PPP3CB-AS1

Summary

PPP3CB-AS1 (PPP3CB antisense RNA 1, HGNC:50750) is a long non-coding RNA gene on chromosome 10q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50750
Approved symbol	PPP3CB-AS1
Name	PPP3CB antisense RNA 1
Location	10q22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	USP54-AS1
Ensembl gene	ENSG00000221817
Ensembl biotype	lncRNA
Entrez	101929145
RNAcentral	URS00008E3A07 — lncRNA, 3100 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 76 — 75 lncRNA, 1 retained_intron

ENST00000422977, ENST00000439792, ENST00000442133, ENST00000593790, ENST00000595069, ENST00000595935, ENST00000596320, ENST00000597958, ENST00000600206, ENST00000600607, ENST00000600887, ENST00000610317, ENST00000620302, ENST00000620432, ENST00000620559, ENST00000687563, ENST00000690300, ENST00000690541, ENST00000700757, ENST00000700845, ENST00000700942, ENST00000847337, ENST00000847338, ENST00000847339, ENST00000847340, ENST00000847341, ENST00000847342, ENST00000847343, ENST00000847344, ENST00000847345, ENST00000847346, ENST00000847347, ENST00000847348, ENST00000847349, ENST00000847350, ENST00000847351, ENST00000847352, ENST00000847353, ENST00000847354, ENST00000847355, ENST00000847356, ENST00000847357, ENST00000847358, ENST00000847359, ENST00000847360, ENST00000847361, ENST00000847362, ENST00000847363, ENST00000847364, ENST00000847365, ENST00000847366, ENST00000847367, ENST00000847368, ENST00000847369, ENST00000847370, ENST00000847371, ENST00000847372, ENST00000847373, ENST00000847374, ENST00000847375, ENST00000847376, ENST00000847377, ENST00000847378, ENST00000847379, ENST00000847380, ENST00000847381, ENST00000847382, ENST00000847383, ENST00000847384, ENST00000847385, ENST00000847386, ENST00000847387, ENST00000847388, ENST00000847389, ENST00000847390, ENST00000847391

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000422977 — 5 exons

Exon	Start	End
ENSE00001662877	73504184	73504272
ENSE00001772401	73499595	73499687
ENSE00001774934	73496142	73496906
ENSE00004276035	73495378	73495817
ENSE00004276048	73504538	73505691

Expression profiles

Bgee: expression breadth ubiquitous, 196 present calls, max score 87.62.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.5989 / max 108.5483, expressed in 1400 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
105533	2.7230	1211
105532	0.8759	492

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
epithelial cell of pancreas	CL:0000083	87.62	silver quality
gastrocnemius	UBERON:0001388	82.75	gold quality
muscle of leg	UBERON:0001383	82.34	gold quality
ileal mucosa	UBERON:0000331	82.13	gold quality
monocyte	CL:0000576	81.30	gold quality
leukocyte	CL:0000738	81.24	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.11	gold quality
granulocyte	CL:0000094	80.93	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.60	gold quality
kidney epithelium	UBERON:0004819	80.40	gold quality
right lobe of thyroid gland	UBERON:0001119	79.67	gold quality
pancreatic ductal cell	CL:0002079	79.35	silver quality
left lobe of thyroid gland	UBERON:0001120	79.03	gold quality
hindlimb stylopod muscle	UBERON:0004252	78.18	gold quality
thyroid gland	UBERON:0002046	77.85	gold quality
spleen	UBERON:0002106	77.49	gold quality
rectum	UBERON:0001052	77.41	gold quality
body of pancreas	UBERON:0001150	77.38	gold quality
right uterine tube	UBERON:0001302	77.21	gold quality
small intestine Peyer’s patch	UBERON:0003454	77.21	gold quality
metanephros cortex	UBERON:0010533	76.96	gold quality
vermiform appendix	UBERON:0001154	76.94	gold quality
minor salivary gland	UBERON:0001830	76.76	gold quality
bone marrow cell	CL:0002092	76.63	gold quality
tibialis anterior	UBERON:0001385	76.46	silver quality
body of stomach	UBERON:0001161	76.32	gold quality
transverse colon	UBERON:0001157	76.22	gold quality
sural nerve	UBERON:0015488	76.13	gold quality
small intestine	UBERON:0002108	76.12	gold quality
right lobe of liver	UBERON:0001114	75.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.77

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.