PRKCZ-AS1

Summary

PRKCZ-AS1 (PRKCZ antisense RNA 1, HGNC:40477) is a long non-coding RNA gene on chromosome 1p36.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40477
Approved symbol	PRKCZ-AS1
Name	PRKCZ antisense RNA 1
Location	1p36.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-181G12.2
Ensembl gene	ENSG00000182873
Ensembl biotype	lncRNA
Entrez	100506504
RNAcentral	URS00002E6592 — lncRNA, 1253 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000333854, ENST00000444529

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000333854 — 2 exons

Exon	Start	End
ENSE00001315143	2181794	2182741
ENSE00001546404	2183571	2183875

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 95.34.

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	95.34	gold quality
cerebellar hemisphere	UBERON:0002245	95.12	gold quality
cerebellar cortex	UBERON:0002129	94.87	gold quality
cerebellum	UBERON:0002037	90.89	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.82	gold quality
lower esophagus mucosa	UBERON:0035834	85.26	gold quality
upper lobe of left lung	UBERON:0008952	85.17	gold quality
right lung	UBERON:0002167	84.40	gold quality
adenohypophysis	UBERON:0002196	84.21	gold quality
right lobe of thyroid gland	UBERON:0001119	83.53	gold quality
left lobe of thyroid gland	UBERON:0001120	82.59	gold quality
mucosa of transverse colon	UBERON:0004991	82.39	gold quality
pituitary gland	UBERON:0000007	82.24	gold quality
right frontal lobe	UBERON:0002810	82.21	gold quality
upper lobe of lung	UBERON:0008948	81.71	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.07	silver quality
Brodmann (1909) area 9	UBERON:0013540	81.05	gold quality
small intestine Peyer’s patch	UBERON:0003454	80.73	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	80.31	gold quality
thyroid gland	UBERON:0002046	79.94	gold quality
left testis	UBERON:0004533	79.85	gold quality
right testis	UBERON:0004534	79.71	gold quality
cortical plate	UBERON:0005343	79.60	gold quality
ectocervix	UBERON:0012249	79.39	gold quality
transverse colon	UBERON:0001157	79.13	gold quality
anterior cingulate cortex	UBERON:0009835	78.10	gold quality
right ovary	UBERON:0002118	78.08	gold quality
left ovary	UBERON:0002119	78.05	gold quality
small intestine	UBERON:0002108	77.83	gold quality
stromal cell of endometrium	CL:0002255	77.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.04

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• PRKCZ-AS1 promotes the tumorigenesis of lung adenocarcinoma via sponging miR-766-5p to modulate MAPK1. (PMID:31939714)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.