PRDM16-DT

Summary

PRDM16-DT (PRDM16 divergent transcript, HGNC:48664) is a long non-coding RNA gene on chromosome 1p36.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48664
Approved symbol	PRDM16-DT
Name	PRDM16 divergent transcript
Location	1p36.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ42875, lnc-dPrdm16
Ensembl gene	ENSG00000177133
Ensembl biotype	lncRNA
Entrez	440556
RNAcentral	URS000075CF92 — lncRNA, 3722 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 40 — 40 lncRNA

ENST00000321336, ENST00000321399, ENST00000413472, ENST00000415573, ENST00000445317, ENST00000453118, ENST00000606861, ENST00000667159, ENST00000670730, ENST00000687743, ENST00000702683, ENST00000818092, ENST00000818093, ENST00000818094, ENST00000818095, ENST00000818096, ENST00000818097, ENST00000818098, ENST00000818099, ENST00000818100, ENST00000818101, ENST00000818102, ENST00000818103, ENST00000818104, ENST00000818105, ENST00000818106, ENST00000818107, ENST00000818108, ENST00000818109, ENST00000818110, ENST00000818111, ENST00000818112, ENST00000818113, ENST00000818114, ENST00000818115, ENST00000818116, ENST00000818117, ENST00000818118, ENST00000818119, ENST00000818120

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000321336 — 2 exons

Exon	Start	End
ENSE00004221798	3067337	3068080
ENSE00004221815	3063804	3064302

Expression profiles

Bgee: expression breadth ubiquitous, 189 present calls, max score 97.22.

FANTOM5 (CAGE): breadth broad, TPM avg 3.1143 / max 458.3310, expressed in 341 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9932	2.6665	299
9930	0.3210	171
9929	0.0980	66
9931	0.0289	9

Top tissues by expression

229 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
descending thoracic aorta	UBERON:0002345	97.22	gold quality
ascending aorta	UBERON:0001496	97.07	gold quality
thoracic aorta	UBERON:0001515	97.02	gold quality
right coronary artery	UBERON:0001625	96.80	gold quality
pigmented layer of retina	UBERON:0001782	96.78	gold quality
metanephros cortex	UBERON:0010533	95.80	gold quality
aorta	UBERON:0000947	94.89	gold quality
right lobe of thyroid gland	UBERON:0001119	94.64	gold quality
sural nerve	UBERON:0015488	94.34	gold quality
tibial nerve	UBERON:0001323	94.17	gold quality
renal medulla	UBERON:0000362	93.96	gold quality
left lobe of thyroid gland	UBERON:0001120	93.74	gold quality
kidney epithelium	UBERON:0004819	93.64	gold quality
bone marrow cell	CL:0002092	93.61	gold quality
ventricular zone	UBERON:0003053	93.46	gold quality
popliteal artery	UBERON:0002250	93.44	gold quality
tibial artery	UBERON:0007610	93.42	gold quality
left coronary artery	UBERON:0001626	93.21	gold quality
adult mammalian kidney	UBERON:0000082	93.12	gold quality
caudate nucleus	UBERON:0001873	92.81	gold quality
thyroid gland	UBERON:0002046	92.79	gold quality
body of stomach	UBERON:0001161	92.59	gold quality
putamen	UBERON:0001874	92.55	gold quality
coronary artery	UBERON:0001621	92.36	gold quality
apex of heart	UBERON:0002098	91.86	gold quality
cardiac muscle of right atrium	UBERON:0003379	91.75	gold quality
left ventricle myocardium	UBERON:0006566	91.34	gold quality
stomach	UBERON:0000945	91.31	gold quality
amygdala	UBERON:0001876	90.73	gold quality
nucleus accumbens	UBERON:0001882	90.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Our findings present that decreased lncRNA LINC00982 could be identified as a poor prognostic biomarker in gastric cancer and regulate cell proliferation. (PMID:26334618)
• Study revealed that LINC00982 and PRDM16 may serve as biomarkers or potential drug targets for the diagnosis and therapy of lung adenocarcinoma. (PMID:30132554)
• Overexpression of LINC00982 inhibited proliferation and promoted apoptosis and regulate the activity of PI3K/AKT signaling pathway. (PMID:30840265)
• LINC00982 Inhibits the Proliferation, Migration, and Invasion of Breast Cancer Cells Through the miR-765/DPF3 Axis. (PMID:35325570)
• LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro. (PMID:35441392)
• LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistance. (PMID:38855188)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.