PRR23E

Summary

PRR23E (PRR23 family member E, HGNC:32481) is a protein-coding gene on chromosome 3q21.3, encoding Proline-rich protein 23E (Q8N813).

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 3 total
• MANE Select transcript: NM_001007534

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32481
Approved symbol	PRR23E
Name	PRR23 family member E
Location	3q21.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ40141
Ensembl gene	ENSG00000214324
Ensembl biotype	protein_coding
Entrez	285311

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000624688

RefSeq mRNA: 1 — MANE Select: NM_001007534 NM_001007534

Canonical transcript exons

ENST00000624688 — 2 exons

Exon	Start	End
ENSE00001531658	127193131	127193275
ENSE00003757208	127196591	127198185

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 99.82.

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	99.82	gold quality
secondary oocyte	CL:0000655	99.48	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.93	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.40	gold quality
lower lobe of lung	UBERON:0008949	50.36	silver quality
skin of hip	UBERON:0001554	49.44	silver quality
colonic epithelium	UBERON:0000397	45.93	gold quality
lateral nuclear group of thalamus	UBERON:0002736	45.17	gold quality
bone marrow cell	CL:0002092	44.78	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
epithelium of nasopharynx	UBERON:0001951	42.86	gold quality
layer of synovial tissue	UBERON:0007616	42.00	gold quality
vastus lateralis	UBERON:0001379	41.72	gold quality
quadriceps femoris	UBERON:0001377	41.67	gold quality
inferior vagus X ganglion	UBERON:0005363	41.55	gold quality
pigmented layer of retina	UBERON:0001782	41.40	gold quality
cartilage tissue	UBERON:0002418	41.40	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
sural nerve	UBERON:0015488	41.14	gold quality
ventral tegmental area	UBERON:0002691	41.12	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
amniotic fluid	UBERON:0000173	40.69	gold quality
mammary duct	UBERON:0001765	40.64	gold quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
biceps brachii	UBERON:0001507	40.57	gold quality
myocardium	UBERON:0002349	40.45	gold quality
gingival epithelium	UBERON:0001949	40.43	gold quality
medial globus pallidus	UBERON:0002477	40.36	gold quality
germinal epithelium of ovary	UBERON:0001304	40.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.14

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

35 targeting PRR23E, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-23B-5P	99.98	66.07	587
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-23A-5P	99.94	65.39	468
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-6079	99.84	68.54	1170
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-4666B	99.64	68.69	1282
HSA-MIR-3685	99.62	68.83	1621
HSA-MIR-6507-3P	99.35	67.32	1059
HSA-MIR-4311	99.31	70.47	3041
HSA-MIR-18A-5P	99.29	71.05	806
HSA-MIR-18B-5P	99.29	71.05	806
HSA-MIR-10522-5P	99.26	68.50	2087
HSA-MIR-593-3P	99.22	67.28	1327
HSA-MIR-3973	99.20	69.19	1990
HSA-MIR-4784	99.15	67.41	1733
HSA-MIR-4735-3P	99.14	69.85	777
HSA-MIR-7160-5P	99.11	67.17	2207
HSA-MIR-3150B-3P	98.81	67.21	1728
HSA-MIR-6895-3P	98.79	65.69	996
HSA-MIR-423-5P	98.69	67.48	1522
HSA-MIR-4700-5P	98.63	67.43	1915
HSA-MIR-3184-5P	98.56	67.13	1491
HSA-MIR-6819-5P	97.96	66.59	1071
HSA-MIR-6737-5P	97.75	66.54	1044
HSA-MIR-4329	97.68	66.26	1003
HSA-MIR-6812-5P	97.56	65.39	1059
HSA-MIR-27B-5P	97.34	66.55	549

Cross-species orthologs

0 orthologs

Paralogs (5): PRR23B (ENSG00000184814), PRR23A (ENSG00000206260), PRR23C (ENSG00000233701), PRR23D1 (ENSG00000255251), PRR23D2 (ENSG00000255378)

Protein

Protein identifiers

Proline-rich protein 23E — Q8N813 (reviewed: Q8N813)

All UniProt accessions (1): Q8N813

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the PRR23 family.

RefSeq proteins (1): NP_001007535* (*=MANE)

Domains & families (InterPro)

UniProt features (2 total): chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N813-F1	47.19	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 15 (showing top): chr3q21, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, MIR4729, MIR4311, MIR593_3P, MIR3664_5P, MIR23B_5P, MIR23A_5P, GSE13485_CTRL_VS_DAY21_YF17D_VACCINE_PBMC_DN, GSE13485_DAY3_VS_DAY21_YF17D_VACCINE_PBMC_DN, GSE2770_UNTREATED_VS_ACT_CD4_TCELL_48H_DN, GSE2770_TGFB_AND_IL4_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_2H_UP, ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP, GSE18281_CORTEX_VS_MEDULLA_THYMUS_UP, GSE21927_SPLENIC_C26GM_TUMOROUS_VS_4T1_TUMOR_MONOCYTES_UP

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1

Protein interactions and networks

STRING

50 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PRR23E	OOEP	A6NGQ2	477
PRR23E	OOSP1	A8MZH6	432
PRR23E	PSMD6	Q15008	248
PRR23E	ZC3H6	P61129	233
PRR23E	PLEKHH2	Q8IVE3	219
PRR23E	PIDD1	Q9HB75	209
PRR23E	H1-8	Q8IZA3	204
PRR23E	PLXNA1	Q9UIW2	202
PRR23E	RBM12	Q9NTZ6	200
PRR23E	DPPA5	A6NC42	196
PRR23E	FIGLA	Q6QHK4	195
PRR23E	ZP1	P60852	191
PRR23E	GPR26	Q8NDV2	184
PRR23E	WEE2	P0C1S8	172
PRR23E	INHA	P05111	170

IntAct

5 interactions, top by confidence:

A	B	Type	Score
ROR2	PRR23E	psi-mi:“MI:0915”(physical association)	0.560
PRR23E	mtc28	psi-mi:“MI:0914”(association)	0.350
PRR23E	ROR2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (2): C3orf56 (Two-hybrid), C3orf56 (Affinity Capture-RNA)

ESM2 similar proteins: A0A1L8I316, A2A9I7, A5PJK7, A6NCN8, A6NEV1, A6NFR6, A8WFF7, B1ATL7, O09102, P03140, P12934, P17101, P31868, P31869, P31873, P78412, Q09SZ8, Q0P670, Q0R5R0, Q0VD86, Q2HR73, Q3ZN08, Q4R1R8, Q4R1S6, Q5SSZ7, Q64846, Q67867, Q67926, Q68FV4, Q69606, Q6P1W5, Q6ZRP0, Q76R62, Q77NU1, Q81162, Q8BII1, Q8BM15, Q8C494, Q8C5U4, Q8N813

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

3 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1522 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:127197403:T:C	F240L	0.888
3:127197405:T:A	F240L	0.888
3:127197405:T:G	F240L	0.888
3:127197016:T:C	F111L	0.867
3:127197018:T:A	F111L	0.867
3:127197018:T:G	F111L	0.867
3:127197265:T:C	F194L	0.813
3:127197267:C:A	F194L	0.813
3:127197267:C:G	F194L	0.813
3:127196737:T:C	F18L	0.811
3:127196739:C:A	F18L	0.811
3:127196739:C:G	F18L	0.811
3:127196947:T:A	W88R	0.811
3:127196947:T:C	W88R	0.811
3:127197067:T:C	F128L	0.793
3:127197069:T:A	F128L	0.793
3:127197069:T:G	F128L	0.793
3:127196949:G:C	W88C	0.784
3:127196949:G:T	W88C	0.784
3:127196923:T:A	W80R	0.782
3:127196923:T:C	W80R	0.782
3:127196989:T:A	W102R	0.754
3:127196989:T:C	W102R	0.754
3:127197085:T:C	F134L	0.748
3:127197087:C:A	F134L	0.748
3:127197087:C:G	F134L	0.748
3:127197013:A:C	S110R	0.732
3:127197015:C:A	S110R	0.732
3:127197015:C:G	S110R	0.732
3:127196884:T:C	F67L	0.729

dbSNP variants (sampled 300 via entrez): RS1000252945 (3:127195836 G>A,T), RS1000766536 (3:127197185 G>A), RS1000792431 (3:127196268 C>A,T), RS1000818773 (3:127196972 C>A), RS1001314885 (3:127196473 G>C), RS1001657783 (3:127194637 A>G), RS1002177307 (3:127191360 G>A), RS1002327559 (3:127193384 T>A,G), RS1002554235 (3:127191671 A>C), RS1002788506 (3:127193523 A>T), RS1003039833 (3:127197407 A>G), RS1003336172 (3:127192690 G>C), RS1003739811 (3:127192438 A>G), RS1004149975 (3:127193542 C>G), RS1004182563 (3:127193430 T>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST002180_2	Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel)	3.000000e-06
GCST002337_104	Amyotrophic lateral sclerosis (sporadic)	5.000000e-06
GCST004860_115	Alcoholic chronic pancreatitis	4.000000e-06
GCST004860_138	Alcoholic chronic pancreatitis	2.000000e-06
GCST009440_3	Age-related cognitive decline (attention/processing speed) (slope of z-scores)	9.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007710	cognitive decline measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Valproic Acid	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.