PPFIA2-AS1

Summary

PPFIA2-AS1 (PPFIA2 antisense RNA 1, HGNC:53397) is a long non-coding RNA gene on chromosome 12q21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53397
Approved symbol	PPFIA2-AS1
Name	PPFIA2 antisense RNA 1
Location	12q21.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000257467
Ensembl biotype	lncRNA
Entrez	102724663
RNAcentral	URS000075A7BF — lncRNA, 969 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000547762, ENST00000549161, ENST00000550138, ENST00000550302, ENST00000550938, ENST00000550999, ENST00000551401, ENST00000551699, ENST00000552534, ENST00000553197, ENST00000654866

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000547762 — 5 exons

Exon	Start	End
ENSE00002350985	81296634	81296769
ENSE00002361749	81298063	81298163
ENSE00002369698	81282689	81282794
ENSE00002408048	81292343	81292524
ENSE00002410930	81312047	81312282

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 87.60.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0154 / max 13.9836, expressed in 4 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
127128	0.0154	4

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	87.60	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.84	gold quality
ganglionic eminence	UBERON:0004023	74.31	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.53	gold quality
testis	UBERON:0000473	72.34	gold quality
left testis	UBERON:0004533	71.95	gold quality
calcaneal tendon	UBERON:0003701	69.83	gold quality
right testis	UBERON:0004534	69.70	gold quality
cortical plate	UBERON:0005343	68.61	gold quality
popliteal artery	UBERON:0002250	67.66	gold quality
tibial artery	UBERON:0007610	67.65	gold quality
ventricular zone	UBERON:0003053	66.84	gold quality
superior frontal gyrus	UBERON:0002661	64.77	gold quality
descending thoracic aorta	UBERON:0002345	63.74	gold quality
thoracic aorta	UBERON:0001515	63.63	gold quality
ascending aorta	UBERON:0001496	63.57	gold quality
prefrontal cortex	UBERON:0000451	63.36	gold quality
left coronary artery	UBERON:0001626	63.35	gold quality
frontal cortex	UBERON:0001870	63.09	gold quality
right frontal lobe	UBERON:0002810	62.70	gold quality
skeletal muscle tissue	UBERON:0001134	62.63	gold quality
endometrium	UBERON:0001295	62.37	gold quality
mucosa of stomach	UBERON:0001199	62.14	gold quality
left uterine tube	UBERON:0001303	61.39	gold quality
pituitary gland	UBERON:0000007	61.30	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.77	gold quality
adenohypophysis	UBERON:0002196	60.19	gold quality
primary visual cortex	UBERON:0002436	60.15	gold quality
right coronary artery	UBERON:0001625	60.13	gold quality
endocervix	UBERON:0000458	60.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.55

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.