PRAME-AS

Summary

PRAME-AS (PRAME antisense RNA, HGNC:58774) is a long non-coding RNA gene on chromosome 22q11.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58774
Approved symbol	PRAME-AS
Name	PRAME antisense RNA
Location	22q11.22
Locus type	RNA, long non-coding
Status	Approved
Aliases	LL22NC03-63E9.3
Ensembl gene	ENSG00000220891
Ensembl biotype	lncRNA
Entrez	648691

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000407120

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000407120 — 3 exons

Exon	Start	End
ENSE00001548086	22563667	22566602
ENSE00001560654	22562863	22562972
ENSE00001562086	22559343	22559407

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 77.85.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.85	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.98	gold quality
endometrium	UBERON:0001295	45.21	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	41.38	silver quality
testis	UBERON:0000473	41.03	gold quality
right testis	UBERON:0004534	40.37	gold quality
adrenal gland	UBERON:0002369	40.10	silver quality
right adrenal gland cortex	UBERON:0035827	39.47	silver quality
left adrenal gland	UBERON:0001234	39.41	silver quality
left testis	UBERON:0004533	38.82	gold quality
minor salivary gland	UBERON:0001830	36.60	silver quality
skin of leg	UBERON:0001511	33.81	silver quality
tibial nerve	UBERON:0001323	27.72	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.