PPP1R12A-AS1

Summary

PPP1R12A-AS1 (PPP1R12A antisense RNA 1, HGNC:51903) is a long non-coding RNA gene on chromosome 12q21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51903
Approved symbol	PPP1R12A-AS1
Name	PPP1R12A antisense RNA 1
Location	12q21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	R12A-AS1
Ensembl gene	ENSG00000257557
Ensembl biotype	lncRNA
Entrez	105369865
RNAcentral	URS0000BC45CA — lncRNA, 1537 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000552885, ENST00000798430, ENST00000798431, ENST00000798432

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000552885 — 3 exons

Exon	Start	End
ENSE00002326572	79934901	79935658
ENSE00002364802	79940362	79942712
ENSE00002417993	79938728	79938852

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 84.97.

FANTOM5 (CAGE): breadth broad, TPM avg 1.3730 / max 37.6472, expressed in 770 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
127085	0.9435	466
127086	0.4295	203

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.97	gold quality
sural nerve	UBERON:0015488	78.42	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.14	gold quality
colonic epithelium	UBERON:0000397	66.12	silver quality
popliteal artery	UBERON:0002250	65.65	gold quality
tibial artery	UBERON:0007610	65.63	gold quality
bone marrow cell	CL:0002092	65.57	silver quality
right coronary artery	UBERON:0001625	64.41	gold quality
monocyte	CL:0000576	63.54	gold quality
leukocyte	CL:0000738	62.75	gold quality
left coronary artery	UBERON:0001626	61.67	gold quality
ventricular zone	UBERON:0003053	61.30	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.28	gold quality
lower esophagus	UBERON:0013473	61.24	gold quality
thoracic aorta	UBERON:0001515	61.00	gold quality
ascending aorta	UBERON:0001496	60.97	gold quality
stromal cell of endometrium	CL:0002255	60.94	gold quality
calcaneal tendon	UBERON:0003701	60.71	gold quality
smooth muscle tissue	UBERON:0001135	60.63	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.38	gold quality
endometrium	UBERON:0001295	60.15	gold quality
urinary bladder	UBERON:0001255	60.05	gold quality
ganglionic eminence	UBERON:0004023	59.72	gold quality
islet of Langerhans	UBERON:0000006	59.46	gold quality
descending thoracic aorta	UBERON:0002345	59.43	gold quality
placenta	UBERON:0001987	59.17	gold quality
myometrium	UBERON:0001296	58.98	gold quality
prefrontal cortex	UBERON:0000451	58.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	58.36	gold quality
body of uterus	UBERON:0009853	58.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.07

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.