PRINS

Summary

PRINS (psoriasis associated non-protein coding RNA induced by stress, HGNC:34235) is a long non-coding RNA gene on chromosome 10p12.1.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34235
Approved symbol	PRINS
Name	psoriasis associated non-protein coding RNA induced by stress
Location	10p12.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00074
Entrez	100169750

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• PRINS regulates G1P3, a gene with anti-apoptotic effects in keratinocytes. siRNA-mediated inhibition of PRINS gene resulted in altered cell morphology and gene expression alterations. (PMID:20377629)
• silencing has no effect on LPS-induced NF-kappaB activity in normal human keratinocytes and HaCaT cells (PMID:21750967)
• PRINS may play a role in the NPM-mediated cellular stress response in the skin. (PMID:23344029)
• PRINS directly binds to the mRNA of IL-6 through sequence specific binding and leads to the downregulation of IL-6 at mRNA and protein level. (PMID:28900430)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, decreases expression	1
butyraldehyde	increases expression	1
versicolorin A	decreases expression	1
bisphenol S	affects cotreatment, decreases expression	1
Benzo(a)pyrene	decreases expression	1
Dexamethasone	decreases expression, affects cotreatment	1
Dietary Carbohydrates	increases expression	1
Indomethacin	affects cotreatment, decreases expression	1
1-Methyl-3-isobutylxanthine	decreases expression, affects cotreatment	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.