PPM1E

Summary

PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E, HGNC:19322) is a protein-coding gene on chromosome 17q24.2, encoding Protein phosphatase 1E (Q8WY54). Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2.

This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5’-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene.

Source: NCBI Gene 22843 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 90 total — 1 pathogenic, 1 likely-pathogenic
• MANE Select transcript: NM_014906

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19322
Approved symbol	PPM1E
Name	protein phosphatase, Mg2+/Mn2+ dependent 1E
Location	17q24.2
Locus type	gene with protein product
Status	Approved
Aliases	POPX1, KIAA1072, PP2CH, CaMKP-N
Ensembl gene	ENSG00000175175
Ensembl biotype	protein_coding
OMIM	619308
Entrez	22843

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000308249

RefSeq mRNA: 1 — MANE Select: NM_014906 NM_014906

CCDS: CCDS11613

Canonical transcript exons

ENST00000308249 — 7 exons

Exon	Start	End
ENSE00001208070	58972832	58972925
ENSE00001208077	58972132	58972275
ENSE00001208081	58969539	58969727
ENSE00001208084	58965694	58965893
ENSE00001208090	58955649	58955767
ENSE00001255303	58755854	58756461
ENSE00001314564	58979974	58985179

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 98.97.

FANTOM5 (CAGE): breadth broad, TPM avg 6.2883 / max 280.9247, expressed in 715 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
161936	6.0354	710
208284	0.1212	59
161937	0.1002	44
161935	0.0315	8

Top tissues by expression

279 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	98.97	gold quality
cortical plate	UBERON:0005343	95.03	gold quality
Brodmann (1909) area 23	UBERON:0013554	93.32	gold quality
lateral nuclear group of thalamus	UBERON:0002736	90.96	gold quality
secondary oocyte	CL:0000655	90.87	gold quality
middle temporal gyrus	UBERON:0002771	89.84	gold quality
oocyte	CL:0000023	88.84	gold quality
entorhinal cortex	UBERON:0002728	88.06	gold quality
postcentral gyrus	UBERON:0002581	87.13	gold quality
parietal lobe	UBERON:0001872	85.97	gold quality
ganglionic eminence	UBERON:0004023	85.73	gold quality
superior frontal gyrus	UBERON:0002661	85.21	gold quality
substantia nigra pars compacta	UBERON:0001965	85.18	gold quality
ventricular zone	UBERON:0003053	84.63	gold quality
pons	UBERON:0000988	84.22	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.73	gold quality
primary visual cortex	UBERON:0002436	83.17	gold quality
Ammon’s horn	UBERON:0001954	82.35	gold quality
islet of Langerhans	UBERON:0000006	82.03	gold quality
prefrontal cortex	UBERON:0000451	80.95	gold quality
occipital lobe	UBERON:0002021	80.74	gold quality
sperm	CL:0000019	80.59	gold quality
adrenal tissue	UBERON:0018303	80.55	gold quality
superior vestibular nucleus	UBERON:0007227	79.72	gold quality
cerebral cortex	UBERON:0000956	79.42	gold quality
substantia nigra pars reticulata	UBERON:0001966	78.53	gold quality
frontal cortex	UBERON:0001870	78.25	gold quality
Brodmann (1909) area 46	UBERON:0006483	78.06	gold quality
male germ cell	CL:0000015	78.04	gold quality
neocortex	UBERON:0001950	77.89	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	63.61
E-CURD-119	yes	22.62
E-ANND-3	yes	3.89

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): SPI1, ZNF699

miRNA regulators (miRDB)

269 targeting PPM1E, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-1193	100.00	65.93	529
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-4775	99.98	75.00	6394

Literature-anchored findings (GeneRIF, showing 7)

• The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. (POPX1; POPX2) (PMID:11864573)
• The Ppm1E contributes to dephosphorylation of AMP-activated protein kinase. (PMID:20801214)
• Data show that miR-135b selectively targets the AMPK phosphatase Ppm1e. (PMID:27661114)
• miR-135b-5p expression downregulates Ppm1e to activate AMPK signaling, which inhibits LPS-induced TNFalpha production via suppressing ROS production and NFkappaB activation. (PMID:27793001)
• Ppm1E upregulation in human gastric cancer is important for cell proliferation, possible via regulating AMPK-mTOR signaling. (PMID:28423719)
• our results suggest that miR-135b-induced Ppm1e silence induces AMPK activation to inhibit osteoblastoma cell proliferation. (PMID:28460435)
• Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes. (PMID:36662636)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	ppm1e	ENSDARG00000026499
mus_musculus	Ppm1e	ENSMUSG00000046442
rattus_norvegicus	Ppm1e	ENSRNOG00000024730
drosophila_melanogaster	Pdp	FBGN0029958
drosophila_melanogaster	CG10376	FBGN0032702
caenorhabditis_elegans	pdp-1	WBGENE00022832

Paralogs (16): PPM1F (ENSG00000100034), TAB1 (ENSG00000100324), PPM1A (ENSG00000100614), PPM1H (ENSG00000111110), PPM1G (ENSG00000115241), ILKAP (ENSG00000132323), PPM1B (ENSG00000138032), PPM1J (ENSG00000155367), PPM1L (ENSG00000163590), PPM1K (ENSG00000163644), PPM1M (ENSG00000164088), PDP1 (ENSG00000164951), PPM1D (ENSG00000170836), PDP2 (ENSG00000172840), PP2D1 (ENSG00000183977), PPM1N (ENSG00000213889)

Protein

Protein identifiers

Protein phosphatase 1E — Q8WY54 (reviewed: Q8WY54)

Alternative names: Ca(2+)/calmodulin-dependent protein kinase phosphatase N, CaMKP-nucleus, Partner of PIX 1, Partner of PIX-alpha

All UniProt accessions (1): Q8WY54

UniProt curated annotations — full annotation on UniProt →

Function. Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2. Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2.

Subunit / interactions. Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7).

Subcellular location. Nucleus. Cytoplasm.

Cofactor. Binds 2 magnesium or manganese ions per subunit.

Polymorphism. The poly-Pro-Glu stretch is polymorphic.

Similarity. Belongs to the PP2C family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8WY54-2	2	yes
Q8WY54-3	3

RefSeq proteins (1): NP_055721* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000222	PP2C_BS	Binding_site
IPR001932	PPM-type_phosphatase-like_dom	Domain
IPR015655	PP2C	Family
IPR036457	PPM-type-like_dom_sf	Homologous_superfamily

Pfam: PF00481

Catalyzed reactions (Rhea), 2 shown:

• O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (RHEA:20629)
• O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (RHEA:47004)

UniProt features (34 total): repeat 11, compositionally biased region 5, binding site 5, region of interest 3, sequence variant 3, modified residue 2, sequence conflict 2, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WY54-F1	64.66	0.42

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (5): 273; 273; 274; 435; 479

Post-translational modifications (2): 535, 548

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9617324	Negative regulation of NMDA receptor-mediated neuronal transmission

MSigDB gene sets: 0 (showing top):

GO Biological Process (7): negative regulation of protein kinase activity (GO:0006469), signal transduction (GO:0007165), peptidyl-threonine dephosphorylation (GO:0035970), positive regulation of stress fiber assembly (GO:0051496), cellular response to lipopolysaccharide (GO:0071222), cellular response to xenobiotic stimulus (GO:0071466), protein dephosphorylation (GO:0006470)

GO Molecular Function (6): protein serine/threonine phosphatase activity (GO:0004722), metal ion binding (GO:0046872), phosphoprotein phosphatase activity (GO:0004721), protein binding (GO:0005515), hydrolase activity (GO:0016787), cation binding (GO:0043169)

GO Cellular Component (5): nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytoplasm (GO:0005737), protein-containing complex (GO:0032991)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Activation of NMDA receptors and postsynaptic events	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
nuclear lumen	2
cellular anatomical structure	2
negative regulation of protein phosphorylation	1
protein kinase activity	1
negative regulation of kinase activity	1
regulation of protein kinase activity	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
protein dephosphorylation	1
positive regulation of actin filament bundle assembly	1
stress fiber assembly	1
regulation of stress fiber assembly	1
response to lipopolysaccharide	1
cellular response to molecule of bacterial origin	1
cellular response to lipid	1
cellular response to oxygen-containing compound	1
response to xenobiotic stimulus	1
cellular response to chemical stimulus	1
dephosphorylation	1
protein modification process	1
phosphoprotein phosphatase activity	1
cation binding	1
phosphatase activity	1
catalytic activity, acting on a protein	1
binding	1
catalytic activity	1
ion binding	1
intracellular membrane-bounded organelle	1
intracellular membraneless organelle	1
intracellular anatomical structure	1
cellular_component	1

Protein interactions and networks

STRING

1603 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PPM1E	ARAP1	Q96P48	557
PPM1E	ARHGEF6	Q15052	550
PPM1E	TEX14	Q8IWB6	447
PPM1E	IQSEC3	Q9UPP2	412
PPM1E	MAD1L1	Q9Y6D9	408
PPM1E	MTMR4	Q9NYA4	404
PPM1E	NISCH	Q9Y2I1	397
PPM1E	Q8N1N5	Q8N1N5	392
PPM1E	RFWD3	Q6PCD5	370
PPM1E	TUBD1	Q9UJT1	357
PPM1E	PPM1J	Q5JR12	356
PPM1E	PPTC7	Q8NI37	352
PPM1E	PPM1H	Q9ULR3	349
PPM1E	CAMKK2	Q96RR4	349
PPM1E	PPP5C	P53041	340

IntAct

25 interactions, top by confidence:

A	B	Type	Score
NDUFAF5	XRCC2	psi-mi:“MI:0914”(association)	0.530
PPM1E	NDUFA4	psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
PSME3	C11orf98	psi-mi:“MI:0914”(association)	0.350
S100P	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
HSPA12B	VWA8	psi-mi:“MI:0914”(association)	0.350
PRMT2	KRBA1	psi-mi:“MI:0914”(association)	0.350
KDELR2	CIAO1	psi-mi:“MI:0914”(association)	0.350
PPM1E	SERPINB4	psi-mi:“MI:0914”(association)	0.350
SLC1A3	DDX11L8	psi-mi:“MI:0914”(association)	0.350
SLC22A11	CNOT1	psi-mi:“MI:0914”(association)	0.350
SLC39A9	TRAFD1	psi-mi:“MI:0914”(association)	0.350
MAPT	PITPNM1	psi-mi:“MI:2364”(proximity)	0.270
MAPT	DCTN6	psi-mi:“MI:2364”(proximity)	0.270
MAPT		psi-mi:“MI:2364”(proximity)	0.270
PPM1E	DISC1	psi-mi:“MI:0915”(physical association)	0.000
TNIK	PPM1E	psi-mi:“MI:0915”(physical association)	0.000
DISC1	PPM1E	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (57): PRKAA2 (Affinity Capture-Western), PRKAA1 (Biochemical Activity), PPM1E (Affinity Capture-MS), PPM1E (Affinity Capture-MS), PPM1E (Affinity Capture-MS), COX4I1 (Affinity Capture-MS), DNAJA3 (Affinity Capture-MS), HLA-C (Affinity Capture-MS), MAD2L1 (Affinity Capture-MS), NDUFA4 (Affinity Capture-MS), SLC25A5 (Affinity Capture-MS), SLFN11 (Affinity Capture-MS), SSR4 (Affinity Capture-MS), STX17 (Affinity Capture-MS), TARDBP (Affinity Capture-MS)

ESM2 similar proteins: A0JPH4, A2AGX3, A2RRU4, A3KFU9, A6QM06, A7YWH3, B9U3F2, G5E8P0, O15040, O75129, P97260, Q12770, Q17RG1, Q2M3C6, Q2R2B1, Q32KQ7, Q4R5A4, Q562E2, Q5M9F0, Q5MNU5, Q5RA50, Q5SYB0, Q6GQT6, Q6L8S8, Q6L9W6, Q6PCP7, Q80TL0, Q80Z10, Q80Z30, Q86V42, Q8BHR8, Q8BZB3, Q8C0R7, Q8CIV2, Q8JZL1, Q8K0Z9, Q8K451, Q8NFM7, Q8NFN8, Q8VZJ0

Diamond homologs: A0A7U2MSD6, A0BLX0, A0BQL0, A0CUB5, A0DSB3, A0DTY1, A3A8W2, A3A8W6, A3CCP9, A5PJZ2, A6K136, B8NLZ3, G0RT93, O15297, O62829, O62830, O75688, O81716, P20650, P34221, P35182, P35813, P35814, P35815, P36982, P36993, P38089, P39966, P40371, P49443, P49444, P49596, P49597, P49598, P93006, Q09172, Q09173, Q0D629, Q0DBU3, Q0DZT4

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
PPM1E	“down-regulates activity”	PAK1	dephosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

90 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	1
Uncertain significance	79
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
929382	GRCh37/hg19 17q22(chr17:56780562-57251609)x1	Pathogenic
931109	NM_001005207.5(TRIM37):c.2892-2A>T	Likely pathogenic

SpliceAI

2776 predictions. Top by Δscore:

Variant	Effect	Δscore
17:58756463:T:G	donor_gain	1.0000
17:58756463:T:TG	donor_gain	1.0000
17:58955646:CAGT:C	acceptor_loss	1.0000
17:58955647:A:AG	acceptor_gain	1.0000
17:58955647:AG:A	acceptor_loss	1.0000
17:58955648:G:GC	acceptor_gain	1.0000
17:58955648:GT:G	acceptor_gain	1.0000
17:58955648:GTA:G	acceptor_gain	1.0000
17:58955648:GTAA:G	acceptor_gain	1.0000
17:58955648:GTAAT:G	acceptor_gain	1.0000
17:58955764:GTGG:G	donor_gain	1.0000
17:58955765:TGG:T	donor_gain	1.0000
17:58955766:GG:G	donor_gain	1.0000
17:58955766:GGG:G	donor_gain	1.0000
17:58955767:GG:G	donor_gain	1.0000
17:58955767:GGT:G	donor_loss	1.0000
17:58955768:G:A	donor_loss	1.0000
17:58955768:G:GG	donor_gain	1.0000
17:58969534:GACA:G	acceptor_loss	1.0000
17:58969535:ACAG:A	acceptor_loss	1.0000
17:58969536:CA:C	acceptor_loss	1.0000
17:58969723:GGGAG:G	donor_gain	1.0000
17:58969724:G:GT	donor_gain	1.0000
17:58969724:GGAG:G	donor_gain	1.0000
17:58969725:G:T	donor_gain	1.0000
17:58969725:GAG:G	donor_gain	1.0000
17:58969725:GAGG:G	donor_gain	1.0000
17:58969726:AGGT:A	donor_loss	1.0000
17:58969729:T:A	donor_loss	1.0000
17:58980192:TC:T	donor_gain	1.0000

AlphaMissense

4970 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:58756421:G:C	G142R	1.000
17:58756452:T:C	L152P	1.000
17:58955653:T:C	C157R	1.000
17:58955681:C:A	A166D	1.000
17:58965736:T:C	L209P	1.000
17:58965807:T:C	S233P	1.000
17:58965813:C:G	H235D	1.000
17:58965816:G:C	A236P	1.000
17:58965817:C:A	A236D	1.000
17:58965820:T:A	I237N	1.000
17:58965824:A:C	K238N	1.000
17:58965824:A:T	K238N	1.000
17:58965825:A:G	N239D	1.000
17:58965826:A:T	N239I	1.000
17:58965827:C:A	N239K	1.000
17:58965827:C:G	N239K	1.000
17:58965831:C:A	R241S	1.000
17:58965835:G:C	R242T	1.000
17:58965835:G:T	R242M	1.000
17:58965836:G:C	R242S	1.000
17:58965836:G:T	R242S	1.000
17:58965841:T:A	M244K	1.000
17:58965841:T:C	M244T	1.000
17:58965841:T:G	M244R	1.000
17:58965842:G:A	M244I	1.000
17:58965842:G:C	M244I	1.000
17:58965842:G:T	M244I	1.000
17:58965843:G:A	E245K	1.000
17:58965844:A:T	E245V	1.000
17:58965845:G:C	E245D	1.000

dbSNP variants (sampled 300 via entrez): RS1000002406 (17:58973363 G>C), RS1000045673 (17:58950029 G>T), RS1000050153 (17:58889858 C>T), RS1000050952 (17:58840637 A>G,T), RS1000054671 (17:58779800 C>G), RS1000064733 (17:58924521 A>T), RS1000070570 (17:58877213 A>G), RS1000095617 (17:58924880 A>G), RS1000106949 (17:58833051 C>G), RS1000109107 (17:58974925 C>T), RS1000121081 (17:58806634 G>C), RS1000124139 (17:58866516 C>T), RS1000125657 (17:58893025 A>T), RS1000149980 (17:58789001 C>T), RS1000151726 (17:58772910 C>T)

Disease associations

OMIM: gene MIM:619308 | disease phenotypes: MIM:253250

GenCC curated gene-disease

Mondo (1): mulibrey nanism (MONDO:0009664)

Orphanet (1): Mulibrey nanism (Orphanet:2576)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST000098_13	Cognitive test performance	5.000000e-06
GCST001980_2	Circulating myeloperoxidase levels (plasma)	4.000000e-09
GCST002023_1	Testicular germ cell tumor	4.000000e-13
GCST002774_29	Cognitive function	3.000000e-07
GCST003264_870	Post bronchodilator FEV1/FVC ratio	1.000000e-06
GCST003264_873	Post bronchodilator FEV1/FVC ratio	1.000000e-06
GCST005316_216	Intelligence (MTAG)	4.000000e-10
GCST006624_31	Systolic blood pressure	4.000000e-15
GCST007267_7	Systolic blood pressure	4.000000e-13
GCST010002_126	Refractive error	7.000000e-42

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0003926	neuropsychological test
EFO:0005243	myeloperoxidase measurement
EFO:0004337	intelligence
EFO:0004713	FEV/FVC ratio
EFO:0006335	systolic blood pressure

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D050336	Mulibrey Nanism	C05.116.099.343.796; C16.320.240.875

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation, affects expression, increases expression	5
Estradiol	increases reaction, affects cotreatment, decreases expression, increases expression	3
Benzo(a)pyrene	affects methylation, increases methylation	2
Cyclosporine	increases expression	2
aristolochic acid I	increases expression	1
trichostatin A	increases expression	1
sodium arsenite	decreases expression	1
perfluorooctanoic acid	affects cotreatment, decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment, decreases expression	1
CGP 52608	increases reaction, affects binding	1
ICG 001	increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
incobotulinumtoxinA	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Acetaminophen	increases expression	1
Catechin	affects cotreatment, decreases expression	1
Cosmetics	affects cotreatment, decreases expression	1
Coumestrol	affects cotreatment, increases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Flame Retardants	affects cotreatment, decreases expression	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression, affects cotreatment	1
Methyl Methanesulfonate	increases expression	1
Plasticizers	affects cotreatment, decreases expression	1
Tetrachlorodibenzodioxin	decreases expression, affects cotreatment	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	decreases expression	1
Tunicamycin	increases expression	1
Vanadates	decreases expression	1
Aflatoxin B1	increases methylation	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TF37	HAP1 PPM1E (-) 1	Cancer cell line	Male
CVCL_TF38	HAP1 PPM1E (-) 2	Cancer cell line	Male
CVCL_TF39	HAP1 PPM1E (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.