PRNCR1

Summary

PRNCR1 (prostate cancer associated non-coding RNA 1, HGNC:48942) is a long non-coding RNA gene on chromosome 8q24.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48942
Approved symbol	PRNCR1
Name	prostate cancer associated non-coding RNA 1
Location	8q24.21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000282961
Ensembl biotype	lncRNA
OMIM	615452
Entrez	101867536
RNAcentral	URS0000759F81 — lncRNA, 12722 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000635449

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635449 — 1 exons

Exon	Start	End
ENSE00003790063	127079874	127092600

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 69.82.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tonsil	UBERON:0002372	69.82	gold quality
thoracic mammary gland	UBERON:0005200	64.17	silver quality
esophagus	UBERON:0001043	59.55	silver quality
zone of skin	UBERON:0000014	52.02	silver quality
calcaneal tendon	UBERON:0003701	50.69	silver quality
heart	UBERON:0000948	50.31	silver quality
blood	UBERON:0000178	48.85	silver quality
kidney	UBERON:0002113	47.81	silver quality
intestine	UBERON:0000160	47.33	silver quality
adult mammalian kidney	UBERON:0000082	45.81	silver quality
corpus callosum	UBERON:0002336	44.92	silver quality
liver	UBERON:0002107	42.99	silver quality
stomach	UBERON:0000945	41.74	silver quality
lung	UBERON:0002048	39.11	silver quality
skin of abdomen	UBERON:0001416	37.79	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 24)

• PRNCR1 and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells (PMID:23945587)
• Findings suggest that SNPs in the lncRNA PRNCR1 may contribute to susceptibility to CRC. (PMID:24330491)
• we conclusively demonstrate that PCGEM1 and PRNCR1 are not prognostic lncRNAs in prostate cancer and we refute suggestions that these lncRNAs interact in androgen receptor signaling. (PMID:24727738)
• SNPs in the lncRNA PRNCR1 may be a biomarker for the etiology of gastric cancer (PMID:26206497)
• Results found that PRNCR1 is up-regulated in colorectal cancer (CRC) tissues which correlated with larger tumor and is a potential oncogene of CRC by promoting cancer cell proliferation. (PMID:26530130)
• The variants are located within or near prostate cancer-associated long noncoding RNAs (lncRNAs), including PRNCR1, PCAT1, and PCAT2. The findings highlight ancestry-specific risk variation and implicate prostate-specific lncRNAs at the 8q24 region (PMID:26823525)
• The majority (92 %) of risk-allele carriers at rs138042437 had a consistent estimated haplotype spanning approximately 100 kb of 8q24.21 that contained the minor alleles of three rare SNPs (dosage minor allele frequencies <1.7 %), rs183373024 (PRNCR1), previously associated SNP rs188140481, and rs138042437 (CASC19) (PMID:27262462)
• We identified that PRNCR1 rs1456315 was associated with osteoarthritis susceptibility in Chinese Han population (recessive model: odds ratio = 2.24; 95% CI: 1.05-4.81; additive model: odds ratio = 1.36; 95% CI: 1.03-1.80). Individuals with PRNCR1 rs1456315 mutant G allele were more likely to suffer from osteoarthritis in Chinese Han population. (PMID:29714128)
• LncRNA PRNCR1 up-regulates CXCR4 through targeting miR-211-5p, which affects osteogenic differentiation and thus contributing to osteolysis after hip replacement (PMID:29775758)
• we confirmed that lncRNA PRNCR1 upregulates HEY2 to promote tumor progression in non-small cell lung cancer by competitively binding miR-448. (PMID:30257372)
• the lncRNA PRNCR12 may promote breast cancer cell proliferation, migration, invasion and cell cycle progression. (PMID:30592261)
• our study suggests that the PRNCR1 rs13252298 and rs16901946 polymorphisms are associated with increased GC risk and may exacerbate the development of GC. Moreover, the PRNCR1 rs1016343 polymorphism may contribute to a decreased risk of GC in those aged <60 years showing LNM-negative results. (PMID:31288430)
• the upregulation of PRNCR1 and its variants is associated with increased risk of colorectal cancer in Saudi patients, indicating that PRNCR1 might be a unique and valuable signature for predicting the risk of colorectal cancer in a Saudi population. (PMID:31487296)
• Long non-coding RNA PRNCR1 modulates non-small cell lung cancer cell proliferation, apoptosis, migration, invasion, and EMT through PRNCR1/miR-126-5p/MTDH axis. (PMID:31912882)
• Expression and clinicopathological significance of AOC4P, PRNCR1, and PCAT1 lncRNAs in breast cancer. (PMID:32853955)
• Downregulating lncRNA PRNCR1 ameliorates LPS-induced pulmonary vascular endothelial cell injury by modulating miR-330-5p/TLR4 axis. (PMID:33049095)
• Genetic Polymorphisms of PRNCR1 and Lung Cancer Risk in Chinese Northeast Population: A Case-Control Study and Meta-Analysis. (PMID:33226844)
• LncRNA PRNCR1 Promotes Breast Cancer Proliferation and Inhibits Apoptosis by Modulating microRNA-377/CCND2/MEK/MAPK Axis. (PMID:33608112)
• LncRNA PRNCR1 aggravates the malignancy of oral squamous cell carcinoma by regulating miR-326/FSCN1 axis. (PMID:33928608)
• Association of lncRNA PRNCR1 polymorphisms with cancer susceptibility: a meta-analysis of the current literature. (PMID:34057148)
• PRNCR1: a long non-coding RNA with a pivotal oncogenic role in cancer. (PMID:34727260)
• The association of PRNCR1 rs1456315 polymorphism with the risk of colorectal cancer. (PMID:34844511)
• Long non-coding RNA PRNCR1 promotes ovarian cancer cell proliferation, migration and invasion by targeting the miR-653-5p/ELF2 axis. (PMID:35166984)
• A review on the role of PRNCR1 in human disorders with an especial focus on cancer. (PMID:35849867)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.