PRMT5-DT

Summary

PRMT5-DT (PRMT5 divergent transcript, HGNC:55482) is a long non-coding RNA gene on chromosome 14q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55482
Approved symbol	PRMT5-DT
Name	PRMT5 divergent transcript
Location	14q11.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000257285
Ensembl biotype	lncRNA
Entrez	101926933
RNAcentral	URS000026CF5E — lncRNA, 556 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000548322, ENST00000548819, ENST00000668190, ENST00000702357, ENST00000723461, ENST00000723462, ENST00000723463

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000548322 — 3 exons

Exon	Start	End
ENSE00002343939	22933643	22933692
ENSE00003985553	22955130	22956436
ENSE00004045139	22929645	22929752

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 84.24.

FANTOM5 (CAGE): breadth broad, TPM avg 0.3654 / max 13.2807, expressed in 191 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
138869	0.3654	191

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.24	gold quality
blood	UBERON:0000178	79.32	gold quality
granulocyte	CL:0000094	72.42	gold quality
endometrium	UBERON:0001295	72.21	gold quality
adult mammalian kidney	UBERON:0000082	71.69	gold quality
leukocyte	CL:0000738	71.54	gold quality
monocyte	CL:0000576	71.39	gold quality
duodenum	UBERON:0002114	71.20	gold quality
metanephros cortex	UBERON:0010533	70.85	gold quality
bone marrow cell	CL:0002092	70.82	silver quality
spleen	UBERON:0002106	70.45	gold quality
kidney	UBERON:0002113	70.34	gold quality
lower esophagus mucosa	UBERON:0035834	70.08	gold quality
descending thoracic aorta	UBERON:0002345	69.49	gold quality
left ovary	UBERON:0002119	69.23	gold quality
stromal cell of endometrium	CL:0002255	68.88	gold quality
ovary	UBERON:0000992	68.84	gold quality
cortex of kidney	UBERON:0001225	68.83	gold quality
right ovary	UBERON:0002118	68.55	gold quality
lymph node	UBERON:0000029	68.46	gold quality
vermiform appendix	UBERON:0001154	68.27	gold quality
body of stomach	UBERON:0001161	67.98	gold quality
body of pancreas	UBERON:0001150	67.92	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.79	gold quality
right lobe of liver	UBERON:0001114	67.76	gold quality
right coronary artery	UBERON:0001625	67.67	gold quality
stomach	UBERON:0000945	67.59	gold quality
rectum	UBERON:0001052	67.52	gold quality
tibial nerve	UBERON:0001323	67.52	gold quality
ascending aorta	UBERON:0001496	67.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.68

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.