PRKAR1B-AS2

Summary

PRKAR1B-AS2 (PRKAR1B antisense RNA 2, HGNC:40469) is a long non-coding RNA gene on chromosome 7p22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40469
Approved symbol	PRKAR1B-AS2
Name	PRKAR1B antisense RNA 2
Location	7p22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229380
Ensembl biotype	lncRNA
Entrez	101927000
RNAcentral	URS00008E3A42 — lncRNA, 584 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000453149

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000453149 — 2 exons

Exon	Start	End
ENSE00001623764	565101	565619
ENSE00004093301	561937	562010

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 84.54.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0064 / max 3.3246, expressed in 2 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
76856	0.0064	2

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.54	gold quality
sural nerve	UBERON:0015488	77.42	silver quality
cortex of kidney	UBERON:0001225	72.19	gold quality
skeletal muscle tissue	UBERON:0001134	71.88	gold quality
body of pancreas	UBERON:0001150	69.76	gold quality
metanephros cortex	UBERON:0010533	67.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	67.40	gold quality
kidney	UBERON:0002113	67.33	gold quality
pancreas	UBERON:0001264	66.80	gold quality
bone marrow cell	CL:0002092	66.30	silver quality
adult mammalian kidney	UBERON:0000082	66.28	gold quality
apex of heart	UBERON:0002098	62.21	gold quality
tonsil	UBERON:0002372	61.60	silver quality
islet of Langerhans	UBERON:0000006	58.79	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	57.70	gold quality
muscle of leg	UBERON:0001383	56.77	gold quality
gastrocnemius	UBERON:0001388	55.67	gold quality
right atrium auricular region	UBERON:0006631	55.09	gold quality
stromal cell of endometrium	CL:0002255	54.58	silver quality
primary visual cortex	UBERON:0002436	54.22	gold quality
fallopian tube	UBERON:0003889	54.12	gold quality
cerebellum	UBERON:0002037	53.82	gold quality
cerebellar cortex	UBERON:0002129	53.68	gold quality
cerebellar hemisphere	UBERON:0002245	53.67	gold quality
superior frontal gyrus	UBERON:0002661	53.17	gold quality
monocyte	CL:0000576	53.12	silver quality
vermiform appendix	UBERON:0001154	52.68	gold quality
heart	UBERON:0000948	52.63	gold quality
blood	UBERON:0000178	52.45	silver quality
lymph node	UBERON:0000029	52.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.28

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• PRKAR1B-AS2 Long Noncoding RNA Promotes Tumorigenesis, Survival, and Chemoresistance via the PI3K/AKT/mTOR Pathway. (PMID:33668685)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.