PRRC2C

Summary

PRRC2C (proline rich coiled-coil 2C, HGNC:24903) is a protein-coding gene on chromosome 1q24.3, encoding Protein PRRC2C (Q9Y520). Required for efficient formation of stress granules.

Enables RNA binding activity. Involved in stress granule assembly. Located in cytosol.

Source: NCBI Gene 23215 — RefSeq curated summary.

At a glance

• GWAS associations: 19
• Clinical variants (ClinVar): 390 total
• Druggable target: yes
• MANE Select transcript: NM_001387844

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24903
Approved symbol	PRRC2C
Name	proline rich coiled-coil 2C
Location	1q24.3
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1096, XTP2
Ensembl gene	ENSG00000117523
Ensembl biotype	protein_coding
OMIM	617373
Entrez	23215

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 7 protein_coding, 5 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000338920, ENST00000367742, ENST00000426496, ENST00000463586, ENST00000467601, ENST00000470689, ENST00000476522, ENST00000480806, ENST00000492811, ENST00000495585, ENST00000498596, ENST00000644916, ENST00000647382

RefSeq mRNA: 2 — MANE Select: NM_001387844 NM_001387844, NM_015172

CCDS: CCDS1296, CCDS91104

Canonical transcript exons

ENST00000647382 — 35 exons

Exon	Start	End
ENSE00000789770	171561018	171561103
ENSE00000789771	171566233	171566421
ENSE00000789772	171566592	171566843
ENSE00000789773	171568247	171568339
ENSE00000789774	171571320	171571421
ENSE00000789775	171574927	171575128
ENSE00000789776	171577434	171577637
ENSE00000789777	171579354	171579466
ENSE00000789778	171579828	171579964
ENSE00000958958	171584419	171584526
ENSE00001151012	171550086	171550240
ENSE00001151016	171545479	171545687
ENSE00001226837	171557240	171558143
ENSE00001372716	171591587	171593511
ENSE00001602651	171539971	171542229
ENSE00001608944	171536029	171536278
ENSE00001682082	171532343	171532961
ENSE00001747804	171535428	171535597
ENSE00001794288	171537263	171537473
ENSE00002342555	171587003	171587221
ENSE00002397175	171583956	171584187
ENSE00003460632	171523435	171523522
ENSE00003484235	171527791	171527844
ENSE00003578430	171515734	171515859
ENSE00003588737	171587648	171587751
ENSE00003600536	171524821	171524965
ENSE00003606342	171512995	171513172
ENSE00003628667	171588379	171588505
ENSE00003645844	171522177	171522259
ENSE00003653650	171514536	171514645
ENSE00003660063	171517591	171517814
ENSE00003664356	171512032	171512200
ENSE00003683382	171523221	171523354
ENSE00003823144	171589369	171589605
ENSE00003922021	171485530	171485735

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.61.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 152.3446 / max 7489.8331, expressed in 1828 samples.

FANTOM5 promoters (14 alternative TSS)

Promoter ID	TPM avg	Samples expressed
6609	107.2356	1826
6608	14.9853	1789
6625	7.4331	1429
6626	4.0487	1090
6619	3.7069	1158
6639	3.1797	1224
6640	2.4702	1145
6616	2.0705	1006
6617	1.3971	767
6618	1.3951	701

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
epithelium of nasopharynx	UBERON:0001951	99.61	gold quality
tendon of biceps brachii	UBERON:0008188	99.50	gold quality
germinal epithelium of ovary	UBERON:0001304	99.46	gold quality
tibia	UBERON:0000979	99.35	gold quality
palpebral conjunctiva	UBERON:0001812	99.35	gold quality
visceral pleura	UBERON:0002401	99.34	gold quality
parietal pleura	UBERON:0002400	99.32	gold quality
gingival epithelium	UBERON:0001949	99.24	gold quality
pleura	UBERON:0000977	99.23	gold quality
esophagus squamous epithelium	UBERON:0006920	99.21	gold quality
squamous epithelium	UBERON:0006914	99.15	gold quality
cartilage tissue	UBERON:0002418	99.14	gold quality
Brodmann (1909) area 23	UBERON:0013554	99.08	gold quality
gingiva	UBERON:0001828	98.99	gold quality
cardia of stomach	UBERON:0001162	98.94	gold quality
sural nerve	UBERON:0015488	98.93	gold quality
hair follicle	UBERON:0002073	98.84	gold quality
tongue squamous epithelium	UBERON:0006919	98.74	gold quality
buccal mucosa cell	CL:0002336	98.71	gold quality
pylorus	UBERON:0001166	98.70	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	98.70	gold quality
skin of hip	UBERON:0001554	98.69	gold quality
cervix squamous epithelium	UBERON:0006922	98.65	gold quality
trabecular bone tissue	UBERON:0002483	98.55	gold quality
caput epididymis	UBERON:0004358	98.50	gold quality
mucosa of sigmoid colon	UBERON:0004993	98.49	gold quality
epithelium of esophagus	UBERON:0001976	98.43	gold quality
male germ cell	CL:0000015	98.42	gold quality
sperm	CL:0000019	98.42	gold quality
corpus epididymis	UBERON:0004359	98.42	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-CURD-112	yes	5.38
E-GEOD-130148	yes	4.95
E-MTAB-4850	no	1114.90
E-CURD-135	no	662.24
E-HCAD-4	no	18.92
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

169 targeting PRRC2C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616

Literature-anchored findings (GeneRIF, showing 2)

• The KIAA1096 gene is located at 1q23-24 with no overexpression or amplification in normal urothelium, but was significantly upregulated in 30% of tumors. (PMID:12443540)
• 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h (PMID:15747776)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	prrc2c	ENSDARG00000057583
mus_musculus	Prrc2c	ENSMUSG00000040225
rattus_norvegicus	Prrc2c	ENSRNOG00000068743
caenorhabditis_elegans		WBGENE00018710

Paralogs (2): PRRC2A (ENSG00000204469), PRRC2B (ENSG00000288701)

Protein

Protein identifiers

Protein PRRC2C — Q9Y520 (reviewed: Q9Y520)

Alternative names: BAT2 domain-containing protein 1, HBV X-transactivated gene 2 protein, HBV XAg-transactivated protein 2, HLA-B-associated transcript 2-like 2, Proline-rich and coiled-coil-containing protein 2C

All UniProt accessions (6): A0A2R8Y424, A0A2R8Y7F4, A0A2R8YET2, E7EPN9, Q9Y520, H7C5N8

UniProt curated annotations — full annotation on UniProt →

Function. Required for efficient formation of stress granules.

Subcellular location. Cytoplasm. Stress granule.

Tissue specificity. Overexpressed in bladder cancer.

Isoforms (7)

UniProt ID	Names	Canonical?
Q9Y520-1	1	yes
Q9Y520-2	2
Q9Y520-3	3
Q9Y520-4	4
Q9Y520-5	5
Q9Y520-6	6
Q9Y520-7	7

RefSeq proteins (2): NP_001374773, NP_055987 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009738	BAT2_N	Domain
IPR033184	PRRC2	Family

Pfam: PF07001

UniProt features (127 total): compositionally biased region 46, modified residue 41, region of interest 13, sequence variant 11, splice variant 7, sequence conflict 5, coiled-coil region 2, chain 1, cross-link 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

No AlphaFold model available for Q9Y520 — AlphaFold DB does not currently provide models for proteins above ~3000 aa.

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (42): 2814, 2823, 2823, 1133, 27, 187, 191, 242, 242, 255, 266, 279, 281, 335, 392, 395, 500, 779, 785, 801 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 204 (showing top): E2F_Q4, GOBP_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, MORF_SMC1L1, MORF_HDAC1, MORF_UBE2N, YY1_Q6, PATIL_LIVER_CANCER, PUJANA_CHEK2_PCC_NETWORK, MORF_SKP1A, ACCAATC_MIR509, ONKEN_UVEAL_MELANOMA_UP, E2F_Q3, DOANE_RESPONSE_TO_ANDROGEN_DN, YY1_02

GO Biological Process (2): hematopoietic progenitor cell differentiation (GO:0002244), stress granule assembly (GO:0034063)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (4): cytosol (GO:0005829), cytoplasmic stress granule (GO:0010494), membrane (GO:0016020), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
hemopoiesis	1
cell differentiation	1
membraneless organelle assembly	1
nucleic acid binding	1
binding	1
cytoplasm	1
cytoplasmic ribonucleoprotein granule	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1485 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PRRC2C	UBAP2L	Q14157	789
PRRC2C	CSDE1	O75534	625
PRRC2C	PRRC2A	P48634	562
PRRC2C	G3BP1	Q13283	544
PRRC2C	ZC3H11A	O75152	543
PRRC2C	G3BP2	Q9UN86	535
PRRC2C	RPRD2	Q5VT52	513
PRRC2C	CIMIP7	H3BNL1	507
PRRC2C	PLPP6	Q8IY26	507
PRRC2C	CAPRIN1	Q14444	501
PRRC2C	SMIM9	A6NGZ8	468
PRRC2C	PIGC	Q92535	457
PRRC2C	BPTF	Q12830	446
PRRC2C	CLINT1	Q14677	446
PRRC2C	METTL13	Q8N6R0	436

IntAct

161 interactions, top by confidence:

A	B	Type	Score
CAPN1	CAPNS1	psi-mi:“MI:0914”(association)	0.840
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
YWHAG	BLTP3B	psi-mi:“MI:0914”(association)	0.640
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
QPRT	PIK3C2A	psi-mi:“MI:0914”(association)	0.640
CFTR	HAX1	psi-mi:“MI:0914”(association)	0.610
CANX	PGRMC1	psi-mi:“MI:0914”(association)	0.570
YWHAH	BLTP3B	psi-mi:“MI:0914”(association)	0.570
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
FHL2	CNOT1	psi-mi:“MI:0914”(association)	0.530
BAG2	HGS	psi-mi:“MI:0914”(association)	0.530
FMR1	ACOT7	psi-mi:“MI:0914”(association)	0.500
GSK3B	SEC16A	psi-mi:“MI:0914”(association)	0.420
PRRC2C	HMGN3	psi-mi:“MI:0915”(physical association)	0.400
PRRC2C	H3-4	psi-mi:“MI:0915”(physical association)	0.400
PPFIBP1	PRRC2C	psi-mi:“MI:0915”(physical association)	0.400
BQRF1	PRRC2C	psi-mi:“MI:0915”(physical association)	0.370
	VWA8	psi-mi:“MI:0914”(association)	0.350
BVLF1	VWA8	psi-mi:“MI:0914”(association)	0.350
BCAR1	MYO1C	psi-mi:“MI:0914”(association)	0.350
HSPA8	PPP6C	psi-mi:“MI:0914”(association)	0.350
MAPT	C11orf98	psi-mi:“MI:0914”(association)	0.350
MAPT	POTEF	psi-mi:“MI:0914”(association)	0.350
CD74		psi-mi:“MI:0914”(association)	0.350
DDX60	G6PD	psi-mi:“MI:0914”(association)	0.350
MAB21L2	PTBP1	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350

BioGRID (349): PRRC2C (Affinity Capture-MS), PRRC2C (Affinity Capture-MS), PRRC2C (Affinity Capture-MS), PRRC2C (Affinity Capture-MS), PRRC2C (Affinity Capture-MS), PRRC2C (Affinity Capture-MS), PRRC2C (Proximity Label-MS), PRRC2C (Biochemical Activity), PRRC2C (Affinity Capture-MS), PRRC2C (Affinity Capture-MS), PRRC2C (Affinity Capture-MS), PRRC2C (Affinity Capture-MS), PRRC2C (Affinity Capture-MS), PRRC2C (Affinity Capture-MS), PRRC2C (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4IZ84, A0A1L8H8C0, A0A1L8HFX9, A2RUV4, F1LP90, F5HSE3, O43310, O60237, O75167, O88453, P41110, P61406, Q12830, Q1LVF3, Q2HJG4, Q2PFD7, Q3TLH4, Q5RAK6, Q5ZMS6, Q66HC1, Q6A0A2, Q6NRP6, Q6NZL0, Q6P1U3, Q6PKG0, Q75N33, Q7TN02, Q7TPM1, Q7YZA2, Q7Z6E9, Q80TN7, Q80XI3, Q86UR5, Q86US8, Q8IVL0, Q8IVL1, Q8K0V4, Q8N4C8, Q90YL3, Q90YY5

Diamond homologs: P48634, Q3TLH4, Q5JSZ5, Q5TM26, Q6MG48, Q7TPM1, Q7TSC1, Q9SB63, Q9Y520

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 177 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SARS-CoV-1 modulates host translation machinery	8	19.6×	4e-07
Eukaryotic Translation Initiation	7	17.1×	3e-06
Cap-dependent Translation Initiation	7	17.1×	3e-06
SARS-CoV-1-host interactions	12	16.7×	3e-09
Eukaryotic Translation Elongation	7	15.5×	7e-06
Formation of the ternary complex, and subsequently, the 43S complex	9	15.4×	4e-07
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	7	15.1×	8e-06
SARS-CoV-1 Infection	12	13.6×	1e-08

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of mRNA splicing, via spliceosome	5	24.4×	3e-04
stress granule assembly	5	19.2×	7e-04
cytoplasmic translation	13	15.3×	3e-09
negative regulation of translation	11	13.7×	2e-07
mRNA transport	7	11.7×	4e-04
ribosomal small subunit biogenesis	8	11.6×	1e-04
translational initiation	5	11.4×	6e-03
regulation of alternative mRNA splicing, via spliceosome	7	10.9×	6e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

390 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	307
Likely benign	21
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4467 predictions. Top by Δscore:

Variant	Effect	Δscore
1:171485734:CGGT:C	donor_loss	1.0000
1:171485735:GGTAA:G	donor_loss	1.0000
1:171485736:G:GG	donor_gain	1.0000
1:171485736:GTA:G	donor_loss	1.0000
1:171485737:T:A	donor_loss	1.0000
1:171512018:A:AG	acceptor_gain	1.0000
1:171512019:T:TA	acceptor_gain	1.0000
1:171512025:T:G	acceptor_gain	1.0000
1:171512993:A:AG	acceptor_gain	1.0000
1:171512994:G:GG	acceptor_gain	1.0000
1:171513168:GAAAA:G	donor_gain	1.0000
1:171513173:G:GG	donor_gain	1.0000
1:171514533:A:AG	acceptor_gain	1.0000
1:171514534:A:AG	acceptor_gain	1.0000
1:171514535:G:GG	acceptor_gain	1.0000
1:171514535:GA:G	acceptor_gain	1.0000
1:171514642:GATG:G	donor_gain	1.0000
1:171515721:A:G	acceptor_gain	1.0000
1:171515723:A:G	acceptor_gain	1.0000
1:171515730:ATAG:A	acceptor_gain	1.0000
1:171515732:A:AG	acceptor_gain	1.0000
1:171515733:G:GG	acceptor_gain	1.0000
1:171515856:CCAA:C	donor_gain	1.0000
1:171515858:AA:A	donor_gain	1.0000
1:171515858:AAGT:A	donor_loss	1.0000
1:171515859:AGTAA:A	donor_loss	1.0000
1:171515860:G:A	donor_loss	1.0000
1:171515860:G:GG	donor_gain	1.0000
1:171515861:T:G	donor_loss	1.0000
1:171515866:G:GG	donor_gain	1.0000

AlphaMissense

18733 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000004630 (1:171526986 T>G), RS1000068548 (1:171511663 T>A), RS1000077374 (1:171592935 G>A,T), RS1000130173 (1:171510652 A>G), RS1000179307 (1:171487783 G>A), RS1000184603 (1:171491597 G>A), RS1000209372 (1:171529886 G>A), RS1000251658 (1:171510991 T>C), RS1000272902 (1:171500555 C>T), RS1000297591 (1:171560192 A>T), RS1000306681 (1:171493794 ACT>A), RS1000335629 (1:171566197 A>G), RS1000337885 (1:171586524 G>C,T), RS1000374015 (1:171488318 A>G), RS1000389248 (1:171586247 A>AT)

Disease associations

OMIM: gene MIM:617373 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

19 associations (top):

Study	Trait	p-value
GCST001915_1	Alzheimer’s disease (cognitive decline)	9.000000e-07
GCST003075_1	Cognitive decline rate in late mild cognitive impairment	1.000000e-06
GCST003075_100	Cognitive decline rate in late mild cognitive impairment	9.000000e-07
GCST003075_101	Cognitive decline rate in late mild cognitive impairment	2.000000e-10
GCST003075_9	Cognitive decline rate in late mild cognitive impairment	2.000000e-10
GCST005984_3	Glomerular filtration rate	1.000000e-09
GCST005985_3	Creatinine levels	1.000000e-08
GCST006586_46	Urinary albumin excretion	1.000000e-08
GCST007876_143	Estimated glomerular filtration rate	1.000000e-11
GCST008058_17	Estimated glomerular filtration rate	2.000000e-09
GCST008060_45	Estimated glomerular filtration rate	4.000000e-06
GCST008790_4	Urinary albumin-to-creatinine ratio	2.000000e-08
GCST008791_4	Microalbuminuria	6.000000e-06
GCST008794_44	Urinary albumin-to-creatinine ratio	2.000000e-08
GCST009640_7	Urinary albumin-to-creatinine ratio	2.000000e-08
GCST010242_73	HDL cholesterol levels	5.000000e-09
GCST010988_258	Adult body size	9.000000e-11
GCST011494_88	Daytime nap	2.000000e-15
GCST90002401_369	Platelet distribution width	6.000000e-20

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0007710	cognitive decline measurement
EFO:0004285	albuminuria
EFO:0007778	urinary albumin to creatinine ratio
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0007828	daytime rest measurement
EFO:0007984	platelet component distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067337 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.61	Kd	246	nM	CHEMBL3752910
6.61	ED50	246	nM	CHEMBL3752910
5.60	Kd	2515	nM	CHEMBL5653589
5.60	ED50	2515	nM	CHEMBL5653589

PubChem BioAssay actives

2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149097: Binding affinity to human PRRC2C incubated for 45 mins by Kinobead based pull down assay	kd	0.2460	uM
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149097: Binding affinity to human PRRC2C incubated for 45 mins by Kinobead based pull down assay	kd	2.5152	uM

CTD chemical–gene interactions

75 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Dronabinol	decreases expression, increases expression	4
bisphenol A	decreases expression, increases expression, affects cotreatment	3
Estradiol	decreases expression, increases expression	3
methylmercuric chloride	increases expression	2
trichostatin A	increases expression, affects cotreatment, decreases expression	2
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression, increases expression	2
Acrolein	increases abundance, affects cotreatment, increases oxidation	2
Benzo(a)pyrene	decreases methylation, affects methylation	2
Ozone	affects cotreatment, increases oxidation, increases abundance	2
Tobacco Smoke Pollution	affects expression, increases expression	2
Tretinoin	decreases expression	2
Valproic Acid	affects expression, decreases methylation	2
Aflatoxin B1	decreases methylation, increases methylation	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
bisphenol F	decreases expression, affects cotreatment	1
TAK-243	affects sumoylation	1
dicrotophos	increases expression	1
geldanamycin	increases expression	1
testosterone enanthate	affects expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases abundance, affects cotreatment, increases oxidation	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, affects localization, increases expression	1
kojic acid	increases expression	1
beta-lapachone	decreases expression	1
sodium arsenite	decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
aflatoxin B2	increases methylation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652139	Binding	Binding affinity to human PRRC2C incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_F1QW	HyCyte Huh-7 KO-hPRRC2C	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.