PRKCA-AS1

Summary

PRKCA-AS1 (PRKCA antisense RNA 1, HGNC:51347) is a long non-coding RNA gene on chromosome 17q24.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51347
Approved symbol	PRKCA-AS1
Name	PRKCA antisense RNA 1
Location	17q24.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000264630
Ensembl biotype	lncRNA
Entrez	101928001
RNAcentral	URS000075E50B — lncRNA, 1368 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000583421, ENST00000584614, ENST00000584715

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583421 — 2 exons

Exon	Start	End
ENSE00002696266	66415568	66415785
ENSE00002727926	66416543	66416791

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 87.77.

Top tissues by expression

195 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.77	gold quality
sural nerve	UBERON:0015488	81.41	gold quality
colonic epithelium	UBERON:0000397	73.73	gold quality
bone marrow cell	CL:0002092	73.40	gold quality
adrenal tissue	UBERON:0018303	69.25	gold quality
corpus callosum	UBERON:0002336	63.17	gold quality
buccal mucosa cell	CL:0002336	62.80	silver quality
calcaneal tendon	UBERON:0003701	59.12	gold quality
lower lobe of lung	UBERON:0008949	59.08	silver quality
sperm	CL:0000019	57.84	silver quality
monocyte	CL:0000576	57.15	gold quality
uterine cervix	UBERON:0000002	55.13	silver quality
hindlimb stylopod muscle	UBERON:0004252	54.91	silver quality
tonsil	UBERON:0002372	54.87	silver quality
muscle of leg	UBERON:0001383	54.81	gold quality
stomach	UBERON:0000945	52.64	gold quality
tendon	UBERON:0000043	52.35	gold quality
liver	UBERON:0002107	52.17	gold quality
adrenal gland	UBERON:0002369	51.58	gold quality
left testis	UBERON:0004533	51.28	gold quality
stromal cell of endometrium	CL:0002255	50.73	silver quality
lung	UBERON:0002048	50.58	gold quality
kidney	UBERON:0002113	50.32	gold quality
cortex of kidney	UBERON:0001225	49.94	gold quality
testis	UBERON:0000473	49.87	gold quality
blood	UBERON:0000178	49.79	gold quality
adult mammalian kidney	UBERON:0000082	49.26	gold quality
islet of Langerhans	UBERON:0000006	49.09	gold quality
prefrontal cortex	UBERON:0000451	49.09	gold quality
right lobe of liver	UBERON:0001114	48.37	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Coordination of PRKCA/PRKCA-AS1 interplay facilitates DNA methyltransferase 1 recruitment on DNA methylation to affect protein kinase C alpha transcription in mitral valve of rheumatic heart disease. (PMID:34482802)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.