PRR23B

Summary

PRR23B (proline rich 23B, HGNC:33764) is a protein-coding gene on chromosome 3q23, encoding Proline-rich protein 23B (Q6ZRT6).

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 64 total
• MANE Select transcript: NM_001013650

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33764
Approved symbol	PRR23B
Name	proline rich 23B
Location	3q23
Locus type	gene with protein product
Status	Approved
Aliases	FLJ46116
Ensembl gene	ENSG00000184814
Ensembl biotype	protein_coding
Entrez	389151

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000329447

RefSeq mRNA: 1 — MANE Select: NM_001013650 NM_001013650

CCDS: CCDS33868

Canonical transcript exons

ENST00000329447 — 1 exons

Exon	Start	End
ENSE00001312038	139019031	139020926

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 48.73.

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	48.73	gold quality
testis	UBERON:0000473	45.95	gold quality
left testis	UBERON:0004533	45.80	gold quality
bone marrow cell	CL:0002092	42.26	gold quality
sural nerve	UBERON:0015488	41.60	gold quality
colonic epithelium	UBERON:0000397	40.89	gold quality
stromal cell of endometrium	CL:0002255	39.07	gold quality
skeletal muscle tissue	UBERON:0001134	37.63	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
bone marrow	UBERON:0002371	34.86	gold quality
muscle tissue	UBERON:0002385	34.19	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.96	gold quality
urinary bladder	UBERON:0001255	28.47	gold quality
duodenum	UBERON:0002114	28.14	gold quality
monocyte	CL:0000576	28.13	gold quality
leukocyte	CL:0000738	28.09	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.15	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
uterine cervix	UBERON:0000002	25.66	gold quality
muscle of leg	UBERON:0001383	24.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

41 targeting PRR23B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-6755-5P	99.95	65.59	464
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-139-5P	99.80	69.50	1399
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-548M	99.70	68.87	1749
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-6833-5P	99.50	68.93	1161
HSA-MIR-6165	99.44	67.12	1389
HSA-MIR-7515	99.31	68.22	1795
HSA-MIR-4291	99.20	68.88	2969
HSA-MIR-922	99.02	67.23	1838
HSA-MIR-3619-5P	99.00	68.87	2308
HSA-MIR-214-3P	98.71	68.12	2128
HSA-MIR-761	98.71	68.07	2051
HSA-MIR-648	98.64	66.13	553
HSA-MIR-3135B	98.61	65.33	1470
HSA-MIR-299-5P	98.56	71.14	1140
HSA-MIR-4463	98.56	66.05	1071

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
mus_musculus	Prr23a2	ENSMUSG00000063058
mus_musculus	Prr23a4	ENSMUSG00000074123
mus_musculus	Prr23a3	ENSMUSG00000090470
mus_musculus	Prr23a1	ENSMUSG00000091080
rattus_norvegicus	Prr23d1	ENSRNOG00000061716
rattus_norvegicus	Prr23a2	ENSRNOG00000078785
rattus_norvegicus	Prr23a1	ENSRNOG00000088509
rattus_norvegicus	Prr23a3	ENSRNOG00000090421

Paralogs (5): PRR23A (ENSG00000206260), PRR23E (ENSG00000214324), PRR23C (ENSG00000233701), PRR23D1 (ENSG00000255251), PRR23D2 (ENSG00000255378)

Protein

Protein identifiers

Proline-rich protein 23B — Q6ZRT6 (reviewed: Q6ZRT6)

All UniProt accessions (1): Q6ZRT6

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the PRR23 family.

RefSeq proteins (1): NP_001013672* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018903	PRR23	Family

Pfam: PF10630

UniProt features (6 total): compositionally biased region 3, region of interest 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZRT6-F1	55.85	0.02

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 16 (showing top): ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, MIR570_3P, MIR7_1_3P, MIR7_2_3P, MIR4668_5P, MIR4482_3P, MIR3619_5P, MIR214_3P, MIR761, MIR299_5P, MIR6165, MIR3135B, chr3q23, CC2D1A_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1

Protein interactions and networks

STRING

76 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PRR23B	FAM90A10	A6NDY2	594
PRR23B	DEFB107A	Q8IZN7	545
PRR23B	DEFB105A	Q8NG35	509
PRR23B	A0A0G2JN59	A0A0G2JN59	502
PRR23B	DEFB106A	Q8N104	489
PRR23B	USP17L4	A6NCW7	479
PRR23B	USP17L7	P0C7H9	447
PRR23B	DEFB103A	P81534	409
PRR23B	PAX9	P55771	400
PRR23B	USP17L1	Q7RTZ2	371
PRR23B	DEFB108B	Q8NET1	320
PRR23B	PRR23D1	E9PI22	305
PRR23B	NFKB1	P19838	272
PRR23B	RSPO2	Q6UXX9	270
PRR23B	DEFB126	Q9BYW3	254

IntAct

19 interactions, top by confidence:

A	B	Type	Score
ARID4B	PRR23B	psi-mi:“MI:0915”(physical association)	0.560
ZNF185	PRR23B	psi-mi:“MI:0915”(physical association)	0.560
PRR23B	FAM90A1	psi-mi:“MI:0915”(physical association)	0.560
PRR23B	NTAQ1	psi-mi:“MI:0915”(physical association)	0.560
PRR23B	BANP	psi-mi:“MI:0915”(physical association)	0.560
PRR23B	IGFN1	psi-mi:“MI:0915”(physical association)	0.560
PRR23B	ARID4B	psi-mi:“MI:0915”(physical association)	0.000
PRR23B	ZNF185	psi-mi:“MI:0915”(physical association)	0.000
NTAQ1	PRR23B	psi-mi:“MI:0915”(physical association)	0.000
BANP	PRR23B	psi-mi:“MI:0915”(physical association)	0.000
IGFN1	PRR23B	psi-mi:“MI:0915”(physical association)	0.000
FAM90A1	PRR23B	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (7): PRR23B (Two-hybrid), PRR23B (Two-hybrid), PRR23B (Two-hybrid), PRR23B (Two-hybrid), PRR23B (Two-hybrid), PRR23B (Two-hybrid), PRR23B (Reconstituted Complex)

ESM2 similar proteins: A1YEW3, A1YG31, A2T715, A2T7M0, A6NEV1, A6NGD5, A6NJL1, A6QPT6, A8MXV6, A8MZF0, A8WFF7, O08664, P03327, P06936, P0C6A0, P0DPQ3, P54257, P57086, P86478, P86479, P86480, P86481, P86496, Q13487, Q32PG5, Q505G4, Q5R7P6, Q68FX5, Q6J1H4, Q6NZN1, Q6ZMS7, Q6ZRT6, Q76NI1, Q7L3V2, Q7TPK6, Q7YR42, Q7Z6I6, Q80UE6, Q8IY33, Q8K2W9

Diamond homologs: A6NEV1, Q6ZRP0, Q6ZRT6, Q9CWP9, E9PI22, P0DMB1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

64 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

194 predictions. Top by Δscore:

Variant	Effect	Δscore
3:139020432:TCG:T	donor_gain	0.8700
3:139020487:AGGT:A	donor_loss	0.8700
3:139020488:GG:G	donor_loss	0.8700
3:139020490:T:G	donor_loss	0.8700
3:139020755:G:GA	donor_gain	0.8600
3:139020491:GA:G	donor_loss	0.8300
3:139020737:G:GT	donor_gain	0.7900
3:139020740:G:GG	donor_gain	0.7800
3:139020486:G:GT	donor_gain	0.7700
3:139020739:A:AG	donor_gain	0.7500
3:139020724:TG:T	donor_gain	0.7300
3:139020754:T:TA	donor_gain	0.7300
3:139020485:GGAG:G	donor_gain	0.7200
3:139020486:GAG:G	donor_gain	0.6500
3:139020492:AG:A	donor_loss	0.6400
3:139020350:G:GT	donor_gain	0.6200
3:139020015:TCA:T	donor_gain	0.6100
3:139020493:G:C	donor_loss	0.6100
3:139020489:G:GG	donor_gain	0.5900
3:139020746:GAT:G	donor_gain	0.5900
3:139020725:GA:G	donor_gain	0.5800
3:139020726:AA:A	donor_gain	0.5800
3:139020743:A:AG	donor_gain	0.5700
3:139020173:G:GT	acceptor_gain	0.5600
3:139020168:TCCGG:T	acceptor_gain	0.5500
3:139020169:CCGGG:C	acceptor_gain	0.5400
3:139020629:G:T	donor_gain	0.5400
3:139019289:T:TC	acceptor_gain	0.5200
3:139019959:G:T	donor_gain	0.5200
3:139019992:GCTCC:G	acceptor_gain	0.5100

AlphaMissense

1667 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:139019873:G:C	F263L	0.934
3:139019873:G:T	F263L	0.934
3:139019875:A:G	F263L	0.934
3:139019891:C:A	K257N	0.925
3:139019891:C:G	K257N	0.925
3:139020363:A:G	I100T	0.910
3:139019882:T:A	R260S	0.906
3:139019882:T:G	R260S	0.906
3:139020423:A:T	L80Q	0.901
3:139020581:C:A	K27N	0.896
3:139020581:C:G	K27N	0.896
3:139019874:A:G	F263S	0.863
3:139020423:A:C	L80R	0.863
3:139020366:A:T	L99Q	0.858
3:139020429:A:G	L78P	0.858
3:139020372:A:G	L97P	0.856
3:139020456:A:G	L69P	0.850
3:139020372:A:T	L97H	0.848
3:139020366:A:G	L99P	0.847
3:139020363:A:C	I100S	0.843
3:139020423:A:G	L80P	0.841
3:139020281:G:C	F127L	0.838
3:139020281:G:T	F127L	0.838
3:139020283:A:G	F127L	0.838
3:139020369:A:G	I98T	0.836
3:139020366:A:C	L99R	0.828
3:139020239:G:C	F141L	0.825
3:139020239:G:T	F141L	0.825
3:139020241:A:G	F141L	0.825
3:139020477:A:T	V62D	0.825

dbSNP variants (sampled 300 via entrez): RS1000293341 (3:139021853 T>A), RS1000323974 (3:139022116 T>G), RS1001296311 (3:139020300 C>G,T), RS1001329010 (3:139020580 G>T), RS1002331271 (3:139019127 GA>G), RS1002445845 (3:139019608 A>G), RS1002892192 (3:139022066 T>A), RS1003173384 (3:139018650 A>G), RS1004616299 (3:139022886 A>C), RS1005863960 (3:139022696 T>C), RS1006867704 (3:139021256 A>C), RS1006897121 (3:139021539 C>G,T), RS1007699087 (3:139019620 A>T), RS1007884739 (3:139019976 G>A,C), RS1010531250 (3:139019531 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006661_139	Male-pattern baldness	3.000000e-19

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation	1
Endosulfan	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Aflatoxin B1	decreases methylation	1
Permethrin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.