POP7

Summary

POP7 (POP7 ribonuclease P/MRP subunit, HGNC:19949) is a protein-coding gene on chromosome 7q22.1, encoding Ribonuclease P protein subunit p20 (O75817). Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5’-ends. It is a selective cancer dependency (DepMap: 77.3% of cell lines).

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5’-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex.

Source: NCBI Gene 10248 — RefSeq curated summary.

At a glance

• GWAS associations: 13
• Clinical variants (ClinVar): 24 total
• Cancer dependency (DepMap): dependent in 77.3% of screened cell lines
• MANE Select transcript: NM_005837

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19949
Approved symbol	POP7
Name	POP7 ribonuclease P/MRP subunit
Location	7q22.1
Locus type	gene with protein product
Status	Approved
Aliases	RPP20, RPP2
Ensembl gene	ENSG00000172336
Ensembl biotype	protein_coding
OMIM	606113
Entrez	10248

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 protein_coding

ENST00000303151, ENST00000457480, ENST00000910791, ENST00000934891, ENST00000934892, ENST00000934893, ENST00000934894, ENST00000934895, ENST00000934896, ENST00000934897, ENST00000934898, ENST00000934899, ENST00000947209

RefSeq mRNA: 1 — MANE Select: NM_005837 NM_005837

CCDS: CCDS5704

Canonical transcript exons

ENST00000303151 — 2 exons

Exon	Start	End
ENSE00001130441	100706121	100706304
ENSE00001144096	100706821	100707486

Expression profiles

Bgee: expression breadth ubiquitous, 268 present calls, max score 94.06.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 38.4912 / max 192.1535, expressed in 1811 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
80052	31.1112	1796
80051	7.3801	1753

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	94.06	gold quality
gastrocnemius	UBERON:0001388	94.02	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.89	gold quality
right frontal lobe	UBERON:0002810	93.66	gold quality
muscle of leg	UBERON:0001383	93.61	gold quality
middle temporal gyrus	UBERON:0002771	93.55	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.31	gold quality
Brodmann (1909) area 9	UBERON:0013540	93.24	gold quality
skin of leg	UBERON:0001511	93.06	gold quality
right lobe of liver	UBERON:0001114	92.99	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	92.81	gold quality
skin of abdomen	UBERON:0001416	92.69	gold quality
mucosa of transverse colon	UBERON:0004991	92.66	gold quality
pancreatic ductal cell	CL:0002079	92.44	gold quality
cortical plate	UBERON:0005343	92.34	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.30	gold quality
apex of heart	UBERON:0002098	92.09	gold quality
cerebellar hemisphere	UBERON:0002245	92.05	gold quality
cerebellar cortex	UBERON:0002129	91.96	gold quality
cingulate cortex	UBERON:0003027	91.96	gold quality
anterior cingulate cortex	UBERON:0009835	91.95	gold quality
primary visual cortex	UBERON:0002436	91.83	gold quality
Brodmann (1909) area 23	UBERON:0013554	91.62	gold quality
zone of skin	UBERON:0000014	91.60	gold quality
neocortex	UBERON:0001950	91.43	gold quality
frontal cortex	UBERON:0001870	91.33	gold quality
muscle organ	UBERON:0001630	91.13	gold quality
nucleus accumbens	UBERON:0001882	91.06	gold quality
cerebellum	UBERON:0002037	91.00	gold quality
caudate nucleus	UBERON:0001873	90.90	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.65
E-GEOD-109979	no	113.83

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

21 targeting POP7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-130A-3P	99.90	73.31	1861
HSA-MIR-130B-3P	99.90	73.27	1850
HSA-MIR-301A-3P	99.90	73.15	1839
HSA-MIR-301B-3P	99.90	73.19	1836
HSA-MIR-3666	99.90	73.24	1833
HSA-MIR-4295	99.90	73.11	1838
HSA-MIR-4671-3P	99.88	72.46	1045
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-8076	99.78	68.52	1170
HSA-MIR-7150	99.62	66.80	1322
HSA-MIR-1290	99.59	69.90	2079
HSA-MIR-12117	99.50	67.57	868
HSA-MIR-6080	99.43	69.43	373
HSA-MIR-942-3P	98.81	69.04	876
HSA-MIR-7113-5P	97.88	67.33	1735
HSA-MIR-512-5P	97.47	66.48	591
HSA-MIR-4712-5P	97.24	67.79	775
HSA-MIR-770-5P	97.24	68.10	758
HSA-MIR-7847-3P	96.63	64.58	952
HSA-MIR-12115	94.19	66.37	738

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 77.3% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• analyses of interactions with deletion mutant proteins indicate that the Alba-type core domain of both Rpp20 and Rpp25 contains most of the determinants for mutual association and P3 RNA recognition. (PMID:20215441)
• Study showed the crystal structure of Rpp20/Rpp25 complex, and confirmed that Rpp20 and Rpp25 exhibit similar molecular structures to one another, to their yeast homologs (Pop7 andPop6, respectively), and to archaeal Alba proteins. These proteins do not seem to undergo significant conformational change upon RNA binding, suggesting that they interact with their cognate RNAs via a pre-formed binding surface. (PMID:29625199)
• RNA binding protein POP7 regulates ILF3 mRNA stability and expression to promote breast cancer progression. (PMID:35579257)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	pop7	ENSDARG00000036394
mus_musculus	Pop7	ENSMUSG00000029715
rattus_norvegicus	Pop7	ENSRNOG00000025310
drosophila_melanogaster	Rpp20	FBGN0066304
caenorhabditis_elegans		WBGENE00302968

Protein

Protein identifiers

Ribonuclease P protein subunit p20 — O75817 (reviewed: O75817)

Alternative names: Ribonucleases P/MRP protein subunit POP7 homolog

All UniProt accessions (2): O75817, C9JYM0

UniProt curated annotations — full annotation on UniProt →

Function. Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.

Subunit / interactions. Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the ‘finger’ subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the ‘palm’ subcomplex, and RPP21, POP4 and RPP38 form the ‘wrist’ subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.

Subcellular location. Nucleus. Nucleolus. Cytoplasm. Cytoplasmic granule.

Similarity. Belongs to the histone-like Alba family.

RefSeq proteins (1): NP_005828* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR014612	Pop7/Rpp20	Family
IPR036882	Alba-like_dom_sf	Homologous_superfamily

Pfam: PF12328

Enzyme classification (BRENDA):

• EC 3.1.26.5 — ribonuclease P (BRENDA: 188 organisms, 407 substrates, 80 inhibitors, 54 Km, 43 kcat entries)

Substrate kinetics (BRENDA)

24 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
HUMAN PRE-TRNATYR	0.0001–0.0005	5
PRE-TRNATYR	—	5
PRE-TRNAASP	—	4
PTRNATYR	0.0002–0.0305	4
TRNA PRECURSOR	—	4
PRE-TRNA-TYR	0.0001	2
PRE-TRNATHR(AGT)	0.0035–0.05	2
RNASE P RIBOSWITCH A	0.0064–0.0081	2
TRNAPHE (G+1) PRECURSOR	—	2
TRNATYR	—	2
PMINI3PBUG	0.0013	1
PRE-TRNA	—	1
PRE-TRNA SUPS1 TRNASER	0.0002	1
PRE-TRNA-ASP	0.0003	1
PRE-TRNA-CYS	0.0006	1

UniProt features (13 total): strand 6, helix 3, chain 1, mutagenesis site 1, sequence conflict 1, turn 1

Structure

Experimental structures (PDB)

7 structures.

PDB	Method	Resolution (Å)
6CWX	X-RAY DIFFRACTION	2.25
6LT7	X-RAY DIFFRACTION	2.7
9UH7	ELECTRON MICROSCOPY	2.84
9UH9	ELECTRON MICROSCOPY	3.47
6AHU	ELECTRON MICROSCOPY	3.66
6AHR	ELECTRON MICROSCOPY	3.92
9UHA	ELECTRON MICROSCOPY	3.93

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75817-F1	83.21	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (1):

Position	Phenotype
40	strongly reduced interaction with rpp25.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6784531	tRNA processing in the nucleus

MSigDB gene sets: 164 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOMF_ENDONUCLEASE_ACTIVITY, GOMF_RNA_NUCLEASE_ACTIVITY, TGCGCANK_UNKNOWN, GOMF_NUCLEASE_ACTIVITY, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOBP_TRNA_METABOLIC_PROCESS, BROWNE_HCMV_INFECTION_16HR_UP, WEI_MYCN_TARGETS_WITH_E_BOX, MUELLER_PLURINET, GOMF_RNA_ENDONUCLEASE_ACTIVITY, JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, MODULE_98, FISCHER_DREAM_TARGETS

GO Biological Process (4): tRNA 5’-leader removal (GO:0001682), rRNA processing (GO:0006364), tRNA processing (GO:0008033), RNA processing (GO:0006396)

GO Molecular Function (5): RNA binding (GO:0003723), ribonuclease P RNA binding (GO:0033204), nucleic acid binding (GO:0003676), ribonuclease P activity (GO:0004526), protein binding (GO:0005515)

GO Cellular Component (7): ribonuclease MRP complex (GO:0000172), nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolar ribonuclease P complex (GO:0005655), nucleolus (GO:0005730), cytoplasm (GO:0005737), multimeric ribonuclease P complex (GO:0030681)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
tRNA processing	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
binding	2
nuclear lumen	2
cellular anatomical structure	2
tRNA 5’-end processing	1
rRNA metabolic process	1
ribosome biogenesis	1
tRNA metabolic process	1
gene expression	1
RNA biosynthetic process	1
primary metabolic process	1
nucleic acid binding	1
RNA binding	1
tRNA-specific ribonuclease activity	1
RNA endonuclease activity producing 5’-phosphomonoesters, hydrolytic mechanism	1
sno(s)RNA-containing ribonucleoprotein complex	1
endoribonuclease complex	1
intracellular membrane-bounded organelle	1
nucleolus	1
multimeric ribonuclease P complex	1
nuclear protein-containing complex	1
intracellular membraneless organelle	1
intracellular anatomical structure	1
ribonuclease P complex	1

Protein interactions and networks

STRING

608 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
POP7	POP5	Q969H6	891
POP7	RPP25	Q9BUL9	773
POP7	POP4	O95707	769
POP7	RPLP1	P05386	660
POP7	RPP38	P78345	582
POP7	RPP30	P78346	582
POP7	PTER	Q96BW5	557
POP7	RPP40	O75818	447
POP7	TERT	O14746	434
POP7	RPP25L	Q8N5L8	432
POP7	DCLRE1A	Q6PJP8	431
POP7	POP1	Q99575	430
POP7	LTN1	O94822	406
POP7	PRORP	O15091	394
POP7	NAA40	Q86UY6	357

IntAct

77 interactions, top by confidence:

A	B	Type	Score
RPP25L	POP7	psi-mi:“MI:0915”(physical association)	0.870
POP7	RPP25L	psi-mi:“MI:0915”(physical association)	0.870
POP7	RPP25	psi-mi:“MI:0915”(physical association)	0.810
RPP25	POP7	psi-mi:“MI:0914”(association)	0.810
POP7	LAGE3	psi-mi:“MI:0915”(physical association)	0.740
KBTBD7	METTL15	psi-mi:“MI:0914”(association)	0.730
RPP30	POP7	psi-mi:“MI:0914”(association)	0.730
C18orf21	POP7	psi-mi:“MI:0914”(association)	0.640
POP4	POP7	psi-mi:“MI:0914”(association)	0.640
POP7	SMN1	psi-mi:“MI:0407”(direct interaction)	0.570
SMN1	POP7	psi-mi:“MI:0915”(physical association)	0.570
POP7	SMN1	psi-mi:“MI:0403”(colocalization)	0.570
C9orf72	POP7	psi-mi:“MI:0915”(physical association)	0.560
POP7	C9orf72	psi-mi:“MI:0915”(physical association)	0.560
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
POP4	NME2P1	psi-mi:“MI:0914”(association)	0.530
RPP21	POP7	psi-mi:“MI:0914”(association)	0.530
KLHDC3	DPYSL4	psi-mi:“MI:0914”(association)	0.530

BioGRID (110): RPP25L (Two-hybrid), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS), POP7 (Affinity Capture-MS)

ESM2 similar proteins: A0JNQ6, A2RT67, A2RUS2, A6NC42, A6NGQ2, A9X185, O75031, O75817, O94955, O95267, P50747, Q06VW1, Q0II25, Q0ZFW8, Q1RMS8, Q1RMZ1, Q29108, Q2TBA3, Q3T0J1, Q3TYS2, Q4VX76, Q568D5, Q568M3, Q587J7, Q5JSQ8, Q5T9G4, Q5ZLS2, Q62522, Q69ZK0, Q6AYA6, Q6P5G6, Q7Z7H3, Q80X86, Q86WV5, Q8BXK4, Q8C0Q9, Q8CHQ0, Q8TCU6, Q8WUE5, Q91Z62

Diamond homologs: O75817, Q0II25, Q2MGL3, Q9DCH2

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
POP7	“form complex”	“Ribonuclease MRP complex”	binding
POP7	“form complex”	“Nucleolar ribonuclease P complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 58 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
tRNA processing	7	59.5×	4e-09
rRNA processing in the nucleus and cytosol	8	30.6×	2e-08
tRNA processing in the nucleus	6	28.1×	3e-06
rRNA processing	8	27.9×	3e-08
Major pathway of rRNA processing in the nucleolus and cytosol	10	14.7×	6e-08
Metabolism of RNA	11	10.9×	1e-07

GO biological processes:

GO term	Partners	Fold	FDR
ribosomal small subunit biogenesis	5	22.3×	3e-04
rRNA processing	8	22.2×	5e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

24 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	22
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

304 predictions. Top by Δscore:

Variant	Effect	Δscore
7:100706301:GAGA:G	donor_gain	1.0000
7:100706303:GA:G	donor_gain	1.0000
7:100706305:G:GG	donor_gain	1.0000
7:100706815:C:CA	acceptor_gain	0.9900
7:100706819:AG:A	acceptor_gain	0.9900
7:100706820:GG:G	acceptor_gain	0.9900
7:100706302:A:T	donor_gain	0.9800
7:100706818:CAGG:C	acceptor_loss	0.9800
7:100706819:A:AG	acceptor_gain	0.9800
7:100706819:A:C	acceptor_loss	0.9800
7:100706819:AGG:A	acceptor_gain	0.9800
7:100706820:G:A	acceptor_loss	0.9800
7:100706820:G:GG	acceptor_gain	0.9800
7:100706820:GGG:G	acceptor_gain	0.9800
7:100706814:AC:A	acceptor_gain	0.9700
7:100706300:AGAGA:A	donor_gain	0.9600
7:100706301:GAGAG:G	donor_gain	0.9600
7:100706820:GGGC:G	acceptor_gain	0.9600
7:100706302:AGAG:A	donor_loss	0.9500
7:100706304:AG:A	donor_loss	0.9500
7:100706305:G:T	donor_loss	0.9500
7:100706306:TAA:T	donor_loss	0.9500
7:100706820:GGGCA:G	acceptor_gain	0.9500
7:100706307:AA:A	donor_loss	0.9400
7:100706818:CAGGG:C	acceptor_gain	0.9400
7:100706302:AGA:A	donor_gain	0.9300
7:100706303:GAG:G	donor_gain	0.9300
7:100706314:G:GT	donor_gain	0.9000
7:100706080:G:GT	donor_gain	0.8900
7:100706308:AGC:A	donor_loss	0.8900

AlphaMissense

896 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:100706946:T:A	V39D	1.000
7:100707053:G:C	G75R	1.000
7:100707054:G:A	G75D	1.000
7:100707054:G:T	G75V	1.000
7:100707084:C:A	A85E	1.000
7:100707219:T:A	I130N	1.000
7:100706942:T:G	Y38D	0.999
7:100706984:T:C	C52R	0.999
7:100706985:G:A	C52Y	0.999
7:100706986:C:G	C52W	0.999
7:100707042:T:A	I71N	0.999
7:100707044:C:G	H72D	0.999
7:100707046:C:A	H72Q	0.999
7:100707046:C:G	H72Q	0.999
7:100707047:G:C	G73R	0.999
7:100707048:G:A	G73D	0.999
7:100707053:G:A	G75S	0.999
7:100707053:G:T	G75C	0.999
7:100707054:G:C	G75A	0.999
7:100707060:C:A	A77D	0.999
7:100707071:G:C	A81P	0.999
7:100707072:C:A	A81D	0.999
7:100707075:T:A	I82N	0.999
7:100707087:T:C	L86P	0.999
7:100707093:T:C	L88P	0.999
7:100707129:C:A	A100D	0.999
7:100707135:C:T	T102I	0.999
7:100707137:T:C	S103P	0.999
7:100707141:C:T	T104I	0.999
7:100707203:C:A	R125S	0.999

dbSNP variants (sampled 300 via entrez): RS1000347074 (7:100705247 C>T), RS1001309383 (7:100707254 T>A,C), RS1002349287 (7:100707441 G>A,T), RS1003357921 (7:100705226 T>G), RS1003426310 (7:100704956 G>A), RS1004713085 (7:100705525 A>G), RS1004998680 (7:100705945 T>C,G), RS1005331682 (7:100705275 G>A), RS1006323945 (7:100706718 G>A,C), RS1006355307 (7:100706389 A>C), RS1006687815 (7:100707935 C>T), RS1006890275 (7:100704262 G>A), RS1007937432 (7:100706550 C>T), RS1008972211 (7:100705299 C>A), RS1008994357 (7:100705873 C>A,T)

Disease associations

OMIM: gene MIM:606113 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

Study	Trait	p-value
GCST004601_101	Red blood cell count	3.000000e-38
GCST004615_50	Hemoglobin concentration	3.000000e-14
GCST005028_7	Pursuit maintenance gain in psychotic disorders	1.000000e-08
GCST007201_348	Schizophrenia	3.000000e-06
GCST007201_74	Schizophrenia	1.000000e-07
GCST007932_103	Medication use (thyroid preparations)	1.000000e-08
GCST010204_198	Low density lipoprotein cholesterol levels	2.000000e-17
GCST90002383_432	Hematocrit	8.000000e-10
GCST90002383_433	Hematocrit	3.000000e-102
GCST90002384_152	Hemoglobin	3.000000e-29
GCST90002384_157	Hemoglobin	4.000000e-09
GCST90002384_158	Hemoglobin	9.000000e-105
GCST90002403_585	Red blood cell count	9.000000e-85

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004305	erythrocyte count
EFO:0004509	hemoglobin measurement
EFO:0008433	pursuit maintenance gain measurement
EFO:0009933	Thyroid preparation use measurement
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0004348	hematocrit

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
aristolochic acid I	increases expression	1
bisphenol A	decreases expression	1
arsenite	affects binding, increases reaction	1
cobaltous chloride	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
K 7174	decreases expression	1
ICG 001	affects expression	1
Leflunomide	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Copper	decreases expression	1
Oxygen	decreases expression	1
Piroxicam	decreases expression	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Tretinoin	decreases expression	1
Valproic Acid	increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Asbestos, Crocidolite	increases expression	1
Thapsigargin	decreases expression	1
Okadaic Acid	increases expression	1
Copper Sulfate	decreases expression	1
Vitamin K 3	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.