PPP1R14B-AS1

Summary

PPP1R14B-AS1 (PPP1R14B antisense RNA 1, HGNC:54233) is a long non-coding RNA gene on chromosome 11q13.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54233
Approved symbol	PPP1R14B-AS1
Name	PPP1R14B antisense RNA 1
Location	11q13.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000256940
Ensembl biotype	lncRNA
Entrez	105369340
RNAcentral	URS0000A76754 — lncRNA, 499 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000538355, ENST00000544553, ENST00000652899, ENST00000663760, ENST00000729138

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000538355 — 2 exons

Exon	Start	End
ENSE00002270993	64247054	64247259
ENSE00002275963	64247953	64248177

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 91.22.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.5033 / max 144.9108, expressed in 1333 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
114912	6.3960	1247
114913	1.8212	741
114914	0.1256	46
114911	0.0976	17
206329	0.0629	17

Top tissues by expression

136 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	91.22	gold quality
esophagus mucosa	UBERON:0002469	90.14	gold quality
right testis	UBERON:0004534	88.56	gold quality
left testis	UBERON:0004533	88.51	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.50	gold quality
testis	UBERON:0000473	87.88	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.31	gold quality
right adrenal gland	UBERON:0001233	83.88	gold quality
mucosa of transverse colon	UBERON:0004991	83.25	gold quality
right adrenal gland cortex	UBERON:0035827	82.99	gold quality
left adrenal gland	UBERON:0001234	82.79	gold quality
left adrenal gland cortex	UBERON:0035825	82.76	gold quality
thymus	UBERON:0002370	82.53	silver quality
adrenal gland	UBERON:0002369	80.65	gold quality
body of pancreas	UBERON:0001150	78.45	gold quality
placenta	UBERON:0001987	78.33	gold quality
metanephros cortex	UBERON:0010533	78.18	gold quality
gastrocnemius	UBERON:0001388	78.17	gold quality
stromal cell of endometrium	CL:0002255	78.16	gold quality
muscle of leg	UBERON:0001383	77.64	gold quality
duodenum	UBERON:0002114	77.53	gold quality
skin of abdomen	UBERON:0001416	77.46	gold quality
vagina	UBERON:0000996	77.30	gold quality
zone of skin	UBERON:0000014	76.82	gold quality
skin of leg	UBERON:0001511	76.44	gold quality
pancreas	UBERON:0001264	75.96	gold quality
cortical plate	UBERON:0005343	75.75	gold quality
esophagus	UBERON:0001043	75.71	gold quality
ganglionic eminence	UBERON:0004023	74.83	gold quality
skeletal muscle tissue	UBERON:0001134	73.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.35

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA PPP1R14B-AS1 imitates microRNA-134-3p to facilitate breast cancer progression by upregulating LIM and SH3 protein 1. (PMID:37303940)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.