PPP1R13B-DT

Summary

PPP1R13B-DT (PPP1R13B divergent transcript, HGNC:27069) is a long non-coding RNA gene on chromosome 14q32.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27069
Approved symbol	PPP1R13B-DT
Name	PPP1R13B divergent transcript
Location	14q32.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	HITT
Ensembl gene	ENSG00000258735
Ensembl biotype	lncRNA
OMIM	620544
Entrez	145216
RNAcentral	URS00004415FC — lncRNA, 2056 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 lncRNA

ENST00000556586, ENST00000556653, ENST00000654695, ENST00000658303, ENST00000660176, ENST00000667526, ENST00000716871, ENST00000780813, ENST00000780814, ENST00000780815, ENST00000780816, ENST00000780817, ENST00000780818, ENST00000780819, ENST00000780820, ENST00000780821, ENST00000780822, ENST00000780823, ENST00000780824

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000556586 — 3 exons

Exon	Start	End
ENSE00002456883	103856124	103858049
ENSE00002527823	103854296	103854402
ENSE00004030936	103847721	103847743

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 75.91.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.91	gold quality
cortical plate	UBERON:0005343	59.42	silver quality
ganglionic eminence	UBERON:0004023	57.05	silver quality
islet of Langerhans	UBERON:0000006	50.85	gold quality
blood	UBERON:0000178	50.35	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	50.00	gold quality
duodenum	UBERON:0002114	48.04	silver quality
pancreas	UBERON:0001264	47.58	gold quality
mucosa of transverse colon	UBERON:0004991	47.36	gold quality
liver	UBERON:0002107	47.14	silver quality
right uterine tube	UBERON:0001302	46.99	gold quality
prefrontal cortex	UBERON:0000451	46.74	silver quality
fallopian tube	UBERON:0003889	46.35	gold quality
right lobe of liver	UBERON:0001114	46.18	silver quality
cortex of kidney	UBERON:0001225	46.11	silver quality
fundus of stomach	UBERON:0001160	45.49	gold quality
muscle of leg	UBERON:0001383	44.64	silver quality
gall bladder	UBERON:0002110	44.60	silver quality
left adrenal gland cortex	UBERON:0035825	44.40	silver quality
transverse colon	UBERON:0001157	44.02	gold quality
colon	UBERON:0001155	43.98	gold quality
endometrium	UBERON:0001295	43.91	silver quality
right lobe of thyroid gland	UBERON:0001119	43.75	silver quality
right testis	UBERON:0004534	43.72	gold quality
small intestine	UBERON:0002108	43.67	silver quality
testis	UBERON:0000473	43.62	gold quality
metanephros cortex	UBERON:0010533	43.50	gold quality
cerebellar hemisphere	UBERON:0002245	43.46	silver quality
rectum	UBERON:0001052	43.39	gold quality
left testis	UBERON:0004533	43.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• A novel LncRNA HITT forms a regulatory loop with HIF-1alpha to modulate angiogenesis and tumor growth. (PMID:31700144)
• A lncRNA coordinates with Ezh2 to inhibit HIF-1alpha transcription and suppress cancer cell adaption to hypoxia. (PMID:31784651)
• lncRNA HITT interacts with Ataxia-telangiectasia mutated (ATM) at the HEAT repeat domain, blocking MRE11-RAD50-NBS1 complex-dependent ATM recruitment, leading to restrained homologous recombination repair and enhanced chemosensitization. Following DNA double-strand breaks, HITT is elevated by the activation of Early Growth Response 1, resulting in retarded and restricted ATM activation. (PMID:32203529)
• lncRNA HITT inhibits metastasis by attenuating Rab5-mediated endocytosis in lung adenocarcinoma. (PMID:35017116)
• Upregulation of lncRNA HITT promotes cell apoptosis by suppressing the maturation of miR-602 in gastric cancer. (PMID:35852131)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.