12:120579582:C:T	C110Y	0.995
12:120581247:A:G	C11R	0.995
12:120581257:C:A	R7S	0.995
12:120581257:C:G	R7S	0.995
12:120579591:A:T	I107K	0.994
12:120579546:A:G	L122P	0.993
12:120579579:T:G	Q111P	0.993
12:120579777:C:G	G104R	0.993
12:120579777:C:T	G104R	0.993
12:120579845:A:C	L81R	0.993
12:120579923:A:T	V55D	0.993
12:120581249:A:T	L10H	0.993

dbSNP variants (sampled 300 via entrez): RS1000106196 (12:120581524 A>C), RS1000492739 (12:120582506 A>C,G), RS1001534288 (12:120581355 C>A,G), RS1001604947 (12:120578475 G>A,T), RS1004872725 (12:120578695 G>A,C), RS1005010871 (12:120578873 T>C), RS1005310461 (12:120578416 G>A), RS1005554142 (12:120580731 G>A), RS1005891867 (12:120581774 C>T), RS1007574554 (12:120583288 C>A), RS1008747622 (12:120580334 A>G), RS1009056512 (12:120578990 A>G), RS1009111251 (12:120580608 TCAAA>T), RS1009673470 (12:120582791 C>G), RS1010356746 (12:120578824 T>C)

Disease associations

OMIM: gene MIM:609992 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST004611_192	High light scatter reticulocyte count	2.000000e-83
GCST007576_31	Chronotype	3.000000e-09
GCST008759_15	Intake of total sugars	3.000000e-07

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007986	reticulocyte count
EFO:0008328	chronotype measurement
EFO:0010158	sugar consumption measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, affects cotreatment, increases expression	5
Particulate Matter	increases abundance, affects cotreatment, decreases expression	3
bisphenol A	decreases expression, increases expression	2
Air Pollutants	increases abundance, decreases expression	2
Cyclosporine	decreases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	decreases expression	1
FR900359	increases phosphorylation	1
dicrotophos	decreases expression	1
arsenite	increases reaction, affects binding	1
sodium arsenite	decreases expression	1
cobaltous chloride	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
isobutyl alcohol	affects cotreatment, decreases expression, increases abundance	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
deguelin	decreases expression	1
K 7174	decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	decreases expression	1
abrine	decreases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	decreases expression, increases response to substance	1
jinfukang	affects cotreatment, increases expression	1
picoxystrobin	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Vorinostat	increases expression	1
Leflunomide	decreases expression	1
Cisplatin	affects cotreatment, increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dexamethasone	increases expression	1
Diuron	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3EA	Abcam HEK293T POP5 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.