PRRT3-AS1

Summary

PRRT3-AS1 (PRRT3 antisense RNA 1, HGNC:41151) is a long non-coding RNA gene on chromosome 3p25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41151
Approved symbol	PRRT3-AS1
Name	PRRT3 antisense RNA 1
Location	3p25.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230082
Ensembl biotype	lncRNA
OMIM	619106
Entrez	100874032
RNAcentral	URS0000008D1D — lncRNA, 614 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000431558, ENST00000773194, ENST00000773195, ENST00000773196, ENST00000773197, ENST00000773198

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000431558 — 4 exons

Exon	Start	End
ENSE00001613089	9948067	9948180
ENSE00001638215	9948355	9948469
ENSE00004137949	9954604	9954793
ENSE00004137951	9947357	9947604

Expression profiles

Bgee: expression breadth ubiquitous, 215 present calls, max score 85.62.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.5542 / max 54.5147, expressed in 963 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
35264	2.5542	963

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	85.62	gold quality
gastrocnemius	UBERON:0001388	85.10	gold quality
muscle of leg	UBERON:0001383	84.11	gold quality
tibialis anterior	UBERON:0001385	83.50	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.98	silver quality
deltoid	UBERON:0001476	82.85	gold quality
quadriceps femoris	UBERON:0001377	82.40	silver quality
vastus lateralis	UBERON:0001379	81.68	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	80.16	gold quality
left ventricle myocardium	UBERON:0006566	79.92	gold quality
skeletal muscle tissue	UBERON:0001134	78.48	gold quality
biceps brachii	UBERON:0001507	78.03	gold quality
muscle tissue	UBERON:0002385	77.63	gold quality
adipose tissue	UBERON:0001013	77.24	gold quality
adipose tissue of abdominal region	UBERON:0007808	76.64	gold quality
omental fat pad	UBERON:0010414	76.18	gold quality
peritoneum	UBERON:0002358	76.13	gold quality
ileal mucosa	UBERON:0000331	74.90	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	74.86	gold quality
sural nerve	UBERON:0015488	74.71	gold quality
mucosa of transverse colon	UBERON:0004991	74.70	gold quality
subcutaneous adipose tissue	UBERON:0002190	74.63	gold quality
left coronary artery	UBERON:0001626	74.55	gold quality
tibial nerve	UBERON:0001323	74.39	gold quality
coronary artery	UBERON:0001621	74.00	gold quality
body of pancreas	UBERON:0001150	73.99	gold quality
germinal epithelium of ovary	UBERON:0001304	73.72	silver quality
colonic epithelium	UBERON:0000397	72.57	gold quality
mucosa of paranasal sinus	UBERON:0005030	72.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	72.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Long non-coding RNA PRRT3-AS1 silencing inhibits prostate cancer cell proliferation and promotes apoptosis and autophagy. (PMID:32086850)
• The integration of single-cell sequencing, TCGA, and GEO data analysis revealed that PRRT3-AS1 is a biomarker and therapeutic target of SKCM. (PMID:36211371)
• LncRNA PRRT3-AS1 exerts oncogenic effects on nonsmall cell lung cancer by targeting microRNA-507/homeobox B5 axis. (PMID:37304647)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.