PRKG1-AS1

Summary

PRKG1-AS1 (PRKG1 antisense RNA 1, HGNC:45029) is a long non-coding RNA gene on chromosome 10q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45029
Approved symbol	PRKG1-AS1
Name	PRKG1 antisense RNA 1
Location	10q21.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-573I11.2
Ensembl gene	ENSG00000236671
Ensembl biotype	lncRNA
Entrez	100506939
RNAcentral	URS000075EB1A — lncRNA, 2268 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 26 lncRNA

ENST00000420193, ENST00000426785, ENST00000452247, ENST00000649494, ENST00000657174, ENST00000658196, ENST00000837171, ENST00000837172, ENST00000837173, ENST00000837174, ENST00000837175, ENST00000837176, ENST00000837177, ENST00000837178, ENST00000837179, ENST00000837180, ENST00000837181, ENST00000837182, ENST00000837183, ENST00000837184, ENST00000837185, ENST00000837186, ENST00000837187, ENST00000837188, ENST00000837189, ENST00000837190

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420193 — 9 exons

Exon	Start	End
ENSE00001654631	52309400	52309537
ENSE00001688130	52293915	52293967
ENSE00001698250	52304229	52304302
ENSE00001761264	52313398	52313485
ENSE00001767126	52301261	52301400
ENSE00004257376	52197435	52197719
ENSE00004257390	52194057	52195507
ENSE00004257410	52300792	52300838
ENSE00004257413	52313634	52314128

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 96.44.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3962 / max 17.4840, expressed in 139 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
109375	0.1990	114
109374	0.1972	89

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	96.44	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.35	gold quality
bone marrow cell	CL:0002092	86.98	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.40	silver quality
stromal cell of endometrium	CL:0002255	70.85	gold quality
tonsil	UBERON:0002372	67.41	gold quality
calcaneal tendon	UBERON:0003701	66.08	gold quality
ascending aorta	UBERON:0001496	64.61	gold quality
thoracic aorta	UBERON:0001515	64.50	gold quality
aorta	UBERON:0000947	63.52	gold quality
sural nerve	UBERON:0015488	63.41	silver quality
hindlimb stylopod muscle	UBERON:0004252	63.40	gold quality
ventricular zone	UBERON:0003053	63.15	gold quality
descending thoracic aorta	UBERON:0002345	63.11	gold quality
popliteal artery	UBERON:0002250	63.03	gold quality
tibial artery	UBERON:0007610	62.99	gold quality
uterine cervix	UBERON:0000002	60.64	gold quality
left coronary artery	UBERON:0001626	60.26	gold quality
cortical plate	UBERON:0005343	60.20	gold quality
ganglionic eminence	UBERON:0004023	59.89	gold quality
adrenal tissue	UBERON:0018303	59.05	gold quality
coronary artery	UBERON:0001621	59.04	gold quality
muscle of leg	UBERON:0001383	58.95	gold quality
right coronary artery	UBERON:0001625	58.64	gold quality
gastrocnemius	UBERON:0001388	58.57	gold quality
prefrontal cortex	UBERON:0000451	57.56	gold quality
tendon	UBERON:0000043	56.30	gold quality
bone marrow	UBERON:0002371	54.87	gold quality
right adrenal gland cortex	UBERON:0035827	54.64	gold quality
urinary bladder	UBERON:0001255	54.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.52

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Integrated analysis of long non-coding RNAs (lncRNAs) and mRNA expression profiles identifies lncRNA PRKG1-AS1 playing important roles in skeletal muscle aging. (PMID:34051073)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.