PSMA3-AS1

Summary

PSMA3-AS1 (PSMA3 antisense RNA 1, HGNC:26445) is a long non-coding RNA gene on chromosome 14q23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26445
Approved symbol	PSMA3-AS1
Name	PSMA3 antisense RNA 1
Location	14q23.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ31306
Ensembl gene	ENSG00000257621
Ensembl biotype	lncRNA
Entrez	379025
RNAcentral	URS000075C5A6 — lncRNA, 2498 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000551597, ENST00000553657, ENST00000554309, ENST00000554360, ENST00000554378, ENST00000555037, ENST00000555162, ENST00000555275, ENST00000555707, ENST00000556002, ENST00000556225, ENST00000556400, ENST00000557412, ENST00000557660, ENST00000654187, ENST00000667365, ENST00000787645, ENST00000787646

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000551597 — 4 exons

Exon	Start	End
ENSE00002353095	58293314	58293544
ENSE00002460407	58285732	58285756
ENSE00002486815	58297955	58298132
ENSE00003543448	58291635	58291707

Expression profiles

Bgee: expression breadth ubiquitous, 252 present calls, max score 98.04.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 48.8892 / max 520.5188, expressed in 1818 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
143432	48.8892	1818
143429	5.1085	1411

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	98.04	gold quality
thymus	UBERON:0002370	97.33	gold quality
left ovary	UBERON:0002119	97.21	gold quality
left lobe of thyroid gland	UBERON:0001120	97.17	gold quality
right lobe of thyroid gland	UBERON:0001119	97.09	gold quality
spleen	UBERON:0002106	97.00	gold quality
right ovary	UBERON:0002118	97.00	gold quality
adenohypophysis	UBERON:0002196	96.94	gold quality
monocyte	CL:0000576	96.85	gold quality
thyroid gland	UBERON:0002046	96.82	gold quality
body of pancreas	UBERON:0001150	96.69	gold quality
endocervix	UBERON:0000458	96.67	gold quality
left uterine tube	UBERON:0001303	96.64	gold quality
small intestine Peyer’s patch	UBERON:0003454	96.57	gold quality
leukocyte	CL:0000738	96.56	gold quality
body of uterus	UBERON:0009853	96.53	gold quality
vermiform appendix	UBERON:0001154	96.51	gold quality
cerebellar hemisphere	UBERON:0002245	96.51	gold quality
pituitary gland	UBERON:0000007	96.47	gold quality
lymph node	UBERON:0000029	96.45	gold quality
cerebellar cortex	UBERON:0002129	96.45	gold quality
metanephros cortex	UBERON:0010533	96.40	gold quality
right lung	UBERON:0002167	96.38	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.25	gold quality
cerebellum	UBERON:0002037	95.88	gold quality
bone marrow cell	CL:0002092	95.87	gold quality
rectum	UBERON:0001052	95.87	gold quality
ectocervix	UBERON:0012249	95.87	gold quality
colonic epithelium	UBERON:0000397	95.76	gold quality
tibial nerve	UBERON:0001323	95.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	15.69

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Study identified that PSMA3 and PSMA3-AS1 in mesenchymal stem cells (MSCs) could be packaged into exosomes and transferred to myeloma cells, thus promoting proteasome inhibitor resistance through a novel exosomal PSMA3-AS1/PSMA3 signaling pathway. PSMA3-AS1 could form an RNA duplex with pre-PSMA3, which transcriptionally promoted PSMA3 expression by increasing its stability. (PMID:30610101)
• Long noncoding RNA PSMA3AS1 functions as a microRNA4093p sponge to promote the progression of nonsmall cell lung carcinoma by targeting spindlin 1. (PMID:32945481)
• LncRNA PSMA3-AS1 promotes colorectal cancer cell migration and invasion via regulating miR-4429. (PMID:33275226)
• Long non-coding RNA PSMA3-AS1 promotes glioma progression through modulating the miR-411-3p/HOXA10 pathway. (PMID:34294084)
• Targeting lncRNA PSMA3-AS1, a Prognostic Marker, Suppresses Malignant Progression of Oral Squamous Cell Carcinoma. (PMID:34457087)
• lncRNA PSMA3-AS1 promotes the progression of non-small cell lung cancer through targeting miR-17-5p/PD-L1. (PMID:34610219)
• YY1-induced long non-coding RNA PSMA3 antisense RNA 1 functions as a competing endogenous RNA for microRNA 214-5p to expedite the viability and restrict the apoptosis of bladder cancer cells via regulating programmed cell death-ligand 1. (PMID:34720049)
• METTL3 affects FLT3-ITD+ acute myeloid leukemia by mediating autophagy by regulating PSMA3-AS1 stability. (PMID:37088992)
• LncRNA PSMA3-AS1 promotes preterm delivery by inducing ferroptosis via miR-224-3p/Nrf2 axis. (PMID:38158666)
• LncRNA PSMA3-AS1 activates the progression of triple-negative breast cancer cells by blocking miR-186-5p-mediated PSME3 inhibition. (PMID:38279473)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.