PPP2R2B-IT1

Summary

PPP2R2B-IT1 (PPP2R2B intronic transcript 1, HGNC:42984) is a long non-coding RNA gene on chromosome 5q32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42984
Approved symbol	PPP2R2B-IT1
Name	PPP2R2B intronic transcript 1
Location	5q32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000249553
Ensembl biotype	lncRNA
Entrez	100874361
RNAcentral	URS0000344375 — lncRNA, 447 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000505921

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000505921 — 4 exons

Exon	Start	End
ENSE00002038199	146914207	146914434
ENSE00002049715	146919392	146919506
ENSE00002076010	146917823	146917911
ENSE00002476980	146918374	146918388

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 95.41.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	95.41	gold quality
sural nerve	UBERON:0015488	83.74	gold quality
calcaneal tendon	UBERON:0003701	59.46	gold quality
muscle of leg	UBERON:0001383	56.69	gold quality
superior frontal gyrus	UBERON:0002661	55.05	gold quality
prefrontal cortex	UBERON:0000451	53.82	gold quality
adult mammalian kidney	UBERON:0000082	52.53	gold quality
blood	UBERON:0000178	52.46	gold quality
body of pancreas	UBERON:0001150	51.78	gold quality
primary visual cortex	UBERON:0002436	51.43	gold quality
right atrium auricular region	UBERON:0006631	49.38	gold quality
stomach	UBERON:0000945	48.68	gold quality
esophagus mucosa	UBERON:0002469	48.61	gold quality
small intestine	UBERON:0002108	48.56	silver quality
substantia nigra	UBERON:0002038	47.74	gold quality
tibial nerve	UBERON:0001323	47.48	gold quality
Brodmann (1909) area 9	UBERON:0013540	47.21	gold quality
amygdala	UBERON:0001876	47.11	gold quality
body of stomach	UBERON:0001161	47.08	gold quality
putamen	UBERON:0001874	46.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	46.68	gold quality
brain	UBERON:0000955	46.64	gold quality
multicellular organism	UBERON:0000468	46.31	gold quality
frontal cortex	UBERON:0001870	46.25	gold quality
Ammon’s horn	UBERON:0001954	46.03	gold quality
left testis	UBERON:0004533	45.83	gold quality
testis	UBERON:0000473	45.81	gold quality
cerebellar cortex	UBERON:0002129	45.70	gold quality
right lobe of thyroid gland	UBERON:0001119	45.62	gold quality
cerebral cortex	UBERON:0000956	45.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.96

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.