PPP1R37

Summary

PPP1R37 (protein phosphatase 1 regulatory subunit 37, HGNC:27607) is a protein-coding gene on chromosome 19q13.32, encoding Protein phosphatase 1 regulatory subunit 37 (O75864). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

Predicted to enable protein phosphatase inhibitor activity.

Source: NCBI Gene 284352 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 139 total
• MANE Select transcript: NM_019121

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27607
Approved symbol	PPP1R37
Name	protein phosphatase 1 regulatory subunit 37
Location	19q13.32
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000104866
Ensembl biotype	protein_coding
Entrez	284352

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 7 protein_coding, 5 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000221462, ENST00000422370, ENST00000496125, ENST00000540059, ENST00000542809, ENST00000544069, ENST00000544897, ENST00000545910, ENST00000593240, ENST00000872788, ENST00000872789, ENST00000872790, ENST00000945762, ENST00000945763

RefSeq mRNA: 1 — MANE Select: NM_019121 NM_019121

CCDS: CCDS56096

Canonical transcript exons

ENST00000221462 — 13 exons

Exon	Start	End
ENSE00000712319	45145094	45145260
ENSE00000861646	45143521	45143633
ENSE00000861647	45142303	45142458
ENSE00000861648	45142061	45142211
ENSE00000861649	45141322	45141441
ENSE00001786673	45145353	45146049
ENSE00002292476	45093179	45093527
ENSE00002321089	45144854	45144995
ENSE00002879226	45146571	45147285
ENSE00003489706	45146390	45146480
ENSE00003532492	45140236	45140281
ENSE00003554306	45138514	45138611
ENSE00003627748	45140506	45140606

Expression profiles

Bgee: expression breadth ubiquitous, 190 present calls, max score 93.85.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 29.0302 / max 173.7470, expressed in 1814 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
176389	22.6835	1813
176388	1.3142	913
176384	1.2749	775
176386	1.2107	723
176385	0.8983	529
176390	0.8892	489
176387	0.7283	368
176391	0.0310	11

Top tissues by expression

268 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adenohypophysis	UBERON:0002196	93.85	gold quality
right hemisphere of cerebellum	UBERON:0014890	93.05	gold quality
cerebellar hemisphere	UBERON:0002245	92.40	gold quality
cerebellar cortex	UBERON:0002129	92.19	gold quality
pituitary gland	UBERON:0000007	92.10	gold quality
right frontal lobe	UBERON:0002810	91.83	gold quality
body of stomach	UBERON:0001161	91.62	gold quality
lower esophagus mucosa	UBERON:0035834	91.59	gold quality
right adrenal gland cortex	UBERON:0035827	91.53	gold quality
right adrenal gland	UBERON:0001233	91.37	gold quality
left adrenal gland	UBERON:0001234	91.07	gold quality
left adrenal gland cortex	UBERON:0035825	91.05	gold quality
adrenal cortex	UBERON:0001235	90.00	gold quality
right lobe of thyroid gland	UBERON:0001119	89.82	gold quality
apex of heart	UBERON:0002098	89.57	gold quality
cerebellum	UBERON:0002037	89.50	gold quality
cingulate cortex	UBERON:0003027	89.50	gold quality
anterior cingulate cortex	UBERON:0009835	89.37	gold quality
mucosa of transverse colon	UBERON:0004991	89.31	gold quality
stomach	UBERON:0000945	89.13	gold quality
adrenal gland	UBERON:0002369	89.10	gold quality
stromal cell of endometrium	CL:0002255	88.84	gold quality
left lobe of thyroid gland	UBERON:0001120	88.62	gold quality
amygdala	UBERON:0001876	88.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	87.99	gold quality
Brodmann (1909) area 9	UBERON:0013540	87.80	gold quality
nucleus accumbens	UBERON:0001882	87.73	gold quality
skin of abdomen	UBERON:0001416	87.70	gold quality
skin of leg	UBERON:0001511	87.55	gold quality
minor salivary gland	UBERON:0001830	87.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.48

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ppp1r37	ENSDARG00000078458
mus_musculus	Ppp1r37	ENSMUSG00000051403
rattus_norvegicus	Ppp1r37	ENSRNOG00000017692
drosophila_melanogaster	CG31635	FBGN0051635
caenorhabditis_elegans		WBGENE00009201

Paralogs (4): RNH1 (ENSG00000023191), CARMIL1 (ENSG00000079691), CARMIL2 (ENSG00000159753), CARMIL3 (ENSG00000186648)

Protein

Protein identifiers

Protein phosphatase 1 regulatory subunit 37 — O75864 (reviewed: O75864)

Alternative names: Leucine-rich repeat-containing protein 68

All UniProt accessions (2): O75864, F5H3P7

UniProt curated annotations — full annotation on UniProt →

Function. Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

Subunit / interactions. Interacts with PPP1CA.

Miscellaneous. Due to an intron retention.

Similarity. Belongs to the PPP1R37 family.

Isoforms (2)

UniProt ID	Names	Canonical?
O75864-1	1	yes
O75864-2	2

RefSeq proteins (1): NP_061994* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001611	Leu-rich_rpt	Repeat
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR051279	PP1-Reg/Actin-Interact_Protein	Family

Pfam: PF13516

UniProt features (17 total): repeat 5, compositionally biased region 4, modified residue 3, splice variant 2, region of interest 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75864-F1	74.48	0.55

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 50, 56, 561

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 109 (showing top): GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, GOMF_PHOSPHATASE_INHIBITOR_ACTIVITY, GOMF_ENZYME_INHIBITOR_ACTIVITY, GOMF_ENZYME_REGULATOR_ACTIVITY, GSE13522_WT_VS_IFNG_KO_SKIN_DN, GOMF_PHOSPHATASE_REGULATOR_ACTIVITY, WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D, PDGF_ERK_DN.V1_UP, PDGF_UP.V1_UP, BARX1_TARGET_GENES, CREB3L4_TARGET_GENES, DIDO1_TARGET_GENES, DLX4_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (2): protein phosphatase inhibitor activity (GO:0004864), protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
phosphoprotein phosphatase activity	1
phosphatase inhibitor activity	1
protein phosphatase regulator activity	1
binding	1

Protein interactions and networks

STRING

446 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PPP1R37	MS4A10	Q96PG2	431
PPP1R37	CCDC183	Q5T5S1	413
PPP1R37	PRSS36	Q5K4E3	410
PPP1R37	AGAP4	Q96P64	404
PPP1R37	ZFAT	Q9P243	401
PPP1R37	MS4A15	Q8N5U1	391
PPP1R37	ANOS1	P23352	386
PPP1R37	POLR1G	O15446	378
PPP1R37	TRAPPC6A	O75865	376
PPP1R37	EXOC3L2	Q2M3D2	376
PPP1R37	POTEI	P0CG38	374
PPP1R37	POTEJ	P0CG39	372
PPP1R37	ARMC8	Q8IUR7	371
PPP1R37	A0A087WTP8	A0A087WTP8	356
PPP1R37	TIMM22	Q9Y584	352

IntAct

43 interactions, top by confidence:

A	B	Type	Score
PPP1CA	PPP1R37	psi-mi:“MI:0407”(direct interaction)	0.830
PPP1R37	PPP1CA	psi-mi:“MI:0915”(physical association)	0.830
PPP1CB	CCDC85C	psi-mi:“MI:0914”(association)	0.750
PPP1CB	CCDC85C	psi-mi:“MI:2364”(proximity)	0.750
PPP1CA	CCDC85C	psi-mi:“MI:0914”(association)	0.670
PPP1CA	CCDC85C	psi-mi:“MI:2364”(proximity)	0.670
KRTAP6-3	PPP1R37	psi-mi:“MI:0915”(physical association)	0.560
PPP1R37	RBPMS2	psi-mi:“MI:0915”(physical association)	0.560
PPP1R37	ZNF837	psi-mi:“MI:0915”(physical association)	0.560
PPP1R37	BEND7	psi-mi:“MI:0915”(physical association)	0.560
FOXH1	PPP1R37	psi-mi:“MI:0915”(physical association)	0.560
PPP1R37	PATZ1	psi-mi:“MI:0915”(physical association)	0.560
PPP1R37	RBMY1F	psi-mi:“MI:0915”(physical association)	0.560
HNRNPCL2	PPP1R37	psi-mi:“MI:0915”(physical association)	0.560
PPP1R37	ZNF764	psi-mi:“MI:0915”(physical association)	0.560
DCP1A	TBX3	psi-mi:“MI:0914”(association)	0.350
SEH1L	POM121C	psi-mi:“MI:0914”(association)	0.350
PPP1CA	CCDC85C	psi-mi:“MI:0914”(association)	0.350
S100A2	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
TGOLN2	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270
TGOLN2	TRAPPC13	psi-mi:“MI:2364”(proximity)	0.270
CDH1	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
PPP1R37	KRTAP6-3	psi-mi:“MI:0915”(physical association)	0.000
PPP1R37	RBPMS2	psi-mi:“MI:0915”(physical association)	0.000
PPP1R37	ZNF837	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (60): PPP1R37 (Affinity Capture-MS), PPP1R37 (Two-hybrid), PPP1R37 (Two-hybrid), PPP1R37 (Affinity Capture-MS), PPP1R37 (Affinity Capture-MS), PPP1R37 (Proximity Label-MS), PPP1R37 (Affinity Capture-MS), PPP1R37 (Affinity Capture-MS), PPP1R37 (Affinity Capture-MS), PPP1R37 (Affinity Capture-MS), PPP1R37 (Proximity Label-MS), PPP1R37 (Proximity Label-MS), PPP1R37 (Affinity Capture-MS), PPP1R37 (Proximity Label-MS), PPP1R37 (Proximity Label-MS)

ESM2 similar proteins: A5PJM7, A6QL63, A7YY62, A7Z026, B2RYF1, E9PV86, O35393, O54951, O70141, O75864, P42229, P42230, P42231, P51692, Q15768, Q29RM4, Q3SZB3, Q3U2I3, Q3UFK8, Q5R5M3, Q5R8V2, Q5U2R3, Q5ZJA4, Q5ZJB7, Q66H54, Q6DN14, Q6GQW0, Q6IA17, Q6ZN54, Q6ZUT9, Q7Z6G3, Q7Z6J6, Q86VR8, Q8BKR5, Q8N5X7, Q8N612, Q8NBT3, Q8TBP0, Q8TF64, Q8WXS5

Diamond homologs: A7Z026, A8Y3R9, B2RYF1, O75864, Q19857, Q1L994, Q8BKR5, D9I2F9, D9I2G1, D9I2G3, D9I2G4, D9I2H0, A1Z198

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

139 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	127
Likely benign	5
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2312 predictions. Top by Δscore:

Variant	Effect	Δscore
19:45138512:A:AG	acceptor_gain	1.0000
19:45138513:G:GT	acceptor_gain	1.0000
19:45138513:GCCCA:G	acceptor_gain	1.0000
19:45138610:AGGTA:A	donor_loss	1.0000
19:45138611:GG:G	donor_loss	1.0000
19:45138613:T:G	donor_loss	1.0000
19:45140233:CA:C	acceptor_loss	1.0000
19:45140234:A:AC	acceptor_loss	1.0000
19:45140234:A:AG	acceptor_gain	1.0000
19:45140234:AG:A	acceptor_gain	1.0000
19:45140235:G:GG	acceptor_gain	1.0000
19:45140235:GG:G	acceptor_gain	1.0000
19:45140235:GGA:G	acceptor_gain	1.0000
19:45140235:GGAA:G	acceptor_gain	1.0000
19:45140282:G:GA	donor_loss	1.0000
19:45140504:A:AG	acceptor_gain	1.0000
19:45140504:AG:A	acceptor_gain	1.0000
19:45140504:AGGT:A	acceptor_gain	1.0000
19:45140505:G:GG	acceptor_gain	1.0000
19:45140505:GG:G	acceptor_gain	1.0000
19:45140505:GGT:G	acceptor_gain	1.0000
19:45140505:GGTG:G	acceptor_gain	1.0000
19:45140505:GGTGA:G	acceptor_gain	1.0000
19:45140603:AGAT:A	donor_gain	1.0000
19:45140604:G:GT	donor_gain	1.0000
19:45140604:GAT:G	donor_gain	1.0000
19:45140605:A:G	donor_gain	1.0000
19:45140605:AT:A	donor_gain	1.0000
19:45140605:ATGTG:A	donor_loss	1.0000
19:45140606:TGTGA:T	donor_loss	1.0000

AlphaMissense

4468 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:45093467:T:C	F48L	1.000
19:45093468:T:G	F48C	1.000
19:45093469:C:A	F48L	1.000
19:45093469:C:G	F48L	1.000
19:45141352:T:G	Y160D	1.000
19:45141374:T:C	L167P	1.000
19:45141409:G:C	G179R	1.000
19:45141412:T:A	W180R	1.000
19:45141412:T:C	W180R	1.000
19:45141422:C:A	A183D	1.000
19:45142164:T:C	L224P	1.000
19:45142339:T:C	L252P	1.000
19:45142345:T:C	L254P	1.000
19:45142432:T:C	L283P	1.000
19:45143575:T:C	L310P	1.000
19:45144879:T:C	L338P	1.000
19:45145181:T:C	L406P	1.000
19:45093462:T:A	V46D	0.999
19:45093468:T:C	F48S	0.999
19:45093518:T:A	W65R	0.999
19:45093518:T:C	W65R	0.999
19:45093520:G:C	W65C	0.999
19:45093520:G:T	W65C	0.999
19:45138549:T:G	Y80D	0.999
19:45140276:T:C	L114P	0.999
19:45140539:T:C	L127P	0.999
19:45140541:G:A	E128K	0.999
19:45140542:A:T	E128V	0.999
19:45140543:A:C	E128D	0.999
19:45140543:A:T	E128D	0.999

dbSNP variants (sampled 300 via entrez): RS1000010832 (19:45108283 G>A), RS1000059203 (19:45136661 C>A), RS1000111050 (19:45114855 C>T), RS1000132894 (19:45141791 C>T), RS1000193147 (19:45147103 G>A,C), RS1000213071 (19:45113039 C>T), RS1000241329 (19:45107096 A>C,G), RS1000250552 (19:45108018 G>A), RS1000281863 (19:45118778 C>T), RS1000303527 (19:45143010 C>T), RS1000315363 (19:45132653 C>T), RS1000479494 (19:45103219 G>A), RS1000480326 (19:45117291 A>C,G,T), RS1000496380 (19:45122275 C>T), RS1000514037 (19:45123323 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST001947_2	Alzheimer’s disease (late onset)	5.000000e-39
GCST004069_16	Cerebrospinal fluid AB1-42 levels	6.000000e-10
GCST005950_15	Body mass index x sex x age interaction (4df test)	2.000000e-10
GCST005951_56	Body mass index	1.000000e-06
GCST005952_8	Body mass index (age>50)	9.000000e-12
GCST005954_4	Body mass index x age interaction	2.000000e-07
GCST007827_13	Alzheimer’s disease or HDL levels (pleiotropy)	7.000000e-22
GCST007827_3	Alzheimer’s disease or HDL levels (pleiotropy)	1.000000e-97
GCST007827_5	Alzheimer’s disease or HDL levels (pleiotropy)	7.000000e-74
GCST007827_8	Alzheimer’s disease or HDL levels (pleiotropy)	3.000000e-36
GCST009496_18	Alzheimer’s disease (onset between ages 58 and 79)	9.000000e-16
GCST90013406_74	Liver enzyme levels (alkaline phosphatase)	6.000000e-15

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004670	beta-amyloid 1-42 measurement
EFO:0004340	body mass index
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004533	alkaline phosphatase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, decreases expression, increases abundance, increases expression	2
FR900359	increases phosphorylation	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
aflatoxin B2	decreases methylation	1
coumarin	increases phosphorylation	1
perfluorodecanoic acid	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluoro-n-nonanoic acid	decreases expression	1
abrine	increases expression	1
Sunitinib	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Quercetin	increases phosphorylation	1
Silicon Dioxide	increases expression	1
Smoke	decreases expression	1
Testosterone	increases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Aflatoxin B1	decreases methylation	1
Cadmium Chloride	decreases expression	1
Particulate Matter	increases abundance, increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TF78	HAP1 PPP1R37 (-) 1	Cancer cell line	Male
CVCL_TF79	HAP1 PPP1R37 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.