PRADX

Summary

PRADX (PRC2 and DDX5 associated lncRNA, HGNC:40168) is a long non-coding RNA gene on chromosome 11p15.5.

At a glance

• Gene type: non-coding (lncRNA) — no protein product.
• GTEx eGene: eQTL in 15 tissues, sQTL in 0 (q < 0.05)

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40168
Approved symbol	PRADX
Name	PRC2 and DDX5 associated lncRNA
Location	11p15.5
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000235027
Ensembl biotype	lncRNA
Entrez	126568849
RNAcentral	URS000027B716 — lncRNA, 2015 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1

ENST00000449248

RefSeq mRNA: 0

Canonical transcript exons

ENST00000449248 — 2 exons

Exon	Start	End
ENSE00001633782	1761319	1762486
ENSE00001777178	1760348	1761194

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 76.24.

Highest expression (Bgee): blood, bone marrow, bone marrow cell, adrenal gland cortex, adrenal gland.

Genetic regulation across tissues (GTEx eQTL / sQTL)

PRADX is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 15 tissues and its splicing (sQTL) in 0 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

15 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Skin Sun Exposed Lower leg	eqtl	3.1e-15	+0.53	11:1772322:C:T
Skin Not Sun Exposed Suprapubic	eqtl	4.1e-10	+0.48	11:1767669:G:C
Testis	eqtl	2.2e-07	+0.56	11:1761531:T:C
Adipose Subcutaneous	eqtl	1.0e-03	+0.23	11:1732147:A:G
Nerve Tibial	eqtl	1.0e-03	+0.24	11:1753704:A:G
Artery Tibial	eqtl	1.3e-03	+0.24	11:1730756:G:A
Breast Mammary Tissue	eqtl	1.6e-03	+0.19	11:1728734:A:G
Brain Caudate basal ganglia	eqtl	2.8e-03	+1.17	11:2179643:C:T
Pituitary	eqtl	5.6e-03	+0.45	11:1757655:C:T
Esophagus Gastroesophageal Junction	eqtl	1.9e-02	+0.29	11:1752906:T:G
Thyroid	eqtl	2.4e-02	+0.45	11:1781918:C:T
Artery Aorta	eqtl	2.5e-02	-0.12	11:2167206:A:G
Brain Cerebellum	eqtl	4.3e-02	+0.43	11:1757655:C:T
Cells Cultured fibroblasts	eqtl	4.3e-02	+0.17	11:1760560:T:C
Brain Frontal Cortex BA9	eqtl	4.5e-02	-0.72	11:1756739:C:T

Top tissues by expression

showing 100 of 128 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.24	gold quality
bone marrow	UBERON:0002371	71.58	gold quality
bone marrow cell	CL:0002092	71.24	gold quality
right adrenal gland cortex	UBERON:0035827	67.45	gold quality
right adrenal gland	UBERON:0001233	67.04	gold quality
left adrenal gland	UBERON:0001234	67.03	gold quality
upper lobe of left lung	UBERON:0008952	66.24	gold quality
left adrenal gland cortex	UBERON:0035825	66.04	gold quality
adrenal gland	UBERON:0002369	65.84	gold quality
sural nerve	UBERON:0015488	65.16	gold quality
lung	UBERON:0002048	64.49	gold quality
cortex of kidney	UBERON:0001225	64.26	gold quality
apex of heart	UBERON:0002098	63.60	gold quality
colonic epithelium	UBERON:0000397	62.82	silver quality
monocyte	CL:0000576	61.81	gold quality
metanephros cortex	UBERON:0010533	61.61	gold quality
spleen	UBERON:0002106	61.56	gold quality
kidney	UBERON:0002113	61.34	gold quality
right lung	UBERON:0002167	61.11	gold quality
skin of leg	UBERON:0001511	60.96	gold quality
skeletal muscle tissue	UBERON:0001134	60.86	gold quality
liver	UBERON:0002107	60.57	gold quality
urinary bladder	UBERON:0001255	60.55	gold quality
lower esophagus mucosa	UBERON:0035834	60.38	gold quality
ganglionic eminence	UBERON:0004023	60.29	gold quality
heart left ventricle	UBERON:0002084	60.08	gold quality
zone of skin	UBERON:0000014	60.03	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.62	gold quality
minor salivary gland	UBERON:0001830	59.37	gold quality
granulocyte	CL:0000094	59.20	gold quality
saliva-secreting gland	UBERON:0001044	59.08	gold quality
skin of abdomen	UBERON:0001416	58.93	gold quality
duodenum	UBERON:0002114	58.35	gold quality
vagina	UBERON:0000996	58.10	gold quality
adult mammalian kidney	UBERON:0000082	57.97	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.90	gold quality
heart	UBERON:0000948	57.88	gold quality
cortical plate	UBERON:0005343	57.50	silver quality
right lobe of liver	UBERON:0001114	57.34	gold quality
ventricular zone	UBERON:0003053	57.27	silver quality
tonsil	UBERON:0002372	57.12	gold quality
muscle of leg	UBERON:0001383	57.08	gold quality
gastrocnemius	UBERON:0001388	56.93	gold quality
right atrium auricular region	UBERON:0006631	56.78	gold quality
stromal cell of endometrium	CL:0002255	56.69	gold quality
tibial nerve	UBERON:0001323	56.51	gold quality
ascending aorta	UBERON:0001496	56.15	gold quality
esophagus mucosa	UBERON:0002469	56.07	gold quality
gall bladder	UBERON:0002110	56.00	gold quality
adipose tissue	UBERON:0001013	55.82	gold quality
lymph node	UBERON:0000029	55.70	gold quality
body of stomach	UBERON:0001161	55.55	gold quality
thoracic aorta	UBERON:0001515	55.52	gold quality
small intestine	UBERON:0002108	55.30	gold quality
stomach	UBERON:0000945	55.26	gold quality
popliteal artery	UBERON:0002250	55.16	gold quality
multicellular organism	UBERON:0000468	55.15	gold quality
small intestine Peyer’s patch	UBERON:0003454	55.12	gold quality
tibial artery	UBERON:0007610	55.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	54.81	gold quality
mucosa of transverse colon	UBERON:0004991	54.74	gold quality
uterine cervix	UBERON:0000002	54.56	gold quality
transverse colon	UBERON:0001157	54.03	gold quality
descending thoracic aorta	UBERON:0002345	53.92	gold quality
left coronary artery	UBERON:0001626	53.46	gold quality
omental fat pad	UBERON:0010414	53.35	gold quality
ectocervix	UBERON:0012249	53.33	gold quality
thoracic mammary gland	UBERON:0005200	53.07	gold quality
intestine	UBERON:0000160	52.60	gold quality
prefrontal cortex	UBERON:0000451	52.54	gold quality
vermiform appendix	UBERON:0001154	52.34	gold quality
endocervix	UBERON:0000458	52.23	gold quality
esophagus	UBERON:0001043	52.06	gold quality
adrenal tissue	UBERON:0018303	51.86	gold quality
body of pancreas	UBERON:0001150	51.82	gold quality
pancreas	UBERON:0001264	51.74	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	51.71	gold quality
colon	UBERON:0001155	51.68	gold quality
right hemisphere of cerebellum	UBERON:0014890	51.59	gold quality
placenta	UBERON:0001987	51.50	gold quality
fundus of stomach	UBERON:0001160	51.37	gold quality
cerebellum	UBERON:0002037	50.90	gold quality
prostate gland	UBERON:0002367	50.71	gold quality
left uterine tube	UBERON:0001303	50.70	gold quality
cerebellar cortex	UBERON:0002129	50.69	gold quality
cerebellar hemisphere	UBERON:0002245	50.60	gold quality
superior frontal gyrus	UBERON:0002661	49.99	gold quality
right lobe of thyroid gland	UBERON:0001119	49.81	gold quality
primary visual cortex	UBERON:0002436	49.54	silver quality
frontal cortex	UBERON:0001870	49.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	48.94	gold quality
smooth muscle tissue	UBERON:0001135	48.86	gold quality
myometrium	UBERON:0001296	48.86	gold quality
substantia nigra	UBERON:0002038	48.61	gold quality
endometrium	UBERON:0001295	48.59	gold quality
right coronary artery	UBERON:0001625	48.51	gold quality
muscle layer of sigmoid colon	UBERON:0035805	47.94	gold quality
cerebral cortex	UBERON:0000956	47.49	gold quality
islet of Langerhans	UBERON:0000006	47.42	gold quality
right ovary	UBERON:0002118	47.38	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	14.92
E-ANND-3	no	5.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
CTSD	protein-coding	1509
SYT8	protein-coding	90019
IFITM10	protein-coding	402778
LINC02708	ncRNA	100505570
KRTAP5-6	protein-coding	440023
TNNI2	protein-coding	7136
FAM99B	ncRNA	100132464

Protein

Non-coding RNA — no protein product.

Function

Gene-set membership (MSigDB)

This non-coding RNA is a member of 1 curated MSigDB gene set — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data).

chr11p15

ncRNA interactions

Experimentally supported non-coding-RNA interaction partners (NPInter).

1 interaction partners:

Partner	Partner type	Level	Source
EZH2	protein	RNA-Protein	Literature mining

Disease & clinical

ncRNA disease associations

Curated non-coding-RNA → disease associations (LncRNADisease, HMDD) — these are RNA-level associations for this gene, not the positional variant data omitted above.

1 ncRNA–disease associations:

Disease	Causal?	Validated by
Gliosarcoma	Yes	In Vivo Experiment, IHC, Western Blot, Transfection, Co-IP, CCK8, qRT-PCR, Luciferase Report Assay, Colony Formation Assay, ChIP

Drugs & pharmacology

No curated drug or pharmacology associations for this gene.