PRMT5-AS1

Summary

PRMT5-AS1 (PRMT5 antisense RNA 1, HGNC:40533) is a long non-coding RNA gene on chromosome 14q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40533
Approved symbol	PRMT5-AS1
Name	PRMT5 antisense RNA 1
Location	14q11.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237054
Ensembl biotype	lncRNA
Entrez	100505758
RNAcentral	URS00003DFFFD — lncRNA, 2104 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000424245, ENST00000457443, ENST00000587245, ENST00000590290, ENST00000595662, ENST00000599580, ENST00000609885, ENST00000795320, ENST00000795321, ENST00000795322

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000424245 — 2 exons

Exon	Start	End
ENSE00001687470	22922969	22923407
ENSE00001697683	22918947	22921120

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 87.49.

FANTOM5 (CAGE): breadth broad, TPM avg 1.8074 / max 241.4213, expressed in 402 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
138866	1.5111	359
138867	0.2962	110

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.49	gold quality
left testis	UBERON:0004533	81.35	gold quality
right testis	UBERON:0004534	81.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.80	gold quality
testis	UBERON:0000473	78.82	gold quality
lower esophagus mucosa	UBERON:0035834	77.01	gold quality
apex of heart	UBERON:0002098	75.36	gold quality
sperm	CL:0000019	74.84	gold quality
right uterine tube	UBERON:0001302	73.99	gold quality
mucosa of transverse colon	UBERON:0004991	72.96	gold quality
right ovary	UBERON:0002118	71.88	gold quality
left ovary	UBERON:0002119	71.64	gold quality
stromal cell of endometrium	CL:0002255	71.00	gold quality
left lobe of thyroid gland	UBERON:0001120	70.89	gold quality
right lobe of liver	UBERON:0001114	70.76	gold quality
right lobe of thyroid gland	UBERON:0001119	70.13	gold quality
body of uterus	UBERON:0009853	69.06	gold quality
thyroid gland	UBERON:0002046	69.03	gold quality
left adrenal gland cortex	UBERON:0035825	68.71	gold quality
right adrenal gland cortex	UBERON:0035827	68.71	gold quality
bone marrow cell	CL:0002092	68.68	silver quality
body of pancreas	UBERON:0001150	68.54	gold quality
esophagus mucosa	UBERON:0002469	68.35	gold quality
adenohypophysis	UBERON:0002196	68.28	gold quality
right adrenal gland	UBERON:0001233	68.25	gold quality
hindlimb stylopod muscle	UBERON:0004252	68.15	gold quality
ventricular zone	UBERON:0003053	68.04	gold quality
colonic epithelium	UBERON:0000397	67.77	silver quality
left adrenal gland	UBERON:0001234	67.76	gold quality
metanephros cortex	UBERON:0010533	67.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.11

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.