PRSS23

Summary

PRSS23 (serine protease 23, HGNC:14370) is a protein-coding gene on chromosome 11q14.2, encoding Serine protease 23 (O95084).

This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 11098 — RefSeq curated summary.

At a glance

• GWAS associations: 13
• Clinical variants (ClinVar): 147 total — 4 pathogenic, 5 likely-pathogenic
• MANE Select transcript: NM_007173

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14370
Approved symbol	PRSS23
Name	serine protease 23
Location	11q14.2
Locus type	gene with protein product
Status	Approved
Aliases	SPUVE, SIG13
Ensembl gene	ENSG00000150687
Ensembl biotype	protein_coding
OMIM	618376
Entrez	11098

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 8 protein_coding, 4 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000280258, ENST00000527521, ENST00000528769, ENST00000531475, ENST00000531521, ENST00000532234, ENST00000532572, ENST00000533880, ENST00000533902, ENST00000893185, ENST00000893186, ENST00000915854, ENST00000965678, ENST00000965679

RefSeq mRNA: 3 — MANE Select: NM_007173 NM_001293179, NM_001293180, NM_007173

CCDS: CCDS8278

Canonical transcript exons

ENST00000280258 — 2 exons

Exon	Start	End
ENSE00001315190	86807631	86811233
ENSE00002145691	86800542	86800651

Expression profiles

Bgee: expression breadth ubiquitous, 289 present calls, max score 99.65.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 213.4842 / max 2359.2879, expressed in 1593 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
116127	200.8979	1587
116126	11.9869	1384
116128	0.4406	264
116125	0.1587	31

Top tissues by expression

297 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nasal cavity epithelium	UBERON:0005384	99.65	gold quality
nasal cavity mucosa	UBERON:0001826	99.13	gold quality
mucosa of paranasal sinus	UBERON:0005030	99.06	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	99.00	gold quality
cartilage tissue	UBERON:0002418	98.88	gold quality
endometrium epithelium	UBERON:0004811	98.86	gold quality
right coronary artery	UBERON:0001625	98.81	gold quality
saphenous vein	UBERON:0007318	98.50	gold quality
decidua	UBERON:0002450	98.41	gold quality
urethra	UBERON:0000057	98.40	gold quality
epithelium of bronchus	UBERON:0002031	98.21	gold quality
bronchus	UBERON:0002185	98.20	gold quality
bronchial epithelial cell	CL:0002328	98.08	gold quality
cauda epididymis	UBERON:0004360	97.96	gold quality
trachea	UBERON:0003126	97.90	gold quality
gall bladder	UBERON:0002110	97.77	gold quality
smooth muscle tissue	UBERON:0001135	97.73	gold quality
epithelium of nasopharynx	UBERON:0001951	97.72	gold quality
nasopharynx	UBERON:0001728	97.70	gold quality
descending thoracic aorta	UBERON:0002345	97.46	gold quality
islet of Langerhans	UBERON:0000006	97.27	gold quality
colonic epithelium	UBERON:0000397	97.24	gold quality
popliteal artery	UBERON:0002250	97.16	gold quality
tibial artery	UBERON:0007610	97.15	gold quality
aorta	UBERON:0000947	97.14	gold quality
ascending aorta	UBERON:0001496	97.13	gold quality
thoracic aorta	UBERON:0001515	97.13	gold quality
seminal vesicle	UBERON:0000998	97.06	gold quality
right lung	UBERON:0002167	97.02	gold quality
stromal cell of endometrium	CL:0002255	96.95	gold quality

Single-cell (SCXA)

Detected in 28 experiment(s), a significant marker in 26.

Experiment	Marker?	Max mean expression
E-HCAD-9	yes	2293.42
E-MTAB-10553	yes	2233.17
E-CURD-126	yes	2216.61
E-MTAB-7051	yes	2062.00
E-GEOD-134144	yes	1600.82
E-MTAB-6308	yes	1470.57
E-CURD-114	yes	1312.73
E-GEOD-114530	yes	1164.57
E-MTAB-8142	yes	1162.54
E-GEOD-124472	yes	946.05
E-MTAB-7052	yes	934.13
E-GEOD-135922	yes	867.13
E-MTAB-3929	yes	666.47
E-MTAB-6701	yes	122.51
E-HCAD-1	yes	49.45

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ESR1

miRNA regulators (miRDB)

98 targeting PRSS23, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-6772-5P	99.94	67.01	577
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-6079	99.84	68.54	1170
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548AJ-5P	99.78	71.12	3085

Literature-anchored findings (GeneRIF, showing 4)

• PRSS23 might be a critical component of estrogen-mediated cell proliferation of ERalpha-positive breast cancer cells. (PMID:22291950)
• PRSS23 knockdown could suppress tumor growth of gastric cancer in vitro and in vivo through inhibiting EIF2 signaling, and EIF4E maybe a potential target of PRSS23. PRSS23 could serve as a potential target for gastric cancer therapy, and also a biomarker for the prediction of prognosis of gastric cancer. (PMID:30769097)
• Exosomal microRNA-1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure. (PMID:34270841)
• Serine protease PRSS23 drives gastric cancer by enhancing tumor associated macrophage infiltration via FGF2. (PMID:36189305)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Prss23	ENSMUSG00000039405
rattus_norvegicus	Prss23	ENSRNOG00000017307

Paralogs (1): PRSS35 (ENSG00000146250)

Protein

Protein identifiers

Serine protease 23 — O95084 (reviewed: O95084)

Alternative names: Putative secreted protein Zsig13

All UniProt accessions (4): O95084, E9PIB7, E9PMX2, E9PRR2

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Secreted.

Similarity. Belongs to the peptidase S1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
O95084-1	1	yes
O95084-2	2

RefSeq proteins (3): NP_001280108, NP_001280109, NP_009104* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001254	Trypsin_dom	Domain
IPR009003	Peptidase_S1_PA	Homologous_superfamily
IPR018114	TRYPSIN_HIS	Active_site
IPR043504
IPR050966	Glutamyl_endopeptidase	Family

Pfam: PF00089

UniProt features (10 total): active site 3, glycosylation site 2, signal peptide 1, chain 1, modified residue 1, disulfide bond 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95084-F1	82.18	0.56

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (3): 175 (charge relay system); 240 (charge relay system); 316 (charge relay system)

Post-translational modifications (1): 109

Disulfide bonds (1): 160–176

Glycosylation sites (2): 93, 207

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275	Post-translational protein phosphorylation

MSigDB gene sets: 277 (showing top): MODULE_172, MODULE_52, BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN, LEE_NEURAL_CREST_STEM_CELL_DN, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_DN, TSENG_IRS1_TARGETS_UP, KAAB_HEART_ATRIUM_VS_VENTRICLE_UP, GOZGIT_ESR1_TARGETS_DN, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP, DITTMER_PTHLH_TARGETS_UP, KYNG_DNA_DAMAGE_DN, BRUECKNER_TARGETS_OF_MIRLET7A3_DN, HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_UP

GO Biological Process (1): proteolysis (GO:0006508)

GO Molecular Function (5): serine-type endopeptidase activity (GO:0004252), protein binding (GO:0005515), peptidase activity (GO:0008233), serine-type peptidase activity (GO:0008236), hydrolase activity (GO:0016787)

GO Cellular Component (4): nucleus (GO:0005634), endoplasmic reticulum lumen (GO:0005788), extracellular exosome (GO:0070062), extracellular region (GO:0005576)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Metabolism of proteins	1
Post-translational protein modification	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein metabolic process	1
endopeptidase activity	1
serine-type peptidase activity	1
binding	1
hydrolase activity	1
catalytic activity, acting on a protein	1
peptidase activity	1
serine hydrolase activity	1
catalytic activity	1
intracellular membrane-bounded organelle	1
endoplasmic reticulum	1
intracellular organelle lumen	1
extracellular vesicle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

858 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PRSS23	FAM20A	Q96MK3	553
PRSS23	WFDC2	Q14508	547
PRSS23	ODF2L	Q9ULJ1	497
PRSS23	MXRA8	Q9BRK3	452
PRSS23	SERPINA11	Q86U17	440
PRSS23	FAM181B	A6NEQ2	434
PRSS23	SERPINA3	P01011	422
PRSS23	F2RL3	Q96RI0	419
PRSS23	SERPINA10	Q9UK55	419
PRSS23	SERPINA9	Q86WD7	419
PRSS23	SERPINA4	P29622	407
PRSS23	SERPINA12	Q8IW75	401
PRSS23	WFS1	O76024	396
PRSS23	SERPINA6	P08185	396
PRSS23	COL6A2	P12110	393

IntAct

56 interactions, top by confidence:

A	B	Type	Score
PRSS23	SEC11C	psi-mi:“MI:0915”(physical association)	0.560
KLRG2	GXYLT2	psi-mi:“MI:0914”(association)	0.530
PRSS23	COL5A1	psi-mi:“MI:0914”(association)	0.530
CRP	QSOX1	psi-mi:“MI:0914”(association)	0.530
PRSS23	H1-0	psi-mi:“MI:0915”(physical association)	0.400
Ppp2r1a	CCHCR1	psi-mi:“MI:0914”(association)	0.350
Cep152	SH3PXD2B	psi-mi:“MI:0914”(association)	0.350
Nup98	POM121C	psi-mi:“MI:0914”(association)	0.350
Snw1	AKR7A2	psi-mi:“MI:0914”(association)	0.350
CTR9	POLR2B	psi-mi:“MI:0914”(association)	0.350
Rbm8a	GOSR1	psi-mi:“MI:0914”(association)	0.350
Ube2i	POM121C	psi-mi:“MI:0914”(association)	0.350
Nfyc	BDP1	psi-mi:“MI:0914”(association)	0.350
TENT5A	GOLGA8R	psi-mi:“MI:0914”(association)	0.350
BAX	BDP1	psi-mi:“MI:0914”(association)	0.350
NOP9	ENDOV	psi-mi:“MI:0914”(association)	0.350
SRPRA	PKD2	psi-mi:“MI:0914”(association)	0.350
SCGB2A2	GXYLT2	psi-mi:“MI:0914”(association)	0.350
CRP	QSOX1	psi-mi:“MI:0914”(association)	0.350
PDGFRA	GXYLT2	psi-mi:“MI:0914”(association)	0.350
CCL3	KRBA1	psi-mi:“MI:0914”(association)	0.350
C1orf54	AGRN	psi-mi:“MI:0914”(association)	0.350
C1QTNF7	AGRN	psi-mi:“MI:0914”(association)	0.350
CRLF1	PRSS23	psi-mi:“MI:0914”(association)	0.350
PRSS23	HBD	psi-mi:“MI:0914”(association)	0.350
CDH5	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
PRSS23	SEC11C	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (68): ACTB (Affinity Capture-MS), LRP2 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS), PRSS23 (Affinity Capture-MS)

ESM2 similar proteins: A4VCL2, O19112, O62589, O73797, O75072, O75339, O95084, P13721, P18292, P19221, P30432, P79701, Q08629, Q09101, Q0VBN2, Q0WQD2, Q1LZE9, Q1WK23, Q1WK24, Q4G148, Q5E9X7, Q5K027, Q5R212, Q5R537, Q5XIL2, Q5XV99, Q60HG0, Q62288, Q66K08, Q6AY61, Q701R0, Q701R1, Q701R2, Q8C0F9, Q8CBQ5, Q8GWW4, Q8GZ81, Q8IZU8, Q8N3Z0, Q8R507

Diamond homologs: O19045, O46644, O95084, Q1LZE9, Q1WK23, Q1WK24, Q5E9X7, Q5R212, Q63207, Q6AY61, Q8C0F9, Q8N3Z0, Q9D6X6, P08217

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

147 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	4
Likely pathogenic	5
Uncertain significance	107
Likely benign	6
Benign	21

Top pathogenic / likely-pathogenic (9)

Variant ID	HGVS	Classification
1076601	NM_012193.4(FZD4):c.1510_1528del (p.Trp504fs)	Pathogenic
2858425	NM_012193.4(FZD4):c.647del (p.Lys216fs)	Pathogenic
523865	NM_012193.4(FZD4):c.666G>A (p.Trp222Ter)	Pathogenic
5486	NM_012193.4(FZD4):c.1250G>A (p.Arg417Gln)	Pathogenic
2735717	NM_012193.4(FZD4):c.314T>C (p.Met105Thr)	Likely pathogenic
3382395	NM_012193.4(FZD4):c.1051G>C (p.Ala351Pro)	Likely pathogenic
4293656	NM_012193.4(FZD4):c.1512G>A (p.Trp504Ter)	Likely pathogenic
450699	NM_012193.4(FZD4):c.1218TGC[1] (p.Ala408del)	Likely pathogenic
929303	NM_012193.4(FZD4):c.615del (p.Tyr206fs)	Likely pathogenic

SpliceAI

551 predictions. Top by Δscore:

Variant	Effect	Δscore
11:86800342:G:T	donor_gain	1.0000
11:86800405:G:T	donor_gain	0.9900
11:86952450:A:C	acceptor_gain	0.9900
11:86807630:GAACA:G	acceptor_gain	0.9800
11:86952449:C:CT	acceptor_gain	0.9800
11:86800650:GG:G	donor_gain	0.9700
11:86800651:GG:G	donor_gain	0.9700
11:86952471:C:CC	acceptor_gain	0.9700
11:86800341:G:GT	donor_gain	0.9600
11:86800648:GCGG:G	donor_gain	0.9600
11:86800649:CGGGT:C	donor_loss	0.9600
11:86800650:GGGTG:G	donor_loss	0.9600
11:86800652:G:A	donor_loss	0.9600
11:86800653:T:A	donor_loss	0.9600
11:86800654:G:GC	donor_loss	0.9600
11:86800655:AGTG:A	donor_loss	0.9600
11:86800342:G:GT	donor_gain	0.9500
11:86800652:G:GG	donor_gain	0.9500
11:86800405:G:GT	donor_gain	0.9400
11:86807629:A:AG	acceptor_gain	0.9300
11:86807630:G:GG	acceptor_gain	0.9300
11:86952468:GAA:G	acceptor_gain	0.9300
11:86800418:GTT:G	donor_gain	0.9200
11:86800419:TTT:T	donor_gain	0.9200
11:86952443:T:TC	acceptor_gain	0.9200
11:86804650:GTT:G	acceptor_gain	0.9100
11:86952262:TCATC:T	donor_gain	0.9100
11:86952467:AGAA:A	acceptor_gain	0.9100
11:86800357:GCCC:G	donor_gain	0.9000
11:86952441:C:CT	acceptor_gain	0.9000

AlphaMissense

2496 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:86808050:G:C	R136T	1.000
11:86808050:G:T	R136M	1.000
11:86808091:T:C	F150L	1.000
11:86808092:T:G	F150C	1.000
11:86808093:C:A	F150L	1.000
11:86808093:C:G	F150L	1.000
11:86808121:T:A	C160S	1.000
11:86808121:T:C	C160R	1.000
11:86808122:G:A	C160Y	1.000
11:86808122:G:C	C160S	1.000
11:86808122:G:T	C160F	1.000
11:86808123:C:G	C160W	1.000
11:86808127:G:C	G162R	1.000
11:86808128:G:A	G162D	1.000
11:86808152:T:A	V170D	1.000
11:86808155:T:A	L171H	1.000
11:86808155:T:C	L171P	1.000
11:86808164:C:A	A174D	1.000
11:86808169:T:A	C176S	1.000
11:86808169:T:C	C176R	1.000
11:86808170:G:A	C176Y	1.000
11:86808170:G:C	C176S	1.000
11:86808170:G:T	C176F	1.000
11:86808171:C:G	C176W	1.000
11:86808221:G:A	G193D	1.000
11:86808340:T:A	W233R	1.000
11:86808340:T:C	W233R	1.000
11:86808342:G:C	W233C	1.000
11:86808342:G:T	W233C	1.000
11:86808380:A:T	D246V	1.000

dbSNP variants (sampled 300 via entrez): RS1000001306 (11:86842740 A>C,G), RS1000021698 (11:86875295 C>A,T), RS1000033568 (11:86837357 A>G,T), RS1000097327 (11:86791958 G>A), RS1000128536 (11:86800721 A>T), RS1000162222 (11:86857294 C>A,G), RS1000168492 (11:86820423 G>A), RS1000170107 (11:86940968 G>C), RS1000202493 (11:86873933 T>A), RS1000227263 (11:86894687 G>A), RS1000240633 (11:86890343 C>A,T), RS1000284752 (11:86912878 T>C), RS1000309800 (11:86823722 G>A,C), RS1000330994 (11:86846990 A>T), RS1000361602 (11:86823822 C>T)

Disease associations

OMIM: gene MIM:618376 | disease phenotypes: MIM:133780

GenCC curated gene-disease

Mondo (1): exudative vitreoretinopathy 1 (MONDO:0007589)

Orphanet (2): Familial exudative vitreoretinopathy (Orphanet:891), Retinopathy of prematurity (Orphanet:90050)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

Study	Trait	p-value
GCST004183_16	Lung function (FEV1)	9.000000e-09
GCST005580_252	Intraocular pressure	2.000000e-10
GCST005580_268	Intraocular pressure	4.000000e-10
GCST006288_186	Heel bone mineral density	3.000000e-07
GCST006288_425	Heel bone mineral density	8.000000e-06
GCST006288_46	Heel bone mineral density	1.000000e-11
GCST006412_6	Intraocular pressure	6.000000e-10
GCST006979_411	Heel bone mineral density	9.000000e-61
GCST007430_118	Peak expiratory flow	5.000000e-10
GCST007431_162	Lung function (FEV1/FVC)	5.000000e-20
GCST007432_144	FEV1	2.000000e-13
GCST007692_67	Chronic obstructive pulmonary disease	7.000000e-10
GCST008062_79	Blood urea nitrogen levels	6.000000e-13

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0004314	forced expiratory volume
EFO:0004695	intraocular pressure measurement
EFO:0009270	heel bone mineral density
EFO:0009718	peak expiratory flow
EFO:0004713	FEV/FVC ratio

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C536382	Exudative vitreoretinopathy 1 (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs10898563	FZD4, PRSS23		0.00	0

CTD chemical–gene interactions

103 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Estradiol	increases reaction, decreases reaction, affects cotreatment, decreases expression, increases expression	12
Valproic Acid	decreases expression, increases expression, affects cotreatment	8
bisphenol A	decreases reaction, affects expression, increases expression, affects cotreatment, increases methylation (+1 more)	5
Benzo(a)pyrene	affects methylation, increases expression	5
methylmercuric chloride	decreases expression, affects cotreatment	4
Particulate Matter	decreases expression, increases abundance, affects cotreatment, increases expression	4
trichostatin A	affects cotreatment, decreases expression	3
Ethinyl Estradiol	decreases expression, affects expression	3
Tetrachlorodibenzodioxin	affects cotreatment, decreases expression, affects expression, increases expression	3
Tobacco Smoke Pollution	decreases expression, decreases methylation	3
Genistein	decreases reaction, increases expression, decreases expression	3
sodium arsenite	increases abundance, increases expression	2
cobaltous chloride	decreases expression	2
mercuric bromide	decreases expression, affects cotreatment	2
perfluorooctane sulfonic acid	decreases expression	2
entinostat	decreases expression, affects cotreatment	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression, decreases expression	2
belinostat	decreases expression, affects cotreatment	2
Resveratrol	affects cotreatment, increases expression, decreases expression	2
Fulvestrant	affects cotreatment, increases methylation, decreases expression	2
Vorinostat	affects cotreatment, decreases expression	2
Panobinostat	affects cotreatment, decreases expression	2
Air Pollutants	decreases expression, increases abundance	2
Copper	affects cotreatment, increases expression, affects binding	2
Doxorubicin	increases expression	2
Nickel	increases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Progesterone	decreases expression, increases expression	2
Cyclosporine	decreases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, decreases expression	2

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2CA	Abcam HeLa PRSS23 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.