PRR33

Summary

PRR33 (proline rich 33, HGNC:35118) is a protein-coding gene on chromosome 11p15.5, encoding Proline-rich protein 33 (A8MZF0).

Predicted to act upstream of or within response to wounding.

Source: NCBI Gene 102724536 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001395380

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35118
Approved symbol	PRR33
Name	proline rich 33
Location	11p15.5
Locus type	gene with protein product
Status	Approved
Aliases	LOC728008
Ensembl gene	ENSG00000283787
Ensembl biotype	protein_coding
Entrez	102724536

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000640310

RefSeq mRNA: 1 — MANE Select: NM_001395380 NM_001395380

CCDS: CCDS91402

Canonical transcript exons

ENST00000640310 — 1 exons

Exon	Start	End
ENSE00003808206	1888078	1891895

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 91.45.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	91.45	gold quality
spleen	UBERON:0002106	86.22	gold quality
right adrenal gland	UBERON:0001233	85.56	gold quality
right adrenal gland cortex	UBERON:0035827	85.14	gold quality
granulocyte	CL:0000094	84.11	gold quality
left adrenal gland cortex	UBERON:0035825	83.48	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.27	gold quality
apex of heart	UBERON:0002098	83.17	gold quality
left adrenal gland	UBERON:0001234	82.87	gold quality
skeletal muscle tissue	UBERON:0001134	79.60	gold quality
adrenal gland	UBERON:0002369	79.35	gold quality
muscle of leg	UBERON:0001383	78.08	gold quality
gastrocnemius	UBERON:0001388	77.17	gold quality
bone marrow	UBERON:0002371	76.60	gold quality
vermiform appendix	UBERON:0001154	75.42	gold quality
monocyte	CL:0000576	75.38	gold quality
leukocyte	CL:0000738	75.34	gold quality
heart left ventricle	UBERON:0002084	74.95	gold quality
lymph node	UBERON:0000029	74.87	gold quality
bone marrow cell	CL:0002092	74.19	gold quality
muscle tissue	UBERON:0002385	73.06	gold quality
skin of abdomen	UBERON:0001416	72.31	gold quality
zone of skin	UBERON:0000014	71.81	gold quality
skin of leg	UBERON:0001511	71.41	gold quality
ectocervix	UBERON:0012249	70.86	gold quality
mucosa of transverse colon	UBERON:0004991	70.36	gold quality
endocervix	UBERON:0000458	69.48	gold quality
small intestine Peyer’s patch	UBERON:0003454	69.22	gold quality
body of uterus	UBERON:0009853	69.04	gold quality
small intestine	UBERON:0002108	68.97	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-112	yes	6.95
E-ANND-3	yes	4.78

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Prr33	ENSMUSG00000043795
rattus_norvegicus	Prr33	ENSRNOG00000051534

Protein

Protein identifiers

Proline-rich protein 33 — A8MZF0 (reviewed: A8MZF0)

All UniProt accessions (1): A0A1W2PPC1

RefSeq proteins (1): NP_001382309* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR028004	DUF4643	Family

Pfam: PF15485

UniProt features (8 total): compositionally biased region 4, region of interest 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A8MZF0-F1	59.22	0.03

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 5 (showing top): GENES_CORRELATED_WITH_MCL1_DELETION, GENES_CORRELATED_WITH_RAC2_DELETION, GSE22601_DOUBLE_NEGATIVE_VS_IMMATURE_CD4_SP_THYMOCYTE_DN, GSE22601_IMMATURE_CD4_SINGLE_POSITIVE_VS_DOUBLE_POSITIVE_THYMOCYTE_UP, chr11p15

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

200 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PRR33	FAM218A	Q96MZ4	526
PRR33	LMNTD2	Q8IXW0	506
PRR33	HOATZ	Q6PI97	433
PRR33	ARB2A	Q8WUF8	400
PRR33	DDIAS	Q8IXT1	367
PRR33	BZW2	Q9Y6E2	349
PRR33	OR10H5	Q8NGA6	349
PRR33	JCAD	Q9P266	320
PRR33	VWC2L	B2RUY7	315
PRR33	IMPG2	Q9BZV3	312
PRR33	PIGC	Q92535	311
PRR33	TSPAN4	O14817	311
PRR33	COPG2	Q9UBF2	311
PRR33	TRPC4AP	Q8TEL6	305
PRR33	CC2D2B	Q6DHV5	299

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A1YEW3, A1YG31, A2T715, A2T7M0, A6NEV1, A6NGD5, A6NJL1, A6QPT6, A8MXV6, A8MZF0, A8WFF7, O08664, P03327, P06936, P0C6A0, P0DPQ3, P54257, P57086, P86478, P86479, P86480, P86481, P86496, Q13487, Q32PG5, Q505G4, Q5R7P6, Q68FX5, Q6J1H4, Q6NZN1, Q6ZMS7, Q6ZRT6, Q76NI1, Q7L3V2, Q7TPK6, Q7YR42, Q7Z6I6, Q80UE6, Q8IY33, Q8K2W9

Diamond homologs: A8MZF0, Q8C494

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

98 predictions. Top by Δscore:

Variant	Effect	Δscore
11:1890713:T:TA	donor_gain	0.9500
11:1890786:A:AC	donor_gain	0.8200
11:1890784:CCA:C	donor_gain	0.8100
11:1890724:CAGA:C	donor_gain	0.6200
11:1890725:AGAA:A	donor_gain	0.6200
11:1890732:G:A	donor_gain	0.6000
11:1889272:CGG:C	acceptor_gain	0.5800
11:1889273:G:T	acceptor_gain	0.5700
11:1890355:T:TA	donor_gain	0.5700
11:1889593:T:G	acceptor_gain	0.5500
11:1890126:A:AT	donor_gain	0.5500
11:1890849:G:A	donor_gain	0.5300
11:1889591:C:CC	acceptor_gain	0.4900
11:1889592:T:TG	acceptor_gain	0.4700
11:1890125:C:CT	donor_gain	0.4500
11:1890674:G:GT	donor_gain	0.4500
11:1889590:A:AC	acceptor_gain	0.4300
11:1890164:T:TA	donor_gain	0.4200
11:1890723:CCAG:C	donor_gain	0.4200
11:1890791:CCTAG:C	donor_gain	0.4200
11:1890792:C:T	donor_gain	0.4100
11:1890758:G:A	donor_gain	0.4000
11:1890722:CCCA:C	donor_gain	0.3700
11:1889592:T:C	acceptor_gain	0.3600
11:1890455:T:TA	donor_gain	0.3200
11:1889461:T:TA	donor_gain	0.3100
11:1890727:A:T	donor_gain	0.3100
11:1890842:A:AC	donor_gain	0.3100
11:1890589:GTGTC:G	acceptor_loss	0.3000
11:1890590:TGTC:T	acceptor_loss	0.3000

AlphaMissense

3031 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000020674 (11:1890617 A>G), RS1000066081 (11:1910411 A>G), RS1000095165 (11:1910739 G>A), RS1000248178 (11:1905127 T>C), RS1000250162 (11:1896349 T>A), RS1000298468 (11:1901899 T>C,G), RS1000328800 (11:1902108 T>G), RS1000348816 (11:1899539 A>C,G), RS1000369511 (11:1916699 G>A,C), RS1000378639 (11:1899183 A>G), RS1000488123 (11:1899859 C>G,T), RS1000531994 (11:1906566 G>A), RS1000593969 (11:1918200 G>T), RS1000684589 (11:1900971 C>A), RS1000883228 (11:1895224 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
triphenyl phosphate	affects expression	1
di-n-butylphosphoric acid	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.