PPIC

Summary

PPIC (peptidylprolyl isomerase C, HGNC:9256) is a protein-coding gene on chromosome 5q23.2, encoding Peptidyl-prolyl cis-trans isomerase C (P45877). PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A.

Source: NCBI Gene 5480 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 28 total
• Druggable target: yes
• MANE Select transcript: NM_000943

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9256
Approved symbol	PPIC
Name	peptidylprolyl isomerase C
Location	5q23.2
Locus type	gene with protein product
Status	Approved
Aliases	CYPC
Ensembl gene	ENSG00000168938
Ensembl biotype	protein_coding
OMIM	123842
Entrez	5480

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 4 protein_coding, 1 retained_intron

ENST00000306442, ENST00000415659, ENST00000910735, ENST00000910736, ENST00000953401

RefSeq mRNA: 1 — MANE Select: NM_000943 NM_000943

CCDS: CCDS4133

Canonical transcript exons

ENST00000306442 — 5 exons

Exon	Start	End
ENSE00001120824	123025784	123025968
ENSE00001120828	123028775	123028868
ENSE00001120834	123029305	123029418
ENSE00001126305	123036509	123036725
ENSE00001251281	123023250	123024003

Expression profiles

Bgee: expression breadth ubiquitous, 284 present calls, max score 99.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 41.0314 / max 328.5590, expressed in 1581 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
63148	41.0314	1581

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibia	UBERON:0000979	99.44	gold quality
esophagus squamous epithelium	UBERON:0006920	99.38	gold quality
epithelium of esophagus	UBERON:0001976	99.14	gold quality
tendon of biceps brachii	UBERON:0008188	99.07	gold quality
squamous epithelium	UBERON:0006914	98.66	gold quality
skin of hip	UBERON:0001554	98.43	gold quality
gingiva	UBERON:0001828	98.24	gold quality
gingival epithelium	UBERON:0001949	98.12	gold quality
pancreatic ductal cell	CL:0002079	98.06	gold quality
mucosa of sigmoid colon	UBERON:0004993	97.99	gold quality
cervix squamous epithelium	UBERON:0006922	97.87	gold quality
periodontal ligament	UBERON:0008266	97.87	gold quality
colonic mucosa	UBERON:0000317	97.76	gold quality
palpebral conjunctiva	UBERON:0001812	97.42	gold quality
parotid gland	UBERON:0001831	97.33	gold quality
oviduct epithelium	UBERON:0004804	97.05	gold quality
upper leg skin	UBERON:0004262	96.99	gold quality
cauda epididymis	UBERON:0004360	96.98	gold quality
stromal cell of endometrium	CL:0002255	96.83	gold quality
cervix epithelium	UBERON:0004801	96.83	gold quality
hair follicle	UBERON:0002073	96.77	gold quality
heart right ventricle	UBERON:0002080	96.67	gold quality
corpus epididymis	UBERON:0004359	96.58	gold quality
descending thoracic aorta	UBERON:0002345	96.32	gold quality
synovial joint	UBERON:0002217	96.30	gold quality
oral cavity	UBERON:0000167	96.26	gold quality
myocardium	UBERON:0002349	96.18	gold quality
jejunal mucosa	UBERON:0000399	96.15	gold quality
vena cava	UBERON:0004087	96.10	gold quality
visceral pleura	UBERON:0002401	96.00	gold quality

Single-cell (SCXA)

Detected in 13 experiment(s), a significant marker in 13.

Experiment	Marker?	Max mean expression
E-MTAB-6701	yes	65.28
E-CURD-114	yes	55.27
E-MTAB-8410	yes	34.41
E-MTAB-5061	yes	26.92
E-CURD-112	yes	17.66
E-GEOD-125970	yes	16.88
E-GEOD-135922	yes	12.03
E-GEOD-83139	yes	11.03
E-MTAB-9388	yes	10.92
E-HCAD-11	yes	9.57
E-CURD-46	yes	8.04
E-MTAB-6678	yes	4.09
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

65 targeting PPIC, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488
HSA-MIR-548W	99.94	71.24	3488
HSA-MIR-548Y	99.94	71.28	3514
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-498-3P	99.91	71.27	1114

Literature-anchored findings (GeneRIF, showing 4)

• These findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclophilins B and C in ER redox homeostasis (PMID:24990953)
• Cyclophilin C participates in cytomegalovirus US2 protein-mediated degradation of major histocompatibility complex class I molecules. (PMID:26691022)
• Independent validation with glioma patients tissue (n = 70) and normal brain tissue (n = 19) found PPIC, EMP3 and CHI3L1 were up-regulated in glioma tissue. Survival value validation showed that the three genes correlated with patient survival by Kaplan-Meir analysis, including grades, age and therapy. (PMID:27801851)
• Cyclophilin C as a Novel Diagnostic and Prognostic Biomarker of Coronary Artery Diseases. A Systematic Review and Meta-Analysis. (PMID:37209796)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
		ENSDARG00000104343
mus_musculus	Ppic	ENSMUSG00000024538
rattus_norvegicus	Ppic	ENSRNOG00000017416
drosophila_melanogaster	Cyp40	FBGN0036020
caenorhabditis_elegans		WBGENE00000885

Paralogs (22): PPIE (ENSG00000084072), PPIL2 (ENSG00000100023), PPIF (ENSG00000108179), PPWD1 (ENSG00000113593), NKTR (ENSG00000114857), PPIL4 (ENSG00000131013), PPIL1 (ENSG00000137168), PPIG (ENSG00000138398), CWC27 (ENSG00000153015), PPIB (ENSG00000166794), PPID (ENSG00000171497), PPIH (ENSG00000171960), PPIL6 (ENSG00000185250), PPIA (ENSG00000196262), PPIAL4G (ENSG00000236334), PPIL3 (ENSG00000240344), PPIAL4A (ENSG00000263353), PPIAL4H (ENSG00000270339), PPIAL4E (ENSG00000271567), PPIAL4F (ENSG00000279782), PPIAL4C (ENSG00000288867), PPIAL4D (ENSG00000289549)

Protein

Protein identifiers

Peptidyl-prolyl cis-trans isomerase C — P45877 (reviewed: P45877)

Alternative names: Cyclophilin C, Rotamase C

All UniProt accessions (1): P45877

UniProt curated annotations — full annotation on UniProt →

Function. PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.

Subcellular location. Cytoplasm.

Tissue specificity. Expressed in kidney, skeletal muscle, pancreas, heart, lung, liver and to a lower extent in brain.

Activity regulation. Inhibited by cyclosporin A (CsA).

Similarity. Belongs to the cyclophilin-type PPIase family.

RefSeq proteins (1): NP_000934* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002130	Cyclophilin-type_PPIase_dom	Domain
IPR020892	Cyclophilin-type_PPIase_CS	Conserved_site
IPR029000	Cyclophilin-like_dom_sf	Homologous_superfamily

Pfam: PF00160

Enzyme classification (BRENDA):

• EC 5.2.1.8 — peptidylprolyl isomerase (BRENDA: 69 organisms, 374 substrates, 222 inhibitors, 24 Km, 30 kcat entries)

Substrate kinetics (BRENDA)

11 substrates with measured Km, best-characterized 11. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
N-SUCCINYL-ALA-GLU-(TRANS)-PRO-PHE-4-NITROANILID	0.17–0.7	5
N-SUCCINYL-ALA-ALA-(CIS)-PRO-PHE-4-NITROANILIDE	0.104–0.814	2
RNASE T1	0.0004–0.0006	2
SUCCINYL-ALA-ALA-PRO-PHE 4-NITROANILIDE	0.451–1.247	2
SUCCINYL-ALA-LYS-PRO-PHE-4-NITROANILIDE	0.585–0.788	2
ALA-GLY-PSI[CS-N]-PRO-PHE-4-NITROANILIDE	0.53	1
N-SUCCINYL-ALA-LEU-(CIS)-PRO-PHE-4-NITROANILIDE	0.059	1
SUCCINYL-ALA-GLU-PRO-PHE-7-AMIDO-4-METHYLCOUMARI	0.12	1
TRYWNAKMK-(CIS)-PFIFGA	2	1
SUCCINYL-ALA-ALA-(CIS)-PRO-LYS-4-METHYLCOUMARIN-	—	0
SUCCINYL-ALA-ALA-(CIS)-PRO-PHE 4-METHYLCOUMARIN	—	0

Catalyzed reactions (Rhea), 1 shown:

• [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) (RHEA:16237)

UniProt features (23 total): strand 11, turn 4, helix 3, sequence variant 3, chain 1, domain 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2ESL	X-RAY DIFFRACTION	1.9

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P45877-F1	91.88	0.84

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 238 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, LI_CISPLATIN_RESISTANCE_DN, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, DARWICHE_SKIN_TUMOR_PROMOTER_UP, DARWICHE_PAPILLOMA_RISK_LOW_UP, DARWICHE_PAPILLOMA_RISK_HIGH_UP, DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP, PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP, GOBP_PROTEIN_MATURATION, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP, GOBP_PROTEIN_FOLDING, BASSO_HAIRY_CELL_LEUKEMIA_UP, JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP, WANG_TARGETS_OF_MLL_CBP_FUSION_DN

GO Biological Process (2): protein folding (GO:0006457), protein peptidyl-prolyl isomerization (GO:0000413)

GO Molecular Function (4): peptidyl-prolyl cis-trans isomerase activity (GO:0003755), cyclosporin A binding (GO:0016018), protein binding (GO:0005515), isomerase activity (GO:0016853)

GO Cellular Component (2): cytoplasm (GO:0005737), extracellular exosome (GO:0070062)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
cellular process	1
protein maturation	1
peptidyl-proline modification	1
cis-trans isomerase activity	1
catalytic activity, acting on a protein	1
catalytic activity	1
intracellular anatomical structure	1
cellular anatomical structure	1
extracellular vesicle	1

Protein interactions and networks

STRING

3033 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PPIC	BSG	P35613	679
PPIC	LGALS3BP	Q08380	602
PPIC	CALM1	P02593	481
PPIC	CALML3	P27482	466
PPIC	CALML6	Q8TD86	466
PPIC	CALML4	Q96GE6	466
PPIC	CALML5	Q9NZT1	466
PPIC	EPRS1	P07814	460
PPIC	MINAR1	Q9UPX6	457
PPIC	PVALB	P20472	441
PPIC	APAF1	O14727	430
PPIC	PDCL	Q13371	419
PPIC	CD248	Q9HCU0	398
PPIC	CCR5	P51681	396
PPIC	COL1A2	P02464	378

IntAct

44 interactions, top by confidence:

A	B	Type	Score
SGTA	PPIC	psi-mi:“MI:0915”(physical association)	0.720
PPIC	SGTA	psi-mi:“MI:0915”(physical association)	0.720
BANP	PPIC	psi-mi:“MI:0915”(physical association)	0.560
UBAP1	PPIC	psi-mi:“MI:0915”(physical association)	0.560
PPIC	UBQLN1	psi-mi:“MI:0915”(physical association)	0.560
UBQLN1	PPIC	psi-mi:“MI:0915”(physical association)	0.560
PPIC	BANP	psi-mi:“MI:0915”(physical association)	0.560
PPIC	UBQLN2	psi-mi:“MI:0915”(physical association)	0.560
PPIC	SGTB	psi-mi:“MI:0915”(physical association)	0.560
FAM25C	PPIC	psi-mi:“MI:0915”(physical association)	0.560
PPIC	CAPNS2	psi-mi:“MI:0915”(physical association)	0.560
CLEC4A	SEMA7A	psi-mi:“MI:0914”(association)	0.530
PPIC	P4HA2	psi-mi:“MI:0915”(physical association)	0.400
PPIC	ARSA	psi-mi:“MI:0915”(physical association)	0.370
TEX101	MAP4K4	psi-mi:“MI:0914”(association)	0.350
	SHTN1	psi-mi:“MI:0914”(association)	0.350
SLC25A14	PLOD3	psi-mi:“MI:0914”(association)	0.350
PPIC	UBQLN2	psi-mi:“MI:0915”(physical association)	0.000
PPIC	SGTA	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (35): SGTA (Two-hybrid), UBQLN1 (Two-hybrid), UBAP1 (Two-hybrid), BANP (Two-hybrid), PPIC (Co-fractionation), PPIC (Affinity Capture-MS), PPIC (Affinity Capture-MS), PPIC (Affinity Capture-MS), PPIC (Two-hybrid), BANP (Two-hybrid), UBQLN2 (Two-hybrid), FAM25A (Two-hybrid), FAM25G (Two-hybrid), SGTB (Two-hybrid), CAPNS2 (Two-hybrid)

ESM2 similar proteins: B3A0R0, D4AY02, O43447, O49605, O74729, O93826, O94273, P0C1H9, P0C1I0, P0C1I3, P0CP78, P0CP79, P0CP82, P0CP83, P15425, P23284, P23285, P24368, P24369, P25719, P28517, P30412, P35176, P45877, P52013, P52014, P52018, P80311, P84343, Q01490, Q08E11, Q0P5D0, Q26551, Q27774, Q2TZ33, Q2UGK2, Q4I5R9, Q4IPH4, Q4P6X6, Q4WCM6

Diamond homologs: A0A0R0H9T5, A2AR02, A8X8D0, D4AY02, O49605, O49886, O55035, O74729, O93826, O94273, P0C1H7, P0C1H8, P0C1H9, P0C1I1, P0C1I7, P0C1I8, P0C1I9, P0CP82, P0CP83, P14832, P17742, P18253, P21568, P21569, P22011, P24367, P24368, P24525, P25719, P26882, P30414, P30415, P34790, P34791, P35627, P45877, P52009, P52010, P52011, P52015

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

28 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	21
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

935 predictions. Top by Δscore:

Variant	Effect	Δscore
5:123024000:CTGT:C	acceptor_gain	1.0000
5:123024004:C:CC	acceptor_gain	1.0000
5:123025779:TTTA:T	donor_loss	1.0000
5:123025780:TTA:T	donor_loss	1.0000
5:123025781:TACCA:T	donor_loss	1.0000
5:123025782:A:AT	donor_loss	1.0000
5:123025782:ACCAT:A	donor_gain	1.0000
5:123025783:C:CG	donor_loss	1.0000
5:123025783:CCAT:C	donor_gain	1.0000
5:123025783:CCATC:C	donor_gain	1.0000
5:123025786:T:A	donor_gain	1.0000
5:123025787:C:A	donor_gain	1.0000
5:123025810:C:CT	donor_gain	1.0000
5:123025964:CACAC:C	acceptor_gain	1.0000
5:123025965:ACAC:A	acceptor_gain	1.0000
5:123025966:CAC:C	acceptor_gain	1.0000
5:123025966:CACC:C	acceptor_gain	1.0000
5:123025969:C:CC	acceptor_gain	1.0000
5:123025970:T:G	acceptor_loss	1.0000
5:123025975:C:CT	acceptor_gain	1.0000
5:123025976:A:T	acceptor_gain	1.0000
5:123029300:CATA:C	donor_loss	1.0000
5:123029301:ATAC:A	donor_loss	1.0000
5:123029302:TA:T	donor_loss	1.0000
5:123029303:A:AC	donor_gain	1.0000
5:123029304:C:CC	donor_gain	1.0000
5:123029304:CCT:C	donor_gain	1.0000
5:123029304:CCTCT:C	donor_gain	1.0000
5:123029417:ACC:A	acceptor_loss	1.0000
5:123029419:C:CG	acceptor_loss	1.0000

AlphaMissense

1388 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:123028834:C:G	R89P	0.999
5:123025803:C:T	G164E	0.998
5:123025856:G:C	F146L	0.998
5:123025856:G:T	F146L	0.998
5:123025858:A:G	F146L	0.998
5:123025895:G:C	S133R	0.998
5:123025895:G:T	S133R	0.998
5:123025897:T:G	S133R	0.998
5:123028818:G:C	F94L	0.998
5:123028818:G:T	F94L	0.998
5:123028820:A:G	F94L	0.998
5:123025803:C:A	G164V	0.997
5:123025827:A:G	L156S	0.997
5:123025857:A:G	F146S	0.997
5:123025961:G:C	S111R	0.997
5:123025961:G:T	S111R	0.997
5:123025963:T:G	S111R	0.997
5:123029329:A:C	N69K	0.997
5:123029329:A:T	N69K	0.997
5:123025797:A:T	V166D	0.996
5:123025805:A:C	F163L	0.996
5:123025805:A:T	F163L	0.996
5:123025807:A:G	F163L	0.996
5:123025851:A:T	I148N	0.996
5:123025868:A:C	N142K	0.996
5:123025868:A:T	N142K	0.996
5:123025899:A:T	V132D	0.996
5:123025943:A:C	F117L	0.996
5:123025943:A:T	F117L	0.996
5:123025944:A:G	F117S	0.996

dbSNP variants (sampled 300 via entrez): RS1000915658 (5:123026816 C>A,G), RS1001074038 (5:123034355 A>G), RS1001178867 (5:123028002 T>C), RS1001295742 (5:123027192 T>C), RS1001733446 (5:123031239 G>T), RS1001783362 (5:123035270 A>G,T), RS1001899276 (5:123025722 T>A,C), RS1001973317 (5:123033505 C>A,G,T), RS1002142314 (5:123032355 C>T), RS1002371062 (5:123025324 C>T), RS1003813604 (5:123022844 G>T), RS1004062911 (5:123036803 G>A), RS1004377592 (5:123038675 AT>A,ATT), RS1004408270 (5:123036568 G>A,C), RS1004937972 (5:123034455 T>C)

Disease associations

OMIM: gene MIM:123842 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST000442_5	Aortic root size	1.000000e-11
GCST006479_146	Diverticular disease	6.000000e-08
GCST010701_69	Cortical surface area (MOSTest)	2.000000e-09
GCST010702_176	Subcortical volume (MOSTest)	8.000000e-35
GCST010703_344	Brain morphology (MOSTest)	4.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009959	diverticular disease
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2424505 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

1 potent at pChembl≥5 of 1 total, top 1 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.93	Ki	118	nM	CHEMBL2424822

PubChem BioAssay actives

1 with measured affinity, of 5 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
2-[(2R,3R)-3-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacont-2-yl]-3-hydroxy-2-methylpropyl]-3H-benzimidazole-5-carboxylic acid	770488: Inhibition of CypC PPIase activity (unknown origin)	ki	0.1180	uM

CTD chemical–gene interactions

53 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation, affects cotreatment, increases expression	9
trichostatin A	affects cotreatment, increases expression	3
cobaltous chloride	decreases expression	2
mercuric bromide	increases expression, affects cotreatment	2
entinostat	affects cotreatment, increases expression	2
belinostat	increases expression, affects cotreatment	2
Decitabine	affects expression, increases expression	2
Panobinostat	affects cotreatment, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Tobacco Smoke Pollution	affects expression, increases expression	2
Tretinoin	increases expression	2
Particulate Matter	decreases expression, increases abundance, affects cotreatment	2
bisphenol F	affects cotreatment, increases expression	1
dicrotophos	decreases expression	1
bisphenol A	increases expression, affects cotreatment	1
sodium arsenite	decreases expression	1
isobutyl alcohol	affects cotreatment, decreases expression, increases abundance	1
beta-methylcholine	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
ICG 001	increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
MRK 003	decreases expression	1
bisphenol S	affects cotreatment, increases expression	1
prothioconazole	increases expression	1
bisphenol AF	increases expression	1
Temozolomide	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Atrazine	increases expression	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL2428215	Binding	Inhibition of CypC PPIase activity (unknown origin)	Anti-inflammatory effects of extracellular cyclosporins are exclusively mediated by CD147. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.