POT1-AS1

Summary

POT1-AS1 (POT1 antisense RNA 1, HGNC:49459) is a long non-coding RNA gene on chromosome 7q31.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49459
Approved symbol	POT1-AS1
Name	POT1 antisense RNA 1
Location	7q31.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224897
Ensembl biotype	lncRNA
Entrez	401398
RNAcentral	URS00007E4BE4 — lncRNA, 3983 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 51 — 51 lncRNA

ENST00000415715, ENST00000415896, ENST00000424515, ENST00000429134, ENST00000435452, ENST00000449642, ENST00000453278, ENST00000453342, ENST00000458437, ENST00000651909, ENST00000652238, ENST00000653619, ENST00000655668, ENST00000657042, ENST00000657149, ENST00000657167, ENST00000657213, ENST00000657243, ENST00000659682, ENST00000660124, ENST00000660851, ENST00000661562, ENST00000661643, ENST00000663263, ENST00000664377, ENST00000667446, ENST00000667489, ENST00000667793, ENST00000670073, ENST00000686986, ENST00000688362, ENST00000688691, ENST00000730837, ENST00000730838, ENST00000730839, ENST00000730840, ENST00000730841, ENST00000730842, ENST00000730843, ENST00000730844, ENST00000730845, ENST00000730846, ENST00000730847, ENST00000730848, ENST00000730849, ENST00000730850, ENST00000730851, ENST00000730852, ENST00000730853, ENST00000730854, ENST00000730855

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415715 — 6 exons

Exon	Start	End
ENSE00001592206	125080712	125080813
ENSE00001603617	125089690	125089776
ENSE00001620321	125099404	125099513
ENSE00001734071	125020333	125020413
ENSE00004059739	125101960	125102059
ENSE00004059759	124993008	124993199

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 85.50.

FANTOM5 (CAGE): breadth broad, TPM avg 2.1661 / max 117.4471, expressed in 752 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
80872	1.4122	501
80871	0.3502	165
80873	0.2236	107
80874	0.0842	43
80881	0.0325	5
80879	0.0321	5
80880	0.0200	3
80877	0.0073	3
80878	0.0039	3

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.50	gold quality
colonic epithelium	UBERON:0000397	84.02	gold quality
ventricular zone	UBERON:0003053	79.17	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.02	gold quality
right testis	UBERON:0004534	77.46	gold quality
left testis	UBERON:0004533	77.18	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	76.68	gold quality
cortical plate	UBERON:0005343	76.24	gold quality
testis	UBERON:0000473	75.75	gold quality
right adrenal gland	UBERON:0001233	75.54	gold quality
left adrenal gland	UBERON:0001234	74.29	gold quality
right adrenal gland cortex	UBERON:0035827	74.00	gold quality
spinal cord	UBERON:0002240	73.39	gold quality
ganglionic eminence	UBERON:0004023	72.94	gold quality
left adrenal gland cortex	UBERON:0035825	72.64	gold quality
adrenal gland	UBERON:0002369	71.63	gold quality
adrenal tissue	UBERON:0018303	71.56	gold quality
left coronary artery	UBERON:0001626	70.91	gold quality
adult mammalian kidney	UBERON:0000082	70.81	gold quality
adrenal cortex	UBERON:0001235	70.65	gold quality
hypothalamus	UBERON:0001898	70.18	gold quality
nucleus accumbens	UBERON:0001882	69.62	gold quality
amygdala	UBERON:0001876	69.39	gold quality
thoracic aorta	UBERON:0001515	69.09	gold quality
coronary artery	UBERON:0001621	69.07	gold quality
putamen	UBERON:0001874	69.05	gold quality
ascending aorta	UBERON:0001496	69.04	gold quality
anterior cingulate cortex	UBERON:0009835	68.97	gold quality
right coronary artery	UBERON:0001625	68.66	gold quality
descending thoracic aorta	UBERON:0002345	68.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.