PPEF1

Summary

PPEF1 (protein phosphatase with EF-hand domain 1, HGNC:9243) is a protein-coding gene on chromosome Xp22.13, encoding Serine/threonine-protein phosphatase with EF-hands 1 (O14829). May have a role in the recovery or adaptation response of photoreceptors.

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described.

Source: NCBI Gene 5475 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 149 total — 1 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_001377996

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9243
Approved symbol	PPEF1
Name	protein phosphatase with EF-hand domain 1
Location	Xp22.13
Locus type	gene with protein product
Status	Approved
Aliases	PPP7CA
Ensembl gene	ENSG00000086717
Ensembl biotype	protein_coding
OMIM	300109
Entrez	5475

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 11 protein_coding, 1 nonsense_mediated_decay

ENST00000349874, ENST00000361511, ENST00000379962, ENST00000470157, ENST00000471570, ENST00000472826, ENST00000496075, ENST00000496616, ENST00000689646, ENST00000692488, ENST00000908182, ENST00000908183

RefSeq mRNA: 14 — MANE Select: NM_001377996 NM_001377986, NM_001377993, NM_001377994, NM_001377995, NM_001377996, NM_001378381, NM_001378382, NM_001389620, NM_001389621, NM_001389623, NM_001389624, NM_006240, NM_152224, NM_152226

CCDS: CCDS14188, CCDS43920, CCDS94563

Canonical transcript exons

ENST00000470157 — 16 exons

Exon	Start	End
ENSE00001832170	18707645	18707826
ENSE00003485870	18730181	18730308
ENSE00003505447	18818039	18818145
ENSE00003557900	18827276	18827917
ENSE00003564137	18757627	18757741
ENSE00003564298	18783899	18784048
ENSE00003565165	18806403	18806545
ENSE00003569506	18825751	18825835
ENSE00003595862	18749792	18749952
ENSE00003597609	18733748	18733808
ENSE00003603657	18823923	18824086
ENSE00003642035	18782366	18782402
ENSE00003659126	18789121	18789273
ENSE00003662510	18803892	18804077
ENSE00003684031	18779010	18779176
ENSE00003790184	18761530	18761576

Expression profiles

Bgee: expression breadth ubiquitous, 180 present calls, max score 93.11.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4196 / max 69.9440, expressed in 136 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
195692	0.2532	81
195689	0.1017	41
195693	0.0384	18
195690	0.0165	7
195691	0.0097	5

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	93.11	gold quality
male germ cell	CL:0000015	91.47	gold quality
cortical plate	UBERON:0005343	85.41	gold quality
secondary oocyte	CL:0000655	82.86	gold quality
endothelial cell	CL:0000115	82.63	silver quality
dorsal root ganglion	UBERON:0000044	82.17	gold quality
oocyte	CL:0000023	81.76	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.64	gold quality
left testis	UBERON:0004533	81.63	gold quality
right testis	UBERON:0004534	81.22	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	80.34	gold quality
testis	UBERON:0000473	79.60	gold quality
spinal cord	UBERON:0002240	78.86	gold quality
prefrontal cortex	UBERON:0000451	75.97	gold quality
orbitofrontal cortex	UBERON:0004167	75.90	gold quality
trigeminal ganglion	UBERON:0001675	73.97	gold quality
Brodmann (1909) area 10	UBERON:0013541	73.94	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.45	gold quality
frontal cortex	UBERON:0001870	72.05	gold quality
Brodmann (1909) area 46	UBERON:0006483	71.82	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	71.76	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.49	gold quality
neocortex	UBERON:0001950	71.18	gold quality
cingulate cortex	UBERON:0003027	70.04	gold quality
anterior cingulate cortex	UBERON:0009835	69.80	gold quality
frontal pole	UBERON:0002795	69.61	silver quality
right frontal lobe	UBERON:0002810	69.27	gold quality
diaphragm	UBERON:0001103	68.88	gold quality
cerebral cortex	UBERON:0000956	68.48	gold quality
superior frontal gyrus	UBERON:0002661	67.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.38

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

28 targeting PPEF1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-888-3P	99.53	69.77	1057
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-12132	99.47	68.90	1341
HSA-MIR-1244	99.33	68.38	832
HSA-MIR-3922-3P	99.25	64.96	1136
HSA-MIR-3176	99.25	64.35	954
HSA-MIR-3978	99.24	68.39	2201
HSA-MIR-4426	99.17	66.74	1949
HSA-MIR-4270	99.02	66.26	1987
HSA-MIR-6728-3P	98.63	67.63	1534
HSA-MIR-5187-5P	98.54	67.94	952
HSA-MIR-4662B	98.33	66.37	1163
HSA-MIR-653-3P	98.31	67.71	1542
HSA-MIR-4647	98.30	66.41	1139
HSA-MIR-1304-3P	98.29	66.44	1207
HSA-MIR-6728-5P	97.79	66.33	891
HSA-MIR-490-3P	97.79	65.54	606
HSA-MIR-12128	96.67	66.98	1471
HSA-MIR-6782-5P	96.45	64.42	612
HSA-MIR-3169	96.40	67.58	698
HSA-MIR-10525-3P	96.32	68.04	699
HSA-MIR-668-3P	96.18	65.80	673
HSA-MIR-6815-5P	96.05	65.55	662
HSA-MIR-6865-5P	96.05	65.58	675
HSA-MIR-4654	95.86	65.72	751
HSA-MIR-4769-5P	95.37	66.09	570

Literature-anchored findings (GeneRIF, showing 3)

• PPEF-1V is a 350bp deletion in the nucleotide sequence of PPEF-1 from 128-477bp and a 152-amino-acid N-terminal deletion in the amino acid sequence of PPEF-1. (PMID:22292511)
• Collectively, these data demonstrate that PPEF-1 plays a pivotal role in tumorigenesis of lung cancer cells by reducing PDCD5-mediated genotoxic stress responses. (PMID:28051100)
• The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility. (PMID:33783058)

Cross-species orthologs

33 orthologs

Organism	Symbol	Gene ID
danio_rerio	ppef1	ENSDARG00000020191
mus_musculus	Ppef1	ENSMUSG00000062168
rattus_norvegicus	Ppef1	ENSRNOG00000027331
drosophila_melanogaster	PpD5	FBGN0005778
drosophila_melanogaster	Pp1-Y1	FBGN0261399
drosophila_melanogaster	rdgC	FBGN0265959
caenorhabditis_elegans		WBGENE00001748
caenorhabditis_elegans		WBGENE00003969
caenorhabditis_elegans		WBGENE00007354
caenorhabditis_elegans		WBGENE00007699
caenorhabditis_elegans		WBGENE00007700
caenorhabditis_elegans		WBGENE00007763
caenorhabditis_elegans		WBGENE00008124
caenorhabditis_elegans	F22D6.9	WBGENE00009054
caenorhabditis_elegans		WBGENE00009079
caenorhabditis_elegans		WBGENE00009101
caenorhabditis_elegans		WBGENE00009893
caenorhabditis_elegans		WBGENE00010265
caenorhabditis_elegans		WBGENE00011133
caenorhabditis_elegans		WBGENE00012008
caenorhabditis_elegans		WBGENE00012741
caenorhabditis_elegans		WBGENE00013476
caenorhabditis_elegans		WBGENE00014158
caenorhabditis_elegans		WBGENE00016010
caenorhabditis_elegans		WBGENE00016081
caenorhabditis_elegans	F26B1.5	WBGENE00017817
caenorhabditis_elegans		WBGENE00018359
caenorhabditis_elegans		WBGENE00018410
caenorhabditis_elegans		WBGENE00019951
caenorhabditis_elegans	W03D8.2	WBGENE00020985
caenorhabditis_elegans		WBGENE00022617
caenorhabditis_elegans		WBGENE00022710
caenorhabditis_elegans	Y71G12B.30	WBGENE00044347

Paralogs (12): PPP5C (ENSG00000011485), PPP2CB (ENSG00000104695), PPP3CB (ENSG00000107758), PPP2CA (ENSG00000113575), PPP6C (ENSG00000119414), PPP3CC (ENSG00000120910), PPP3CA (ENSG00000138814), PPP4C (ENSG00000149923), PPEF2 (ENSG00000156194), PPP1CA (ENSG00000172531), PPP1CC (ENSG00000186298), PPP1CB (ENSG00000213639)

Protein

Protein identifiers

Serine/threonine-protein phosphatase with EF-hands 1 — O14829 (reviewed: O14829)

Alternative names: Protein phosphatase with EF calcium-binding domain, Serine/threonine-protein phosphatase 7

All UniProt accessions (6): O14829, A0A8I5KXD3, A0A8I5QKI8, C9JY08, F8WC69, H7C592

UniProt curated annotations — full annotation on UniProt →

Function. May have a role in the recovery or adaptation response of photoreceptors. May have a role in development.

Tissue specificity. Detected in retina and retinal derived Y-79 retinoblastoma cells. Also found in fetal brain.

Activity regulation. Activated by calcium.

Cofactor. Binds 2 manganese ions per subunit.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. May have no functional significance.

Similarity. Belongs to the PPP phosphatase family.

Isoforms (5)

UniProt ID	Names	Canonical?
O14829-1	1	yes
O14829-2	1A
O14829-3	1B
O14829-4	2
O14829-5	3

RefSeq proteins (14): NP_001364915, NP_001364922, NP_001364923, NP_001364924, NP_001364925, NP_001365310, NP_001365311, NP_001376549, NP_001376550, NP_001376552, NP_001376553, NP_006231, NP_689410, NP_689412 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000048	IQ_motif_EF-hand-BS	Binding_site
IPR002048	EF_hand_dom	Domain
IPR004843	Calcineurin-like_PHP	Domain
IPR006186	Ser/Thr-sp_prot-phosphatase	Domain
IPR011992	EF-hand-dom_pair	Homologous_superfamily
IPR012008	Ser/Thr-Pase_EF-hand_contain	Family
IPR013235	PPP_dom	Domain
IPR018247	EF_Hand_1_Ca_BS	Binding_site
IPR029052	Metallo-depent_PP-like	Homologous_superfamily
IPR051134	PPP_phosphatase	Family

Pfam: PF00149, PF00612, PF08321, PF13499

Catalyzed reactions (Rhea), 2 shown:

• O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (RHEA:20629)
• O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (RHEA:47004)

UniProt features (30 total): binding site 16, splice variant 5, domain 4, sequence variant 2, chain 1, region of interest 1, active site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O14829-F1	80.64	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 234 (proton donor)

Ligand- & substrate-binding residues (16): 201; 233; 285; 403; 579; 581; 583; 590; 619; 621; 623; 625 …

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade

MSigDB gene sets: 72 (showing top): GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOBP_DEPHOSPHORYLATION, GOBP_PROTEIN_DEPHOSPHORYLATION, CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN, GOMF_MANGANESE_ION_BINDING, GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS, GOMF_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY, GOMF_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY, GOMF_IRON_ION_BINDING, chrXp22, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GOMF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY, GOMF_PHOSPHATASE_ACTIVITY, P53_DN.V2_UP

GO Biological Process (2): protein dephosphorylation (GO:0006470), detection of stimulus involved in sensory perception (GO:0050906)

GO Molecular Function (8): protein serine/threonine phosphatase activity (GO:0004722), iron ion binding (GO:0005506), calcium ion binding (GO:0005509), manganese ion binding (GO:0030145), phosphoprotein phosphatase activity (GO:0004721), protein binding (GO:0005515), hydrolase activity (GO:0016787), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
The phototransduction cascade	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transition metal ion binding	2
dephosphorylation	1
protein modification process	1
sensory perception	1
detection of stimulus	1
phosphoprotein phosphatase activity	1
metal ion binding	1
phosphatase activity	1
catalytic activity, acting on a protein	1
binding	1
catalytic activity	1
cation binding	1
intracellular membrane-bounded organelle	1
cytoplasm	1
cellular anatomical structure	1

Protein interactions and networks

STRING

3193 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PPEF1	GOLPH3	Q9H4A6	918
PPEF1	SCML2	Q9UQR0	845
PPEF1	CDKL5	O76039	738
PPEF1	RHO	P08100	686
PPEF1	ENDOU	P21128	540
PPEF1	STOML2	Q9UJZ1	527
PPEF1	CALML5	Q9NZT1	526
PPEF1	CALML3	P27482	525
PPEF1	CALML4	Q96GE6	522
PPEF1	CALML6	Q8TD86	516
PPEF1	DUSP9	Q99956	482
PPEF1	CALM1	P02593	469
PPEF1	MDN1	Q9NU22	448
PPEF1	PWWP2B	Q6NUJ5	440
PPEF1	ASB12	Q8WXK4	426

IntAct

21 interactions, top by confidence:

A	B	Type	Score
CCM2	KRIT1	psi-mi:“MI:0914”(association)	0.960
CALR	PPEF1	psi-mi:“MI:0915”(physical association)	0.560
PPEF1	DLST	psi-mi:“MI:0915”(physical association)	0.560
PPEF1	AHCYL1	psi-mi:“MI:0915”(physical association)	0.560
PPEF1	NEK7	psi-mi:“MI:0915”(physical association)	0.560
PPEF1	CALM1	psi-mi:“MI:0915”(physical association)	0.560
PPEF1	Calm1	psi-mi:“MI:0915”(physical association)	0.510
PPEF1	HSPA8	psi-mi:“MI:0915”(physical association)	0.400
PPEF1	PPEF1	psi-mi:“MI:0915”(physical association)	0.370
PPEF1	IRS4	psi-mi:“MI:0914”(association)	0.350
PPEF1	ILVBL	psi-mi:“MI:0914”(association)	0.350

BioGRID (53): PPEF1 (Two-hybrid), CALM2 (Affinity Capture-MS), HSPA8 (Affinity Capture-MS), IRS4 (Affinity Capture-MS), UBR5 (Affinity Capture-MS), ACSL3 (Affinity Capture-MS), BAG2 (Affinity Capture-MS), GLUD1 (Affinity Capture-MS), ATP2A2 (Affinity Capture-MS), DNAJA1 (Affinity Capture-MS), TUBB4B (Affinity Capture-MS), TUBB2A (Affinity Capture-MS), HERC1 (Affinity Capture-MS), NTPCR (Affinity Capture-MS), TUBB2B (Affinity Capture-MS)

ESM2 similar proteins: A0A4X1T4U3, A4IFD0, F1QWA8, O02697, O14829, O14830, O14936, O35099, O35385, O35655, O60308, O70589, O76074, O77746, P26045, P33402, P48736, Q21029, Q28156, Q32M07, Q3SWT6, Q3USB7, Q3UYK3, Q3V3E1, Q4R3W4, Q502L7, Q5M7G4, Q5VRN0, Q62688, Q62915, Q68FP8, Q6AZT7, Q6P618, Q6ZT07, Q8BGG7, Q8BTI9, Q8CG03, Q8TEU7, Q8TF42, Q8VDY4

Diamond homologs: A0CNL9, A0DJ90, G5EBX9, G5EGK8, O04857, O14829, O14830, O15757, O35385, O35655, O43049, O76932, O82733, O82734, P11493, P11611, P11612, P12982, P13681, P20654, P22198, P23594, P23595, P23733, P23734, P23777, P23880, P30366, P32598, P33329, P36873, P36874, P40421, P48461, P48462, P48463, P48480, P48481, P48482, P48483

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
PPEF1	“down-regulates quantity by destabilization”	PDCD5	dephosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

149 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	25
Likely benign	8
Benign	2

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
833472	NC_000023.10:g.(?18660114)(19377781_?)del	Pathogenic

SpliceAI

3091 predictions. Top by Δscore:

Variant	Effect	Δscore
X:18727584:C:G	donor_gain	1.0000
X:18730162:A:AG	acceptor_gain	1.0000
X:18730163:T:G	acceptor_gain	1.0000
X:18730164:A:AG	acceptor_gain	1.0000
X:18730164:ATTCT:A	acceptor_gain	1.0000
X:18730168:T:TA	acceptor_gain	1.0000
X:18730170:T:TA	acceptor_gain	1.0000
X:18730171:G:A	acceptor_gain	1.0000
X:18730180:G:GA	acceptor_gain	1.0000
X:18730180:GCA:G	acceptor_gain	1.0000
X:18730304:TGCAG:T	donor_loss	1.0000
X:18730306:CAGGT:C	donor_loss	1.0000
X:18730307:AGG:A	donor_loss	1.0000
X:18730308:GGT:G	donor_loss	1.0000
X:18730309:GT:G	donor_loss	1.0000
X:18730310:T:A	donor_loss	1.0000
X:18733746:A:AG	acceptor_gain	1.0000
X:18733747:G:GA	acceptor_gain	1.0000
X:18733747:GTT:G	acceptor_gain	1.0000
X:18747341:G:GT	donor_gain	1.0000
X:18749790:A:AG	acceptor_gain	1.0000
X:18749791:G:GA	acceptor_gain	1.0000
X:18749791:GAA:G	acceptor_gain	1.0000
X:18749791:GAAT:G	acceptor_gain	1.0000
X:18749952:GGTA:G	donor_loss	1.0000
X:18749953:G:GG	donor_gain	1.0000
X:18749954:T:A	donor_loss	1.0000
X:18779005:CACA:C	acceptor_loss	1.0000
X:18779007:CA:C	acceptor_loss	1.0000
X:18779008:A:AG	acceptor_gain	1.0000

AlphaMissense

774 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:18827308:T:A	W595R	0.987
X:18827308:T:C	W595R	0.987
X:18825808:T:C	F575L	0.986
X:18825810:T:A	F575L	0.986
X:18825810:T:G	F575L	0.986
X:18827417:T:C	F631S	0.984
X:18818107:T:A	L488H	0.983
X:18818119:T:C	F492S	0.981
X:18827297:T:C	F591S	0.979
X:18818107:T:G	L488R	0.978
X:18825797:T:C	L571P	0.977
X:18825832:T:C	S583P	0.977
X:18827414:A:T	E630V	0.977
X:18827282:T:A	I586N	0.974
X:18827428:T:C	F635L	0.968
X:18827430:C:A	F635L	0.968
X:18827430:C:G	F635L	0.968
X:18827282:T:G	I586S	0.967
X:18827382:C:A	D619E	0.964
X:18827382:C:G	D619E	0.964
X:18827402:T:A	I626N	0.963
X:18827282:T:C	I586T	0.960
X:18827387:A:T	N621I	0.960
X:18825806:T:A	I574K	0.958
X:18825809:T:C	F575S	0.958
X:18827380:G:C	D619H	0.958
X:18825820:G:C	D579H	0.956
X:18825822:C:A	D579E	0.956
X:18825822:C:G	D579E	0.956
X:18827425:G:C	A634P	0.953

dbSNP variants (sampled 300 via entrez): RS1000015083 (X:18819184 A>T), RS1000017683 (X:18688292 C>T), RS1000032113 (X:18677638 A>T), RS1000065896 (X:18794767 T>A), RS1000086467 (X:18713589 G>A), RS1000086852 (X:18819643 G>A,C), RS1000095299 (X:18677031 C>A), RS1000115363 (X:18733159 T>G), RS1000130846 (X:18724602 C>T), RS1000143502 (X:18712043 C>T), RS1000146341 (X:18677324 C>G), RS1000175438 (X:18724248 C>G), RS1000214523 (X:18778828 T>G), RS1000241149 (X:18765502 A>G), RS1000269440 (X:18786848 T>A)

Disease associations

OMIM: gene MIM:300109 | disease phenotypes: MIM:312170

GenCC curated gene-disease

Mondo (1): pyruvate dehydrogenase E1-alpha deficiency (MONDO:0010717)

Orphanet (1): Pyruvate dehydrogenase E1-alpha deficiency (Orphanet:79243)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C564071	Pyruvate Dehydrogenase E1 Alpha Deficiency (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5465274 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

15 total (human), top 15 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases methylation, increases mutagenesis	2
Thapsigargin	decreases expression, increases expression	2
bufotalin	decreases expression	1
propionaldehyde	increases expression	1
bisphenol A	decreases methylation	1
ethyl-p-hydroxybenzoate	decreases expression	1
entinostat	increases expression	1
abrine	increases expression	1
licochalcone B	decreases expression	1
(+)-JQ1 compound	decreases expression	1
Carbamazepine	affects expression	1
Tunicamycin	decreases expression	1
Cadmium Chloride	decreases expression	1
Okadaic Acid	increases expression	1
Permethrin	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5326483	Binding	Inhibition of PP7 (unknown origin) phosphatase domain	Dual function of protein phosphatase 5 (PPP5C): An emerging therapeutic target for drug discovery. — Eur J Med Chem

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TF28	HAP1 PPEF1 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

1 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT05257005	Not specified	UNKNOWN	Natural History Study of Pyruvate Dehydrogenase Deficiency