PPM1F-AS1

Summary

PPM1F-AS1 (PPM1F antisense RNA 1, HGNC:40888) is a long non-coding RNA gene on chromosome 22q11.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40888
Approved symbol	PPM1F-AS1
Name	PPM1F antisense RNA 1
Location	22q11.22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224086
Ensembl biotype	lncRNA
Entrez	100286925
RNAcentral	URS0000BC44E8 — lncRNA, 3710 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000458178, ENST00000653280, ENST00000846341

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000458178 — 2 exons

Exon	Start	End
ENSE00001615538	21938293	21939613
ENSE00001738777	21941102	21977632

Expression profiles

Bgee: expression breadth ubiquitous, 178 present calls, max score 79.77.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3287 / max 28.0545, expressed in 118 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
191206	0.3287	118

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	79.77	gold quality
buccal mucosa cell	CL:0002336	79.43	gold quality
cerebellar vermis	UBERON:0004720	74.07	gold quality
layer of synovial tissue	UBERON:0007616	71.52	gold quality
apex of heart	UBERON:0002098	71.11	gold quality
tendon of biceps brachii	UBERON:0008188	70.65	gold quality
pancreatic ductal cell	CL:0002079	69.50	silver quality
stromal cell of endometrium	CL:0002255	68.87	gold quality
colonic epithelium	UBERON:0000397	68.32	silver quality
tendon	UBERON:0000043	68.06	gold quality
cortical plate	UBERON:0005343	67.90	gold quality
bone marrow cell	CL:0002092	67.51	silver quality
prefrontal cortex	UBERON:0000451	66.76	gold quality
cerebellar cortex	UBERON:0002129	66.13	gold quality
monocyte	CL:0000576	66.11	gold quality
cerebellum	UBERON:0002037	66.10	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.08	gold quality
leukocyte	CL:0000738	66.04	gold quality
cerebellar hemisphere	UBERON:0002245	66.02	gold quality
calcaneal tendon	UBERON:0003701	65.98	gold quality
primary visual cortex	UBERON:0002436	65.19	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.08	gold quality
right frontal lobe	UBERON:0002810	64.79	gold quality
granulocyte	CL:0000094	64.78	gold quality
frontal cortex	UBERON:0001870	64.52	gold quality
neocortex	UBERON:0001950	64.30	gold quality
adipose tissue	UBERON:0001013	64.00	gold quality
right coronary artery	UBERON:0001625	63.98	gold quality
amniotic fluid	UBERON:0000173	63.97	silver quality
ganglionic eminence	UBERON:0004023	63.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.56

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.