PRECSIT

Summary

PRECSIT (p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript, HGNC:27492) is a long non-coding RNA gene on chromosome 13q34.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27492
Approved symbol	PRECSIT
Name	p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript
Location	13q34
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000255874
Ensembl biotype	lncRNA
Entrez	283487
RNAcentral	URS00007599F5 — lncRNA, 6322 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000538077, ENST00000693706, ENST00000749866, ENST00000749867, ENST00000749868, ENST00000749869, ENST00000749870, ENST00000749871, ENST00000749872, ENST00000749873, ENST00000749874

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000538077 — 1 exons

Exon	Start	End
ENSE00004093800	110863987	110870454

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 86.32.

FANTOM5 (CAGE): breadth broad, TPM avg 2.3401 / max 94.2954, expressed in 733 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
138272	1.6967	623
138271	0.3376	140
138273	0.1585	77
138269	0.1172	43
138270	0.0301	14

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	86.32	gold quality
gastrocnemius	UBERON:0001388	84.16	gold quality
muscle of leg	UBERON:0001383	84.05	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.10	gold quality
placenta	UBERON:0001987	69.07	gold quality
calcaneal tendon	UBERON:0003701	66.54	gold quality
endometrium	UBERON:0001295	65.21	gold quality
descending thoracic aorta	UBERON:0002345	64.42	gold quality
thoracic aorta	UBERON:0001515	63.74	gold quality
ascending aorta	UBERON:0001496	63.45	gold quality
stromal cell of endometrium	CL:0002255	62.25	gold quality
smooth muscle tissue	UBERON:0001135	59.69	gold quality
apex of heart	UBERON:0002098	59.52	gold quality
ventricular zone	UBERON:0003053	59.44	gold quality
popliteal artery	UBERON:0002250	58.61	gold quality
tibial artery	UBERON:0007610	58.58	gold quality
islet of Langerhans	UBERON:0000006	58.37	gold quality
right coronary artery	UBERON:0001625	58.02	gold quality
mucosa of stomach	UBERON:0001199	57.61	gold quality
left coronary artery	UBERON:0001626	57.27	gold quality
cortical plate	UBERON:0005343	57.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	56.83	gold quality
gall bladder	UBERON:0002110	56.65	gold quality
ganglionic eminence	UBERON:0004023	55.95	silver quality
adipose tissue	UBERON:0001013	55.91	gold quality
myometrium	UBERON:0001296	55.52	gold quality
body of uterus	UBERON:0009853	55.48	gold quality
fallopian tube	UBERON:0003889	55.30	gold quality
heart left ventricle	UBERON:0002084	54.75	gold quality
ectocervix	UBERON:0012249	54.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• We found that linc00346 was upregulated in bladder cancer tissues compared to normal tissues. Knockdown of linc00346 inhibited bladder cancer cell proliferation and migration, induced cell cycle arrest and cell apoptosis. CONCLUSION: Our study demonstrates that linc00346 could be a potential oncogene and a therapeutic target in bladder cancer. (PMID:28705739)
• The interference in LINC 00346 expression could inhibit the in vivo tumorigenic ability of tumor cells through regulating the Janus kinase/signal transducer and activator of transcription 3 (JAK-STAT3) signaling pathway. (PMID:29228425)
• LINC00346 shows the ability to promote pancreatic cancer growth and gemcitabine resistance, which is in part mediated by antagonization of miR-188-3p and induction of BRD4. Targeting LINC00346 may improve gemcitabine-based therapeutic efficacy. (PMID:30728036)
• LINC00346 promotes hepatocellular carcinoma progression via activating the JAK-STAT3 signaling pathway. (PMID:31478228)
• A positive feedback loop involving the LINC00346/beta-catenin/MYC axis promotes hepatocellular carcinoma development. (PMID:31691159)
• High PRECSIT expression promotes Progression of Cutaneous Squamous Cell Carcinoma via STAT3 Signaling. (PMID:31837949)
• Long non-coding RNA LINC00346 regulates proliferation and apoptosis by targeting miR-128-3p/SZRD1 axis in glioma. (PMID:33015801)
• Upregulation of VDR-associated lncRNAs in Schizophrenia. (PMID:34499334)
• Aberrant expression of LINC00346 regulates cell migration and proliferation via competitively binding to miRNA-148a-3p/Dnmt1 in Hirschsprung’s disease. (PMID:35836014)
• A novel inflammation-related lncRNAs prognostic signature identifies LINC00346 in promoting proliferation, migration, and immune infiltration of glioma. (PMID:36311792)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.