PRAL

Summary

PRAL (p53 regulation associated lncRNA, HGNC:52646) is a long non-coding RNA gene on chromosome 17p13.1.

At a glance

• Gene type: non-coding (TEC) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52646
Approved symbol	PRAL
Name	p53 regulation associated lncRNA
Location	17p13.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncRNA-PRAL
Ensembl gene	ENSG00000279296
Ensembl biotype	TEC
Entrez	109245082
RNAcentral	URS00008BAAAE — lncRNA, 3286 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 TEC

ENST00000624952

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000624952 — 1 exons

Exon	Start	End
ENSE00003755897	6772831	6776116

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 80.37.

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.37	gold quality
bone marrow cell	CL:0002092	76.61	gold quality
right lobe of liver	UBERON:0001114	76.60	gold quality
granulocyte	CL:0000094	73.77	gold quality
liver	UBERON:0002107	73.59	gold quality
apex of heart	UBERON:0002098	72.11	gold quality
calcaneal tendon	UBERON:0003701	71.62	gold quality
endometrium	UBERON:0001295	71.17	gold quality
colonic epithelium	UBERON:0000397	69.78	gold quality
left ovary	UBERON:0002119	68.77	gold quality
ovary	UBERON:0000992	68.39	gold quality
spleen	UBERON:0002106	68.09	gold quality
right ovary	UBERON:0002118	67.59	gold quality
blood	UBERON:0000178	67.18	gold quality
skeletal muscle tissue	UBERON:0001134	65.33	gold quality
leukocyte	CL:0000738	64.80	gold quality
muscle tissue	UBERON:0002385	64.72	gold quality
lower esophagus mucosa	UBERON:0035834	64.57	gold quality
stromal cell of endometrium	CL:0002255	64.55	gold quality
myometrium	UBERON:0001296	64.45	gold quality
putamen	UBERON:0001874	64.40	gold quality
lymph node	UBERON:0000029	64.38	gold quality
monocyte	CL:0000576	64.21	gold quality
heart left ventricle	UBERON:0002084	64.06	gold quality
sural nerve	UBERON:0015488	63.86	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.24	gold quality
cortical plate	UBERON:0005343	62.96	gold quality
omental fat pad	UBERON:0010414	62.79	gold quality
cortex of kidney	UBERON:0001225	62.65	gold quality
right lung	UBERON:0002167	62.56	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	7.74
E-ANND-3	no	2.18

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Overexpression of PRAL inhibited cell proliferation by upregulating the expression of P53. Results indicate that PRAL might be a tumor suppressor in lung cancer and thus provides novel clues for the diagnosis and treatment for lung cancer in clinical practice. (PMID:28396580)
• Over-expression of PRAL blocked proliferation, migration, and invasion in non-small-cell lung carcinoma cell lines. (PMID:30274002)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.