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PPP1R12B

gene
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Also known as M20MGC87886MGC131980PP1bp55

Summary

PPP1R12B (protein phosphatase 1 regulatory subunit 12B, HGNC:7619) is a protein-coding gene on chromosome 1q32.1, encoding Protein phosphatase 1 regulatory subunit 12B (O60237). Regulates myosin phosphatase activity.

Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated–MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome.

Source: NCBI Gene 4660 — RefSeq curated summary.

At a glance

  • GWAS associations: 5
  • Clinical variants (ClinVar): 170 total
  • MANE Select transcript: NM_002481

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:7619
Approved symbolPPP1R12B
Nameprotein phosphatase 1 regulatory subunit 12B
Location1q32.1
Locus typegene with protein product
StatusApproved
AliasesM20, MGC87886, MGC131980, PP1bp55
Ensembl geneENSG00000077157
Ensembl biotypeprotein_coding
OMIM603768
Entrez4660

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 12 protein_coding, 4 protein_coding_CDS_not_defined, 3 retained_intron, 3 nonsense_mediated_decay

ENST00000290419, ENST00000356764, ENST00000367269, ENST00000391959, ENST00000434615, ENST00000462074, ENST00000464965, ENST00000465284, ENST00000466273, ENST00000466968, ENST00000476364, ENST00000480184, ENST00000488330, ENST00000491336, ENST00000498070, ENST00000608999, ENST00000618451, ENST00000634903, ENST00000704899, ENST00000969198, ENST00000969199, ENST00000969200

RefSeq mRNA: 8 — MANE Select: NM_002481 NM_001167857, NM_001167858, NM_001197131, NM_001331029, NM_001410283, NM_002481, NM_032103, NM_032104

CCDS: CCDS1426, CCDS30973, CCDS44294, CCDS44295, CCDS53458, CCDS53459, CCDS73005, CCDS81416

Canonical transcript exons

ENST00000608999 — 24 exons

ExonStartEnd
ENSE00001895027202348699202349142
ENSE00002252595202440706202440788
ENSE00002263309202422620202422738
ENSE00002277899202437821202438024
ENSE00002292127202442447202442572
ENSE00002318911202416787202416917
ENSE00003458446202493114202493317
ENSE00003475535202428855202428929
ENSE00003501572202495293202495482
ENSE00003537086202495570202495682
ENSE00003549601202448989202449171
ENSE00003550736202564443202564547
ENSE00003554338202434656202434768
ENSE00003563501202567778202567831
ENSE00003573458202430731202430810
ENSE00003574578202562778202562922
ENSE00003593853202496781202496822
ENSE00003631092202569147202569197
ENSE00003653455202431480202431619
ENSE00003664118202425566202425725
ENSE00003674642202558877202558893
ENSE00003690761202427040202427184
ENSE00003692978202488533202488623
ENSE00003846276202580474202592702

Expression profiles

Bgee: expression breadth ubiquitous, 285 present calls, max score 99.07.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.7974 / max 720.2219, expressed in 1629 samples.

FANTOM5 promoters (17 alternative TSS)

Promoter IDTPM avgSamples expressed
77986.65391485
78161.4521170
78151.2590240
78000.9827478
78090.211525
78030.195785
78050.192654
78010.185393
78120.159829
78100.103821

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
saphenous veinUBERON:000731899.07gold quality
blood vessel layerUBERON:000479798.97gold quality
left ventricle myocardiumUBERON:000656698.74gold quality
right coronary arteryUBERON:000162598.68gold quality
cardiac muscle of right atriumUBERON:000337998.52gold quality
myocardiumUBERON:000234998.37gold quality
heart right ventricleUBERON:000208098.25gold quality
popliteal arteryUBERON:000225098.24gold quality
tibial arteryUBERON:000761098.23gold quality
aortaUBERON:000094798.15gold quality
arteryUBERON:000163798.08gold quality
thoracic aortaUBERON:000151598.04gold quality
cauda epididymisUBERON:000436098.04gold quality
ascending aortaUBERON:000149698.02gold quality
body of uterusUBERON:000985397.96gold quality
colonic epitheliumUBERON:000039797.85gold quality
descending thoracic aortaUBERON:000234597.82gold quality
mucosa of stomachUBERON:000119997.80gold quality
lower esophagus muscularis layerUBERON:003583397.68gold quality
seminal vesicleUBERON:000099897.67gold quality
lower esophagusUBERON:001347397.62gold quality
muscle layer of sigmoid colonUBERON:003580597.61gold quality
cardiac atriumUBERON:000208197.44gold quality
gall bladderUBERON:000211097.35gold quality
right atrium auricular regionUBERON:000663197.32gold quality
heartUBERON:000094897.18gold quality
esophagogastric junction muscularis propriaUBERON:003584197.10gold quality
coronary arteryUBERON:000162197.07gold quality
cardiac ventricleUBERON:000208297.05gold quality
myometriumUBERON:000129697.01gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

ExperimentMarker?Max mean expression
E-MTAB-10287yes48.70
E-MTAB-8410yes22.37
E-ANND-3yes11.98
E-CURD-119yes10.65
E-MTAB-6142no69.70

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

  • Results describe the characterization and function of MYPT2, a target subunit of myosin phosphatase in heart. (PMID:16431080)
  • analysis of the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase (PMID:18782776)
  • PPP1R12B is associated with childhood asthma in a Russian population. (PMID:23640410)
  • PEAK1-PPP1R12B axis inhibits colorectal tumorigenesis and metastasis through deactivation of the Grb2/PI3K/Akt pathway. (PMID:30472186)
  • MicroRNA-4463 facilitates the development of colon cancer by suppression of the expression of PPP1R12B. (PMID:35064454)
  • FAT10 differentially stabilizes MYPT2 isoforms. (PMID:37506472)
  • Revealing PPP1R12B and COL1A1 as piRNA pathway genes contributing to abdominal aortic aneurysm through integrated analysis and experimental validation. (PMID:38070790)

Cross-species orthologs

4 orthologs

OrganismSymbolGene ID
mus_musculusPpp1r12bENSMUSG00000073557
rattus_norvegicusPpp1r12bENSRNOG00000051440
drosophila_melanogasterMbsFBGN0005536
caenorhabditis_elegansWBGENE00003196

Paralogs (3): PPP1R12A (ENSG00000058272), PPP1R12C (ENSG00000125503), PPP1R27 (ENSG00000182676)

Protein

Protein identifiers

Protein phosphatase 1 regulatory subunit 12B — O60237 (reviewed: O60237)

Alternative names: Myosin phosphatase-targeting subunit 2

All UniProt accessions (7): O60237, A0A0U1RQI8, A0A0U1RQP2, A0A994J7P4, E1CKY7, H7C4R6, Q6GQY8

UniProt curated annotations — full annotation on UniProt →

Function. Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.

Subunit / interactions. PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12B mediates binding to myosin. Isoform 3 and isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself. Binds IL16.

Subcellular location. Cytoplasm. Cytoskeleton. Stress fiber.

Tissue specificity. Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific.

Miscellaneous. Produced by alternative promoter usage. Produced by alternative splicing of isoform 1. Produced by alternative splicing of isoform 4. Produced by alternative promoter usage.

Isoforms (6)

UniProt IDNamesCanonical?
O60237-11yes
O60237-22
O60237-33, hHS-M21B, Heart-specific myosin light chain phosphatase small subunit B
O60237-44, hHS-M21A, Heart-specific myosin light chain phosphatase small subunit A
O60237-55
O60237-66

RefSeq proteins (8): NP_001161329, NP_001161330, NP_001184060, NP_001317958, NP_001397212, NP_002472, NP_115286, NP_115287 (=MANE)

Domains & families (InterPro)

IDNameType
IPR002110Ankyrin_rptRepeat
IPR017401MYPT1/MYPT2/Mbs85Family
IPR031775PRKG1_interactDomain
IPR036770Ankyrin_rpt-contain_sfHomologous_superfamily
IPR051226PP1_Regulatory_SubunitFamily

Pfam: PF12796, PF15898

Enzyme classification (BRENDA):

  • EC 3.1.3.53 — [myosin-light-chain] phosphatase (BRENDA: 14 organisms, 76 substrates, 62 inhibitors, 13 Km, 0 kcat entries)

Substrate kinetics (BRENDA)

5 substrates with measured Km, best-characterized 5. Km ranges are aggregated across organisms/conditions.

SubstrateKm (mM)Measurements
MYOSIN LIGHT-CHAIN PHOSPHATE0.001–0.01126
MYOSIN LIGHT-CHAIN0.0015–0.053
PHOSPHORYLATED MYOSIN0.0004–0.00242
HEAVY MEROMYOSIN0.00591
[MYOSIN LIGHT-CHAIN] PHOSPHATE0.011

UniProt features (44 total): compositionally biased region 18, splice variant 7, modified residue 6, repeat 5, region of interest 5, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-O60237-F162.370.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 29, 445, 646, 808, 839, 947

Function

Pathways and Gene Ontology

Reactome pathways

9 pathways

IDPathway
R-HSA-5625740RHO GTPases activate PKNs
R-HSA-5625900RHO GTPases activate CIT
R-HSA-5627117RHO GTPases Activate ROCKs
R-HSA-5627123RHO GTPases activate PAKs
R-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
R-HSA-162582Signal Transduction
R-HSA-194315Signaling by Rho GTPases
R-HSA-195258RHO GTPase Effectors
R-HSA-9716542Signaling by Rho GTPases, Miro GTPases and RHOBTB3

MSigDB gene sets: 233 (showing top): BIOCARTA_RHO_PATHWAY, GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, ACTACCT_MIR196A_MIR196B, MORF_MSH3, MORF_BRCA1, THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN, GOBP_NEUROGENESIS, MODULE_329, TOMLINS_PROSTATE_CANCER_DN, CHANDRAN_METASTASIS_DN, STOSSI_RESPONSE_TO_ESTRADIOL, YY1_Q6, MORF_RAD51L3, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, GOBP_REGULATION_OF_MUSCLE_CONTRACTION

GO Biological Process (3): regulation of muscle contraction (GO:0006937), signal transduction (GO:0007165), neuron projection morphogenesis (GO:0048812)

GO Molecular Function (6): enzyme inhibitor activity (GO:0004857), enzyme activator activity (GO:0008047), myosin phosphatase regulator activity (GO:0017020), protein kinase binding (GO:0019901), protein binding (GO:0005515), phosphatase regulator activity (GO:0019208)

GO Cellular Component (7): stress fiber (GO:0001725), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), Z disc (GO:0030018), A band (GO:0031672), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-5 pathways:

CategoryPathways
RHO GTPase Effectors4
G2/M Transition1
Signaling by Rho GTPases, Miro GTPases and RHOBTB31
Signaling by Rho GTPases1
Signal Transduction1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure5
enzyme regulator activity3
catalytic activity2
muscle contraction1
regulation of muscle system process1
cell communication1
cellular process1
signaling1
regulation of cellular process1
cellular response to stimulus1
neuron projection development1
plasma membrane bounded cell projection morphogenesis1
molecular function inhibitor activity1
molecular function activator activity1
myosin phosphatase activity1
protein phosphatase regulator activity1
kinase binding1
binding1
phosphatase activity1
phosphatase binding1
actomyosin1
contractile actin filament bundle1
nuclear lumen1
intracellular anatomical structure1
cytoplasm1
I band1
sarcomere1
intracellular membraneless organelle1

Protein interactions and networks

STRING

1634 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
PPP1R12BPPP1CBP37140860
PPP1R12BFKBP8Q14318547
PPP1R12BPPP1CCP36873531
PPP1R12BACTG2P12718491
PPP1R12BMYH11P35749490
PPP1R12BPPP1R26Q5T8A7458
PPP1R12BRPSAP08865457
PPP1R12BPPP1R16BQ96T49454
PPP1R12BPPP1R12CQ9BZL4453
PPP1R12BMYLK3Q32MK0452
PPP1R12BPPP1R14AQ96A00446
PPP1R12BMYLKQ15746441
PPP1R12BMYL9P24844437
PPP1R12BUSP9XQ93008391
PPP1R12BZNF157P51786381

IntAct

38 interactions, top by confidence:

ABTypeScore
PPP1CBCCDC85Cpsi-mi:“MI:0914”(association)0.750
PPP1CBCCDC85Cpsi-mi:“MI:2364”(proximity)0.750
FKBP6EEF2Kpsi-mi:“MI:0914”(association)0.530
PPP1R12APPP1R12Bpsi-mi:“MI:2364”(proximity)0.420
Cep72psi-mi:“MI:0915”(physical association)0.400
PCNAPPP1R12Bpsi-mi:“MI:0915”(physical association)0.370
Ppp1cbMYO1Cpsi-mi:“MI:0914”(association)0.350
MYH9PLEKHG3psi-mi:“MI:0914”(association)0.350
ANLNPLEKHG3psi-mi:“MI:0914”(association)0.350
MYO18APLEKHG3psi-mi:“MI:0914”(association)0.350
MYO19PLEKHG3psi-mi:“MI:0914”(association)0.350
Actbpsi-mi:“MI:0914”(association)0.350
SYNPOLMO7psi-mi:“MI:0914”(association)0.350
Myh9PLEKHG3psi-mi:“MI:0914”(association)0.350
Myo1cPLEKHG3psi-mi:“MI:0914”(association)0.350
Myh9GOSR1psi-mi:“MI:0914”(association)0.350
MYH9NAP1L1psi-mi:“MI:0914”(association)0.350
Myh10NAP1L1psi-mi:“MI:0914”(association)0.350
IQGAP1PLEKHG3psi-mi:“MI:0914”(association)0.350
CD14PHF20L1psi-mi:“MI:0914”(association)0.350
PPP1CBPLEKHG3psi-mi:“MI:0914”(association)0.350
PPP1R12ATRDMT1psi-mi:“MI:0914”(association)0.350
ESR1ESYT2psi-mi:“MI:0914”(association)0.350
COPS6DDX3Xpsi-mi:“MI:0914”(association)0.350
repABLIM1psi-mi:“MI:0914”(association)0.350
ZBTB18DNASE1L1psi-mi:“MI:0914”(association)0.350

BioGRID (89): PPP1R12B (Affinity Capture-MS), SKP1 (Co-fractionation), PPP1R12B (Two-hybrid), PPP1R12B (Affinity Capture-Luminescence), PPP1R12B (Affinity Capture-MS), PPP1R12B (Affinity Capture-MS), PPP1R12B (Affinity Capture-MS), PPP1R12B (Affinity Capture-MS), PPP1R12B (Affinity Capture-MS), PPP1R12B (Affinity Capture-MS), PPP1R12B (Affinity Capture-MS), PPP1R12B (Affinity Capture-MS), PPP1R12B (Affinity Capture-MS), PPP1R12B (Affinity Capture-MS), PPP1R12B (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4IZ84, A0A1L8H8C0, A0A1L8HFX9, A2RUV4, F1LP90, F5HSE3, O43310, O60237, O75167, O88453, P41110, P61406, Q12830, Q1LVF3, Q2HJG4, Q2PFD7, Q3TLH4, Q5RAK6, Q5ZMS6, Q66HC1, Q6A0A2, Q6NRP6, Q6NZL0, Q6P1U3, Q6PKG0, Q75N33, Q7TN02, Q7TPM1, Q7YZA2, Q7Z6E9, Q80TN7, Q80XI3, Q86UR5, Q86US8, Q8IVL0, Q8IVL1, Q8K0V4, Q8N4C8, Q90YL3, Q90YY5

Diamond homologs: A2AQH4, O14974, O60237, Q10728, Q3UMT1, Q6DRG7, Q8BG95, Q90623, Q923M0, Q96I34, Q9BZL4, Q9DBR7, Q8VHQ3, Q95N27, Q96T49, A4II29, B2RR83, G3I6Z6, O00522, O13987, P46531, P83757, Q01705, Q02979, Q03017, Q07008, Q0VC93, Q18297, Q1RJ94, Q28FJ2, Q337A0, Q3SX00, Q3UES3, Q3V096, Q4FE45, Q4JHE0, Q5H9F3, Q5I1X5, Q5R746, Q5R8C8

SIGNOR signaling

1 interactions.

AEffectBMechanism
ROCK1down-regulatesPPP1R12Bphosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

170 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance121
Likely benign8
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

5822 predictions. Top by Δscore:

VariantEffectΔscore
1:202416781:TTTCA:Tacceptor_loss1.0000
1:202416782:TTCA:Tacceptor_loss1.0000
1:202416783:TCA:Tacceptor_loss1.0000
1:202416784:CAG:Cacceptor_loss1.0000
1:202416785:A:ACacceptor_loss1.0000
1:202416785:A:AGacceptor_gain1.0000
1:202416785:AG:Aacceptor_gain1.0000
1:202416786:G:GGacceptor_gain1.0000
1:202416786:G:GTacceptor_loss1.0000
1:202416786:GG:Gacceptor_gain1.0000
1:202416786:GGC:Gacceptor_gain1.0000
1:202416786:GGCA:Gacceptor_gain1.0000
1:202416786:GGCAT:Gacceptor_gain1.0000
1:202416913:GCAGA:Gdonor_gain1.0000
1:202416916:GA:Gdonor_gain1.0000
1:202416916:GAGT:Gdonor_loss1.0000
1:202416917:AGT:Adonor_loss1.0000
1:202416918:GTGA:Gdonor_gain1.0000
1:202416919:TGA:Tdonor_gain1.0000
1:202416920:GA:Gdonor_gain1.0000
1:202416920:GAG:Gdonor_gain1.0000
1:202416922:G:GGdonor_gain1.0000
1:202422734:GCAAG:Gdonor_gain1.0000
1:202422740:T:Adonor_loss1.0000
1:202425554:T:TAacceptor_gain1.0000
1:202425555:G:Aacceptor_gain1.0000
1:202425562:GTA:Gacceptor_loss1.0000
1:202425564:A:AGacceptor_gain1.0000
1:202425564:AG:Aacceptor_gain1.0000
1:202425564:AGG:Aacceptor_loss1.0000

AlphaMissense

6412 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
1:202416868:T:AW125R1.000
1:202416868:T:CW125R1.000
1:202580508:T:CL966P1.000
1:202580529:T:CL973P1.000
1:202348927:T:AW26R0.999
1:202348927:T:CW26R0.999
1:202348929:G:CW26C0.999
1:202348929:G:TW26C0.999
1:202349036:T:CF62S0.999
1:202349047:T:CC66R0.999
1:202349049:C:GC66W0.999
1:202349115:C:AN88K0.999
1:202349115:C:GN88K0.999
1:202349132:C:AA94D0.999
1:202349141:A:CQ97P0.999
1:202416787:G:CA98P0.999
1:202416790:T:CC99R0.999
1:202416792:T:GC99W0.999
1:202416824:T:CL110P0.999
1:202427089:T:AW251R0.999
1:202427089:T:CW251R0.999
1:202437878:T:AW438R0.999
1:202437878:T:CW438R0.999
1:202493133:T:CL654P0.999
1:202569166:G:CR944P0.999
1:202580487:T:CL959P0.999
1:202580529:T:AL973H0.999
1:202580550:T:CL980P0.999
1:202349017:T:CF56L0.998
1:202349019:C:AF56L0.998

dbSNP variants (sampled 300 via entrez): RS1000032005 (1:202380848 A>G), RS1000076988 (1:202524784 G>C), RS1000112881 (1:202504733 A>G), RS1000133777 (1:202396623 T>A), RS1000139814 (1:202435323 G>T), RS1000151333 (1:202373717 G>A), RS1000172094 (1:202574540 G>A), RS1000177596 (1:202455043 A>G), RS1000207629 (1:202349217 G>T), RS1000214703 (1:202354174 G>A), RS1000215141 (1:202359764 A>G), RS1000232970 (1:202448503 T>A,C), RS1000260305 (1:202366353 T>C), RS1000260826 (1:202448804 G>A,T), RS1000267029 (1:202354474 C>T)

Disease associations

OMIM: gene MIM:603768 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

StudyTraitp-value
GCST001762_106Obesity-related traits1.000000e-06
GCST002112_2Celiac disease3.000000e-07
GCST002298_1Coronary heart disease3.000000e-07
GCST003331_1Sex ratio3.000000e-46
GCST011435_1Chronic obstructive pulmonary disease3.000000e-07

EFO canonical traits (2, from GWAS)

EFO IDTrait name
EFO:0004697estradiol measurement
EFO:0004820sex ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
sodium arsenitedecreases expression, increases abundance4
Aflatoxin B1decreases expression, decreases methylation, increases methylation3
monomethylarsonous aciddecreases expression, increases expression2
Air Pollutantsaffects expression, increases abundance, increases expression2
Benzo(a)pyrenedecreases expression, decreases methylation2
Tobacco Smoke Pollutiondecreases expression, affects expression2
triphenyl phosphateaffects expression1
bisphenol Aincreases expression1
sodium arsenatedecreases expression, increases abundance1
arsenitedecreases expression, increases abundance1
butyraldehydedecreases expression1
monomethylarsonic aciddecreases expression1
arsenic aciddecreases expression, increases abundance1
3,4,3’,4’-tetrachlorobiphenylaffects expression1
di-n-butylphosphoric acidaffects expression1
CGP 52608affects binding, increases reaction1
dimethylmonothioarsinic aciddecreases expression1
incobotulinumtoxinAdecreases expression1
Cacodylic Aciddecreases expression1
Dietary Carbohydratesdecreases expression1
Doxorubicindecreases expression1
Fenfluramineincreases expression1
Methyl Methanesulfonateincreases expression1
Nickeldecreases expression1
Niclosamideincreases expression1
Oligomycinsaffects response to substance, increases expression1
Ozoneincreases abundance, affects expression1
Rotenoneincreases expression1
Tamoxifenaffects expression1
Dronabinolincreases expression1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_E0UTUbigene Hep G2 PPP1R12B KOCancer cell lineMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot