POU6F2-AS2

Summary

POU6F2-AS2 (POU6F2 antisense RNA 2, HGNC:21887) is a long non-coding RNA gene on chromosome 7p14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21887
Approved symbol	POU6F2-AS2
Name	POU6F2 antisense RNA 2
Location	7p14.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ12971
Ensembl gene	ENSG00000233854
Ensembl biotype	lncRNA
Entrez	100689074
RNAcentral	URS0000A76D4A — lncRNA, 2336 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000420243, ENST00000787257

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420243 — 6 exons

Exon	Start	End
ENSE00001610877	39005063	39005212
ENSE00001645725	39013457	39013551
ENSE00001651619	38984232	38984405
ENSE00001667890	39002012	39002072
ENSE00001756716	38984877	38984921
ENSE00003867441	38980370	38981477

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 61.56.

Top tissues by expression

182 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	61.56	gold quality
mucosa of transverse colon	UBERON:0004991	55.62	gold quality
gastrocnemius	UBERON:0001388	55.43	silver quality
placenta	UBERON:0001987	55.41	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
prefrontal cortex	UBERON:0000451	53.98	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
epithelial cell of pancreas	CL:0000083	53.43	gold quality
tibialis anterior	UBERON:0001385	52.74	silver quality
gall bladder	UBERON:0002110	50.68	gold quality
myocardium	UBERON:0002349	50.25	gold quality
transverse colon	UBERON:0001157	50.04	gold quality
pancreatic ductal cell	CL:0002079	49.92	silver quality
deltoid	UBERON:0001476	49.40	gold quality
islet of Langerhans	UBERON:0000006	48.31	gold quality
lower lobe of lung	UBERON:0008949	47.83	silver quality
Brodmann (1909) area 9	UBERON:0013540	47.23	gold quality
nasal cavity epithelium	UBERON:0005384	47.03	gold quality
pancreas	UBERON:0001264	46.98	gold quality
frontal cortex	UBERON:0001870	46.69	gold quality
quadriceps femoris	UBERON:0001377	46.60	gold quality
left ovary	UBERON:0002119	46.24	gold quality
right lobe of liver	UBERON:0001114	46.22	silver quality
metanephros	UBERON:0000081	46.07	gold quality
neocortex	UBERON:0001950	46.01	gold quality
primary visual cortex	UBERON:0002436	45.98	gold quality
left adrenal gland	UBERON:0001234	45.52	gold quality
vastus lateralis	UBERON:0001379	45.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.96

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• current study represents the first description of an OSCC associated lncRNA that modulates DNA repair. (PMID:27033944)
• Long non-coding RNA POU6F2-AS2 promotes cell proliferation and drug resistance in colon cancer by regulating miR-377/BRD4. (PMID:32100443)
• LncRNA POU6F2-AS2 contributes to malignant phenotypes and paclitaxel resistance by promoting SKP2 expression in stomach adenocarcinoma. (PMID:36797828)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.