PPP4R2

Summary

PPP4R2 (protein phosphatase 4 regulatory subunit 2, HGNC:18296) is a protein-coding gene on chromosome 3p13, encoding Serine/threonine-protein phosphatase 4 regulatory subunit 2 (Q9NY27). Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). It is a selective cancer dependency (DepMap: 73.6% of cell lines).

The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 151987 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 68 total
• Cancer dependency (DepMap): dependent in 73.6% of screened cell lines
• MANE Select transcript: NM_174907

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18296
Approved symbol	PPP4R2
Name	protein phosphatase 4 regulatory subunit 2
Location	3p13
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000163605
Ensembl biotype	protein_coding
OMIM	613822
Entrez	151987

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 6 protein_coding, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000356692, ENST00000460360, ENST00000470976, ENST00000476505, ENST00000482242, ENST00000488810, ENST00000495566, ENST00000710398

RefSeq mRNA: 5 — MANE Select: NM_174907 NM_001318025, NM_001318026, NM_001318027, NM_001318028, NM_174907

CCDS: CCDS2917, CCDS82805

Canonical transcript exons

ENST00000356692 — 9 exons

Exon	Start	End
ENSE00001076470	73061023	73061060
ENSE00001076472	73063673	73063747
ENSE00001076473	73064852	73065141
ENSE00001076474	73064003	73064146
ENSE00001857042	72996811	72997071
ENSE00001895742	73065397	73069198
ENSE00003511452	73059037	73059130
ENSE00003592578	72998077	72998158
ENSE00003611594	73047186	73047356

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 97.97.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.4440 / max 1234.6092, expressed in 1808 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
37332	23.4440	1808

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	97.97	gold quality
oviduct epithelium	UBERON:0004804	97.73	gold quality
epithelial cell of pancreas	CL:0000083	96.83	gold quality
adrenal tissue	UBERON:0018303	96.38	gold quality
cardiac muscle of right atrium	UBERON:0003379	96.12	gold quality
left ventricle myocardium	UBERON:0006566	95.99	gold quality
bone marrow	UBERON:0002371	95.46	gold quality
tibialis anterior	UBERON:0001385	94.67	gold quality
germinal epithelium of ovary	UBERON:0001304	94.59	gold quality
mucosa of sigmoid colon	UBERON:0004993	94.49	gold quality
oocyte	CL:0000023	94.43	gold quality
bone marrow cell	CL:0002092	94.43	gold quality
ileal mucosa	UBERON:0000331	94.38	gold quality
colonic epithelium	UBERON:0000397	94.34	gold quality
myocardium	UBERON:0002349	94.33	gold quality
islet of Langerhans	UBERON:0000006	94.30	gold quality
placenta	UBERON:0001987	94.29	gold quality
colonic mucosa	UBERON:0000317	94.15	gold quality
deltoid	UBERON:0001476	94.12	gold quality
esophagus squamous epithelium	UBERON:0006920	94.07	gold quality
amniotic fluid	UBERON:0000173	94.02	gold quality
mucosa of paranasal sinus	UBERON:0005030	94.01	gold quality
cartilage tissue	UBERON:0002418	93.91	gold quality
tibia	UBERON:0000979	93.82	gold quality
ventricular zone	UBERON:0003053	93.82	gold quality
endometrium	UBERON:0001295	93.69	gold quality
pigmented layer of retina	UBERON:0001782	93.48	gold quality
heart right ventricle	UBERON:0002080	93.05	gold quality
cerebellar vermis	UBERON:0004720	93.05	gold quality
trabecular bone tissue	UBERON:0002483	93.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.32

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

245 targeting PPP4R2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-27A-3P	99.98	72.13	2955

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 73.6% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 4)

• A three-protein PP4 phosphatase complex in mammalian cells, containing PP4C, PP4R2, and PP4R3beta, specifically dephosphorylates ATR-mediated gamma-H2AX generated during DNA replication. (PMID:18614045)
• PP4R2, a regulatory subunit of PP4, mediates the DNA damage-dependent association between RPA2 and the PP4C catalytic subunit. (PMID:20154705)
• PPP4R2 affects the survival of neuronal cells in response to DNA damage. (PMID:22559936)
• Results from a study on gene expression variability markers in early-stage human embryos shows that PPP4R2 is a putative expression variability marker for the 3-day, 8-cell embryo stage. (PMID:26288249)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Serine/threonine-protein phosphatase 4 regulatory subunit 2 — Q9NY27 (reviewed: Q9NY27)

All UniProt accessions (7): Q9NY27, A0AA34QVI2, C9IZ04, C9IZF4, F8WCA1, F8WDK3, H7C559

UniProt curated annotations — full annotation on UniProt →

Function. Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on ‘Ser-140’ (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.

Subunit / interactions. Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A and PPP4C-PPP4R2-PPP4R3B. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with DDX20/GEMIN3 and GEMIN4. Interacts with RPA2; this DNA damage-dependent interaction recruits PPP4C leading to RPA2 dephosphorylation.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Nucleus.

Tissue specificity. Widely expressed.

Similarity. Belongs to the PPP4R2 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NY27-1	1	yes
Q9NY27-2	2
Q9NY27-3	3

RefSeq proteins (5): NP_001304954, NP_001304955, NP_001304956, NP_001304957, NP_777567* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR015267	PPP4R2	Family

Pfam: PF09184

UniProt features (26 total): compositionally biased region 15, mutagenesis site 3, modified residue 2, splice variant 2, sequence variant 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NY27-F1	62.82	0.27

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 159, 226

Mutagenesis-validated functional residues (3):

Position	Phenotype
99	no effect on rpa2-binding; decrease in ppp4c-binding.
103	no effect on rpa2-binding; loss of ppp4c-binding.
106	no effect on rpa2-binding, nor on ppp4c-binding.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-5693607	Processing of DNA double-strand break ends

MSigDB gene sets: 245 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_UP, GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR, GOBP_REGULATION_OF_DNA_RECOMBINATION, MODULE_255, MODULE_45, MODULE_317, GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION, GOBP_REGULATION_OF_DNA_REPAIR, GOCC_MICROTUBULE_ORGANIZING_CENTER, MODULE_66, MODULE_118, MODULE_379, chr3p13, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, KMCATNNWGGA_UNKNOWN

GO Biological Process (5): mRNA processing (GO:0006397), RNA splicing (GO:0008380), regulation of double-strand break repair via homologous recombination (GO:0010569), protein modification process (GO:0036211), regulation of double-strand break repair (GO:2000779)

GO Molecular Function (3): protein phosphatase regulator activity (GO:0019888), protein-macromolecule adaptor activity (GO:0030674), protein binding (GO:0005515)

GO Cellular Component (7): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), centrosome (GO:0005813), protein phosphatase 4 complex (GO:0030289), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
RNA processing	2
mRNA metabolic process	1
regulation of DNA recombination	1
double-strand break repair via homologous recombination	1
regulation of double-strand break repair	1
protein metabolic process	1
macromolecule modification	1
regulation of DNA repair	1
double-strand break repair	1
phosphoprotein phosphatase activity	1
phosphatase regulator activity	1
protein phosphatase binding	1
protein binding	1
molecular adaptor activity	1
binding	1
chromosome	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
centriole	1
microtubule organizing center	1
protein serine/threonine phosphatase complex	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1890 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PPP4R2	PPP4C	P33172	998
PPP4R2	PPP4R3A	Q6IN85	995
PPP4R2	PPP4R1	Q8TF05	971
PPP4R2	PPP4R3B	Q5MIZ7	954
PPP4R2	PPP4R4	Q6NUP7	774
PPP4R2	GEMIN4	P57678	725
PPP4R2	DDX20	Q9UHI6	714
PPP4R2	PPP6C	O00743	646
PPP4R2	PPP6R2	O75170	599
PPP4R2	PPP6R1	Q9UPN7	519
PPP4R2	PPP4R3C	Q6ZMV5	498
PPP4R2	MAP2K1	Q02750	455
PPP4R2	PPP2CA	P05323	446
PPP4R2	RPA2	P15927	443
PPP4R2	GXYLT2	A0PJZ3	441

IntAct

82 interactions, top by confidence:

A	B	Type	Score
PPP4R2	PPP4C	psi-mi:“MI:0914”(association)	0.950
PPP4R2	PPP4C	psi-mi:“MI:0915”(physical association)	0.950
PPP4C	PPP4R2	psi-mi:“MI:0915”(physical association)	0.950
PPME1	PPP2R1A	psi-mi:“MI:0914”(association)	0.950
PPP4R3A	PPP4C	psi-mi:“MI:0914”(association)	0.920
PPP4C	PPP4R3A	psi-mi:“MI:0914”(association)	0.920
PPP4R3B	PPP4C	psi-mi:“MI:0914”(association)	0.890
PPME1	PPP2CA	psi-mi:“MI:0914”(association)	0.880
TIPRL	PPP4C	psi-mi:“MI:0914”(association)	0.850
PPP4R2	TIPRL	psi-mi:“MI:0914”(association)	0.800
PPP4C	TCP1	psi-mi:“MI:0914”(association)	0.730
SNRPD2	GEMIN2	psi-mi:“MI:0914”(association)	0.710
PPP4C	SUPT5H	psi-mi:“MI:0914”(association)	0.640
DNAJC8	SF3B1	psi-mi:“MI:0914”(association)	0.640
SF3B1	SAP18	psi-mi:“MI:0914”(association)	0.640
SNRPA1	U2SURP	psi-mi:“MI:0914”(association)	0.640
DHX38	DHX16	psi-mi:“MI:0914”(association)	0.630
SF3B4	SF3B1	psi-mi:“MI:0914”(association)	0.610
USP10	ANKRD28	psi-mi:“MI:0914”(association)	0.610
PPP4R2	SF3B1	psi-mi:“MI:0914”(association)	0.570
PPP4R2	SF3B1	psi-mi:“MI:2364”(proximity)	0.570
MARCKSL1	NMT2	psi-mi:“MI:0914”(association)	0.530

BioGRID (216): PPP4R2 (Affinity Capture-MS), PPP4R2 (Affinity Capture-MS), PPP4R2 (Affinity Capture-MS), PPP4R2 (Affinity Capture-MS), PPP4R2 (Affinity Capture-MS), CUTA (Co-fractionation), DNAJA1 (Co-fractionation), PPP4C (Co-fractionation), PPP4R2 (Co-fractionation), SMEK1 (Co-fractionation), SMEK2 (Co-fractionation), PPP4C (Affinity Capture-MS), SLC4A1AP (Affinity Capture-MS), SMEK1 (Affinity Capture-MS), SMEK2 (Affinity Capture-MS)

ESM2 similar proteins: A0FKI7, A1L1M4, A5X7A0, A7XYJ6, A8MW92, E1BE02, F8VPQ2, O18805, O35613, O94885, P59598, P59808, Q0VGB7, Q13029, Q28IG6, Q4V9H5, Q5M7D6, Q5R9U6, Q5RJ80, Q5TJE1, Q5XG73, Q5ZHQ6, Q5ZM88, Q5ZMU6, Q63755, Q640U0, Q641E3, Q6DCQ0, Q6I6G8, Q6KAQ7, Q6P964, Q6ZQ03, Q76L83, Q76LL6, Q76N89, Q7TT18, Q8BLG0, Q8BZ32, Q8C9B9, Q8CCJ9

Diamond homologs: A1L1M4, Q0VGB7, Q28IG6, Q5M7D6, Q5R9U6, Q5ZMU6, Q6DCQ0, Q6P964, Q9NY27, Q9W2U4, P0C5B7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 87 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Splicing - Minor Pathway	9	31.0×	6e-10
mRNA Splicing	14	23.6×	7e-14
mRNA Polyadenylation	14	18.9×	1e-12
CHD1 and CHD2 subfamily	11	18.4×	8e-10
Processing of Capped Intron-Containing Pre-mRNA	14	17.7×	2e-12
mRNA Splicing - Major Pathway	20	16.8×	5e-17
Influenza Infection	5	13.5×	1e-03
Metabolism of RNA	20	12.8×	5e-15

GO biological processes:

GO term	Partners	Fold	FDR
U2-type prespliceosome assembly	10	79.0×	5e-15
RNA splicing, via transesterification reactions	6	47.4×	2e-07
mRNA splicing, via spliceosome	17	19.7×	4e-15
RNA splicing	12	13.4×	1e-08

Disease & clinical

Clinical variants and AI predictions

ClinVar

68 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	48
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2177 predictions. Top by Δscore:

Variant	Effect	Δscore
3:72997059:G:GT	donor_gain	1.0000
3:72998071:A:AG	acceptor_gain	1.0000
3:72998072:TCTA:T	acceptor_loss	1.0000
3:72998073:CTA:C	acceptor_loss	1.0000
3:72998075:A:AG	acceptor_gain	1.0000
3:72998075:AGA:A	acceptor_loss	1.0000
3:72998076:G:GA	acceptor_gain	1.0000
3:72998076:GA:G	acceptor_gain	1.0000
3:72998076:GAT:G	acceptor_gain	1.0000
3:72998076:GATT:G	acceptor_gain	1.0000
3:72998076:GATTT:G	acceptor_gain	1.0000
3:72998154:ACAAT:A	donor_gain	1.0000
3:72998155:CAATG:C	donor_loss	1.0000
3:72998156:AATGT:A	donor_loss	1.0000
3:72998157:AT:A	donor_gain	1.0000
3:72998157:ATG:A	donor_loss	1.0000
3:72998158:TGT:T	donor_loss	1.0000
3:72998159:G:GG	donor_gain	1.0000
3:72998159:GTGAG:G	donor_loss	1.0000
3:72998160:T:G	donor_loss	1.0000
3:72998161:GAGTT:G	donor_loss	1.0000
3:73047181:TATA:T	acceptor_loss	1.0000
3:73047183:TAG:T	acceptor_loss	1.0000
3:73047184:A:AG	acceptor_gain	1.0000
3:73047184:A:C	acceptor_loss	1.0000
3:73047185:G:GG	acceptor_gain	1.0000
3:73047322:G:GT	donor_gain	1.0000
3:73047323:A:T	donor_gain	1.0000
3:73047355:GG:G	donor_gain	1.0000
3:73047355:GGGT:G	donor_loss	1.0000

AlphaMissense

2789 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:72998125:T:C	F28S	1.000
3:72998128:T:C	L29P	1.000
3:72998139:G:C	A33P	1.000
3:72998140:C:A	A33D	1.000
3:72998148:G:A	G36R	1.000
3:72998148:G:C	G36R	1.000
3:72998149:G:A	G36E	1.000
3:72998149:G:T	G36V	1.000
3:73047193:T:A	W42R	1.000
3:73047193:T:C	W42R	1.000
3:73047194:G:C	W42S	1.000
3:73047195:G:C	W42C	1.000
3:73047195:G:T	W42C	1.000
3:73047215:T:C	F49S	1.000
3:73047225:A:C	K52N	1.000
3:73047225:A:T	K52N	1.000
3:73047227:T:C	L53P	1.000
3:73047247:T:C	F60L	1.000
3:73047248:T:C	F60S	1.000
3:73047248:T:G	F60C	1.000
3:73047249:C:A	F60L	1.000
3:73047249:C:G	F60L	1.000
3:73047293:T:A	V75D	1.000
3:73047307:T:C	F80L	1.000
3:73047309:T:A	F80L	1.000
3:73047309:T:G	F80L	1.000
3:73047321:G:C	K84N	1.000
3:73047321:G:T	K84N	1.000
3:73047329:T:A	I87K	1.000
3:73047329:T:G	I87R	1.000

dbSNP variants (sampled 300 via entrez): RS1000001682 (3:73033817 C>T), RS1000100460 (3:73038851 T>C), RS1000104804 (3:73025158 A>G), RS1000139143 (3:73044443 G>A,C), RS1000176054 (3:73005872 A>G,T), RS1000196140 (3:73040058 G>GA), RS1000212310 (3:73012593 G>A), RS1000232733 (3:73010554 C>G,T), RS1000246206 (3:73044185 A>T), RS1000251805 (3:72996914 C>A,G,T), RS1000253956 (3:73044269 C>T), RS1000267381 (3:73010348 C>T), RS1000279281 (3:73062983 G>A,C), RS1000306728 (3:73010089 T>C), RS1000397764 (3:73048977 C>G,T)

Disease associations

OMIM: gene MIM:613822 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST006626_45	Pulse pressure	3.000000e-10
GCST007269_29	Pulse pressure	7.000000e-09
GCST007392_2	Mitochondrial DNA copy number (white blood cells)	6.000000e-07
GCST010002_431	Refractive error	3.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005763	pulse pressure measurement
EFO:0006312	mitochondrial DNA measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

54 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, decreases methylation	7
Cadmium	decreases reaction, increases abundance, increases expression	2
Formaldehyde	decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Tobacco Smoke Pollution	increases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
dicrotophos	decreases expression	1
2,4,6-tribromophenol	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects expression	1
decabromobiphenyl ether	increases expression	1
beta-lapachone	decreases expression	1
arsenite	affects binding, decreases reaction	1
tetrabromobisphenol A	decreases expression	1
benzo(e)pyrene	decreases methylation	1
coumarin	affects phosphorylation	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Resveratrol	increases expression, affects cotreatment	1
Sunitinib	increases expression	1
Leflunomide	increases expression	1
Cidofovir	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Azathioprine	increases expression	1
Benzo(a)pyrene	decreases expression	1

Cellosaurus cell lines

3 cell lines: 2 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3EL	Abcam HEK293T PPP4R2 KO	Transformed cell line	Female
CVCL_TG24	HAP1 PPP4R2 (-) 1	Cancer cell line	Male
CVCL_TG25	HAP1 PPP4R2 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.