POU6F2-AS1

Summary

POU6F2-AS1 (POU6F2 antisense RNA 1, HGNC:40979) is a long non-coding RNA gene on chromosome 7p14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40979
Approved symbol	POU6F2-AS1
Name	POU6F2 antisense RNA 1
Location	7p14.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224122
Ensembl biotype	lncRNA
Entrez	100861520
RNAcentral	URS000075DDF6 — lncRNA, 393 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000433519, ENST00000653564, ENST00000663864, ENST00000729145, ENST00000729146, ENST00000729147

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433519 — 4 exons

Exon	Start	End
ENSE00001631904	39404598	39404783
ENSE00001646438	39406017	39406119
ENSE00001699780	39404927	39405005
ENSE00004056391	39406334	39406414

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 83.10.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0286 / max 5.6983, expressed in 17 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
83718	0.0286	17

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.10	silver quality
muscle tissue	UBERON:0002385	71.69	gold quality
liver	UBERON:0002107	71.43	gold quality
right lobe of liver	UBERON:0001114	71.02	gold quality
ganglionic eminence	UBERON:0004023	65.85	gold quality
islet of Langerhans	UBERON:0000006	65.61	gold quality
gall bladder	UBERON:0002110	65.07	gold quality
body of stomach	UBERON:0001161	64.98	gold quality
stomach	UBERON:0000945	64.33	gold quality
fundus of stomach	UBERON:0001160	62.90	gold quality
blood	UBERON:0000178	59.41	gold quality
duodenum	UBERON:0002114	58.26	gold quality
adult mammalian kidney	UBERON:0000082	56.75	gold quality
pancreas	UBERON:0001264	56.72	gold quality
kidney	UBERON:0002113	56.56	gold quality
intestine	UBERON:0000160	55.49	gold quality
monocyte	CL:0000576	54.03	gold quality
cortex of kidney	UBERON:0001225	52.97	gold quality
left adrenal gland cortex	UBERON:0035825	52.82	gold quality
prefrontal cortex	UBERON:0000451	52.72	gold quality
multicellular organism	UBERON:0000468	51.73	gold quality
primary visual cortex	UBERON:0002436	50.75	gold quality
ascending aorta	UBERON:0001496	50.06	gold quality
thoracic aorta	UBERON:0001515	50.05	gold quality
gastrocnemius	UBERON:0001388	49.68	gold quality
colon	UBERON:0001155	49.09	gold quality
left testis	UBERON:0004533	49.07	gold quality
testis	UBERON:0000473	48.62	gold quality
right testis	UBERON:0004534	48.00	gold quality
body of pancreas	UBERON:0001150	47.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The m[6]A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN. (PMID:38491348)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.