PPM1K-DT

Summary

PPM1K-DT (PPM1K divergent transcript, HGNC:54093) is a long non-coding RNA gene on chromosome 4q22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54093
Approved symbol	PPM1K-DT
Name	PPM1K divergent transcript
Location	4q22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246375
Ensembl biotype	lncRNA
Entrez	105369192
RNAcentral	URS0000A76A54 — lncRNA, 1718 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 65 — 65 lncRNA

ENST00000500009, ENST00000652965, ENST00000661337, ENST00000661338, ENST00000662571, ENST00000685747, ENST00000686103, ENST00000686365, ENST00000687426, ENST00000689612, ENST00000690428, ENST00000701526, ENST00000702217, ENST00000726976, ENST00000726977, ENST00000726978, ENST00000726979, ENST00000726980, ENST00000726981, ENST00000726982, ENST00000726983, ENST00000726984, ENST00000726985, ENST00000726986, ENST00000726987, ENST00000726988, ENST00000726989, ENST00000726990, ENST00000726991, ENST00000726992, ENST00000726993, ENST00000726994, ENST00000726995, ENST00000726996, ENST00000726997, ENST00000726998, ENST00000726999, ENST00000727000, ENST00000727001, ENST00000727002, ENST00000727003, ENST00000727004, ENST00000727005, ENST00000727006, ENST00000727007, ENST00000727008, ENST00000727009, ENST00000727010, ENST00000727011, ENST00000727012, ENST00000727013, ENST00000727014, ENST00000727015, ENST00000727016, ENST00000727017, ENST00000727018, ENST00000727019, ENST00000727020, ENST00000727021, ENST00000727022, ENST00000727023, ENST00000727024, ENST00000727025, ENST00000727026, ENST00000727027

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500009 — 5 exons

Exon	Start	End
ENSE00001961630	88311796	88311871
ENSE00001969877	88319331	88319425
ENSE00001976494	88330181	88331421
ENSE00001986105	88284936	88285061
ENSE00001989146	88316686	88316807

Expression profiles

Bgee: expression breadth ubiquitous, 151 present calls, max score 77.27.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9652 / max 179.4347, expressed in 212 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
48795	0.4979	88
48796	0.3868	126
203280	0.0806	31

Top tissues by expression

230 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.27	gold quality
palpebral conjunctiva	UBERON:0001812	71.93	silver quality
apex of heart	UBERON:0002098	68.10	gold quality
cortical plate	UBERON:0005343	67.69	gold quality
bone marrow cell	CL:0002092	67.48	silver quality
caudate nucleus	UBERON:0001873	64.50	gold quality
lower lobe of lung	UBERON:0008949	64.33	silver quality
putamen	UBERON:0001874	64.16	gold quality
amygdala	UBERON:0001876	64.02	gold quality
nucleus accumbens	UBERON:0001882	64.00	gold quality
anterior cingulate cortex	UBERON:0009835	63.99	gold quality
ventricular zone	UBERON:0003053	63.80	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.58	gold quality
heart left ventricle	UBERON:0002084	63.48	gold quality
cardiac ventricle	UBERON:0002082	62.85	gold quality
spinal cord	UBERON:0002240	62.43	gold quality
right atrium auricular region	UBERON:0006631	62.03	gold quality
substantia nigra	UBERON:0002038	61.85	gold quality
cardiac atrium	UBERON:0002081	61.58	gold quality
right frontal lobe	UBERON:0002810	61.52	gold quality
ganglionic eminence	UBERON:0004023	61.45	gold quality
heart	UBERON:0000948	60.91	gold quality
hypothalamus	UBERON:0001898	60.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	60.72	gold quality
left uterine tube	UBERON:0001303	60.13	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.12	gold quality
midbrain	UBERON:0001891	60.04	gold quality
temporal lobe	UBERON:0001871	59.98	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	59.34	gold quality
neocortex	UBERON:0001950	59.23	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	10.40
E-ANND-3	no	1.74

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.