PRR20G

Summary

PRR20G (proline rich 20G, HGNC:53837) is a protein-coding gene on chromosome 3q21.3, encoding Proline-rich protein 20G (P0DPQ3).

At a glance

• MANE Select transcript: NM_001362810

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53837
Approved symbol	PRR20G
Name	proline rich 20G
Location	3q21.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000239620
Ensembl biotype	protein_coding
Entrez	100419008

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000465482

RefSeq mRNA: 1 — MANE Select: NM_001362810 NM_001362810

CCDS: CCDS93365

Canonical transcript exons

ENST00000465482 — 3 exons

Exon	Start	End
ENSE00001847924	127283783	127284640
ENSE00003832017	127287314	127287372
ENSE00003835990	127287879	127288046

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 85.07.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2432 / max 29.5609, expressed in 47 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
44363	0.2432	47

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.07	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.09	gold quality
right testis	UBERON:0004534	77.02	gold quality
left testis	UBERON:0004533	73.55	gold quality
testis	UBERON:0000473	73.53	gold quality
apex of heart	UBERON:0002098	37.42	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
duodenum	UBERON:0002114	33.17	silver quality
muscle tissue	UBERON:0002385	32.35	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
tonsil	UBERON:0002372	30.41	gold quality
prefrontal cortex	UBERON:0000451	30.23	gold quality
monocyte	CL:0000576	29.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
leukocyte	CL:0000738	29.72	gold quality
blood	UBERON:0000178	28.78	gold quality
liver	UBERON:0002107	28.30	gold quality
lymph node	UBERON:0000029	27.57	gold quality
body of stomach	UBERON:0001161	27.33	silver quality
superior frontal gyrus	UBERON:0002661	27.04	gold quality
stomach	UBERON:0000945	26.78	silver quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
frontal cortex	UBERON:0001870	26.44	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-36552	yes	1516.86
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (5): PRR20B (ENSG00000204918), PRR20A (ENSG00000204919), PRR20D (ENSG00000227151), PRR20C (ENSG00000229665), PRR20E (ENSG00000234278)

Protein

Protein identifiers

Proline-rich protein 20G — P0DPQ3 (reviewed: P0DPQ3)

All UniProt accessions (1): P0DPQ3

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the PRR20 family.

RefSeq proteins (1): NP_001349739* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR031439	PRR20	Family

Pfam: PF15708

UniProt features (4 total): compositionally biased region 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DPQ3-F1	50.21	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr3q21

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A1YEW3, A1YG31, A2T715, A2T7M0, A6NEV1, A6NGD5, A6NJL1, A6QPT6, A8MXV6, A8MZF0, A8WFF7, O08664, P03327, P06936, P0C6A0, P0DPQ3, P54257, P57086, P86478, P86479, P86480, P86481, P86496, Q13487, Q32PG5, Q505G4, Q5R7P6, Q68FX5, Q6J1H4, Q6NZN1, Q6ZMS7, Q6ZRT6, Q76NI1, Q7L3V2, Q7TPK6, Q7YR42, Q7Z6I6, Q80UE6, Q8IY33, Q8K2W9

Diamond homologs: P0DPQ3, P86478, P86479, P86480, P86481, P86496

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1329 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:127284159:G:C	F178L	0.888
3:127284159:G:T	F178L	0.888
3:127284161:A:G	F178L	0.888
3:127284561:T:A	K44N	0.851
3:127284561:T:G	K44N	0.851
3:127284081:G:C	F204L	0.847
3:127284081:G:T	F204L	0.847
3:127284083:A:G	F204L	0.847
3:127284312:A:C	F127L	0.844
3:127284312:A:T	F127L	0.844
3:127284314:A:G	F127L	0.844
3:127284318:G:C	F125L	0.837
3:127284318:G:T	F125L	0.837
3:127284320:A:G	F125L	0.837
3:127284547:A:G	V49A	0.816
3:127284553:G:T	A47D	0.793
3:127284541:G:T	P51H	0.774
3:127284547:A:T	V49E	0.751
3:127284538:A:G	M52T	0.740
3:127287342:T:A	K8N	0.739
3:127287342:T:G	K8N	0.739
3:127284127:A:T	I189N	0.733
3:127284534:T:A	R53S	0.727
3:127284534:T:G	R53S	0.727
3:127284551:A:C	Y48D	0.720
3:127284542:G:A	P51S	0.719
3:127284551:A:G	Y48H	0.710
3:127284547:A:C	V49G	0.697
3:127284562:T:A	K44I	0.685
3:127284537:C:A	M52I	0.683

dbSNP variants (sampled 300 via entrez): RS1000117196 (3:127286207 G>A), RS1000463247 (3:127285926 G>A), RS1000902284 (3:127289300 G>A,C), RS1001452413 (3:127288627 T>C), RS1001501074 (3:127288501 G>A), RS1001851886 (3:127288798 G>A,C,T), RS1001904408 (3:127289036 G>A), RS1002416925 (3:127283490 G>A), RS1002691689 (3:127284179 G>A), RS1002741306 (3:127286994 T>G), RS1002897528 (3:127286962 A>AGGGTGTGGGCCCTGGGAT), RS1003360438 (3:127288045 C>T), RS1003977680 (3:127287492 C>T), RS1004821899 (3:127288053 G>A), RS1005323716 (3:127288322 T>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment	1
Lipopolysaccharides	increases expression, affects response to substance, affects cotreatment	1
Thiram	increases expression	1
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.