PROX1-AS1

Summary

PROX1-AS1 (PROX1 antisense RNA 1, HGNC:43656) is a long non-coding RNA gene on chromosome 1q32.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43656
Approved symbol	PROX1-AS1
Name	PROX1 antisense RNA 1
Location	1q32.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230461
Ensembl biotype	lncRNA
Entrez	100505832
RNAcentral	URS0000812192 — lncRNA, 3399 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 51 — 50 lncRNA, 1 retained_intron

ENST00000413560, ENST00000433082, ENST00000451396, ENST00000593620, ENST00000598091, ENST00000598105, ENST00000600591, ENST00000601335, ENST00000601744, ENST00000601854, ENST00000601907, ENST00000608035, ENST00000608138, ENST00000608328, ENST00000608399, ENST00000608936, ENST00000609140, ENST00000609394, ENST00000610094, ENST00000613050, ENST00000615085, ENST00000625209, ENST00000625344, ENST00000625511, ENST00000625722, ENST00000626034, ENST00000626228, ENST00000626372, ENST00000626670, ENST00000627331, ENST00000627511, ENST00000627723, ENST00000627855, ENST00000628143, ENST00000628896, ENST00000628999, ENST00000629207, ENST00000629383, ENST00000629743, ENST00000630095, ENST00000630124, ENST00000630180, ENST00000630223, ENST00000630355, ENST00000630538, ENST00000630588, ENST00000653715, ENST00000658271, ENST00000659552, ENST00000702695, ENST00000716788

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413560 — 4 exons

Exon	Start	End
ENSE00001594720	213966071	213966258
ENSE00001643470	213894663	213894743
ENSE00001672833	213840728	213840829
ENSE00001768913	213895394	213895518

Expression profiles

Bgee: expression breadth ubiquitous, 150 present calls, max score 85.55.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1626 / max 54.2742, expressed in 58 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
17439	0.0842	23
17438	0.0588	18
17437	0.0196	11

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	85.55	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.58	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.77	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	74.01	gold quality
metanephros cortex	UBERON:0010533	73.91	gold quality
liver	UBERON:0002107	73.73	gold quality
right testis	UBERON:0004534	72.83	gold quality
left testis	UBERON:0004533	72.64	gold quality
adrenal tissue	UBERON:0018303	72.33	gold quality
body of pancreas	UBERON:0001150	71.68	gold quality
spinal cord	UBERON:0002240	70.97	gold quality
pancreas	UBERON:0001264	70.68	gold quality
testis	UBERON:0000473	70.51	gold quality
islet of Langerhans	UBERON:0000006	70.10	gold quality
cerebellar cortex	UBERON:0002129	69.68	gold quality
cerebellar hemisphere	UBERON:0002245	69.65	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.90	gold quality
left adrenal gland	UBERON:0001234	68.57	gold quality
amygdala	UBERON:0001876	68.30	gold quality
right adrenal gland cortex	UBERON:0035827	68.15	gold quality
left adrenal gland cortex	UBERON:0035825	67.87	gold quality
cerebellum	UBERON:0002037	67.76	gold quality
adrenal gland	UBERON:0002369	67.69	gold quality
right adrenal gland	UBERON:0001233	67.56	gold quality
calcaneal tendon	UBERON:0003701	67.08	gold quality
sural nerve	UBERON:0015488	67.04	gold quality
hypothalamus	UBERON:0001898	66.72	gold quality
ventricular zone	UBERON:0003053	66.64	gold quality
adrenal cortex	UBERON:0001235	66.00	gold quality
ganglionic eminence	UBERON:0004023	65.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.54

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• lncRNA PROX1-AS1 mediates the migration and invasion of placental trophoblast cells via the miR-211-5p/caspase-9 axis. (PMID:34288800)
• SP1-induced PROX1-AS1 contributes to tumor progression by regulating miR-326/FBXL20 axis in colorectal cancer. (PMID:36374774)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.