PRRG3

Summary

PRRG3 (proline rich and Gla domain 3, HGNC:30798) is a protein-coding gene on chromosome Xq28, encoding Transmembrane gamma-carboxyglutamic acid protein 3 (Q9BZD7).

This gene encodes a protein which contains a vitamin K-dependent carboxylation/gamma-carboxyglutamic domain. The encoded protein is a member of a family of vitamin K-dependent transmembrane proteins which contain a glutamate-rich extracellular domain.

Source: NCBI Gene 79057 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 58 total
• GTEx eGene: eQTL in 45 tissues, sQTL in 0 (q < 0.05)
• MANE Select transcript: NM_001372163
• Notable: 58 clinical variants but no curated precision-oncology (CIViC) evidence yet

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30798
Approved symbol	PRRG3
Name	proline rich and Gla domain 3
Location	Xq28
Locus type	gene with protein product
Status	Approved
Aliases	TMG3
Ensembl gene	ENSG00000130032
Ensembl biotype	protein_coding
OMIM	300685
Entrez	79057

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 protein_coding

MANE Select: ENST00000674457

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1, TSL 3: 2, TSL 5: 2

ENST00000674457, ENST00000370353, ENST00000370354, ENST00000448324, ENST00000448726, ENST00000538575, ENST00000652529, ENST00000674374, ENST00000674441, ENST00000884468, ENST00000913985

RefSeq mRNA: 3 — MANE Select: NM_001372163 NM_001372163, NM_001372165, NM_024082

CCDS: CCDS14699, CCDS94688

Canonical transcript exons

ENST00000674457 — 4 exons

Exon	Start	End
ENSE00001310099	151699996	151700156
ENSE00001452454	151698784	151698821
ENSE00003898222	151695458	151695544
ENSE00004779773	151700506	151705924

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 97.24.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1202 / max 8.4983, expressed in 55 samples.

Highest expression (Bgee): sural nerve, primordial germ cell in gonad, trigeminal ganglion, prefrontal cortex, tibial nerve.

Genetic regulation across tissues (GTEx eQTL / sQTL)

PRRG3 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 45 tissues and its splicing (sQTL) in 0 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 45 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Thyroid	eqtl	1.1e-128	-0.79	X:151695519:C:T
Skin Not Sun Exposed Suprapubic	eqtl	1.7e-67	-0.40	X:151694751:CG:C
Skin Sun Exposed Lower leg	eqtl	7.3e-64	-0.34	X:151695519:C:T
Esophagus Mucosa	eqtl	6.3e-61	-0.41	X:151695519:C:T
Pituitary	eqtl	7.0e-53	-0.78	X:151695519:C:T
Muscle Skeletal	eqtl	5.1e-42	-0.30	X:151694751:CG:C
Adipose Visceral Omentum	eqtl	4.3e-38	-0.32	X:151695519:C:T
Lung	eqtl	1.8e-34	-0.36	X:151695519:C:T
Testis	eqtl	4.7e-34	-0.58	X:151695519:C:T
Prostate	eqtl	5.3e-34	-0.58	X:151695519:C:T
Heart Atrial Appendage	eqtl	1.1e-33	-0.43	X:151695519:C:T
Adipose Subcutaneous	eqtl	7.8e-33	-0.20	X:151695519:C:T
Heart Left Ventricle	eqtl	4.7e-32	-0.33	X:151694751:CG:C
Colon Sigmoid	eqtl	8.9e-30	-0.34	X:151695519:C:T
Esophagus Muscularis	eqtl	5.4e-28	-0.27	X:151695519:C:T
Nerve Tibial	eqtl	5.7e-28	+0.13	X:151702241:C:G
Breast Mammary Tissue	eqtl	5.2e-27	-0.24	X:151695519:C:T
Brain Hypothalamus	eqtl	1.2e-20	-0.22	X:151695519:C:T
Brain Cerebellum	eqtl	1.6e-20	-0.50	X:151694751:CG:C
Colon Transverse	eqtl	1.1e-19	-0.19	X:151695519:C:T

FANTOM5 promoters

1 alternative TSS:

Promoter ID	TPM avg	Samples expressed
209865	0.1202	55

Top tissues by expression

showing 100 of 250 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.24	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.31	gold quality
trigeminal ganglion	UBERON:0001675	83.69	gold quality
prefrontal cortex	UBERON:0000451	81.53	gold quality
tibial nerve	UBERON:0001323	81.34	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.62	gold quality
superior frontal gyrus	UBERON:0002661	80.41	gold quality
Brodmann (1909) area 23	UBERON:0013554	80.26	gold quality
cortical plate	UBERON:0005343	80.04	gold quality
frontal cortex	UBERON:0001870	79.83	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	79.77	gold quality
hypothalamus	UBERON:0001898	79.72	gold quality
neocortex	UBERON:0001950	79.58	gold quality
anterior cingulate cortex	UBERON:0009835	79.32	gold quality
Brodmann (1909) area 9	UBERON:0013540	78.75	gold quality
ganglionic eminence	UBERON:0004023	78.73	gold quality
right frontal lobe	UBERON:0002810	78.71	gold quality
dorsal root ganglion	UBERON:0000044	78.48	gold quality
primary visual cortex	UBERON:0002436	78.35	gold quality
nucleus accumbens	UBERON:0001882	78.30	gold quality
cerebral cortex	UBERON:0000956	78.26	gold quality
middle temporal gyrus	UBERON:0002771	78.05	gold quality
entorhinal cortex	UBERON:0002728	77.81	gold quality
postcentral gyrus	UBERON:0002581	76.41	gold quality
temporal lobe	UBERON:0001871	75.13	gold quality
parietal lobe	UBERON:0001872	74.84	gold quality
forebrain	UBERON:0001890	74.82	gold quality
occipital lobe	UBERON:0002021	74.45	gold quality
skin of hip	UBERON:0001554	74.27	gold quality
lateral nuclear group of thalamus	UBERON:0002736	74.06	gold quality
amygdala	UBERON:0001876	73.97	gold quality
ventricular zone	UBERON:0003053	73.96	gold quality
Brodmann (1909) area 46	UBERON:0006483	73.58	gold quality
Ammon’s horn	UBERON:0001954	73.09	gold quality
caudate nucleus	UBERON:0001873	72.65	gold quality
endocervix	UBERON:0000458	72.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	72.44	gold quality
ectocervix	UBERON:0012249	72.06	gold quality
putamen	UBERON:0001874	71.91	gold quality
brain	UBERON:0000955	71.33	gold quality
adrenal tissue	UBERON:0018303	71.32	gold quality
colonic epithelium	UBERON:0000397	70.77	gold quality
uterine cervix	UBERON:0000002	70.30	gold quality
apex of heart	UBERON:0002098	69.85	gold quality
tendon of biceps brachii	UBERON:0008188	67.82	gold quality
cerebellar vermis	UBERON:0004720	67.65	gold quality
tendon	UBERON:0000043	67.22	gold quality
superior vestibular nucleus	UBERON:0007227	66.95	gold quality
nasal cavity epithelium	UBERON:0005384	66.84	gold quality
substantia nigra	UBERON:0002038	66.79	gold quality
calcaneal tendon	UBERON:0003701	66.79	gold quality
layer of synovial tissue	UBERON:0007616	66.53	silver quality
midbrain	UBERON:0001891	66.07	gold quality
gall bladder	UBERON:0002110	65.88	gold quality
epithelium of nasopharynx	UBERON:0001951	65.12	gold quality
epithelial cell of pancreas	CL:0000083	64.78	gold quality
vagina	UBERON:0000996	64.22	gold quality
pigmented layer of retina	UBERON:0001782	64.16	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.89	gold quality
left ovary	UBERON:0002119	63.71	gold quality
mucosa of stomach	UBERON:0001199	63.63	gold quality
thoracic mammary gland	UBERON:0005200	63.57	gold quality
smooth muscle tissue	UBERON:0001135	63.52	gold quality
corpus epididymis	UBERON:0004359	63.45	gold quality
parotid gland	UBERON:0001831	63.39	gold quality
mammary gland	UBERON:0001911	63.30	gold quality
ovary	UBERON:0000992	63.14	gold quality
mammary duct	UBERON:0001765	63.08	silver quality
epithelium of mammary gland	UBERON:0003244	62.96	silver quality
muscle tissue	UBERON:0002385	62.87	gold quality
heart left ventricle	UBERON:0002084	62.73	gold quality
endothelial cell	CL:0000115	62.62	gold quality
skeletal muscle tissue	UBERON:0001134	62.61	gold quality
cardiac ventricle	UBERON:0002082	62.61	gold quality
right uterine tube	UBERON:0001302	62.58	gold quality
right ovary	UBERON:0002118	62.48	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.19	gold quality
vena cava	UBERON:0004087	62.04	gold quality
upper leg skin	UBERON:0004262	62.04	gold quality
superficial temporal artery	UBERON:0001614	61.98	gold quality
body of uterus	UBERON:0009853	61.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	61.89	gold quality
pons	UBERON:0000988	61.66	silver quality
mammalian vulva	UBERON:0000997	61.41	gold quality
zone of skin	UBERON:0000014	61.35	gold quality
minor salivary gland	UBERON:0001830	61.23	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.08	gold quality
lower esophagus	UBERON:0013473	61.04	gold quality
adipose tissue	UBERON:0001013	61.01	gold quality
saliva-secreting gland	UBERON:0001044	60.98	gold quality
dorsal plus ventral thalamus	UBERON:0001897	60.98	silver quality
skin of leg	UBERON:0001511	60.94	gold quality
lateral globus pallidus	UBERON:0002476	60.88	gold quality
synovial joint	UBERON:0002217	60.55	gold quality
substantia nigra pars compacta	UBERON:0001965	60.43	silver quality
mouth mucosa	UBERON:0003729	60.38	gold quality
skin of abdomen	UBERON:0001416	60.35	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	60.16	gold quality
muscle of leg	UBERON:0001383	60.13	gold quality
ileal mucosa	UBERON:0000331	60.04	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.36
E-MTAB-6678	no	2.42

HPA expression

RNA tissue specificity: Tissue enhanced

showing 60 of 74 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM
Postcentral gyrus	tissue	33.7
Locus coeruleus	tissue	22.6
Nucleus accumbens	tissue	20.3
Prefrontal cortex	tissue	18.9
Cerebral cortex	tissue	18.9
Motor cortex	tissue	17.6
Insular cortex	tissue	17.2
Hypothalamus	tissue	16.8
Hippocampus	tissue	16.5
Hippocampal formation	tissue	16.4
Entorhinal cortex	tissue	16.4
Retrosplenial and cingulate cortex	tissue	16.3
Somatosensory cortex	tissue	16.3
Temporal cortex	tissue	15.5
Retrosplenial cortex	tissue	15.3
Occipital cortex	tissue	14.9
Frontal cortex	tissue	14.5
Spinal cord	tissue	13.4
Amygdala	tissue	12.1
Septum	tissue	12.1
Pons	tissue	12.0
Thalamus	tissue	11.4
Midbrain	tissue	9.8
Ventral forebrain	tissue	9.8
Periaqueductal gray	tissue	9.7
Substantia nigra	tissue	9.0
Olfactory bulb	tissue	9.0
Basal ganglia	tissue	8.9
Caudate putamen	tissue	8.6
Superior colliculi	tissue	8.0
Putamen	tissue	7.8
Epididymis	tissue	7.0
Choroid plexus	tissue	6.5
Medulla oblongata	tissue	6.0
Cervix	tissue	4.5
Vagina	tissue	2.6
Ovary	tissue	2.5
Esophagus	tissue	2.2
Skeletal muscle	tissue	2.2
Adipose tissue	tissue	1.8
Tongue	tissue	1.8
Gallbladder	tissue	1.8
Spleen	tissue	1.6
Corpus callosum	tissue	1.6
Endometrium 1	tissue	1.5
Pituitary gland	tissue	1.4
Skin 1	tissue	1.4
Smooth muscle	tissue	1.3
Breast	tissue	1.1
Lung	tissue	1.1
Thymus	tissue	1.1
Heart muscle	tissue	0.9
Urinary bladder	tissue	0.9
Salivary gland	tissue	0.7
Placenta	tissue	0.7
Retina	tissue	0.6
Colon	tissue	0.6
Rectum	tissue	0.5
Fallopian tube	tissue	0.5
Cerebellum	tissue	0.4

Brain sub-regions (HPA Brain Atlas): detected in 189; highest nTPM — Olfactory area (34.2), Stria terminalis, bed nucleus (33.9), Olfactory tubercle (32.8), Precentral gyrus (31.2), Ventromedial nucleus (31.2).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting PRRG3 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

showing 30 of 37 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-12133	99.92	71.82	2006
HSA-MIR-1271-5P	99.91	71.99	1972
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-5002-5P	99.76	70.84	1763
HSA-MIR-3975	99.62	65.97	697
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084
HSA-MIR-186-3P	99.51	66.24	1685
HSA-MIR-4687-3P	99.48	66.41	968
HSA-MIR-4318	99.38	66.94	1505
HSA-MIR-3978	99.24	68.39	2201
HSA-MIR-593-3P	99.22	67.28	1327
HSA-MIR-196A-3P	99.19	67.34	1204
HSA-MIR-6734-3P	99.15	66.27	1627
HSA-MIR-4695-5P	99.06	64.87	1151
HSA-MIR-6852-3P	98.54	67.60	1468
HSA-MIR-6792-3P	98.41	66.86	1359
HSA-MIR-4691-5P	98.41	66.77	1343
HSA-MIR-891A-3P	98.05	67.99	970
HSA-MIR-4443	98.02	66.25	1928
HSA-MIR-3936	97.64	64.47	732

Functional genomics

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000674457 — one region, missense o/e 1.25.

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:dkey-38k9.5	ENSDARG00000079102
mus_musculus	Prrg3	ENSMUSG00000033361
rattus_norvegicus	Prrg3	ENSRNOG00000066176

Paralogs (3): PRRG1 (ENSG00000130962), PRRG4 (ENSG00000135378), OVCH2 (ENSG00000183378)

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Pongo abelii	Q5RCB6	99.5%	Diamond
Macaca mulatta	Q28520	96.0%	Diamond
Bos taurus	A7Z070	94.0%	Diamond
Oryctolagus cuniculus	P98118	83.1%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
PASD1	protein-coding	139135
VMA21	protein-coding	203547
MAGEA4-AS1	ncRNA	105373368
MAGEA4	protein-coding	4103
FATE1	protein-coding	89885
CNGA2	protein-coding	1260

Protein

Protein identifiers

Transmembrane gamma-carboxyglutamic acid protein 3 — Q9BZD7 (reviewed: Q9BZD7)

Alternative names: Proline-rich gamma-carboxyglutamic acid protein 3

All UniProt accessions (6): Q9BZD7, A0A494BZY9, A0A6I8PL69, A6NDZ7, C9J7E6, H7C0C2

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Tissue specificity. Expressed in brain, lung, kidney and heart.

Post-translational modifications. Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.

RefSeq proteins (3): NP_001359092, NP_001359094, NP_076987 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000294	GLA_domain	Domain
IPR017857	Coagulation_fac-like_Gla_dom	Homologous_superfamily
IPR035972	GLA-like_dom_SF	Homologous_superfamily
IPR050442	Peptidase_S1_coag_factors	Family

Pfam: PF00594

UniProt features (25 total): modified residue 13, topological domain 2, region of interest 2, propeptide 1, chain 1, disulfide bond 1, sequence variant 1, sequence conflict 1, transmembrane region 1, domain 1, compositionally biased region 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BZD7-F1	64.48	0.10

Human Protein Atlas

Protein class: Predicted membrane proteins, Predicted intracellular proteins, UniProt - Evidence at transcript level

Protein evidence: Evidence at protein level

Antibody reliability (HPA): IH uncertain

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (13)

Type	Positions
4-carboxyglutamate	25, 26, 33, 35, 38, 39, 44, 45, 48, 51, 54, 58, 22

Disulfide bonds (1)

Type	Positions
Disulfide bond	36–41

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 64 (showing top): GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_UP, GOBP_WOUND_HEALING, RYTTCCTG_ETS2_B, GOBP_HEMOSTASIS, MODULE_48, MODULE_95, GOBP_REGULATION_OF_BODY_FLUID_LEVELS, GOBP_PROTEOLYSIS, GOMF_PEPTIDASE_ACTIVITY, MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED, chrXq28, PILON_KLF1_TARGETS_UP, MODULE_163, P53_DN.V2_UP, LMTK3_TARGET_GENES

GO Biological Process (2): proteolysis (GO:0006508), blood coagulation (GO:0007596)

GO Molecular Function (2): serine-type endopeptidase activity (GO:0004252), calcium ion binding (GO:0005509)

GO Cellular Component (2): membrane (GO:0016020), extracellular region (GO:0005576)

GO top-level categories

8 GO namespaces:

Category	Terms
cellular anatomical structure	2
protein metabolic process	1
hemostasis	1
wound healing	1
coagulation	1
endopeptidase activity	1
serine-type peptidase activity	1
metal ion binding	1

Protein interactions and networks

STRING

showing 15 of 274 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PRRG3	GGCX	P38435	490
PRRG3	CCDC116	Q8IYX3	466
PRRG3	SSX3	Q99909	456
PRRG3	UCMA	Q8WVF2	443
PRRG3	LRRC52	Q8N7C0	416
PRRG3	RNASE10	Q5GAN6	385
PRRG3	AGFG2	O95081	360
PRRG3	LRRC23	Q53EV4	356
PRRG3	MGP	P08493	352
PRRG3	ZNF3	P13683	351
PRRG3	RFX7	Q2KHR2	351
PRRG3	KANK3	Q6NY19	347
PRRG3	GALNT15	Q8N3T1	345
PRRG3	B4GALT4	O60513	345
PRRG3	TCF23	Q7RTU1	329

IntAct

Human interaction partners of PRRG3 in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

1 partners by confidence:

Partner	Interaction type	MIscore	Records
NEDD4	association	0.350	2

BioGRID (9 interactions; top human partners by supporting records): NDFIP1 (Affinity Capture-MS; 3 records), NEDD4L (Affinity Capture-MS; 3 records), NEDD4 (Affinity Capture-MS; 2 records), RNF149 (Affinity Capture-MS)

Disease & clinical

Genetic variants

Variant evidence for PRRG3: 58 ClinVar records (0 pathogenic / likely pathogenic).

ClinVar

58 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	43
Likely benign	2
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 26 predictions of 527):

Position(s)	Effect	Δscore	Sites
X:151700114	donor_gain	1.0000
X:151700130	donor_gain	1.0000
X:151695545–151695546	donor_loss	0.9900	5
X:151698782–151698783	acceptor_loss	0.9900	6
X:151700131	donor_gain	0.9900
X:151700504–151700505	acceptor_loss	0.9900	5
X:151695546	donor_loss	0.9800
X:151698778	acceptor_gain	0.9800
X:151698822–151698823	donor_loss	0.9800	4
X:151698823	acceptor_loss	0.9800

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

1 prognostic cancer types:

Cancer	Prognostic	p-value
Glioblastoma Multiforme (TCGA)	unfavorable	0.000143

Disease associations

OMIM: gene MIM:300685 | disease phenotypes:

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation, affects cotreatment, decreases expression	4
bisphenol F	affects cotreatment, decreases expression	1
sodium arsenite	increases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Vorinostat	decreases expression	1
Benzo(a)pyrene	decreases methylation, affects methylation	1
Dexamethasone	decreases expression, affects cotreatment	1
Indomethacin	affects cotreatment, decreases expression	1
Nickel	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1
Antirheumatic Agents	increases expression	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.