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PPP4R3A

gene
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Also known as FLJ20707MSTP033FLFL1smk-1smk1PP4R3

Summary

PPP4R3A (protein phosphatase 4 regulatory subunit 3A, HGNC:20219) is a protein-coding gene on chromosome 14q32.12, encoding Serine/threonine-protein phosphatase 4 regulatory subunit 3A (Q6IN85). Regulatory subunit of serine/threonine-protein phosphatase 4.

Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage response and regulation of double-strand break repair. Predicted to act upstream of or within positive regulation of gluconeogenesis and protein dephosphorylation. Located in cytosol and nuclear speck.

Source: NCBI Gene 55671 — RefSeq curated summary.

At a glance

  • GWAS associations: 13
  • Clinical variants (ClinVar): 24 total
  • Druggable target: yes
  • MANE Select transcript: NM_001366432

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:20219
Approved symbolPPP4R3A
Nameprotein phosphatase 4 regulatory subunit 3A
Location14q32.12
Locus typegene with protein product
StatusApproved
AliasesFLJ20707, MSTP033, FLFL1, smk-1, smk1, PP4R3
Ensembl geneENSG00000100796
Ensembl biotypeprotein_coding
OMIM610351
Entrez55671

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 21 protein_coding, 2 retained_intron, 1 nonsense_mediated_decay, 1 non_stop_decay, 1 protein_coding_CDS_not_defined

ENST00000554308, ENST00000554390, ENST00000554511, ENST00000554574, ENST00000554684, ENST00000554943, ENST00000555029, ENST00000555462, ENST00000555470, ENST00000555718, ENST00000557018, ENST00000557382, ENST00000858579, ENST00000858580, ENST00000919368, ENST00000919369, ENST00000962259, ENST00000962260, ENST00000962261, ENST00000962262, ENST00000962263, ENST00000962264, ENST00000962265, ENST00000962266, ENST00000962267, ENST00000962268

RefSeq mRNA: 3 — MANE Select: NM_001366432 NM_001284280, NM_001284281, NM_001366432

CCDS: CCDS61532, CCDS91918, CCDS9895

Canonical transcript exons

ENST00000554943 — 15 exons

ExonStartEnd
ENSE000008086449147083791470995
ENSE000008086459147303391473135
ENSE000008086469147323991473370
ENSE000008086509148157691482193
ENSE000016465189147581191475966
ENSE000017580799149074791490802
ENSE000025011539150950691510310
ENSE000025231689145750891458869
ENSE000035191389147640891476524
ENSE000035534949146525091465419
ENSE000035933049146273591462877
ENSE000036223289146204991462239
ENSE000036769909147690991476986
ENSE000036790869146138191461607
ENSE000037902849148563291485730

Expression profiles

Bgee: expression breadth ubiquitous, 282 present calls, max score 97.09.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 36.2005 / max 290.2873, expressed in 1818 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter IDTPM avgSamples expressed
14451720.50031810
14452110.83061751
1445222.86181184
1445190.9456517
1445200.6898363
1445180.3028140
1445160.069521

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
ventricular zoneUBERON:000305397.09gold quality
right uterine tubeUBERON:000130296.96gold quality
granulocyteCL:000009496.69gold quality
calcaneal tendonUBERON:000370196.42gold quality
ganglionic eminenceUBERON:000402396.25gold quality
skin of legUBERON:000151196.12gold quality
skin of abdomenUBERON:000141696.07gold quality
leukocyteCL:000073896.02gold quality
monocyteCL:000057695.96gold quality
mononuclear cellCL:000084295.92gold quality
right lungUBERON:000216795.82gold quality
rectumUBERON:000105295.78gold quality
endocervixUBERON:000045895.66gold quality
body of pancreasUBERON:000115095.56gold quality
small intestine Peyer’s patchUBERON:000345495.51gold quality
right testisUBERON:000453495.43gold quality
lower esophagus mucosaUBERON:003583495.42gold quality
left testisUBERON:000453395.36gold quality
body of uterusUBERON:000985395.29gold quality
minor salivary glandUBERON:000183095.27gold quality
ectocervixUBERON:001224995.24gold quality
mucosa of stomachUBERON:000119995.16gold quality
left ovaryUBERON:000211995.16gold quality
spleenUBERON:000210695.15gold quality
right ovaryUBERON:000211895.13gold quality
mucosa of transverse colonUBERON:000499194.99gold quality
right lobe of liverUBERON:000111494.90gold quality
tibial nerveUBERON:000132394.89gold quality
muscle layer of sigmoid colonUBERON:003580594.86gold quality
left uterine tubeUBERON:000130394.85gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes8.19
E-MTAB-7008no122.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

  • The N-terminal of BLU was observed to interact with the C-terminal of SMEK1, a regulatory subunit of protein phosphatase 4. Furthermore, we determined the binding domains that are required for interaction between BLU and sMEK1. The N-terminal of BLU was observed to interact with the C-terminal of sMEK1. (PMID:22349239)
  • Loss of sMEK1 is associated with Ovarian Neoplasms. (PMID:26378810)
  • sMEK1 significantly inhibited BMI-1-stimulated oncogenesis. (PMID:27878292)
  • A variant in PPP4R3A was associated with reduced metabolic decline in Alzheimer’s disease patients. (PMID:29130521)
  • New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate. (PMID:36731689)
  • Tumour suppressor protein sMEK1 links to IRE1 signalling pathway to modulate its activity during ER stress. (PMID:38838857)

Cross-species orthologs

5 orthologs

OrganismSymbolGene ID
danio_reriosmek1ENSDARG00000042187
mus_musculusPpp4r3aENSMUSG00000041846
rattus_norvegicusPpp4r3aENSRNOG00000027773
drosophila_melanogasterflflFBGN0024555
caenorhabditis_elegansWBGENE00018285

Paralogs (2): PPP4R3C (ENSG00000224960), PPP4R3B (ENSG00000275052)

Protein

Protein identifiers

Serine/threonine-protein phosphatase 4 regulatory subunit 3A — Q6IN85 (reviewed: Q6IN85)

Alternative names: SMEK homolog 1

All UniProt accessions (7): Q6IN85, G3V231, G3V4R3, G3V5A2, G3V5Z3, H0YIY8, H0YJN6

UniProt curated annotations — full annotation on UniProt →

Function. Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on ‘Ser-140’ (gamma-H2AX) generated during DNA replication and required for DNA DSB repair.

Subunit / interactions. Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A. Interacts with PPP4C; the interaction requires PPP4R2.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Nucleus.

Similarity. Belongs to the SMEK family.

Isoforms (4)

UniProt IDNamesCanonical?
Q6IN85-11yes
Q6IN85-22
Q6IN85-44
Q6IN85-55

RefSeq proteins (3): NP_001271209, NP_001271210, NP_001353361* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR006887P4R3-like_central_domDomain
IPR011993PH-like_dom_sfHomologous_superfamily
IPR016024ARM-type_foldHomologous_superfamily
IPR051137PP4R3-likeFamily
IPR055236EVH1_PP4R3Domain

Pfam: PF04802, PF22972

UniProt features (33 total): modified residue 10, strand 8, compositionally biased region 5, splice variant 3, region of interest 2, turn 2, chain 1, domain 1, helix 1

Structure

Experimental structures (PDB)

1 structures.

PDBMethodResolution (Å)
6R8IX-RAY DIFFRACTION1.52

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q6IN85-F178.020.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 127, 655, 698, 741, 768, 771, 774, 777, 780, 117

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 223 (showing top): GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR, GGGACCA_MIR133A_MIR133B, AAGCAAT_MIR137, RORA1_01, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, TACAATC_MIR508, CACCAGC_MIR138, ACTGCAG_MIR173P, GOBP_REGULATION_OF_DNA_REPAIR, GOBP_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS, GOBP_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS, DOANE_RESPONSE_TO_ANDROGEN_DN

GO Biological Process (4): gluconeogenesis (GO:0006094), DNA damage response (GO:0006974), positive regulation of gluconeogenesis (GO:0045722), regulation of double-strand break repair (GO:2000779)

GO Molecular Function (2): protein phosphatase activator activity (GO:0072542), protein phosphatase regulator activity (GO:0019888)

GO Cellular Component (8): nucleoplasm (GO:0005654), centrosome (GO:0005813), cytosol (GO:0005829), nuclear speck (GO:0016607), protein phosphatase 4 complex (GO:0030289), nucleus (GO:0005634), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure3
phosphoprotein phosphatase activity2
glucose metabolic process1
hexose biosynthetic process1
cellular response to stress1
gluconeogenesis1
regulation of gluconeogenesis1
positive regulation of biosynthetic process1
positive regulation of glucose metabolic process1
regulation of DNA repair1
double-strand break repair1
phosphatase activator activity1
protein phosphatase regulator activity1
phosphatase regulator activity1
protein phosphatase binding1
nuclear lumen1
centriole1
microtubule organizing center1
cytoplasm1
nuclear ribonucleoprotein granule1
protein serine/threonine phosphatase complex1
intracellular membrane-bounded organelle1
intracellular anatomical structure1
intracellular membraneless organelle1

Protein interactions and networks

STRING

1600 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
PPP4R3APPP4R2Q9NY27995
PPP4R3APPP4CP33172979
PPP4R3APPP4R1Q8TF05785
PPP4R3ARANBP1P43487719
PPP4R3AVASPP50552703
PPP4R3AMAP2K1Q02750661
PPP4R3APPP4R4Q6NUP7633
PPP4R3APLEK2Q9NYT0498
PPP4R3ASCGB1D4Q6XE38479
PPP4R3APLEKP08567471
PPP4R3ASYDE2Q5VT97458
PPP4R3ACATSPER3Q86XQ3436
PPP4R3AREC8O95072435
PPP4R3ACEP55Q53EZ4429
PPP4R3AHCFC1P51610425

IntAct

124 interactions, top by confidence:

ABTypeScore
PPP4R2PPP4Cpsi-mi:“MI:0914”(association)0.950
PPP4R3APPP4Cpsi-mi:“MI:0914”(association)0.920
PPP4CPPP4R3Apsi-mi:“MI:0914”(association)0.920
CDK8MED19psi-mi:“MI:2364”(proximity)0.850
PPP4R2TIPRLpsi-mi:“MI:0914”(association)0.800
PPP4CTCP1psi-mi:“MI:0914”(association)0.730
DHX38PPP4Cpsi-mi:“MI:0914”(association)0.730
SNRPD2GEMIN2psi-mi:“MI:0914”(association)0.710
RHPN1PODXLpsi-mi:“MI:0914”(association)0.690
CCDC120AIPpsi-mi:“MI:0914”(association)0.640
PPP4CSUPT5Hpsi-mi:“MI:0914”(association)0.640
DNAJC8SF3B1psi-mi:“MI:0914”(association)0.640
SF3B1SAP18psi-mi:“MI:0914”(association)0.640
SNRPA1U2SURPpsi-mi:“MI:0914”(association)0.640
DHX38PPP4R3Apsi-mi:“MI:0914”(association)0.640
SNRPBSART1psi-mi:“MI:0914”(association)0.640
DHX38DHX16psi-mi:“MI:0914”(association)0.630
SF3B4SF3B1psi-mi:“MI:0914”(association)0.610
USP10ANKRD28psi-mi:“MI:0914”(association)0.610
PPP4R2SF3B1psi-mi:“MI:0914”(association)0.570

BioGRID (248): SMEK1 (Affinity Capture-MS), SMEK1 (Affinity Capture-MS), SMEK1 (Affinity Capture-MS), SMEK1 (Affinity Capture-MS), ACAT2 (Co-fractionation), CCAR2 (Co-fractionation), EHMT1 (Co-fractionation), EHMT2 (Co-fractionation), POLR2A (Co-fractionation), SMEK1 (Co-fractionation), SMEK1 (Co-fractionation), SMEK1 (Co-fractionation), SMEK1 (Co-fractionation), SNX12 (Co-fractionation), SNX3 (Co-fractionation)

ESM2 similar proteins: A0A1D5P556, A0A3Q1LSX9, A2A5R2, A2APV2, B0DOB5, B2RQE8, D3ZYR1, D4A631, F1LVW7, F1M775, F4IUX6, G3X9K3, O08808, O46382, O60308, O60610, O75674, O95466, Q07139, Q0IHV1, Q0JRZ9, Q3UQN2, Q4S6U8, Q5MIZ7, Q5R807, Q5SP90, Q6DFT3, Q6IN85, Q6INN7, Q6NTV6, Q6NXC0, Q6P2K6, Q6ZPF4, Q7TSU1, Q7ZX60, Q801Q7, Q80U19, Q86T65, Q8BPM0, Q8IVF7

Diamond homologs: Q3V0Y1, Q4S6U8, Q54I18, Q5MIZ7, Q5SP90, Q6DFT3, Q6IN85, Q6INN7, Q6P2K6, Q6ZMV5, Q7ZX60, Q801Q7, Q922R5, Q9VFS5, Q9Y7J8, Q6CQ91, Q75E32

SIGNOR signaling

1 interactions.

AEffectBMechanism
PPP4R3Aup-regulatesPPP4Cbinding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 129 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
mRNA Splicing - Minor Pathway1024.1×5e-10
mRNA Splicing1922.4×1e-18
Processing of Capped Intron-Containing Pre-mRNA1916.8×3e-16
CHD1 and CHD2 subfamily1315.2×2e-10
mRNA Polyadenylation1615.1×6e-13
mRNA Splicing - Major Pathway2414.1×1e-18
Metabolism of RNA2310.3×3e-15
Dengue Virus-Host Interactions209.8×7e-13

GO biological processes:

GO termPartnersFoldFDR
U2-type prespliceosome assembly1263.5×9e-17
RNA splicing, via transesterification reactions737.0×1e-07
spliceosomal snRNP assembly629.6×6e-06
mRNA splicing, via spliceosome1914.8×1e-14
RNA splicing1511.2×1e-09

Disease & clinical

Clinical variants and AI predictions

ClinVar

24 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance0
Likely benign0
Benign1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2416 predictions. Top by Δscore:

VariantEffectΔscore
14:91458866:CTCC:Cacceptor_gain1.0000
14:91458868:CC:Cacceptor_gain1.0000
14:91458869:CC:Cacceptor_gain1.0000
14:91461376:TGTAC:Tdonor_loss1.0000
14:91461377:GTAC:Gdonor_loss1.0000
14:91461378:TACCT:Tdonor_loss1.0000
14:91461379:A:Tdonor_loss1.0000
14:91461380:C:CGdonor_loss1.0000
14:91461605:TTA:Tacceptor_gain1.0000
14:91461608:C:CCacceptor_gain1.0000
14:91462018:A:Cdonor_gain1.0000
14:91462047:A:ACdonor_gain1.0000
14:91462048:C:CCdonor_gain1.0000
14:91462048:CATTT:Cdonor_gain1.0000
14:91462055:T:TAdonor_gain1.0000
14:91462060:T:Adonor_gain1.0000
14:91462071:A:ACdonor_gain1.0000
14:91462072:C:CCdonor_gain1.0000
14:91462075:A:ACdonor_gain1.0000
14:91462076:T:Cdonor_gain1.0000
14:91462127:CAG:Cdonor_gain1.0000
14:91462141:T:TAdonor_gain1.0000
14:91462235:GCATA:Gacceptor_gain1.0000
14:91462236:CATA:Cacceptor_gain1.0000
14:91462236:CATAC:Cacceptor_gain1.0000
14:91462237:ATA:Aacceptor_gain1.0000
14:91462237:ATACT:Aacceptor_loss1.0000
14:91462238:TA:Tacceptor_gain1.0000
14:91462238:TACT:Tacceptor_loss1.0000
14:91462239:AC:Aacceptor_loss1.0000

AlphaMissense

5528 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
14:91462169:A:GW682R1.000
14:91462169:A:TW682R1.000
14:91462789:A:GL640S1.000
14:91465281:G:TA600D1.000
14:91465284:G:AS599F1.000
14:91465285:A:GS599P1.000
14:91465293:A:GL596P1.000
14:91465295:A:CN595K1.000
14:91465295:A:TN595K1.000
14:91465365:C:GR572P1.000
14:91465400:T:AR560S1.000
14:91465400:T:GR560S1.000
14:91465401:C:GR560T1.000
14:91470845:A:CL551W1.000
14:91470847:G:CF550L1.000
14:91470847:G:TF550L1.000
14:91470849:A:GF550L1.000
14:91470913:C:AK528N1.000
14:91470913:C:GK528N1.000
14:91470915:T:CK528E1.000
14:91470917:A:TI527K1.000
14:91470928:A:CH523Q1.000
14:91470928:A:TH523Q1.000
14:91470942:A:GC519R1.000
14:91470943:A:CF518L1.000
14:91470943:A:TF518L1.000
14:91470945:A:GF518L1.000
14:91470974:A:GL508P1.000
14:91473080:A:GL485P1.000
14:91473113:A:GL474P1.000

dbSNP variants (sampled 300 via entrez): RS1000008007 (14:91496031 C>T), RS1000008518 (14:91511451 C>CGTTCCTTATTTACT), RS1000015651 (14:91474672 G>C,T), RS1000043492 (14:91465805 T>TTAA), RS1000068103 (14:91474416 G>A), RS1000144771 (14:91507855 G>A), RS1000182754 (14:91497340 T>A), RS1000206126 (14:91498828 T>C,G), RS1000294051 (14:91472952 C>G,T), RS1000369405 (14:91480913 T>C), RS1000387801 (14:91488111 G>A), RS1000477624 (14:91509710 G>A,C), RS1000535960 (14:91503907 A>C,G,T), RS1000679565 (14:91492275 C>T), RS1000720694 (14:91459604 A>C)

Disease associations

OMIM: gene MIM:610351 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

StudyTraitp-value
GCST003427_101Alzheimer disease and age of onset8.000000e-07
GCST003518_92Daytime sleep phenotypes8.000000e-06
GCST003801_2Response to selective serotonin reuptake inhibitors in depression7.000000e-07
GCST005956_47Waist-to-hip ratio adjusted for BMI7.000000e-07
GCST005962_28Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)7.000000e-07
GCST006632_3Decline in glucose metabolism in posterior cingulate cortex4.000000e-08
GCST006632_9Decline in glucose metabolism in posterior cingulate cortex4.000000e-08
GCST009379_195Type 2 diabetes7.000000e-09
GCST010703_103Brain morphology (MOSTest)8.000000e-21
GCST010916_24Proportion of activated microglia (inferior temporal cortex)3.000000e-06
GCST90002396_571Mean reticulocyte volume8.000000e-17
GCST90002397_368Mean spheric corpuscular volume3.000000e-13
GCST90002403_517Red blood cell count4.000000e-10

EFO canonical traits (10, from GWAS)

EFO IDTrait name
EFO:0004847age at onset
EFO:0007828daytime rest measurement
EFO:0005658response to selective serotonin reuptake inhibitor
EFO:0007788BMI-adjusted waist-hip ratio
EFO:0008007age at assessment
EFO:0008343sex interaction measurement
EFO:0009392glucose metabolism decline measurement
EFO:0004346neuroimaging measurement
EFO:0010701mean reticulocyte volume
EFO:0004305erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066394 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChemblTypeValueUnitMolecule
7.48Kd32.99nMCHEMBL3752910
7.48ED5032.99nMCHEMBL3752910

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

CompoundAssayTypeValueUnit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide2149938: Binding affinity to human SMEK1 incubated for 45 mins by Kinobead based pull down assaykd0.0330uM

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxidedecreases expression, increases expression2
FR900359increases phosphorylation1
2,4,6-tribromophenoldecreases expression1
sodium arsenatedecreases expression1
trichostatin Aaffects expression1
beta-lapachoneincreases expression1
arseniteaffects binding, decreases reaction1
sodium arseniteincreases expression1
cobaltous chlorideincreases expression1
tetrabromobisphenol Adecreases expression1
zinc chromateincreases abundance, increases expression1
di-n-butylphosphoric acidaffects expression1
chromium hexavalent ionincreases abundance, increases expression1
2,2’,4,4’-tetrabromodiphenyl etherdecreases expression1
pentabrominated diphenyl ether 100increases expression1
Resveratrolincreases expression, affects cotreatment1
Sunitinibincreases expression1
Acetaminophendecreases expression1
Air Pollutantsaffects expression, increases abundance1
Caffeineincreases phosphorylation1
Doxorubicindecreases expression1
Ethyl Methanesulfonateincreases expression1
Formaldehydeincreases expression1
Ivermectindecreases expression1
Methyl Methanesulfonateincreases expression1
Ozoneaffects expression, increases abundance1
Phthalic Acidsincreases methylation1
Plant Extractsaffects cotreatment, increases expression1
Quercetindecreases phosphorylation1
Tobacco Smoke Pollutionincreases expression1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL5652980BindingBinding affinity to human SMEK1 incubated for 45 mins by Kinobead based pull down assayNVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 77

This page pulls from 77 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_assaychembl_documentchembl_moleculechembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot