PPP1R12C

Summary

PPP1R12C (protein phosphatase 1 regulatory subunit 12C, HGNC:14947) is a protein-coding gene on chromosome 19q13.42, encoding Protein phosphatase 1 regulatory subunit 12C (Q9BZL4). Regulates myosin phosphatase activity.

The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Source: NCBI Gene 54776 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 153 total
• MANE Select transcript: NM_017607

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14947
Approved symbol	PPP1R12C
Name	protein phosphatase 1 regulatory subunit 12C
Location	19q13.42
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP434D0412, p84, MBS85, p85, AAVS1
Ensembl gene	ENSG00000125503
Ensembl biotype	protein_coding
OMIM	613245
Entrez	54776

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 17 protein_coding, 5 retained_intron

ENST00000263433, ENST00000435544, ENST00000586197, ENST00000586992, ENST00000588277, ENST00000590268, ENST00000591938, ENST00000592754, ENST00000592993, ENST00000854894, ENST00000854895, ENST00000954565, ENST00000954566, ENST00000954567, ENST00000954568, ENST00000954569, ENST00000954570, ENST00000954571, ENST00000954572, ENST00000954573, ENST00000954574, ENST00000954575

RefSeq mRNA: 2 — MANE Select: NM_017607 NM_001271618, NM_017607

CCDS: CCDS12916

Canonical transcript exons

ENST00000263433 — 22 exons

Exon	Start	End
ENSE00000727609	55092222	55092326
ENSE00001179723	55092442	55092544
ENSE00001179730	55092622	55092662
ENSE00001179739	55092783	55092868
ENSE00001604696	55096051	55096178
ENSE00001619648	55095291	55095358
ENSE00001634664	55098784	55098858
ENSE00001658714	55112665	55112795
ENSE00001676777	55098951	55099095
ENSE00001692594	55094661	55094798
ENSE00001705472	55112467	55112585
ENSE00001716256	55096262	55096335
ENSE00001719402	55103409	55103568
ENSE00001720308	55095867	55095940
ENSE00001782919	55117223	55117637
ENSE00001785260	55095445	55095603
ENSE00003273739	55090918	55091558
ENSE00003480371	55094345	55094435
ENSE00003503949	55091650	55091700
ENSE00003520759	55093153	55093233
ENSE00003533964	55093016	55093076
ENSE00003618424	55091859	55091909

Expression profiles

Bgee: expression breadth ubiquitous, 250 present calls, max score 99.23.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.9362 / max 431.3695, expressed in 1794 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182686	9.3072	1785
182685	1.1573	727
182684	0.2587	89
182683	0.1448	47
182682	0.0682	26

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus	UBERON:0013473	99.23	gold quality
lower esophagus muscularis layer	UBERON:0035833	99.23	gold quality
mucosa of stomach	UBERON:0001199	99.21	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	99.18	gold quality
body of uterus	UBERON:0009853	99.09	gold quality
muscle layer of sigmoid colon	UBERON:0035805	99.09	gold quality
apex of heart	UBERON:0002098	99.04	gold quality
left testis	UBERON:0004533	98.81	gold quality
endocervix	UBERON:0000458	98.80	gold quality
right testis	UBERON:0004534	98.79	gold quality
left uterine tube	UBERON:0001303	98.78	gold quality
lower esophagus mucosa	UBERON:0035834	98.67	gold quality
popliteal artery	UBERON:0002250	98.59	gold quality
tibial artery	UBERON:0007610	98.59	gold quality
right coronary artery	UBERON:0001625	98.51	gold quality
right hemisphere of cerebellum	UBERON:0014890	98.46	gold quality
aorta	UBERON:0000947	98.41	gold quality
ectocervix	UBERON:0012249	98.41	gold quality
adenohypophysis	UBERON:0002196	98.39	gold quality
right frontal lobe	UBERON:0002810	98.38	gold quality
left coronary artery	UBERON:0001626	98.37	gold quality
right atrium auricular region	UBERON:0006631	98.32	gold quality
ascending aorta	UBERON:0001496	98.31	gold quality
thoracic aorta	UBERON:0001515	98.28	gold quality
granulocyte	CL:0000094	98.27	gold quality
heart left ventricle	UBERON:0002084	98.25	gold quality
cerebellar hemisphere	UBERON:0002245	98.17	gold quality
cerebellar cortex	UBERON:0002129	98.15	gold quality
metanephros cortex	UBERON:0010533	98.14	gold quality
small intestine Peyer’s patch	UBERON:0003454	98.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.58

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

28 targeting PPP1R12C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-891B	99.59	69.81	1083
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-3191-3P	99.45	63.94	356
HSA-MIR-135A-5P	99.36	71.85	1601
HSA-MIR-135B-5P	99.36	71.63	1613
HSA-MIR-4999-5P	99.35	69.15	926
HSA-MIR-5589-3P	99.29	68.30	1443
HSA-MIR-196A-3P	99.19	67.34	1204
HSA-MIR-6852-5P	99.17	66.69	2073
HSA-MIR-6815-3P	99.13	68.98	1530
HSA-MIR-3688-5P	99.12	69.67	1091
HSA-MIR-6811-3P	98.62	66.54	944
HSA-MIR-6764-3P	98.44	67.64	1153
HSA-MIR-6824-3P	98.44	67.62	1154
HSA-MIR-6810-5P	98.29	66.21	975
HSA-MIR-4652-5P	96.46	64.22	553
HSA-MIR-668-3P	96.18	65.80	673
HSA-MIR-6805-5P	95.79	64.86	670
HSA-MIR-4281	92.91	63.60	271

Literature-anchored findings (GeneRIF, showing 3)

• M-RIP can assemble a complex containing both RhoA and Myosin phosphatase myosin binding subunit, suggesting that M-RIP may play a role in myosin phosphatase regulation by RhoA (PMID:14506264)
• Authors demonstrate that Rep proteins of adeno-associated virus serotype 2 efficiently repress expression from the target site PPP1R12C promoter. (PMID:24829354)
• PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation. (PMID:37737016)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	ppp1r12c	ENSDARG00000052423
mus_musculus	Ppp1r12c	ENSMUSG00000019254
rattus_norvegicus	Ppp1r12c	ENSRNOG00000053828

Paralogs (3): PPP1R12A (ENSG00000058272), PPP1R12B (ENSG00000077157), PPP1R27 (ENSG00000182676)

Protein

Protein identifiers

Protein phosphatase 1 regulatory subunit 12C — Q9BZL4 (reviewed: Q9BZL4)

Alternative names: Protein phosphatase 1 myosin-binding subunit of 85 kDa

All UniProt accessions (3): Q9BZL4, K7EL81, K7ER83

UniProt curated annotations — full annotation on UniProt →

Function. Regulates myosin phosphatase activity.

Subunit / interactions. PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP. Interacts with NOD2.

Subcellular location. Cytoplasm. Cytoskeleton. Stress fiber.

Tissue specificity. Ubiquitously expressed. Highly expressed in heart.

Post-translational modifications. Phosphorylation at Thr-560 is essential for its interaction with PPP1CB.

Isoforms (5)

UniProt ID	Names	Canonical?
Q9BZL4-1	1	yes
Q9BZL4-2	2
Q9BZL4-3	3
Q9BZL4-4	4
Q9BZL4-5	5

RefSeq proteins (2): NP_001258547, NP_060077* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002110	Ankyrin_rpt	Repeat
IPR017401	MYPT1/MYPT2/Mbs85	Family
IPR031775	PRKG1_interact	Domain
IPR036770	Ankyrin_rpt-contain_sf	Homologous_superfamily
IPR051226	PP1_Regulatory_Subunit	Family

Pfam: PF12796, PF15898

UniProt features (37 total): compositionally biased region 9, modified residue 9, splice variant 5, repeat 4, sequence conflict 3, region of interest 2, coiled-coil region 2, initiator methionine 1, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BZL4-F1	66.74	0.34

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 2, 399, 407, 427, 452, 509, 560, 604, 647

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 113 (showing top): GGGACCA_MIR133A_MIR133B, AAGCCAT_MIR135A_MIR135B, GOBP_NEUROGENESIS, CREBP1_Q2, RACCACAR_AML_Q6, AML_Q6, IRF1_Q6, TGIF_01, GOBP_CELL_PROJECTION_ORGANIZATION, MARIADASON_REGULATED_BY_HISTONE_ACETYLATION_UP, DANG_BOUND_BY_MYC, GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN, GOCC_ACTIN_FILAMENT_BUNDLE, GOCC_ACTOMYOSIN, OSF2_Q6

GO Biological Process (2): signal transduction (GO:0007165), neuron projection morphogenesis (GO:0048812)

GO Molecular Function (5): enzyme inhibitor activity (GO:0004857), myosin phosphatase regulator activity (GO:0017020), protein kinase binding (GO:0019901), protein binding (GO:0005515), phosphatase regulator activity (GO:0019208)

GO Cellular Component (3): stress fiber (GO:0001725), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
enzyme regulator activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
neuron projection development	1
plasma membrane bounded cell projection morphogenesis	1
catalytic activity	1
molecular function inhibitor activity	1
myosin phosphatase activity	1
protein phosphatase regulator activity	1
kinase binding	1
binding	1
phosphatase activity	1
phosphatase binding	1
actomyosin	1
contractile actin filament bundle	1
intracellular anatomical structure	1
cellular anatomical structure	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

2608 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PPP1R12C	PIK3CG	P48736	991
PPP1R12C	MYL9	P24844	884
PPP1R12C	IMMT	Q16891	847
PPP1R12C	PPP1CB	P37140	826
PPP1R12C	PIK3CD	O00329	822
PPP1R12C	PIK3R5	Q8WYR1	774
PPP1R12C	CDC42BPA	Q5VT25	700
PPP1R12C	PIK3CB	P42338	679
PPP1R12C	PIK3CA	P42336	552
PPP1R12C	MYL12B	O14950	536
PPP1R12C	MYL7	Q01449	519
PPP1R12C	CLYBL	Q8N0X4	509
PPP1R12C	PPP1R14A	Q96A00	506
PPP1R12C	RNF112	Q9ULX5	505
PPP1R12C	EMX1	Q04741	482

IntAct

92 interactions, top by confidence:

A	B	Type	Score
PPP1CB	CCDC85C	psi-mi:“MI:0914”(association)	0.750
PPP1CB	CCDC85C	psi-mi:“MI:2364”(proximity)	0.750
NUAK2	PPP1R12A	psi-mi:“MI:0914”(association)	0.640
VAPA	FAM83G	psi-mi:“MI:0914”(association)	0.640
TNKS2	PPP1R12C	psi-mi:“MI:0915”(physical association)	0.590
TNKS2	PPP1R12C	psi-mi:“MI:0407”(direct interaction)	0.590
SPECC1L	PPP1R12C	psi-mi:“MI:0915”(physical association)	0.560
PPP1R12C	IMP3	psi-mi:“MI:0915”(physical association)	0.560
EHHADH	PPP1R12C	psi-mi:“MI:0915”(physical association)	0.560
PPP1R12C	ATP6V1H	psi-mi:“MI:0915”(physical association)	0.560
BHLHA9	PPP1R12C	psi-mi:“MI:0915”(physical association)	0.560
RBM17	PPP1R12C	psi-mi:“MI:0915”(physical association)	0.560
EXOC3	PPP1R12C	psi-mi:“MI:0915”(physical association)	0.560
CCDC185	PPP1R12C	psi-mi:“MI:0915”(physical association)	0.560
THOC1	PPP1R12C	psi-mi:“MI:0915”(physical association)	0.560
PPP1R12C	AIRIM	psi-mi:“MI:0915”(physical association)	0.560
PPP1R12C	NXF1	psi-mi:“MI:0915”(physical association)	0.560
USHBP1	PPP1R12C	psi-mi:“MI:0915”(physical association)	0.560
NOD2	PPP1R12C	psi-mi:“MI:0915”(physical association)	0.550
NOD2	PPP1R12C	psi-mi:“MI:2364”(proximity)	0.550
PPP1R12C	NOD2	psi-mi:“MI:0915”(physical association)	0.550
JPH4	ZSWIM8	psi-mi:“MI:0914”(association)	0.530
SMAD3	PPP1R12C	psi-mi:“MI:0915”(physical association)	0.510
PPP1R12C	SMAD3	psi-mi:“MI:0915”(physical association)	0.510
TSFM	PPP1R12C	psi-mi:“MI:0915”(physical association)	0.490

BioGRID (76): PPP1R12C (Two-hybrid), C1orf109 (Two-hybrid), RBM17 (Two-hybrid), PPP1R12C (Affinity Capture-MS), PPP1R12C (Affinity Capture-MS), PPP1R12C (Affinity Capture-MS), PPP1R12C (Affinity Capture-MS), PPP1R12C (Two-hybrid), PPP1R12C (Affinity Capture-MS), PPP1R12C (Affinity Capture-MS), PPP1R12C (Affinity Capture-MS), PPP1R12C (Two-hybrid), PPP1R12C (Affinity Capture-Western), PPP1R12C (Affinity Capture-MS), PPP1R12C (Affinity Capture-MS)

ESM2 similar proteins: A0A0U1RR37, A1L170, A1L1I3, A1L260, A2AMM0, A4IFJ0, B5G1P1, D3ZQL6, E7F5E1, G5BQH4, O08919, O54724, O60237, O75420, P06759, P33622, P53814, P85125, Q2KI85, Q2TAL5, Q3T044, Q3UMT1, Q4RTJ5, Q4V882, Q5I1X5, Q5U2R6, Q63312, Q6NZI2, Q75AS0, Q80VC9, Q8BG95, Q8BGT6, Q8C0J6, Q8CI12, Q8IV56, Q8K382, Q8N3F8, Q8TEH3, Q8WUF5, Q91VJ2

Diamond homologs: A0A0R4IQZ2, A2AS55, A4II29, B4E2M5, C7B178, G0LXV8, L7X8P2, L7XCU0, L7XDS4, P0C0T2, P0C550, P0DJE3, P19838, P23631, P39010, Q04749, Q04861, Q0JKV1, Q10728, Q18297, Q28C34, Q337A0, Q38998, Q3SX00, Q3UMT1, Q3UX43, Q499M5, Q4JHE0, Q5H9F3, Q5R8C8, Q5U5A6, Q63369, Q68DC2, Q6FJ70, Q6GQX6, Q6NRD0, Q6NY19, Q6P6B7, Q6P9J5, Q6ZVH7

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
PRKAA2	down-regulates	PPP1R12C	phosphorylation
AMPK	down-regulates	PPP1R12C	phosphorylation
CDC42BPA	“down-regulates activity”	PPP1R12C	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 65 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	102.2×	4e-11
Activation of BAD and translocation to mitochondria	6	99.3×	1e-09
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	6	87.6×	3e-09
Activation of BH3-only proteins	6	64.8×	2e-08
RHO GTPases activate PKNs	9	62.1×	4e-12
FOXO-mediated transcription	6	43.8×	2e-07
Intrinsic Pathway for Apoptosis	6	38.2×	3e-07
SARS-CoV-1-host interactions	7	26.7×	2e-07

GO biological processes:

GO term	Partners	Fold	FDR
intracellular protein localization	6	11.2×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

153 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	110
Likely benign	13
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

3139 predictions. Top by Δscore:

Variant	Effect	Δscore
19:55091556:GGCC:G	acceptor_loss	1.0000
19:55091558:CCTG:C	acceptor_loss	1.0000
19:55091559:C:CC	acceptor_gain	1.0000
19:55091644:CCCCA:C	donor_loss	1.0000
19:55091645:CCCA:C	donor_loss	1.0000
19:55091646:CCA:C	donor_loss	1.0000
19:55091647:CACCT:C	donor_loss	1.0000
19:55091649:C:A	donor_loss	1.0000
19:55091660:T:TA	donor_gain	1.0000
19:55091698:CTC:C	acceptor_gain	1.0000
19:55091699:TCC:T	acceptor_loss	1.0000
19:55091701:C:CC	acceptor_gain	1.0000
19:55091702:T:A	acceptor_loss	1.0000
19:55091706:A:AC	acceptor_gain	1.0000
19:55091706:A:C	acceptor_gain	1.0000
19:55091853:A:AC	donor_gain	1.0000
19:55091854:C:CC	donor_gain	1.0000
19:55091854:CTCA:C	donor_gain	1.0000
19:55091855:TCA:T	donor_loss	1.0000
19:55091856:CACG:C	donor_loss	1.0000
19:55091857:A:AC	donor_gain	1.0000
19:55091857:AC:A	donor_loss	1.0000
19:55091858:C:A	donor_loss	1.0000
19:55091858:C:CC	donor_gain	1.0000
19:55091858:CG:C	donor_gain	1.0000
19:55091858:CGA:C	donor_gain	1.0000
19:55091858:CGAA:C	donor_gain	1.0000
19:55091858:CGAAT:C	donor_gain	1.0000
19:55091862:T:C	donor_gain	1.0000
19:55091910:C:CC	acceptor_gain	1.0000

AlphaMissense

4998 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:55099046:A:G	W261R	1.000
19:55099046:A:T	W261R	1.000
19:55112714:A:G	W135R	1.000
19:55112714:A:T	W135R	1.000
19:55091482:A:G	L780P	0.999
19:55091524:A:G	L766P	0.999
19:55099044:C:A	W261C	0.999
19:55099044:C:G	W261C	0.999
19:55103436:G:T	A235D	0.999
19:55103439:G:T	A234D	0.999
19:55112546:G:C	N164K	0.999
19:55112546:G:T	N164K	0.999
19:55112580:A:G	L153P	0.999
19:55112712:C:A	W135C	0.999
19:55112712:C:G	W135C	0.999
19:55112725:T:A	D131V	0.999
19:55112726:C:G	D131H	0.999
19:55112758:A:G	L120S	0.999
19:55112788:A:T	I110N	0.999
19:55112790:G:C	C109W	0.999
19:55112791:C:T	C109Y	0.999
19:55112792:A:G	C109R	0.999
19:55117235:G:C	S103R	0.999
19:55117235:G:T	S103R	0.999
19:55117237:T:G	S103R	0.999
19:55117239:A:G	I102T	0.999
19:55117242:C:A	G101V	0.999
19:55117245:T:A	D100V	0.999
19:55117250:G:C	N98K	0.999
19:55117250:G:T	N98K	0.999

dbSNP variants (sampled 300 via entrez): RS1000026995 (19:55113539 G>A,T), RS1000058284 (19:55113346 T>C,G), RS1000136581 (19:55107462 T>A,C), RS1000159342 (19:55092011 C>T), RS1000375481 (19:55118789 A>C), RS1000449381 (19:55099095 C>G,T), RS1000487726 (19:55107163 C>T), RS1000495902 (19:55108865 C>G), RS1000531878 (19:55117560 C>A,T), RS1000883575 (19:55098704 G>A,C,T), RS1000899492 (19:55095532 G>A,C), RS1000966341 (19:55117280 C>G,T), RS1001109406 (19:55116828 G>A,C), RS1001195589 (19:55108368 C>T), RS1001259831 (19:55107689 G>A)

Disease associations

OMIM: gene MIM:613245 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression	2
Air Pollutants	affects expression, increases abundance, increases expression	2
Benzo(a)pyrene	increases mutagenesis, decreases methylation	2
Valproic Acid	decreases expression, increases expression	2
Particulate Matter	increases abundance, increases expression	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases methylation	1
arsenite	affects binding, decreases reaction	1
cobaltous chloride	decreases expression	1
perfluorooctanoic acid	decreases expression	1
coumarin	affects phosphorylation	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	decreases expression	1
K 7174	increases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Atrazine	decreases expression	1
Vehicle Emissions	increases abundance, increases expression	1
Caffeine	decreases phosphorylation	1
Doxorubicin	decreases expression	1
Ozone	affects expression, increases abundance	1
Smoke	decreases expression	1
Thiram	increases expression	1
Urethane	increases expression	1
Asbestos, Serpentine	decreases methylation	1
Okadaic Acid	increases expression	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TF56	HAP1 PPP1R12C (-) 1	Cancer cell line	Male
CVCL_TF57	HAP1 PPP1R12C (-) 2	Cancer cell line	Male
CVCL_TF58	HAP1 PPP1R12C (-) 3	Cancer cell line	Male
CVCL_TF59	HAP1 PPP1R12C (-) 4	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.