POTEF-AS1

Summary

POTEF-AS1 (POTEF antisense RNA 1, HGNC:41294) is a long non-coding RNA gene on chromosome 2q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41294
Approved symbol	POTEF-AS1
Name	POTEF antisense RNA 1
Location	2q21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224087
Ensembl biotype	lncRNA
Entrez	105373617
RNAcentral	URS00001FFF0A — lncRNA, 578 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000433507

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433507 — 2 exons

Exon	Start	End
ENSE00001662575	130107684	130107806
ENSE00001724916	130109287	130109741

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 86.02.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.02	gold quality
sural nerve	UBERON:0015488	68.52	gold quality
prostate gland	UBERON:0002367	64.81	gold quality
liver	UBERON:0002107	61.62	silver quality
islet of Langerhans	UBERON:0000006	56.04	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	55.89	gold quality
tibial nerve	UBERON:0001323	55.86	gold quality
monocyte	CL:0000576	53.78	gold quality
multicellular organism	UBERON:0000468	51.42	gold quality
thoracic mammary gland	UBERON:0005200	51.14	gold quality
endometrium	UBERON:0001295	51.12	gold quality
blood	UBERON:0000178	50.37	silver quality
lower esophagus muscularis layer	UBERON:0035833	47.16	gold quality
thyroid gland	UBERON:0002046	46.78	silver quality
gastrocnemius	UBERON:0001388	46.10	silver quality
muscle layer of sigmoid colon	UBERON:0035805	46.00	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	46.00	gold quality
rectum	UBERON:0001052	45.16	gold quality
right frontal lobe	UBERON:0002810	44.99	gold quality
esophagus mucosa	UBERON:0002469	43.58	silver quality
heart left ventricle	UBERON:0002084	43.20	silver quality
fallopian tube	UBERON:0003889	42.86	gold quality
body of pancreas	UBERON:0001150	42.57	silver quality
hypothalamus	UBERON:0001898	42.35	gold quality
adipose tissue	UBERON:0001013	41.83	silver quality
omental fat pad	UBERON:0010414	41.65	silver quality
tibial artery	UBERON:0007610	41.46	silver quality
testis	UBERON:0000473	41.20	gold quality
amygdala	UBERON:0001876	41.20	silver quality
body of stomach	UBERON:0001161	40.53	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• These findings suggest that POTEF-AS1 would play a key role in the progression of prostate cancer by repressing Toll-like receptor signaling. (PMID:28032932)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.