PRDM4

Summary

PRDM4 (PR/SET domain 4, HGNC:9348) is a protein-coding gene on chromosome 12q23.3, encoding PR domain zinc finger protein 4 (Q9UKN5). May function as a transcription factor involved in cell differentiation.

The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes.

Source: NCBI Gene 11108 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 118 total
• MANE Select transcript: NM_012406

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9348
Approved symbol	PRDM4
Name	PR/SET domain 4
Location	12q23.3
Locus type	gene with protein product
Status	Approved
Aliases	PFM1
Ensembl gene	ENSG00000110851
Ensembl biotype	protein_coding
OMIM	605780
Entrez	11108

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 12 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000228437, ENST00000547188, ENST00000547268, ENST00000549416, ENST00000550376, ENST00000550659, ENST00000861823, ENST00000861824, ENST00000861825, ENST00000861826, ENST00000861827, ENST00000861828, ENST00000861829, ENST00000917533, ENST00000917534

RefSeq mRNA: 1 — MANE Select: NM_012406 NM_012406

CCDS: CCDS9115

Canonical transcript exons

ENST00000228437 — 12 exons

Exon	Start	End
ENSE00000818376	107751415	107752209
ENSE00000818377	107753924	107754109
ENSE00001366540	107760957	107761137
ENSE00002250300	107732871	107734522
ENSE00003475988	107739383	107739551
ENSE00003555392	107744543	107744661
ENSE00003562610	107740946	107741260
ENSE00003565425	107742221	107742348
ENSE00003577287	107756832	107756965
ENSE00003618573	107760505	107760771
ENSE00003659252	107743197	107743282
ENSE00003671644	107746275	107746424

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 95.47.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.4637 / max 83.8338, expressed in 1786 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133100	6.5729	1758
133101	1.4948	1016
133099	0.2033	71
133098	0.1927	74

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	95.47	gold quality
secondary oocyte	CL:0000655	94.91	gold quality
endothelial cell	CL:0000115	94.49	gold quality
metanephric glomerulus	UBERON:0004736	92.23	gold quality
renal glomerulus	UBERON:0000074	91.74	gold quality
amniotic fluid	UBERON:0000173	91.67	gold quality
cervix epithelium	UBERON:0004801	91.60	gold quality
tongue squamous epithelium	UBERON:0006919	91.46	gold quality
islet of Langerhans	UBERON:0000006	91.42	gold quality
pancreatic ductal cell	CL:0002079	91.37	gold quality
kidney epithelium	UBERON:0004819	91.33	gold quality
cerebellar vermis	UBERON:0004720	90.74	gold quality
cervix squamous epithelium	UBERON:0006922	90.73	gold quality
nephron tubule	UBERON:0001231	90.70	gold quality
epithelium of esophagus	UBERON:0001976	90.69	gold quality
diaphragm	UBERON:0001103	90.49	gold quality
esophagus squamous epithelium	UBERON:0006920	90.30	gold quality
upper arm skin	UBERON:0004263	89.83	gold quality
squamous epithelium	UBERON:0006914	89.83	gold quality
metanephros	UBERON:0000081	89.82	gold quality
hair follicle	UBERON:0002073	89.71	gold quality
middle temporal gyrus	UBERON:0002771	89.35	gold quality
type B pancreatic cell	CL:0000169	89.18	silver quality
cardia of stomach	UBERON:0001162	89.15	gold quality
cortex of kidney	UBERON:0001225	89.13	gold quality
lateral nuclear group of thalamus	UBERON:0002736	89.06	gold quality
renal medulla	UBERON:0000362	88.99	gold quality
pons	UBERON:0000988	88.97	gold quality
epithelium of nasopharynx	UBERON:0001951	88.95	gold quality
lower esophagus mucosa	UBERON:0035834	88.94	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.87
E-GEOD-99795	no	100.94

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

9 targets.

Target	Regulation
BMP4	Activation
C6
ESRRB	Activation
GATA6	Activation
KLF5	Activation
PRDM14	Activation
TBX3	Activation
TET2
TET3

JASPAR motifs

Motif	Name	Family
MA1647.1	PRDM4	Factors with multiple dispersed zinc fingers

JASPAR matrix evidence (PMIDs): PMID:23918801

miRNA regulators (miRDB)

99 targeting PRDM4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-22-3P	99.93	68.13	917
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778

Literature-anchored findings (GeneRIF, showing 3)

• PRDM4 zinc knuckle by NMR spectroscopy. (PMID:21604305)
• Both Prdm 4 and Prdm 5 are expressed in human corneal endothelium, primary hCECs and in HCECs-12 cells, characterised by expression of the Na(+)/K(+)-ATPase. (PMID:28228349)
• results demonstrate that YAP promotes cell invasion by inducing leukocyte-specific integrin expression, and identify PRDM4 as a novel transcription factor for YAP targets. (PMID:29669796)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	prdm4	ENSDARG00000017366
mus_musculus	Prdm4	ENSMUSG00000035529
rattus_norvegicus	Prdm4	ENSRNOG00000004962

Paralogs (51): WIZ (ENSG00000011451), ZNF416 (ENSG00000083817), MYNN (ENSG00000085274), PRDM2 (ENSG00000116731), ZBTB17 (ENSG00000116809), ZNF644 (ENSG00000122482), GZF1 (ENSG00000125812), ZNF426 (ENSG00000130818), ZNF287 (ENSG00000141040), ZNF697 (ENSG00000143067), ZNF687 (ENSG00000143373), ZNF214 (ENSG00000149050), ZNF547 (ENSG00000152433), ZNF776 (ENSG00000152443), ZNF230 (ENSG00000159882), ZNF222 (ENSG00000159885), ZNF233 (ENSG00000159915), ZNF333 (ENSG00000160961), ZNF319 (ENSG00000166188), ZNF592 (ENSG00000166716), ZNF646 (ENSG00000167395), ZNF507 (ENSG00000168813), ZNF768 (ENSG00000169957), ZNF417 (ENSG00000173480), ZNF408 (ENSG00000175213), ZBTB41 (ENSG00000177888), ZNF223 (ENSG00000178386), ZNF852 (ENSG00000178917), ZNF784 (ENSG00000179922), ZNF572 (ENSG00000180938), ZNF707 (ENSG00000181135), ZNF746 (ENSG00000181220), ZNF467 (ENSG00000181444), ZNF530 (ENSG00000183647), ZNF17 (ENSG00000186272), ZNF527 (ENSG00000189164), ZKSCAN7 (ENSG00000196345), ZNF34 (ENSG00000196378), ZNF774 (ENSG00000196391), ZNF777 (ENSG00000196453)

Protein

Protein identifiers

PR domain zinc finger protein 4 — Q9UKN5 (reviewed: Q9UKN5)

Alternative names: PR domain-containing protein 4

All UniProt accessions (4): Q9UKN5, F8VRG2, F8VZQ2, H0YIF6

UniProt curated annotations — full annotation on UniProt →

Function. May function as a transcription factor involved in cell differentiation.

Subcellular location. Nucleus.

Tissue specificity. Expressed in many tissues. Highly expressed in ovary, testis, pancreas, brain, heart and prostate.

Similarity. Belongs to the class V-like SAM-binding methyltransferase superfamily.

RefSeq proteins (1): NP_036538* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001214	SET_dom	Domain
IPR013087	Znf_C2H2_type	Domain
IPR017124	PRDM4	Family
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR041493	PRDM4_Znf	Domain
IPR044404	PRDM4_PR/SET	Domain
IPR046341	SET_dom_sf	Homologous_superfamily
IPR050331	Zinc_finger_PRDM4/PRDM1/PRDM14	Family

Pfam: PF00096, PF18445, PF21549

UniProt features (31 total): strand 10, zinc finger region 6, sequence conflict 4, helix 4, turn 3, chain 1, domain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
3DB5	X-RAY DIFFRACTION	2.15
2L9Z	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UKN5-F1	44.77	0.00

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-193670	p75NTR negatively regulates cell cycle via SC1

MSigDB gene sets: 169 (showing top): GCM_GSPT1, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, BONCI_TARGETS_OF_MIR15A_AND_MIR16_1, CTAGGAA_MIR384, USF_01, GCM_NUMA1, CYTAGCAAY_UNKNOWN, USF_02, GCM_NF2, PID_P75_NTR_PATHWAY, GOBP_METHYLATION, PODAR_RESPONSE_TO_ADAPHOSTIN_UP, KEGG_NEUROTROPHIN_SIGNALING_PATHWAY, GOCC_TRANSFERASE_COMPLEX, GOCC_HISTONE_METHYLTRANSFERASE_COMPLEX

GO Biological Process (4): transcription by RNA polymerase II (GO:0006366), regulation of gene expression (GO:0010468), methylation (GO:0032259), positive regulation of transcription by RNA polymerase II (GO:0045944)

GO Molecular Function (11): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), methyltransferase activity (GO:0008168), zinc ion binding (GO:0008270), histone methyltransferase binding (GO:1990226), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), histone methyltransferase complex (GO:0035097)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
p75 NTR receptor-mediated signalling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
regulation of transcription by RNA polymerase II	2
DNA-templated transcription	1
gene expression	1
regulation of macromolecule biosynthetic process	1
metabolic process	1
transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
transferase activity, transferring one-carbon groups	1
transition metal ion binding	1
enzyme binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
catalytic activity	1
cation binding	1
intracellular membrane-bounded organelle	1
nucleoplasm	1
methyltransferase complex	1
nuclear protein-containing complex	1

Protein interactions and networks

STRING

1184 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PRDM4	PRMT5	O14744	861
PRDM4	SETD4	Q9NVD3	501
PRDM4	SMYD5	Q6GMV2	494
PRDM4	NGF	P01138	480
PRDM4	SMYD4	Q8IYR2	461
PRDM4	ASH1L	Q9NR48	434
PRDM4	TMEM263	Q8WUH6	430
PRDM4	TCP11L2	Q8N4U5	428
PRDM4	VIPAS39	Q9H9C1	428
PRDM4	PRDM2	Q13029	415
PRDM4	SETD3	Q86TU7	414
PRDM4	SETD5	Q9C0A6	401
PRDM4	SETD1B	Q9UPS6	397
PRDM4	POLR3B	Q9NW08	394
PRDM4	SMYD2	Q9NRG4	394

IntAct

22 interactions, top by confidence:

A	B	Type	Score
PRDM4	MSRB3	psi-mi:“MI:0915”(physical association)	0.560
PRDM4	CTNNBL1	psi-mi:“MI:0915”(physical association)	0.560
MSRB3	PRDM4	psi-mi:“MI:0915”(physical association)	0.560
CTNNBL1	PRDM4	psi-mi:“MI:0915”(physical association)	0.560
NCS1	PRDM4	psi-mi:“MI:0915”(physical association)	0.560
PRDM4	PRDM4	psi-mi:“MI:0915”(physical association)	0.370
EMX1	PRDM4	psi-mi:“MI:0915”(physical association)	0.370
PRDM4	SERTAD1	psi-mi:“MI:0915”(physical association)	0.370
EIF4E	PRDM4	psi-mi:“MI:0915”(physical association)	0.370
CFTR	PRDM4	psi-mi:“MI:0915”(physical association)	0.370
SMAD3	PRDM4	psi-mi:“MI:0915”(physical association)	0.370
PRDM4	DBT	psi-mi:“MI:0914”(association)	0.350
FMR1	PRDM4	psi-mi:“MI:0915”(physical association)	0.000
NCS1	PRDM4	psi-mi:“MI:0915”(physical association)	0.000
PRDM4	msbA	psi-mi:“MI:0915”(physical association)	0.000
RCAN1	PRDM4	psi-mi:“MI:0915”(physical association)	0.000
RUNX1	PRDM4	psi-mi:“MI:0915”(physical association)	0.000
DYRK1A	PRDM4	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (24): CTNNBL1 (Two-hybrid), MSRB3 (Two-hybrid), PRDM4 (Affinity Capture-RNA), PRDM4 (Two-hybrid), PRDM4 (Negative Genetic), PRDM4 (Affinity Capture-MS), PRKAR2A (Affinity Capture-MS), PRDM4 (Affinity Capture-MS), ERH (Affinity Capture-MS), PRDM4 (Affinity Capture-MS), NT5C2 (Affinity Capture-MS), PRDM4 (Protein-peptide), PRDM4 (PCA), PRDM4 (Two-hybrid), PRDM4 (Two-hybrid)

ESM2 similar proteins: A1L1J6, A2ANX9, A7Y7X5, E9Q8T2, G5E8B9, O15060, O43167, O43829, O62836, O95625, P08048, P0C6P6, P10925, P17010, P17012, P20662, P52739, Q01611, Q08376, Q0VCB0, Q2FAY8, Q3TTC2, Q4V8R6, Q52V16, Q5DU09, Q5PPG4, Q5R5M1, Q5R5N5, Q5RAU9, Q5SVQ8, Q6B4Z5, Q6GNP2, Q6INV8, Q7TS63, Q7ZVR6, Q80V63, Q80X44, Q811F1, Q8K3J5, Q92010

Diamond homologs: A0A163UT06, A2AGX3, A6QPM3, B8A5Y1, E9Q3T6, E9Q8T2, O75626, P0C6Y7, P14404, P57071, Q3UZD5, Q5R5M1, Q60636, Q6P2A1, Q80V63, Q96EQ9, Q9GZV8, Q9NQV5, Q9NQV7, Q9NQW5, Q9NQX0, Q9QZP2, Q9UKN5, A2BID7, B4F6U4, Q3UTQ7, Q5RAX9, Q9NQV6, Q93560, Q9H4Q3, A1L2U9, B1WAZ8, B1WBU4, Q02026, Q0IH98, Q0VCJ6, Q65XX7, Q6P882, Q8K3J5, Q96BR9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

118 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	93
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1571 predictions. Top by Δscore:

Variant	Effect	Δscore
12:107739381:A:AC	donor_gain	1.0000
12:107739382:C:CC	donor_gain	1.0000
12:107742358:C:CT	acceptor_gain	1.0000
12:107742360:C:CT	acceptor_gain	1.0000
12:107742361:A:C	acceptor_gain	1.0000
12:107742363:T:C	acceptor_gain	1.0000
12:107743278:TATAT:T	acceptor_gain	1.0000
12:107743280:TAT:T	acceptor_gain	1.0000
12:107743281:ATC:A	acceptor_loss	1.0000
12:107743282:TCTGC:T	acceptor_loss	1.0000
12:107743283:C:CC	acceptor_gain	1.0000
12:107743283:C:CG	acceptor_loss	1.0000
12:107743284:T:A	acceptor_loss	1.0000
12:107744538:CTGA:C	donor_loss	1.0000
12:107744539:TGA:T	donor_loss	1.0000
12:107744541:ACC:A	donor_loss	1.0000
12:107744542:C:CT	donor_loss	1.0000
12:107744545:T:A	donor_gain	1.0000
12:107744562:G:GA	donor_gain	1.0000
12:107744659:CAC:C	acceptor_gain	1.0000
12:107746274:CCAA:C	donor_gain	1.0000
12:107746421:CACC:C	acceptor_gain	1.0000
12:107746423:CC:C	acceptor_gain	1.0000
12:107746424:CC:C	acceptor_gain	1.0000
12:107756830:ACCT:A	donor_loss	1.0000
12:107756831:C:T	donor_loss	1.0000
12:107756884:T:TA	donor_gain	1.0000
12:107756961:TCATC:T	acceptor_gain	1.0000
12:107756962:CATC:C	acceptor_gain	1.0000
12:107756962:CATCC:C	acceptor_gain	1.0000

AlphaMissense

5324 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:107734382:A:G	L745P	1.000
12:107734422:A:G	C732R	1.000
12:107734456:A:C	H720Q	1.000
12:107734456:A:T	H720Q	1.000
12:107734506:A:G	C704R	1.000
12:107739410:A:G	L689P	1.000
12:107739450:A:G	C676R	1.000
12:107739484:G:C	H664Q	1.000
12:107739484:G:T	H664Q	1.000
12:107739494:A:G	L661P	1.000
12:107739511:G:C	F655L	1.000
12:107739511:G:T	F655L	1.000
12:107739512:A:G	F655S	1.000
12:107739513:A:G	F655L	1.000
12:107739534:A:G	C648R	1.000
12:107740950:A:C	H640Q	1.000
12:107740950:A:T	H640Q	1.000
12:107740952:G:C	H640D	1.000
12:107740960:A:G	L637P	1.000
12:107740962:G:C	H636Q	1.000
12:107740962:G:T	H636Q	1.000
12:107740964:G:C	H636D	1.000
12:107740964:G:T	H636N	1.000
12:107740972:A:G	L633P	1.000
12:107740989:A:C	F627L	1.000
12:107740989:A:T	F627L	1.000
12:107740990:A:G	F627S	1.000
12:107740991:A:G	F627L	1.000
12:107741001:A:C	C623W	1.000
12:107741003:A:G	C623R	1.000

dbSNP variants (sampled 300 via entrez): RS1000117037 (12:107735727 C>G,T), RS1000172933 (12:107747928 C>T), RS1000187788 (12:107740382 G>A), RS1000251953 (12:107758327 T>G), RS1000349061 (12:107753748 T>C), RS1000486429 (12:107754215 A>T), RS1000538771 (12:107759879 T>C), RS1000584257 (12:107760044 C>T), RS1000593938 (12:107759491 T>C), RS1000936804 (12:107759706 T>C), RS1000944481 (12:107748303 T>C), RS1000962479 (12:107743616 G>A), RS1001001083 (12:107748063 C>A), RS1001096839 (12:107754072 C>A), RS1001293104 (12:107747638 T>G)

Disease associations

OMIM: gene MIM:605780 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002481_2	Acne (severe)	5.000000e-06
GCST007561_70	Sleep duration	3.000000e-08
GCST011494_60	Daytime nap	1.000000e-14

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007828	daytime rest measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	increases expression	3
bisphenol A	affects cotreatment, increases methylation, decreases expression	2
bisphenol F	affects cotreatment, decreases expression	1
triphenyl phosphate	affects expression	1
geraniol	increases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Temozolomide	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Atrazine	decreases expression	1
Caffeine	increases phosphorylation	1
Carbamazepine	affects expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression	1
Formaldehyde	decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
N-Nitrosopyrrolidine	increases expression	1
Piroxicam	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Urethane	increases expression	1
Valproic Acid	affects expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1
Paclitaxel	decreases expression	1
Copper Sulfate	decreases expression	1
Acrylamide	increases expression	1
Particulate Matter	increases expression, increases abundance	1

Cellosaurus cell lines

4 cell lines: 3 embryonic stem cell, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A5Q5	SEES3-1V human PRDM4, clone1	Embryonic stem cell	Male
CVCL_A5Q6	SEES3-1V human PRDM4, clone2	Embryonic stem cell	Male
CVCL_A5Q7	SEES3-1V human PRDM4, clone3	Embryonic stem cell	Male
CVCL_XV74	HEK293 eGFP-PRDM4	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.